Modern rheumatology case reports最新文献

{"title":"Rapidly progressive interstitial lung disease with an organising pneumonia-dominant high-resolution computed tomography pattern in systemic lupus erythematosus: a case report and literature review.","authors":"Kentaro Kuzuya, Yoshinobu Matsuura, Akito Morimoto, Norihiko Yamaguchi, Hiroyuki Yamane","doi":"10.1093/mrcr/rxag090","DOIUrl":"10.1093/mrcr/rxag090","url":null,"abstract":"<p><p>Among pulmonary involvements of systemic lupus erythematosus (SLE), interstitial lung disease (ILD) is an infrequent but clinically significant complication, with fatal cases reported as 'acute lupus pneumonitis' and associated with increased mortality. However, SLE-ILD remains insufficiently stratified according to clinical course, and no predictive factor for rapidly progressive ILD (RP-ILD), including high-resolution computed tomography (HRCT) pattern, has yet been established. Here we report a 71-year-old man who presented with dyspnea, fever, pancytopenia, anti-double-stranded DNA antibody positivity, hypocomplementemia, proteinuria, and neuropsychiatric symptoms. HRCT initially showed bilateral consolidation predominantly in the peripheral lower lung zones, consistent with organising pneumonia (OP), followed by rapid extension with ground-glass opacities. He was diagnosed with rapidly progressive systemic lupus erythematosus-associated interstitial lung disease (RP-SLE-ILD) with neuropsychiatric involvement and nephritis and improved after intensive combined immunosuppressive therapy. To characterise the HRCT findings of RP-SLE-ILD, we performed a systematic literature review and identified 27 patients with RP-SLE-ILD, including the present case. OP-dominant patterns, defined as OP alone or OP combined with nonspecific interstitial pneumonia, were significantly more frequent than in the chronic reference cohorts (77.8% vs 10.0% or 14.6%). In contrast, isolated nonspecific interstitial pneumonia was significantly less frequent than in the chronic cohorts (3.7% vs 55.0% or 31.5%). These findings suggest that OP-dominant HRCT patterns and lower lung zone consolidation may be recurring radiological features among reported RP-SLE-ILD cases, although their predictive value requires validation in consecutive cohorts.</p>","PeriodicalId":94146,"journal":{"name":"Modern rheumatology case reports","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mepolizumab add-on after relapse during rituximab maintenance in myeloperoxidase-antineutrophil cytoplasmic antibodies-positive eosinophilic granulomatosis with polyangiitis: A case report and literature review.","authors":"Genki Kidoguchi, Michinori Ishitoku, Tomohiro Sugimoto, Yusuke Yoshida, Shintaro Hirata","doi":"10.1093/mrcr/rxag050","DOIUrl":"10.1093/mrcr/rxag050","url":null,"abstract":"<p><p>Eosinophilic granulomatosis with polyangiitis is a heterogeneous vasculitic and eosinophilic disorder in which patients who are positive for myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) often develop glomerulonephritis and peripheral neuropathy and may require prolonged immunosuppressive therapy. Although rituximab (RTX) and mepolizumab have been used in selected patients with eosinophilic granulomatosis with polyangiitis, relapse during RTX maintenance remains difficult to manage. We report the case of a 59-year-old woman with adult-onset asthma and chronic rhinosinusitis who presented with severe eosinophilia, mononeuritis multiplex, MPO-ANCA positivity, and pauci-immune necrotising glomerulonephritis. Induction therapy with high-dose glucocorticoids, intravenous immunoglobulin, and RTX achieved clinical remission and allowed the tapering to a low dose of prednisolone. Despite RTX maintenance, she later relapsed with recurrent sinonasal symptoms, worsening neuropathic complaints, and a marked rise in MPO-ANCA levels. In this setting, a further escalation of immunosuppression during maintenance, including cyclophosphamide, may be considered; however, given the possibility that residual eosinophilic inflammation contributed to ongoing disease activity, including autoantibody production, mepolizumab was added after retreatment with RTX as sequential therapy. Symptoms stabilised and improved over the subsequent months, MPO-ANCA titres progressively declined to the normal range, and prednisolone was discontinued. Remission has been maintained on mepolizumab without further RTX maintenance. This case suggests that sequential eosinophil-targeted therapy may help consolidate remission after a relapse during RTX maintenance in MPO-ANCA-positive eosinophilic granulomatosis with polyangiitis.