Neonatology最新文献_第9页

LISA Eligibility and LISA Success in Extremely Preterm Infants: A Single-Center Experience. 极早产儿的 LISA 资格和 LISA 成功率：单中心经验

Neonatology Pub Date : 2024-04-10 DOI: 10.1159/000537904

Ruth Klein, Laura Fastnacht, Angela Kribs, Benjamin Kuehne, K. Mehler

引用次数: 0

Proactive Diagnosis and Tailor-Made Treatment of Patent Ductus Arteriosus in Very Preterm Infants with Routine Echocardiography in Japan: A post hoc Analysis of the PLASE Study. 日本常规超声心动图对早产儿动脉导管未闭的主动诊断和定制治疗：PLASE 研究的事后分析。

Neonatology Pub Date : 2024-04-09 DOI: 10.1159/000538363

Seiichi Tomotaki, Tetsuya Isayama, Tohru Kobayashi, Satoshi Masutani, Hidenori Kawasaki, Atsushi Nakayama, Toshifumi Ikeda, K. Toyoshima

{"title":"Proactive Diagnosis and Tailor-Made Treatment of Patent Ductus Arteriosus in Very Preterm Infants with Routine Echocardiography in Japan: A post hoc Analysis of the PLASE Study.","authors":"Seiichi Tomotaki, Tetsuya Isayama, Tohru Kobayashi, Satoshi Masutani, Hidenori Kawasaki, Atsushi Nakayama, Toshifumi Ikeda, K. Toyoshima","doi":"10.1159/000538363","DOIUrl":"https://doi.org/10.1159/000538363","url":null,"abstract":"INTRODUCTION\u0000A feature of the management of extremely preterm infants in Japan is proactive circulatory management using early routine echocardiography performed by neonatologists.\u0000\u0000\u0000METHODS\u0000This study was a post hoc analysis of the Patent ductus arteriosus and Left Atrial Size Evaluation in preterm infants (PLASE) study, which is a prospective cohort study including preterm infants admitted to 34 tertiary neonatal intensive care units in Japan between October 2015 and December 2016. We described the details of the treatment strategy of patent ductus arteriosus (PDA) based on early routine echocardiography.\u0000\u0000\u0000RESULTS\u0000In total, 613 preterm infants were included into the analysis. Twenty percent of infants with prophylactic indomethacin were switched to therapeutic cyclooxygenase inhibitor (COX-I) before the completion of the full prophylactic indomethacin course. Therapeutic COX-I was mostly administered based on echocardiographic findings before PDA became symptomatic or hemodynamically significant. Therapeutic COX-I was frequently discontinued after one or two doses before the full course (three doses) was completed. The proportion of infants requiring additional treatment (additional therapeutic COX-I course or surgical PDA closure) after discontinued COX-I courses (<3 doses) compared to infants after completed 3 doses course was significantly lower (after the first therapeutic COX-I course 46% vs. 68%, p < 0.001) or without a significant difference (after the second or third course).\u0000\u0000\u0000CONCLUSIONS\u0000The clinical management of PDA in Japan featured (1) COX-I administration based on echocardiographic findings before symptomatic or hemodynamically significant PDA appeared and (2) frequent discontinuation of therapeutic COX-I before completing the standard three doses course.","PeriodicalId":94152,"journal":{"name":"Neonatology","volume":"30 6","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140725366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coupling between Regional Oxygen Saturation of the Brain and Vital Signs during Immediate Transition after Birth. 出生后即刻过渡期间大脑区域氧饱和度与生命体征之间的耦合。

Neonatology Pub Date : 2024-04-08 DOI: 10.1159/000534524

Dries Hendrikx, Alexander Caicedo Dorado, Sabine Van Huffel, Gunnar Naulaers, C. Wolfsberger, B. Urlesberger, G. Pichler

