Maturitas最新文献

{"title":"Would be mandatory Fragile X syndrome screening in Premature Ovarian Insufficiency study?","authors":"Elisabet Robert Marchal, Beatriz Roca Comella, Sandra Rodriguez Veret, Laia Sánchez Paniagua, Maria Jose Gamundi Rodriguez","doi":"10.1016/j.maturitas.2023.04.243","DOIUrl":"https://doi.org/10.1016/j.maturitas.2023.04.243","url":null,"abstract":"Fragile X Syndrome is a confirmed cause of Primary Ovarian Insufficiency (POI). The frequency of women who carry a premutation is 1/300. This has many consequences with the most significant being the loss of reproductive hormones and infertility. However, there are 5-10% of spontaneous pregnancies. For this reason patients must be informed by genetic counselling of the risk of having a newborn who may carry a premutation or Fragile X Syndrome. We report the case of 33-year-old woman referred for 5-month-long amenorrhea. In the study, serum gonadotropins were found at menopausal range. The patient became pregnant without medical intervention and before having the results of the genetic study, which was diagnostic of carrier of Fragile X Syndrome premutation with 90 expanded CGG repeats. An amniocentesis was performed afterwards, which reported the 46XX newborn to be positive for complete mutation of Fragile X Syndrome, with 200 expanded CGG repeats. Finally, a girl with correct weight was born by vaginal delivery at 37.5 weeks. She presented late and slow psychomotor development in the first years of life and is currently receiving paediatric neurology follow-up.","PeriodicalId":94131,"journal":{"name":"Maturitas","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135154708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report - Multidisciplinary approach to sexual dysfunction in post-menopausal women in Singapore","authors":"Jean Jasmin Lee, Farah Safdar, Seng Bin Ang","doi":"10.1016/j.maturitas.2023.04.158","DOIUrl":"https://doi.org/10.1016/j.maturitas.2023.04.158","url":null,"abstract":"Introduction & Rationale: This case highlights the multidisciplinary approach used in the management of sexual dysfunction in post-menopausal women. A 52-year-old Chinese female presented with an 8-month history of worsening dyspareunia, low libido and secondary anorgasmia. She was on continuous menopause hormone therapy (MHT) that was initiated 2 years prior. Her initial presenting complaints were hot flushes, sleep disruption, vaginal dryness and mood instability – all of which resolved with MHT. She was found to have secondary vaginismus contributed by stressors that perpetuated the sexual dysfunction cycle. Predisposing factors included mild stress incontinence since the birth of her second child 18 years ago and work-related stress. Psycho-social factors included anxiety about not being able to satisfy her husband’s sexual needs leading to his infidelity, and the impact on her marriage.","PeriodicalId":94131,"journal":{"name":"Maturitas","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135154488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaginal Erbium Laser as a non-hormonal therapeutical procedure for managing urinary symptoms in breast and gynecological cancer survivors","authors":"Vittoria Frisetti Carpani, Giulia Misasi, Maria Magdalena Montt Guevara, Cristina Zito, Eleonora Russo, Tommaso Simoncini","doi":"10.1016/j.maturitas.2023.04.172","DOIUrl":"https://doi.org/10.1016/j.maturitas.2023.04.172","url":null,"abstract":"","PeriodicalId":94131,"journal":{"name":"Maturitas","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135154709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early menopause and premature ovarian insufficiency may increase the risk of sarcopenia: a systematic review and meta-analysis","authors":"Efstathios Divaris, Panagiotis Anagnostis, Nifon Gkekas, Evangelia Kouidi, Dimitrios Goulis","doi":"10.1016/j.maturitas.2023.04.075","DOIUrl":"https://doi.org/10.1016/j.maturitas.2023.04.075","url":null,"abstract":"","PeriodicalId":94131,"journal":{"name":"Maturitas","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135154694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early menopause and premature ovarian insufficiency are associated with increased risk of dementia: a systematic review and meta-analysis","authors":"Eleni Karamitrou, Panagiotis Anagnostis, Konstantina Vaitsi, Loukas Athanasiadis, Dimitrios Goulis","doi":"10.1016/j.maturitas.2023.04.177","DOIUrl":"https://doi.org/10.1016/j.maturitas.2023.04.177","url":null,"abstract":"Background / Aims: As estrogens play a neuroprotective role, the decline in their concentrations during menopause may compromise cognitive function in postmenopausal women. Whether early menopause (EM) is associated with an increased risk of dementia remains unclear. The purpose of this study was to systematically review and meta-analyze current evidence regarding the association between EM or premature ovarian insufficiency (POI) and the risk of dementia of any type.","PeriodicalId":94131,"journal":{"name":"Maturitas","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135154696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients with chronic diseases: is sexual health brought up by general practitioners during appointments? – A web-based study","authors":"Päivi Polo-Kantola, Sanna-Mari Manninen, Tero Vahlberg, Katja