</p>","PeriodicalId":94146,"journal":{"name":"Modern rheumatology case reports","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148311042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent parvovirus B19 infection in an older patient with rheumatoid arthritis receiving immunosuppressive therapy: A case report and literature review.","authors":"Masako Oyama, Yusuke Yoshida, Tetsumi Yoshida, Hiroki Kobayashi, Yuji Shigemasa, Hirohisa Usagawa, Makoto Fujii, Michinori Ishitoku, Tomohiro Sugimoto, Shintaro Hirata","doi":"10.1093/mrcr/rxag057","DOIUrl":"10.1093/mrcr/rxag057","url":null,"abstract":"<p><p>An 84-year-old man with rheumatoid arthritis undergoing treatment with methotrexate presented with fever, general fatigue, and appetite loss. He had a 3-month history of unexplained normocytic anaemia with reticulocytopenia. Bone marrow examination revealed erythroid hypoplasia with giant pro-erythroblasts, leading to a diagnosis of parvovirus B19 infection. In this case, intravenous immunoglobulin therapy improved the patient's anaemia and systemic symptoms. Six months after the treatment, parvovirus B19 DNA remained detectable using polymerase chain reaction; however, the viral load had markedly decreased, indicating a favourable virological response. Twenty cases of parvovirus B19 infection in older adults (aged ≥65 years) were identified in the literature. Immunocompromised older patients frequently develop persistent parvovirus B19 infections that require treatment with intravenous immunoglobulin therapy, whereas persistent infections are not observed in immunocompetent older individuals. Therefore, this case suggests that clinicians should be aware of persistent parvovirus B19 infection in older immunosuppressed patients who develop unexplained anaemia with reticulocytopenia. Moreover, intravenous immunoglobulin therapy may be considered as an effective therapeutic option for persistent parvovirus B19 infection in immunocompromised patients.</p>","PeriodicalId":94146,"journal":{"name":"Modern rheumatology case reports","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148474980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient aortitis/periaortitis with spontaneous resolution: Report of four cases.","authors":"Yoshikazu Motomura, Nobuhiro Oda, Hiroki Ikai, Hiroshi Shiba, Ryo Hazue, Asami Kiuchi, Naoki Oya, Naoho Takizawa, Masahiro Minoda, Ryo Rokutanda","doi":"10.1093/mrcr/rxag079","DOIUrl":"10.1093/mrcr/rxag079","url":null,"abstract":"<p><p>Periaortitis is an inflammatory condition surrounding the aorta, classified as either idiopathic or secondary to well-defined causes; it typically requires treatment with glucocorticoids (GC) and/or immunosuppressants. We report four cases of transient aortitis/periaortitis and summarise their characteristics and clinical courses. The four patients were all women (age range, 37-80 years). All patients had fever; three had dry cough and two experienced back or neck pain near the affected aortic site. At diagnosis, computed tomography revealed eccentric low-density areas in the periaortic space in all cases, involving the aortic arch or descending thoracic aorta in three patients. No carotid artery involvement was observed. One patient received low-dose GC for erythema nodosum, whereas the others did not receive GC or immunosuppressants. The C-reactive protein level was elevated in all cases. Symptoms and the CRP levels typically improved within ~1 month, and follow-up computed tomography performed within ~3 months showed resolution in all cases. These four cases suggest the presence of a transient form of aortitis/periaortitis that improves without high-dose GC or immunosuppressants. Notably, the thoracic aorta was predominantly affected, which is an unusual finding in chronic periaortitis. These cases may overlap with a spontaneous form of isolated aortitis and share informative features with transient perivascular inflammation of the carotid artery syndrome and granulocyte colony-stimulating factor-induced aortitis. Awareness of this condition may reduce unnecessary diagnostic workup and overtreatment; thus, additional case accumulation and further research are warranted to clarify its clinical spectrum and pathogenesis.