{"title":"Coupling between Regional Oxygen Saturation of the Brain and Vital Signs during Immediate Transition after Birth.","authors":"Dries Hendrikx, Alexander Caicedo Dorado, Sabine Van Huffel, Gunnar Naulaers, C. Wolfsberger, B. Urlesberger, G. Pichler","doi":"10.1159/000534524","DOIUrl":"https://doi.org/10.1159/000534524","url":null,"abstract":"INTRODUCTION\u0000The primary aim was to analyze any coupling of heart rate (HR)/arterial oxygen saturation (SpO2) and regional cerebral oxygen saturation (rScO2) and regional cerebral fractional tissue oxygen extraction (cFTOE) during immediate transition after birth in term and preterm neonates to gain more insight into interactions.\u0000\u0000\u0000METHODS\u0000The present study is a post hoc analysis of data from 106 neonates, obtained from a prospective, observational study. Measurements of HR, SpO2, rScO2, and cFTOE were performed during the first 15 min after birth. The linear and nonlinear correlation were computed between these parameters in a sliding window. The resulting coupling curves were clustered. After clustering, demographic data of the clusters were de-blinded and compared.\u0000\u0000\u0000RESULTS\u0000Due to missing data, 58 out of 106 eligible patients were excluded. Two clusters were obtained: cluster 1 (N = 39) and cluster 2 (N = 9). SpO2 had linear and nonlinear correlations with rScO2 and cFTOE, whereby the correlations with rScO2 were more pronounced in cluster 2. HR-rScO2 and HR-cFTOE demonstrated a nonlinear correlation in both clusters, again being more pronounced in cluster 2, whereby linear correlations were mainly absent. After de-blinding, the demographic data revealed that the neonates in cluster 2 had significantly lower gestational age (mainly preterm) compared to cluster 1 (mainly term).\u0000\u0000\u0000DISCUSSION\u0000Besides SpO2, also HR demonstrated a nonlinear correlation with rScO2 and cFTOE in term and preterm neonates during immediate transition after birth. In addition, the coupling of SpO2 and HR with cerebral oxygenation was more pronounced in neonates with a lower gestational age.","PeriodicalId":94152,"journal":{"name":"Neonatology","volume":"16 9","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140728579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelial-to-Mesenchymal Transition in Human and Murine Models of Congenital Diaphragmatic Hernia. 人类和小鼠先天性膈疝模型中的内皮细胞向间质转化

Neonatology Pub Date : 2024-04-08 DOI: 10.1159/000537802

Jamie Gilley, Sandra K Hanneman, M. Ottosen, B. Shivanna, Sundeep Keswani

{"title":"Endothelial-to-Mesenchymal Transition in Human and Murine Models of Congenital Diaphragmatic Hernia.","authors":"Jamie Gilley, Sandra K Hanneman, M. Ottosen, B. Shivanna, Sundeep Keswani","doi":"10.1159/000537802","DOIUrl":"https://doi.org/10.1159/000537802","url":null,"abstract":"INTRODUCTION\u0000Congenital diaphragmatic hernia (CDH) is a complex congenital disorder, characterized by pulmonary hypertension (PH) and hypoplasia. PH secondary to CDH (CDH-PH) features devastating morbidity and mortality (25-30%) among neonates. An unmet need is determining mechanisms triggering CDH-PH to save infants. Prior data suggest abnormal remodeling of the pulmonary vascular extracellular matrix (ECM), presumed to be driven by endothelial-to-mesenchymal transition (EndoMT), hinders postnatal vasodilation and limits anti-PH therapy in CDH. There are limited data on the role of EndoMT in CDH-PH.\u0000\u0000\u0000METHODS\u0000The purpose of the study was to investigate how EndoMT contributes to CDH-PH by identifying cells undergoing EndoMT noted by alpha smooth muscle actin (α-SMA) expression in human umbilical vein endothelial cells (HUVECs) and lung tissue obtained from murine pups using the nitrofen model. N = 8 CDH, N = 8 control HUVECs were stained for α-SMA and CD31 after being exposed for 24 h to TGFB, a known EndoMT promoter. N = 8 nitrofen, N = 8 control murine pup lungs were also stained for α-SMA and CD31. α-SMA and CD31 expression was quantified in HUVECs and murine tissue using Fiji imaging software and normalized to the total number of cells per slide noted by DAPI staining.\u0000\u0000\u0000RESULTS\u0000CDH HUVECs demonstrated a 1.1-fold increase in α-SMA expression (p = 0.02). The murine model did not show statistical significance between nitrofen and control pup lungs; however, there was a 0.4-fold increase in α-SMA expression with a 0.8-fold decrease in CD31 expression in the nitrofen pup lungs when compared to controls.\u0000\u0000\u0000CONCLUSION\u0000These results suggest that EndoMT could potentially play a role in the ECM remodeling seen in CDH-PH.","PeriodicalId":94152,"journal":{"name":"Neonatology","volume":"5 2","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140728856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Growth and Neurodevelopmental Outcomes of Neonates Infected with SARS-CoV-2 during the COVID-19 Pandemic at 18-24 Months Corrected Age: A Prospective Observational Study. 在 COVID-19 大流行期间感染 SARS-CoV-2 的新生儿在 18-24 个月矫正年龄时的长期生长和神经发育结果：一项前瞻性观察研究。

