{"title":"Echocardiography myocardial work assessment of chemotherapy-induced cardiotoxicity: a systematic review and meta-analysis.","authors":"Guyue Liu, Zhiyue Liu, Mingjian Lang","doi":"10.11152/mu-4502","DOIUrl":"https://doi.org/10.11152/mu-4502","url":null,"abstract":"<p><strong>Aim: </strong>The objective was to assess chemotherapy-induced cardiotoxicity by comparing changes in myocardial work indices (MWI) using echocardiographic myocardial work (MW).</p><p><strong>Material and method: </strong>A comprehensive search was performed in PubMed, Embase, and the Cochrane Library, covering literature up to June 2024.</p><p><strong>Results: </strong>A total of 13 non-randomized experimental studies (n=1,373) assessed changes in MWI of cancer patients treated with anthracyclines, trastuzumab/pertuzumab, or immune checkpoint inhibitors. After chemotherapy, adecrease was observed in the left ventricular ejection fraction (LVEF) (Pooled standard mean difference [SMD] = -0.75, 95% CI: -1.18, -0.31, p=0.001, I 2= 95.9%), global longitudinal strain (GLS) (Pooled SMD = -2.38, 95% CI: -3.10, -1.66, p<0.001, I 2= 97.9%), global work index (Pooled SMD = -1.27, 95% CI: -1.68, -0.86, p<0.001, I2= 95.0%), global constructive work (GCW) (Pooled SMD = -1.55, 95% CI: -2.10, -0.99, p<0.001, I 2= 96.9%), and global work efficiency (Pooled SMD = -1.66, 95% CI: -2.39, -0.94, p<0.001, I2= 98.2%). Conversely, global wasted work (GWW) increased (Pooled SMD = 1.17, 95% CI: 0.44, 1.89, p=0.002, I 2= 98.2%). Post-chemotherapy, GCW and GLS were below normal ranges, GWW exceeded normal values, and LVEF remained within normal limits across all subgroups.</p><p><strong>Conclusions: </strong>Echocardiographic MWI provides a non-invasive method for assessing cardiotoxicity induced by anthracyclines, trastuzumab / pertuzumab, or immune checkpoint inhibitors.</p>","PeriodicalId":94138,"journal":{"name":"Medical ultrasonography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christian Jenssen, Frauke Petersen, Michael Höpfner, Dieter Nürnberg, Deike Strobel, Johanna Vogelpohl, Christoph F Dietrich
{"title":"Why and when are activity scores and advanced ultrasound techniques needed in inflammatory bowel disease (IBD)?","authors":"Christian Jenssen, Frauke Petersen, Michael Höpfner, Dieter Nürnberg, Deike Strobel, Johanna Vogelpohl, Christoph F Dietrich","doi":"10.11152/mu-4500","DOIUrl":"https://doi.org/10.11152/mu-4500","url":null,"abstract":"<p><p>In addition to avoidance of radiation exposure, the main advantages of ultrasound diagnostics in inflammatory bowel disease (IBD) patients are its' immediate availability, also as a component of the physical examination (extended point of care), its' repeatability and its' high patient comfort. The fact that the examination is carried out directly by the treating physician and is not delegated to the radiologist increases compliance and therapy adherence of the patients.In the current series of papers a synopsis of recommendations for ultrasound in IBD guidelines, ultrasound parameters in inflammatory bowel disease including activities scores, the value of contrast enhanced ultrasound (CEUS), small intestinal contrast ultrasound (SICUS) and elastography, perineal ultrasound (PNUS), endoscopic ultrasound (EUS) including endorectal ultrasound (ERUS), interventional ultrasound (INVUS), detection of disease complications (stenoses, fistula, abscess), extraintestinal manifestations, differential diagnosis, evaluation of treatment response and outlook are discussed and illustrated.</p>","PeriodicalId":94138,"journal":{"name":"Medical ultrasonography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Deep learning-based automated detection and diagnosis of gouty arthritis in ultrasound images of the first metatarsophalangeal joint.","authors":"Lishan Xiao, Yizhe Zhao, Yuchen Li, Mengmeng Yan, Manhua Liu, Chunping Ning","doi":"10.11152/mu-4495","DOIUrl":"https://doi.org/10.11152/mu-4495","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to develop a deep learning (DL) model for automatic detection and diagnosis of gouty arthritis (GA) in the first metatarsophalangeal joint (MTPJ) using ultrasound (US) images.</p><p><strong>Materials and methods: </strong>A retrospective study included individuals who underwent first MTPJ ultrasonography between February and July 2023. A five-fold cross-validation method (training set = 4:1) was employed. A deep residual convolutional neural network (CNN) was trained, and Gradient-weighted Class Activation Mapping (Grad-CAM) was used for visualization. Different ResNet18 models with varying residual blocks (2, 3, 4, 6) were compared to select the optimal model for image classification. Diagnostic decisions were based on a threshold proportion of abnormal images, determined from the training set.