</p>","PeriodicalId":94146,"journal":{"name":"Modern rheumatology case reports","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148803913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infliximab for laryngopharyngeal involvement in Behçet's syndrome.","authors":"Miyu Wakatsuki, Hiroyuki Yamashita, Hiroshi Kaneko","doi":"10.1093/mrcr/rxag068","DOIUrl":"10.1093/mrcr/rxag068","url":null,"abstract":"<p><p>Laryngopharyngeal involvement in Behçet's syndrome is rare but clinically significant because it may cause severe odynophagia, dysphagia, and airway compromise. Optimal treatment has not been established, and irreversible structural sequelae, including laryngopharyngeal stenosis and ulcer scarring, may occur. We describe two men with Behçet's syndrome and symptomatic laryngopharyngeal involvement who showed rapid improvement after infliximab administration following an insufficient response to corticosteroids. In case 1, a 25-year-old man was classified as having suspected Behçet's syndrome based on recurrent oral ulcers, pharyngeal ulceration, arthritis, folliculitis-like skin lesions, and previous episodes of abdominal pain. He developed severe pharyngeal pain and dysphagia due to ulcerative lesions extending from the posterior pharyngeal wall to the oesophageal inlet. Intravenous prednisolone resulted in limited endoscopic and symptomatic improvement, whereas infliximab promptly relieved pain and restored oral intake, with no recurrence over 14 years of follow-up. In case 2, a 29-year-old man presented with recurrent fever, oral aphthae, genital ulcers, arthritis, erythema nodosum-like lesions, and pharyngeal and laryngeal mucosal lesions associated with dysphagia. His symptoms and laryngoscopic abnormalities improved promptly after infliximab administration following an inadequate response to prednisolone. These cases underscore the importance of considering early antitumour necrosis factor-α therapy in steroid-refractory or relapsing laryngopharyngeal Behçet's syndrome, because progression to irreversible structural complications, including stenosis and adhesion, may necessitate surgical intervention if inflammation is not controlled before permanent damage occurs.</p>","PeriodicalId":94146,"journal":{"name":"Modern rheumatology case reports","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148427681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Golimumab-induced lupus erythematosus complicated by angioedema and anti-galactocerebroside antibody-positive dysphagia.","authors":"Makoto Misaki, Toshiaki Shimizu, Reo Yamazato, Yuichi Suwa, Yoichi Yasunaga, Keishi Fujio","doi":"10.1093/mrcr/rxag096","DOIUrl":"10.1093/mrcr/rxag096","url":null,"abstract":"<p><p>Drug-induced lupus erythematosus is an autoimmune condition that resembles systemic lupus erythematosus and occurs after exposure to specific medications, including tumour necrosis factor alpha inhibitors. We report a rare case of golimumab-induced lupus erythematosus complicated by macrophage activation syndrome, angioedema, and severe dysphagia with anti-galactocerebroside antibodies detected. A 57-year-old woman with ulcerative colitis developed facial swelling, malar rash, arthritis, pancytopenia, hyperferritinaemia, hypocomplementaemia, and proteinuria after long-term treatment with tumour necrosis factor alpha inhibitors, most recently golimumab. Bone marrow examination demonstrated haemophagocytosis, confirming macrophage activation syndrome. Computed tomography and endoscopy revealed soft tissue and oesophageal oedema consistent with angioedema. Despite improvement of systemic inflammation following high-dose glucocorticoids and intravenous cyclophosphamide, severe dysphagia persisted. A videofluoroscopic swallowing study demonstrated pharyngeal muscle dysfunction, and serum testing detected anti-galactocerebroside immunoglobulin G antibodies. Neurological imaging and electrophysiological studies were unremarkable. Swallowing function gradually recovered after discontinuation of golimumab. This case highlights that golimumab-induced lupus erythematosus may trigger multiple autoimmune complications, including macrophage activation syndrome, angioedema, and antibody-associated neuromuscular dysphagia. Awareness of these potentially life-threatening manifestations is essential for early recognition and appropriate management in patients receiving tumour necrosis factor alpha inhibitors.