Nan Wang, Xiaorong Lv, Peihua Wang, Xiao Huang, Luping Liu, Ju Zhu, Fang Nie
{"title":"基于超声和增强超声预测双表型肝细胞癌的初步研究。","authors":"Nan Wang, Xiaorong Lv, Peihua Wang, Xiao Huang, Luping Liu, Ju Zhu, Fang Nie","doi":"10.11152/mu-4466","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>To investigate the diagnostic value of ultrasound features with dual-phenotype hepatocellular carcinoma (DPHCC). Material and methods: A retrospective analysis was conducted on patients diagnosed with hepatocellular carcinoma (HCC) confirmed by pathology results from October 2016 to December 2023. Patients were categorized into DPHCC and non-DPHCC (NDPHCC) groups based on immunohistochemical findings. Clinical baseline characteristics and ultrasound features were compared between these groups. Multivariable logistic regression was employed to identify predictive factors. A logisticregression model and nomogram were developed to predict DPHCC.</p><p><strong>Results: </strong>This study included 219 HCC patients (average age: 55.84±9.00, 173 males), with 61 cases of DPHCC and 158 cases of NDPHCC. The results of multivariate logistic regression indicated that halo sign (OR=1.93, p=0.049), PVP hypo-enhancement (OR=2.73, p=0.002) and nodule-in-nodule sign (OR=4.23, p=0.003) were independent predictors of DPHCC. The model's AUC value was 0.73 (95%CI: 0.65-0.80). The calibration curve displayed good predictive accuracy.</p><p><strong>Conclusions: </strong>Ultrasound features, including CEUS, may provide additional information for the non-invasive diagnosis of DPHCC.</p>","PeriodicalId":94138,"journal":{"name":"Medical ultrasonography","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prediction of dual-phenotype hepatocellular carcinoma based on ultrasound and contrast enhanced ultrasound - a preliminary study.\",\"authors\":\"Nan Wang, Xiaorong Lv, Peihua Wang, Xiao Huang, Luping Liu, Ju Zhu, Fang Nie\",\"doi\":\"10.11152/mu-4466\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims: </strong>To investigate the diagnostic value of ultrasound features with dual-phenotype hepatocellular carcinoma (DPHCC). Material and methods: A retrospective analysis was conducted on patients diagnosed with hepatocellular carcinoma (HCC) confirmed by pathology results from October 2016 to December 2023. Patients were categorized into DPHCC and non-DPHCC (NDPHCC) groups based on immunohistochemical findings. Clinical baseline characteristics and ultrasound features were compared between these groups. Multivariable logistic regression was employed to identify predictive factors. A logisticregression model and nomogram were developed to predict DPHCC.</p><p><strong>Results: </strong>This study included 219 HCC patients (average age: 55.84±9.00, 173 males), with 61 cases of DPHCC and 158 cases of NDPHCC. The results of multivariate logistic regression indicated that halo sign (OR=1.93, p=0.049), PVP hypo-enhancement (OR=2.73, p=0.002) and nodule-in-nodule sign (OR=4.23, p=0.003) were independent predictors of DPHCC. The model's AUC value was 0.73 (95%CI: 0.65-0.80). The calibration curve displayed good predictive accuracy.</p><p><strong>Conclusions: </strong>Ultrasound features, including CEUS, may provide additional information for the non-invasive diagnosis of DPHCC.</p>\",\"PeriodicalId\":94138,\"journal\":{\"name\":\"Medical ultrasonography\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-12-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical ultrasonography\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.11152/mu-4466\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical ultrasonography","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.11152/mu-4466","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Prediction of dual-phenotype hepatocellular carcinoma based on ultrasound and contrast enhanced ultrasound - a preliminary study.
Aims: To investigate the diagnostic value of ultrasound features with dual-phenotype hepatocellular carcinoma (DPHCC). Material and methods: A retrospective analysis was conducted on patients diagnosed with hepatocellular carcinoma (HCC) confirmed by pathology results from October 2016 to December 2023. Patients were categorized into DPHCC and non-DPHCC (NDPHCC) groups based on immunohistochemical findings. Clinical baseline characteristics and ultrasound features were compared between these groups. Multivariable logistic regression was employed to identify predictive factors. A logisticregression model and nomogram were developed to predict DPHCC.
Results: This study included 219 HCC patients (average age: 55.84±9.00, 173 males), with 61 cases of DPHCC and 158 cases of NDPHCC. The results of multivariate logistic regression indicated that halo sign (OR=1.93, p=0.049), PVP hypo-enhancement (OR=2.73, p=0.002) and nodule-in-nodule sign (OR=4.23, p=0.003) were independent predictors of DPHCC. The model's AUC value was 0.73 (95%CI: 0.65-0.80). The calibration curve displayed good predictive accuracy.
Conclusions: Ultrasound features, including CEUS, may provide additional information for the non-invasive diagnosis of DPHCC.
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