</p><p><strong>Results: </strong>A total of 2401 US images from 260 patients (149 gout, 111 control) were analyzed. The model with 3 residual blocks performed best, achieving an AUC of 0.904 (95% CI: 0.887~0.927). Visualization results aligned with radiologist opinions in 2000 images. The diagnostic model attained an accuracy of 91.1% (95% CI: 90.4%~91.8%) on the testing set, with a diagnostic threshold of 0.328.</p><p><strong>Conclusion: </strong> The DL model demonstrated excellent performance in automatically detecting and diagnosing GA in the first MTPJ.</p>","PeriodicalId":94138,"journal":{"name":"Medical ultrasonography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wei-Ting Wu, Ke-Vin Chang, Kamal Mezian, Vincenzo Ricci, Levent Özçakar
{"title":"\"Sono-vision\" of muscle contractions during peripheral magnetic stimulation.","authors":"Wei-Ting Wu, Ke-Vin Chang, Kamal Mezian, Vincenzo Ricci, Levent Özçakar","doi":"10.11152/mu-4474","DOIUrl":"https://doi.org/10.11152/mu-4474","url":null,"abstract":"<p><p>.</p>","PeriodicalId":94138,"journal":{"name":"Medical ultrasonography","volume":"27 1","pages":"106-107"},"PeriodicalIF":0.0,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of solitary fibrous tumor of the breast.","authors":"Fangtong Teng, Yue You, Hongyan Cui","doi":"10.11152/mu-4482","DOIUrl":"https://doi.org/10.11152/mu-4482","url":null,"abstract":"","PeriodicalId":94138,"journal":{"name":"Medical ultrasonography","volume":"27 1","pages":"107-108"},"PeriodicalIF":0.0,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Umbilical artery thrombosis at 38 weeks of gestation.","authors":"Ziwei Wang, Hong Luo","doi":"10.11152/mu-4488","DOIUrl":"https://doi.org/10.11152/mu-4488","url":null,"abstract":"","PeriodicalId":94138,"journal":{"name":"Medical ultrasonography","volume":"27 1","pages":"114-115"},"PeriodicalIF":0.0,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lukas Pfeifer, Moritz Klueppel, Werner Adler, Barbara Schellhaas, Markus Neurath, Deike Strobel
{"title":"A longitudinal 5-year study for the prediction of HCC, death and liver decompensation by ARFI elastography.","authors":"Lukas Pfeifer, Moritz Klueppel, Werner Adler, Barbara Schellhaas, Markus Neurath, Deike Strobel","doi":"10.11152/mu-4438","DOIUrl":"10.11152/mu-4438","url":null,"abstract":"<p><strong>Aim: </strong>Numerous studies have evaluated elastography for the staging of liver fibrosis. Fewer studies were performed investigating the prognostic relevance using transient elastography (TE), although with promising results. This study was designed to evaluate the prognostic relevance of ARFI elastography.</p><p><strong>Material and method: </strong>Patients receiving ARFI elastography in our ultrasound department between 2010 and 2012 were initially screened for an ARFI examination with a clinical follow-up of at least 5 years. The following events were recorded: liver related death, liver unrelated death, HCC, liver decompensation/ variceal bleeding.</p><p><strong>Results: </strong>A total of 335 patients were included in the final analysis with an ARFI examination of the liver and a follow-up of 60 months. Within the observation interval the number of events with corresponding AUROCs (shown with 95% confidence interval) were: overall death (n=49, 0.76 [0.69 - 0.83]), liver related death (n=25, 0.85 [0.77 - 0.93]), liver unrelated death (n=24, 0.66 [0.55 - 0.77]), HCC (n=15, 0.80 [0.72 - 0.87]), liver related complications/variceal bleeding (n=34, 0.87 [0.82 - 0.93]). In the group of patients with ARFI values suggestive of cirrhosis (equal to or above 1.80 m/s; n=110) higher values (<2.5 m/s vs. >= 2.5 m/s) where associated with a significant decline in liver related survival (p=0.007).</p><p><strong>Conclusion: </strong>ARFI elastography seems to have a good diagnostic accuracy for the prediction of liver related death and decompensation. Further it seems to allow a risk stratification in patients with cirrhosis suspicious elastography values.</p>","PeriodicalId":94138,"journal":{"name":"Medical ultrasonography","volume":" ","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The interesting and deceptive intrauterine vesicular lesions: a case of multiple chorionic cysts and its pregnancy outcome.","authors":"Guilin Ye, Houqing Pang","doi":"10.11152/mu-4481","DOIUrl":"https://doi.org/10.11152/mu-4481","url":null,"abstract":"<p><p>.</p>","PeriodicalId":94138,"journal":{"name":"Medical ultrasonography","volume":"27 1","pages":"115-116"},"PeriodicalIF":0.0,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}