Neonatology Pub Date : 2024-04-05 DOI: 10.1159/000537803

Medha Goyal, Dwayne Mascarenhas, Prashanth Rr, R. Nanavati

{"title":"Long-Term Growth and Neurodevelopmental Outcomes of Neonates Infected with SARS-CoV-2 during the COVID-19 Pandemic at 18-24 Months Corrected Age: A Prospective Observational Study.","authors":"Medha Goyal, Dwayne Mascarenhas, Prashanth Rr, R. Nanavati","doi":"10.1159/000537803","DOIUrl":"https://doi.org/10.1159/000537803","url":null,"abstract":"INTRODUCTION\u0000During the early coronavirus disease (COVID-19) pandemic in 2020, researchers cautioned about the potential neuroinvasive capability of the virus and long-term neurological consequences. Although a few preliminary studies have found delayed communication, fine motor, and problem-solving skills in infants after COVID-19 infection, there continues to be a paucity of data on long-term development of neonates diagnosed with COVID-19.\u0000\u0000\u0000METHODS\u0000We conducted a prospective study of 20 neonates who acquired severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection during the first wave of the pandemic (April-July 2020). At 18-24 months corrected age, we assessed neurodevelopment by Bayley Scales of Infant and Toddler Development, the third edition (BSID-III), along with growth, hearing, and vision evaluation.\u0000\u0000\u0000RESULTS\u0000The mean corrected age at assessment was 21 months 11 days ± 1 month 28 days. We found developmental delay in nearly half of the children with scores below one standard deviation in either of the BSID-III domains. Mild delay in either motor, cognitive, or language domains was found in 9 (45%) children and moderate delay in 2 (10%). Expressive language, fine motor, and receptive language were predominantly affected. None of the children had hearing impairment, blindness, or significant growth faltering including clinically severe microcephaly. The mean composite cognitive, language, and motor scores were significantly lower in those with neurodevelopmental delay (p value - 0.02, 0.000, and 0.03, respectively) without any differences in their disease characteristics.\u0000\u0000\u0000CONCLUSION\u0000Neonates infected with SARS-CoV-2 have an increased risk of developmental delays in expressive language, fine motor, and receptive language skills at 18-24 months of age. The severity of delays is predominantly mild.","PeriodicalId":94152,"journal":{"name":"Neonatology","volume":"6 4","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140738311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computer Vision for Identification of Increased Fetal Heart Variability in Cardiotocogram. 计算机视觉识别胎心图中增加的胎心变异。

Neonatology Pub Date : 2024-04-02 DOI: 10.1159/000538134

Mikko J Tarvonen, Matti Manninen, Petri Lamminaho, Petri Jehkonen, Ville Tuppurainen, Sture Andersson