</p>","PeriodicalId":94146,"journal":{"name":"Modern rheumatology case reports","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous flexor digitorum profundus tendon rupture of the little finger in patients with rheumatoid arthritis: A report of two cases with different mechanisms.","authors":"Kaname Ohashi, Naoki Okubo, Shinji Tsuchida, Ryo Oda, Kenji Takahashi","doi":"10.1093/mrcr/rxag048","DOIUrl":"10.1093/mrcr/rxag048","url":null,"abstract":"<p><p>Subcutaneous flexor tendon rupture in patients with rheumatoid arthritis is rare compared with extensor tendon rupture, with a reported incidence of approximately one-tenth of that of extensor tendons. The pathophysiology of flexor tendon rupture is not fully understood. We report two cases of spontaneous flexor digitorum profundus tendon rupture of the little finger in patients with rheumatoid arthritis despite low disease activity and the absence of advanced joint destruction. Both patients presented with an inability to actively flex their little fingers without any history of significant trauma. Based on magnetic resonance imaging and intraoperative findings, in Case 1, direct invasion by synovitis was identified as the cause. However, in Case 2, a small bone spur on the hook of hamate was responsible for the rupture. In both cases, the suspected causative synovium or bone spur was excised, and a tendon transfer surgery to the flexor digitorum profundus of the ring finger was performed. The postoperative outcomes were favourable, with improved total active motion and no re-rupture observed during follow-up. These cases highlight that flexor tendon rupture can occur even in patients with rheumatoid arthritis with low disease activity and without advanced joint destruction. Careful evaluation of both the local inflammatory activity and mechanical factors is essential to identify the cause of rupture and prevent re-rupture.</p>","PeriodicalId":94146,"journal":{"name":"Modern rheumatology case reports","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148311108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pituitary involvement in granulomatosis with polyangiitis: a diagnostic and therapeutic challenge.","authors":"Fernanda de Sousa Torraca, Nathalia Maria Reis Hypolito, Fernanda Vieira Ramalho de Azevedo, Ana Carolina Gonçalves Brito, Manuella Lima Gomes Ochtrop, Ana Beatriz Winter Tavares","doi":"10.1093/mrcr/rxag042","DOIUrl":"10.1093/mrcr/rxag042","url":null,"abstract":"<p><p>Granulomatosis with polyangiitis (GPA) is a systemic necrotizing vasculitis associated with antineutrophil cytoplasmic antibodies. Although pituitary involvement is rare, it represents a clinically relevant manifestation that may present as a sellar mass mimicking a pituitary neuroendocrine tumour, leading to diagnostic delay and inappropriate management. We report the case of a male patient who initially presented at 24 years of age with recurrent epistaxis and nasal crusting, with histopathological evidence of chronic granulomatous inflammation of undetermined aetiology. Four years later, he developed a headache, diplopia, bitemporal hemianopia, polyuria, and polydipsia. Magnetic resonance imaging revealed a pituitary mass with suprasellar extension. An endocrine evaluation demonstrated hypopituitarism and arginine vasopressin deficiency. The patient underwent transcranial resection under the presumptive diagnosis of a non-functioning pituitary neuroendocrine tumour; however, postoperative imaging showed lesion progression. Further investigation revealed positive C-antineutrophil cytoplasmic antibodies and systemic features consistent with GPA. Histopathological reassessment with immunohistochemistry supported the diagnosis of granulomatous hypophysitis in the context of GPA. Induction therapy with cyclophosphamide achieved initial disease control, but a pituitary relapse occurred during maintenance therapy with azathioprine, prompting treatment escalation to rituximab. Rituximab led to a reduction in the pituitary mass and sustained clinical stability over four years. Persistent hypopituitarism required long-term hormone replacement. Pituitary involvement in GPA is an uncommon but important diagnostic challenge and may closely mimic a pituitary neuroendocrine tumour. This case highlights the need for careful integration of systemic clinical features, endocrine findings, imaging, and histopathological reassessment when evaluating sellar masses. Immunosuppressive therapy with cyclophosphamide and rituximab was effective in controlling pituitary involvement, although permanent pituitary hormone deficiencies may persist despite disease control.