Journal of the Chinese Medical Association : JCMA最新文献

{"title":"Redefined complement C3c structures have significant increase in the plasma of ovarian cancer patients.","authors":"Dong-Hao Chen, Yi-Wen Chang, Chin-Hsiang Chien, Pao-Ling Torng, Yeou-Guang Tsay","doi":"10.1097/JCMA.0000000000001249","DOIUrl":"10.1097/JCMA.0000000000001249","url":null,"abstract":"<p><strong>Background: </strong>Ovarian cancer (OC) is the third most common gynecological cancer. Effective biomarkers are required for OC as in the case of other cancers. Therefore, here we explored whether plasma proteolytic products could serve as potential biomarkers.</p><p><strong>Methods: </strong>We devised a platform that incorporates CyDye labeling, macroporous reversed-phase liquid chromatography, reducing/nonreducing sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAG), and fluorescence imaging. Paired preoperative and postoperative plasma samples from four patients were used to screen for possible proteolytic changes. For identified difference proteins, liquid chromatography-tandem mass spectrometry was used to analyze the protein digests using various proteases. Plasma samples from 33 healthy controls and 85 patients with OC were examined using an enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>Our analyses revealed that the circulating complement C3 derivative was present only in the diseased state. This 145-kDa species, under nonreducing conditions, could split into 72-, 39-, and 29-kDa fragments upon reduction, reminiscent of the C3c structure. While confirming the C3c identity, mass spectrometric analyses showed multiple C-terminal ends in the C3c α'1 fragment, which were utilized differently among patients with OC. Various ends were also observed in serum samples prepared using different complement activators, thus redefining C3c as a mixture of multiple molecular entities. Enzyme-linked immunosorbent assay (ELISA) targeting only canonical C3c demonstrated a strong correlation between increased plasma levels and the occurrence and progression of OC.</p><p><strong>Conclusion: </strong>Our findings suggest that plasma proteolysis during complement deactivation is explicitly involved in ovarian tumorigenesis and the associated protein changes may aid in developing next-generation cancer biomarkers.</p>","PeriodicalId":94115,"journal":{"name":"Journal of the Chinese Medical Association : JCMA","volume":" ","pages":"568-576"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence algorithm improves radiologists' bone age assessment accuracy.","authors":"Tien-Yu Chang, Ting Ywan Chou, I-An Jen, Yeong-Seng Yuh","doi":"10.1097/JCMA.0000000000001248","DOIUrl":"10.1097/JCMA.0000000000001248","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence (AI) algorithms can provide rapid and precise radiographic bone age (BA) assessment. This study assessed the effects of an AI algorithm on the BA assessment performance of radiologists, and evaluated how automation bias could affect radiologists.</p><p><strong>Methods: </strong>In this prospective randomized crossover study, six radiologists with varying levels of experience (senior, mid-level, and junior) assessed cases from a test set of 200 standard BA radiographs. The test set was equally divided into two subsets: datasets A and B. Each radiologist assessed BA independently without AI assistance (A- B-) and with AI assistance (A+ B+). We used the mean of assessments made by two experts as the ground truth for accuracy assessment; subsequently, we calculated the mean absolute difference (MAD) between the radiologists' BA predictions and ground-truth BA and evaluated the proportion of estimates for which the MAD exceeded one year. Additionally, we compared the radiologists' performance under conditions of early AI assistance with their performance under conditions of delayed AI assistance; the radiologists were allowed to reject AI interpretations.</p><p><strong>Results: </strong>The overall accuracy of senior, mid-level, and junior radiologists improved significantly with AI assistance than without AI assistance (MAD: 0.74 vs 0.46 years, p < 0.001; proportion of assessments for which MAD exceeded 1 year: 24.0% vs 8.4%, p < 0.001). The proportion of improved BA predictions with AI assistance (16.8%) was significantly higher than that of less accurate predictions with AI assistance (2.3%; p < 0.001). No consistent timing effect was observed between conditions of early and delayed AI assistance. Most disagreements between radiologists and AI occurred over images for patients aged ≤8 years. Senior radiologists had more disagreements than other radiologists.</p><p><strong>Conclusion: </strong>The AI algorithm improved the BA assessment accuracy of radiologists with varying experience levels. Automation bias was prone to affect less experienced radiologists.</p>","PeriodicalId":94115,"journal":{"name":"Journal of the Chinese Medical Association : JCMA","volume":" ","pages":"530-537"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of retractions in primary health care.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1097/JCMA.0000000000001244","DOIUrl":"10.1097/JCMA.0000000000001244","url":null,"abstract":"","PeriodicalId":94115,"journal":{"name":"Journal of the Chinese Medical Association : JCMA","volume":" ","pages":"577"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and characteristics of Guillain-Barré syndrome in Taiwan before and during the COVID-19 pandemic: A 12-year single-center experience.","authors":"Yu-Hsin Chen, Kuan-Lin Lai, Yi-Chung Lee, Yi-Chu Liao","doi":"10.1097/JCMA.0000000000001251","DOIUrl":"10.1097/JCMA.0000000000001251","url":null,"abstract":"<p><strong>Background: </strong>There is substantial regional disparity in the presentation of Guillain-Barré syndrome (GBS), and coronavirus disease 2019 (COVID-19) possibly influences the development of GBS, but the association remains uncertain. This study aimed to investigate the incidence of GBS before and during the COVID-19 pandemic and delineate the clinical profile of GBS in Taiwanese patients.