{"title":"Computer Vision for Identification of Increased Fetal Heart Variability in Cardiotocogram.","authors":"Mikko J Tarvonen, Matti Manninen, Petri Lamminaho, Petri Jehkonen, Ville Tuppurainen, Sture Andersson","doi":"10.1159/000538134","DOIUrl":"https://doi.org/10.1159/000538134","url":null,"abstract":"INTRODUCTION\u0000Increased fetal heart rate variability (IFHRV), defined as fetal heart rate (FHR) baseline amplitude changes of >25 beats per minute with a duration of ≥1 min, is an early sign of intrapartum fetal hypoxia. This study evaluated the level of agreement of machine learning (ML) algorithms-based recognition of IFHRV patterns with expert analysis.\u0000\u0000\u0000METHODS\u0000Cardiotocographic recordings and cardiotocograms from 4,988 singleton term childbirths were evaluated independently by two expert obstetricians blinded to the outcomes. Continuous FHR monitoring with computer vision analysis was compared with visual analysis by the expert obstetricians. FHR signals were graphically processed and measured by the computer vision model labeled SALKA.\u0000\u0000\u0000RESULTS\u0000In visual analysis, IFHRV pattern occurred in 582 cardiotocograms (11.7%). Compared with visual analysis, SALKA recognized IFHRV patterns with an average Cohen's kappa coefficient of 0.981 (95% CI: 0.972-0.993). The sensitivity of SALKA was 0.981, the positive predictive rate was 0.822 (95% CI: 0.774-0.903), and the false-negative rate was 0.01 (95% CI: 0.00-0.02). The agreement between visual analysis and SALKA in identification of IFHRV was almost perfect (0.993) in cases (N = 146) with neonatal acidemia (i.e., umbilical artery pH <7.10).\u0000\u0000\u0000CONCLUSIONS\u0000Computer vision analysis by SALKA is a novel ML technique that, with high sensitivity and specificity, identifies IFHRV features in intrapartum cardiotocograms. SALKA recognizes potential early signs of fetal distress close to those of expert obstetricians, particularly in cases of neonatal acidemia.","PeriodicalId":94152,"journal":{"name":"Neonatology","volume":"29 5","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140752699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum. 勘误。

Neonatology Pub Date : 2024-01-01 Epub Date: 2024-01-30 DOI: 10.1159/000536368

引用次数: 0

Parental Experiences of Neonatal Care: A Nationwide Study on Determinants of Excellence. 父母对新生儿护理的体验：一项关于优秀决定因素的全国性研究。

Neonatology Pub Date : 2024-01-01 Epub Date: 2023-10-16 DOI: 10.1159/000533900

Agnes Linnér, Ylva Thernström Blomqvist, Kristina Jonsson, Siri Lilliesköld, Mikael Norman

{"title":"Parental Experiences of Neonatal Care: A Nationwide Study on Determinants of Excellence.","authors":"Agnes Linnér, Ylva Thernström Blomqvist, Kristina Jonsson, Siri Lilliesköld, Mikael Norman","doi":"10.1159/000533900","DOIUrl":"10.1159/000533900","url":null,"abstract":"Introduction: Infant- and family-centered developmental care can reduce adverse outcomes in both infants and parents. Parents' experiences of the care and staff treatment remain to be evaluated.Methods: Parents of infants admitted to neonatal units in Sweden from July 2020 to May 2022 responded to a questionnaire with standardized questions about in-hospital care. Exposures were hospital, gestational age, length of hospital stay, unit level, and bed density. The proportions of parents rating aspects of neonatal care as excellent, defined as five on a Likert scale, and the determinants of excellence were described. The results were benchmarked with ratings in adult somatic care.Results: A total of 4,475/13,108 (34%) parents responded. The ratings of excellent care varied by question from 65% to 90%. The largest variation in excellence between neonatal units (range 43-80%) was found for \"participation and involvement.\" The proportion of excellence was significantly lower among parents of extremely preterm infants. Confidence in the staff was lower in parents of extremely preterm infants than in parents of term infants (56% vs. 83%). Longer hospital stays affected the experience of neonatal care adversely, whereas level of care and bed density were overall unrelated to the parental experience. Parents in neonatal care rated the care as excellent to a higher extent than patients cared for in adult medicine.Conclusion: A majority of parents rated neonatal care in Sweden as excellent. The less frequent ratings of excellence among parents of extremely preterm infants indicate that more could be done to optimize parental involvement and support.","PeriodicalId":94152,"journal":{"name":"Neonatology","volume":" ","pages":"46-55"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10836739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41242752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Category-Based Risk Assessment for Neonatal Early-Onset Sepsis: A Prospective Observational Study. 新生儿早期败血症强化分类风险评估：一项前瞻性观察研究。