</p>","PeriodicalId":94146,"journal":{"name":"Modern rheumatology case reports","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148261148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early postoperative onset of immune thrombocytopenia in rheumatoid arthritis with concomitant systemic lupus erythematosus: A case report.","authors":"Kazuhiro Nishikawa, Takahito Suto, Satoshi Shinagawa, Shuhei Takamine, Hiroaki Fujita, Koji Ohdama, Hirotaka Chikuda","doi":"10.1093/mrcr/rxag051","DOIUrl":"10.1093/mrcr/rxag051","url":null,"abstract":"<p><p>Immune thrombocytopenia (ITP) is often already recognised as a pre-existing comorbidity before surgery and managed with interventions to maintain platelet counts at levels considered adequate for surgery. Acute postoperative onset of ITP is extremely rare. We report a case of a 61-year-old woman with rheumatoid arthritis (RA) who developed acute ITP after total hip arthroplasty. Treatment with intravenous immunoglobulin and corticosteroids rapidly improved her platelet count. Further investigation, including antibody testing such as antinuclear antibody and anti-Smith antibodies, revealed comorbid systemic lupus erythematosus (SLE), suggesting the thrombocytopenia was SLE-associated. This case highlights the importance of considering acute ITP and latent autoimmune conditions like SLE in RA patients who experience postoperative thrombocytopenia. Therefore, when markedly elevated antinuclear antibody titres are identified in patients with RA, additional assessment for coexisting SLE may be considered, including further immunological testing and closer perioperative monitoring.</p>","PeriodicalId":94146,"journal":{"name":"Modern rheumatology case reports","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148414482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of neonatal lupus presenting with fever and rash in early infancy with anti-double-stranded DNA (anti-dsDNA) antibodies, born to an asymptomatic mother negative for anti-dsDNA antibodies.","authors":"Mei Takemoto, Koji Nagatani, Sawa Tomomatsu, Hiromitsu Miura, Naoki Yakushiji","doi":"10.1093/mrcr/rxag055","DOIUrl":"10.1093/mrcr/rxag055","url":null,"abstract":"<p><p>Neonatal lupus erythematosus (NLE) is an autoimmune disorder in which maternal antibodies, particularly anti-Sjögren's-syndrome-related antigen A autoantibodies (anti-SS-A) or anti-SS-B antibodies, cause complications in foetal or neonatal cases. We report a case of NLE in an infant born to an asymptomatic mother, presenting with fever and elevated C-reactive protein despite the absence of maternal anti-double-stranded DNA (anti-dsDNA) antibodies. The patient was a 35-day-old male infant who presented with a rash and fever. Laboratory findings included elevated C-reactive protein and ferritin, soluble interleukin-2 receptor, hypocomplementaemia, and elevated D-dimer levels. NLE or urticarial vasculitis secondary to possible infantile-onset systemic lupus erythematosus was considered in the differential diagnosis. The infant and mother tested positive for anti-SS-A and anti-SS-B antibodies, with titres decreasing over time, leading to a final diagnosis of NLE. Although anti-dsDNA antibodies are typically maternal in origin, the mother in this case was repeatedly negative, making transplacental transfer unlikely and suggesting possible de novo antibody production by the infant. Although fever is rare in NLE, this case presented with systemic symptoms similar to systemic lupus erythematosus, including fever, elevated C-reactive protein, and hypocomplementaemia. In some cases of NLE, systemic symptoms similar to systemic lupus erythematosus may be observed in addition to the rash, and anti-dsDNA antibodies may also be positive serologically.</p>","PeriodicalId":94146,"journal":{"name":"Modern rheumatology case reports","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}