Tayssir Ben Achour, Sabrina Khelifa, Maysam Jridi, Ines Naceur, Fatma Said, Monia Smiti
{"title":"Renal AA amyloidosis following COVID-19 infection.","authors":"Tayssir Ben Achour, Sabrina Khelifa, Maysam Jridi, Ines Naceur, Fatma Said, Monia Smiti","doi":"10.1684/ndt.2025.151","DOIUrl":"10.1684/ndt.2025.151","url":null,"abstract":"<p><p>Primarily a respiratory illness, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has a range of extra-pulmonary involvement, including the kidneys, which are often affected. This infection has been associated with the overproduction of serum amyloid A protein, resulting in systemic AA amyloidosis. We report a case of renal AA amyloidosis presenting as a nephrotic syndrome in a patient without any underlying risk factor except COVID-19 infection. This article offers preliminary insights into a potential connection between this emerging viral disease and this complication, awaiting confirmation through future research.</p>","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 6","pages":"525-529"},"PeriodicalIF":0.7,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145566829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adèle Carré, Valérie Chatelet, Claire Presne, Antoine Lanot
{"title":"Rhodococcus equi infections in kidney transplant patients: Three case reports and a review of the literature","authors":"Adèle Carré, Valérie Chatelet, Claire Presne, Antoine Lanot","doi":"10.1684/ndt.2025.148","DOIUrl":"10.1684/ndt.2025.148","url":null,"abstract":"<p><p>Rhodococcus equi is an aerobic actinomycete initially identified in foal pneumonia and later recognized as an opportunistic human pathogen, particularly affecting immunocompromised individuals. Its incidence increased during the AIDS pandemic and with the rise of organ transplantation. Both cellular and humoral immunity contribute to host defense against R. equi, which is typically acquired through inhalation or ingestion of contaminated materials. The bacterium causes pneumonia that frequently progresses to lung cavitation, bacteremia, and potential dissemination to other organs.\u0000We report three cases of R. equi infection in renal transplant patients and review 35 previously published cases. The median age was 49 years, with a male predominance. Most patients presented with necrotizing pneumonia, often associated with bacteremia and soft tissue involvement. Treatment involved reducing immunosuppressive therapy, using bactericidal and intracellularly active antibiotics, and considering surgery when necessary. Prolonged antibiotic therapy and secondary prophylaxis are recommended. Mortality associated with this infection remains high, highlighting the need for early diagnosis and comprehensive treatment strategies.\u0000This report emphasizes the importance of considering infectious causes, such as R. equi, in the differential diagnosis of pulmonary masses in immunocompromised patients. Early diagnosis and combined antibiotic therapy are crucial. Lobectomy, though high-risk, may be required for durable infection control when antibiotic therapy is insufficient.</p>","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 6","pages":"537-544"},"PeriodicalIF":0.7,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145423715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quality of life for dialysis patients: Projects and tools for care teams (DialiCare)","authors":"Pierre-Antoine Michel","doi":"10.1684/ndt.2025.133","DOIUrl":"https://doi.org/10.1684/ndt.2025.133","url":null,"abstract":"<p><p>Chronic kidney disease and dialysis have a major impact on patients’ quality of life, affecting their physical, psychological, and social well-being. The DialiCare project, conducted in partnership with an industry stakeholder and health care professionals involved in dialysis care, aims to address these challenges through a collaborative, patient-centered approach.\u0000Structured in two phases, the project first identified the priority needs of patients and health care professionals through surveys and regional working groups. Various project proposals were then submitted to a jury made up of a patient association (France Rein), two professional associations (ANFIPA and AFIDTN), and health care professionals who had participated in the initiative. Three projects were selected. The second phase led to the cocreation of three innovative educational tools: the “Roue du prurit” (Itch Wheel), the “Évadez-vous” (“Escape”) project designed to help patients envision themselves engaging in enjoyable activities, and the “Comment se sentent nos patients” (“How Our Patients Feel”) project, a placemat designed to help patients express their emotions and experiences. These tools aim to improve communication between caregivers and patients, objectify symptoms, and promote patient autonomy.\u0000The DialiCare project illustrates the importance of a participatory approach in developing concrete solutions tailored to real-world conditions and capable of sustainably improving the quality of life for dialysis patients.</p>","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 S2","pages":"5-10"},"PeriodicalIF":0.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chronic kidney disease: Integrating the patient’s voice into clinical decision-making","authors":"Luc Frimat","doi":"10.1684/ndt.2025.136","DOIUrl":"https://doi.org/10.1684/ndt.2025.136","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) is now clearly defined. O nce the diagnosis is made, health care providers must establish a dialogue with the patient and include them in the decision-making process. It is essential that the patient becomes actively involved in managing their CKD on a daily basis and plays a constructive role during the various transitions that characterize the condition, in order to preserve their personal priorities and meet their expectations. Medical staff should measure symptoms, quality of life, and patient experience of care, in order to integrate these dimensions into the design of a personalized care pathway.</p>","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 S2","pages":"18-23"},"PeriodicalIF":0.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ludivine Videloup, Clémence Bechade, Sarah Brionne