Neonatology Pub Date : 2024-01-01 Epub Date: 2023-10-31 DOI: 10.1159/000534091

Hoi Ying Sharon Lau, Xuelian Wang, Ho Tsun Michelia Wong, Ka Hei Catherine Lam, Hugh Simon Lam

{"title":"Enhanced Category-Based Risk Assessment for Neonatal Early-Onset Sepsis: A Prospective Observational Study.","authors":"Hoi Ying Sharon Lau, Xuelian Wang, Ho Tsun Michelia Wong, Ka Hei Catherine Lam, Hugh Simon Lam","doi":"10.1159/000534091","DOIUrl":"10.1159/000534091","url":null,"abstract":"Introduction: Compared with multivariate risk assessment, traditional category-based risk assessment (CRA) approaches for neonatal early-onset sepsis (EOS) screening are usually straightforward to use, do not require electronic devices, but are associated with higher rates of antibiotic use. This study aims to evaluate the performance of a novel enhanced CRA (eCRA) framework on EOS admissions and antibiotic use and to investigate whether a modified version with adjustments in risk factor weighting can allow its performance to match the EOS calculator while remaining easy to implement.Method: This is a prospective, single-center, two-phase observational study. Infants of all gestations delivered in a tertiary hospital in Hong Kong with risk factors or clinical features of EOS were recruited.Phase i: A novel eCRA framework (period 2) was compared with the CDC 2010-based protocol (period 1).Phase ii: A modified eCRA framework was compared theoretically with the EOS calculator. EOS-specific admissions and antibiotic use were measured.Results: Phase I: 1,025 at-risk infants were recruited during period 2 and compared with 757 infants of period 1. Admissions and antibiotic use decreased from 45.8% to 29.4% and 41.1% to 28.2%, respectively. Antibiotics among those at-risk but well-appearing infants decreased from 25.3% to 16.3% (p < 0.001 for all).Phase ii: antibiotic use was similar (7.3 vs. 6.4%, p = 0.42) between the modified eCRA framework and the EOS calculator.Conclusions: An eCRA framework can effectively and safely provide individualized guidance for EOS screening without the need for tools such as the EOS calculator.","PeriodicalId":94152,"journal":{"name":"Neonatology","volume":" ","pages":"56-64"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10836755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71430653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic Insufficiency, Digestive Enzyme Supplementation, and Postnatal Growth in Preterm Babies. 早产儿胰腺机能不全、消化酶补充剂和产后生长。

Neonatology Pub Date : 2024-01-01 Epub Date: 2024-01-19 DOI: 10.1159/000535964

Allan Jenkinson, Narendra Aladangady, Sven Wellmann, Simon Eaton, Christoph Bührer, Paul Fleming, Charles Roehr

{"title":"Pancreatic Insufficiency, Digestive Enzyme Supplementation, and Postnatal Growth in Preterm Babies.","authors":"Allan Jenkinson, Narendra Aladangady, Sven Wellmann, Simon Eaton, Christoph Bührer, Paul Fleming, Charles Roehr","doi":"10.1159/000535964","DOIUrl":"10.1159/000535964","url":null,"abstract":"Background: Optimising postnatal growth facilitates better long-term neonatal neurodevelopmental outcomes. Early postnatal growth is often hindered by a variety of factors unique to the extrauterine environment and digestive immaturity both contributing to reduced enteral feed tolerance during the first few days and weeks after birth. Preterm infants display varying levels of pancreatic insufficiency that are related to gestational age and providing digestive enzyme supplementation, may be one way in which to improve postnatal growth in enterally fed preterm babies.Summary: In this review, we explore which exocrine pancreatic enzymes are deficient in preterm babies, the methods by which exocrine pancreatic function is measured, potential avenues by which digestive enzyme replacement might improve postnatal growth failure, and which babies might benefit most from this intervention.Key messages: Pancreatic exocrine function exhibits developmental immaturity in extremely preterm infants and may contribute to postnatal growth failure. Stool elastase is a simple, non-invasive method of assessing pancreatic function in preterm infants. Available evidence does not currently support routine use of digestive enzyme supplementation in preterm infants.","PeriodicalId":94152,"journal":{"name":"Neonatology","volume":" ","pages":"283-287"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139514461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0