Kero","doi":"10.1016/j.maturitas.2023.04.055","DOIUrl":"https://doi.org/10.1016/j.maturitas.2023.04.055","url":null,"abstract":"Objectives: Many chronic diseases and their medications may induce sexual problems. This study aimed to evaluate whether general practitioners (GPs) bring up patients’ sexual health issues during appointments with patients who have chronic diseases.","PeriodicalId":94131,"journal":{"name":"Maturitas","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135154700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of menopause on lipoprotein (a) concentrations: a systematic review and meta-analysis","authors":"Panagiotis Anagnostis, Christina Antza, Christina Trakatelli, Irene Lambrinoudaki, Dimitrios Goulis, Vasileios Kotsis","doi":"10.1016/j.maturitas.2023.04.178","DOIUrl":"https://doi.org/10.1016/j.maturitas.2023.04.178","url":null,"abstract":"Objective: Transition to menopause has been associated with an increased risk of cardiovascular disease (CVD), attributed mainly to atherogenic dyslipidemia. Whether lipoprotein (a) [Lp(a)], an independent cardiovascular risk factor, also contributes to menopause-associated CVD has not yet been clarified. The aim of this study was to systematically investigate and meta-analyze the best available evidence regarding the effect of menopause on Lp(a) concentrations.","PeriodicalId":94131,"journal":{"name":"Maturitas","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135154697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of a 0.005% estriol vaginal gel in preventing recurrent urinary tract infections in postmenopausal women with vaginal atrophy. Blissure study","authors":"Nuno Aquilino Muiños Fernández, José Ignacio Pardo González de Quevedo, Maria Pilar Diaz-Merino Martinez, Ildefonso Garcia Martin, Javier Rosado Martin, Maria Palma Santisteban, Eva Garcia Aguilar","doi":"10.1016/j.maturitas.2023.04.207","DOIUrl":"https://doi.org/10.1016/j.maturitas.2023.04.207","url":null,"abstract":"Background: Decreased estrogen levels after menopause result in vaginal atrophy, leading to elevated pH, lower levels of Lactobacilli and dysbiosis, increasing the frequency of Urinary Tract Infections (UTIs). Topical estrogens restore the atrophic vagina stimulating the proliferation of a balanced flora and preventing urinary symptoms. This preventive approach can be considered an alternative to the use of long-term antibiotics.","PeriodicalId":94131,"journal":{"name":"Maturitas","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135154698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does one size fit all? The usefulness of menopause education across low and middle income countries","authors":"Nicole Jaff","doi":"10.1016/j.maturitas.2023.04.190","DOIUrl":"https://doi.org/10.1016/j.maturitas.2023.04.190","url":null,"abstract":"Approximately six million women, globally, will become menopausal annually, with 76% of these living in developing countries. Western studies show that the menopause transition is associated with an increased risk of cardiometabolic disease (CMD), cognitive decline and related risk factors. Longitudinal research found CMD risk factors are increasing, leading to the majority of deaths worldwide, particularly in low- and middle-income countries (LMICs). Data show that CMDs are associated with cognitive decline and subsequent dementia. A laterage at menopause is associated with increased longevity and low morbidity, but women in LMICs, where poor socio-economic conditions are the norm, have been shown to become menopausal earlier than their Western counterparts. A series of socioeconomic challenges, including a lack of adequate human and financial resources to collect robust, accurate data have hindered longitudinal research in LMICs, resulting in a paucity of data on the perimenopause and the increased health risks. Additional challenges includevery limited or no access to gynecological consultations or annual health checkupsfrom under resourced and stressed public health systems, lack of education, and scarcity of information on menopause. Menopause education focussing on modifiable life style risk factors is urgently needed to inform LMIC public healthcare systems and the population, particularly since menopausal hormone therapy is not readily available. However, several challenges suggest that information from Western studies may not be easily generalizable to LMIC women. Cultural and ethnic differencesmay determine a different experience of the MT between LMIC women and their Western counterparts. Socioeconomic status, education level and lifestyle may vary widely. There are limited appropriate screening tools and resources to measure various aspects of the menopause, including accurate staging, CMD risk factors and cognition, meaning menopause research in LMICs focusses primarily on age at menopause, menopausal symptoms and perception of menopause. In order to ensure that women in LMICs receive effective menopause education, there is an urgent need for LMIC menopause research focusing on biological and cultural factors affecting midlife women, using culturally appropriate and validated measures, and carefully designed methodology encompassing the broad range of confounding factors found in LMICs.","PeriodicalId":94131,"journal":{"name":"Maturitas","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135154699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}