{"title":"The care pathway for patients with chronic kidney disease: The essential coordination between community health care professionals and care facilities","authors":"Ludivine Videloup, Clémence Bechade, Sarah Brionne","doi":"10.1684/ndt.2025.143","DOIUrl":"https://doi.org/10.1684/ndt.2025.143","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) is a major public health issue, affecting around 10% of the world’s population. Its silent progression and its numerous etiologies (most commonly diabetes and vascular nephropathies) complicate early detection and management. Many patients reach kidney failure without prior nephrological care. Coordination between outpatient care (GPs, pharmacists, nurses) and specialist facilities is therefore essential to improve screening, delay the progression to dialysis, and improve patients’ quality of life.\u0000The CKD package, introduced in 2019, provides financial support to health care facilities with the aim of facilitating a multidisciplinary approach before end-stage renal diseases. It promotes a patient-centered approach, including nephrologists, nurses, dieticians, psychologists, etc. Community health care professionals play a crucial role in identifying and referring patients to specialists. Coordination with nephrologists means faster diagnosis and better support.\u0000Advanced practice nurses and nurse coordinators play a structuring role in personalized monitoring. Digital tools, remote monitoring, and artificial intelligence offer new ways for optimizing patient care.\u0000Finally, the general public’s persistent lack of knowledge about CKD calls for enhanced information campaigns. The aim of all these initiatives is to build a more fluid, anticipated, and personalized care pathway, centered on the patient’s quality of life.</p>","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 S2","pages":"11-17"},"PeriodicalIF":0.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Towards personalized care for a better quality of life for patients with chronic kidney disease","authors":"Pierre Bataille, Gabriel Choukroun, Luc Frimat","doi":"10.1684/ndt.2025.141","DOIUrl":"https://doi.org/10.1684/ndt.2025.141","url":null,"abstract":"","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 S2","pages":"3-4"},"PeriodicalIF":0.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Green nephrology: Assessment, prospects and practical applications","authors":"Maryvonne Hourmant, Hafsah Hachad","doi":"10.1684/ndt.2025.135","DOIUrl":"https://doi.org/10.1684/ndt.2025.135","url":null,"abstract":"<p><p>Given the current climate stakes, implementing an ecological approach in nephrology departments and dialysis centers has become essential. Hemodialysis, which has a significant environmental impact, was the first activity to be targeted, with an assessment of its carbon footprint followed by best practice recommendations issued by the Green Nephrology Group of the Francophone Society for Nephrology, Dialysis, and Transplantation (SFNDT). Future areas of focus include completing studies on all dialysis modalities and addressing other domains such as transplantation, kidney disease prevention, and appropriate care. Knowledge of the carbon footprint of medications opens the way for eco-prescription, adding a new criterion to guide prescribing choices. This shift cannot take place without the involvement of patients.</p>","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 S2","pages":"24-28"},"PeriodicalIF":0.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Practice survey on tunneled dialysis catheter placement by nephrologists in France","authors":"Jonathan Nicolas","doi":"10.1684/ndt.2025.142","DOIUrl":"https://doi.org/10.1684/ndt.2025.142","url":null,"abstract":"<p><strong>Introduction: </strong>Renal replacement therapy (RRT) ensures the survival of patients with end-stage renal disease. It requires vascular access, such as an arteriovenous fistula or a tunneled central venous catheter. Catheters are inserted by different specialists using different techniques.</p><p><strong>Materials and methods: </strong>We conducted a practice survey on tunneled catheter placement in France developed by the French Intensive Renal Network (FIRN) commission. A comprehensive questionnaire was distributed via social networks to all dialysis centers in France.</p><p><strong>Results: </strong>Given the low response rate from other facilities, only responses from university hospitals were analyzed. Tunneled catheters are inserted by nephrologists in 68% of French university hospitals, of which only 20% use fluoroscopy for right jugular and femoral placement, and 40% for left jugular placement. The procedure is most often performed outside the operating room, in a dedicated room. Of the centers studied, 19% use antibiotic prophylaxis. The average time to insertion is around 48 hours for nephrologists, compared to 1 to 2 weeks for other specialists. Serious complications are rare but do occur and can be life-threatening. Anticoagulation and dual antiplatelet therapy are discontinued for this procedure. A few centers use tunneled catheters in acute renal failure and for plasma exchange.</p><p><strong>Conclusion: </strong>Our survey shows that nephrologists place tunneled dialysis catheters in the majority of French university hospitals, enabling rapid access to the procedure. This procedure is often performed without fluoroscopy but under ultrasound guidance. Fluoroscopy remains the gold standard. Echocardiography, being less invasive than fluoroscopy, could improve guidance and enable early diagnosis of serious complications. The rest of the survey presents the various types of practices observed and could serve as a basis for developing best practice recommendations.</p>","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 4","pages":"221-228"},"PeriodicalIF":0.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pierre Delanaye, Jean-François Focant, Christophe Mariat, Joris Delanghe, Étienne Cavalier
{"title":"Once upon a time in nephrology - Episode 2: A brief history of creatinine measurement","authors":"Pierre Delanaye, Jean-François Focant, Christophe Mariat, Joris Delanghe, Étienne Cavalier","doi":"10.1684/ndt.2025.139","DOIUrl":"https://doi.org/10.1684/ndt.2025.139","url":null,"abstract":"","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"21 4","pages":"199-207"},"PeriodicalIF":0.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}