</p><p><strong>Methods: </strong>Medical records of 185 ascertained GBS cases at Taipei Veterans General Hospital between 2011 and 2022 were reviewed. Patients were analyzed based on age, clinical subtypes, and electrophysiological findings. A multivariable ordinal logistic regression was conducted to identify factors related to outcomes measured by the GBS disability scale (GBS-DS), which ranges from 0 to 6, with higher scores indicating greater disability.</p><p><strong>Results: </strong>The single-center incidence (SCI) of GBS, defined as the number of GBS cases relative to the total number of outpatient and emergency department visits per year, remained stable during the COVID-19 pandemic (14.3 cases per year) compared with the prepandemic period (15.8 cases per year). COVID-19 infection or vaccination was reported as a preceding event in six cases, five of which had good outcomes (GBS-DS ≤2). In our cohort, 12% were diagnosed with Miller-Fisher syndrome (MFS), 13% had GBS/MFS overlap, and the remaining patients had typical GBS. One-third had axonal GBS, associated with significantly worse outcomes compared with demyelinating GBS. The overall mortality rate was 1.1%. Old age, low Medical Research Council sum score, ventilator dependency, and autonomic dysfunction were independent predictors of high GBS-DS scores.</p><p><strong>Conclusion: </strong>This single-center study found no increase in GBS occurrence during the COVID-19 pandemic. In Taiwan, GBS is characterized by a higher occurrence of MFS and GBS/MFS overlap and more frequent axonal GBS, highlighting geographical variations in GBS features between Asian and Western countries.</p>","PeriodicalId":94115,"journal":{"name":"Journal of the Chinese Medical Association : JCMA","volume":" ","pages":"503-512"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacillus coagulans TCI803 confers gastroesophageal protection against Helicobacter pylori -evoked gastric oxidative stress and acid-induced lower esophageal sphincter inflammation.","authors":"Yu-Hsuan Cheng, Hung-Keng Li, Kai-Hsian Chang, Yung-Kai Lin, Yung-Hsiang Lin, Chi-Fu Chiang, Jyh-Chin Yang, Chiang-Ting Chien","doi":"10.1097/JCMA.0000000000001246","DOIUrl":"10.1097/JCMA.0000000000001246","url":null,"abstract":"<p><strong>Background: </strong>Probiotic Bacillus coagulans (BC) may have an impact on gastrointestinal protection. This study was designed to investigate the BC effects on Helicobacter pylori ( H. pylori ) induced gastric inflammation in mice and acid-induced lower esophageal sphincter (LES) dysfunction in rats. We determined the oxidative stress/apoptosis/autophagy signaling pathways in H. pylori -induced gastric inflammation and HCl-evoked LES inflammation.</p><p><strong>Methods: </strong>H. pylori -induced gastric inflammation was used in 40 mice and HCl-evoked LES inflammation in 40 Wistar rats. Western blot, immunohistochemistry and cytokine array were used to determine the pathophysiologic mechanisms.</p><p><strong>Results: </strong>H. pylori increased leukocyte infiltration-mediated inflammation and the expression levels of gastric cytokines, 3NT/4HNE-mediated oxidative stress, and Bax/Caspase3-mediated apoptosis, but decreased Beclin-1/LC3-II-mediated autophagy in the mice gastric mucosa. BC treatment decreased inflammation, cytokines release, oxidative stress, and apoptosis, and reversed autophagy in H. pylori -infected gastric mucosa. To replace the antibiotic therapy, BC TCI803 was selected to inhibit H. pylori infection for commercial interests. Saline esophageal infusion evoked an increase in LES pressure and efferent vagus nerve activity during the emptying phase. However, HCI dysregulated LES motility esophageal infusion by a decrease in threshold pressure, intercontraction interval and an increase in efferent vagus nerve activity. BC treatment significantly recovered the level of threshold pressure, intercontraction interval, and depressed the enhanced efferent vagus nerve activity. In vitro LES wire myography data displayed that HCl-treated LES significantly decreased the contractile response to acetylcholine. BC treatment significantly restored the contractile response to acetylcholine in LES wire myography. LES after HCl stimulation significantly increased leukocyte infiltration-mediated inflammation, whereas BC treatment effectively reduced the leukocyte infiltration-mediated inflammation in the HCl-treated LES.</p><p><strong>Conclusion: </strong>BC via anti-oxidation and anti-inflammation confers gastroesophageal protection against H. pylori involved oxidative stress/inflammation/apoptosis/autophagy signaling in mice with gastric inflammation and HCl-induced LES dysregulation and inflammation.</p>","PeriodicalId":94115,"journal":{"name":"Journal of the Chinese Medical Association : JCMA","volume":" ","pages":"545-560"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 2025 update on treatment strategies for the Alzheimer's disease spectrum.","authors":"Chuang-Kuo Wu, Jong-Ling Fuh","doi":"10.1097/JCMA.0000000000001252","DOIUrl":"10.1097/JCMA.0000000000001252","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder with a continuum of stages ranging from preclinical/asymptomatic phase to severe dementia. Over the past decades, significant advances in diagnostic biomarkers and disease-modifying therapies have reshaped the treatment landscape. This review provides a comprehensive overview of the current treatment paradigm for AD in 2025, incorporating the latest developments in pharmacological and non-pharmacological interventions. The advent of anti-amyloid immunotherapy, including the US Food & Drug Administration (FDA)-approved monoclonal antibodies such as lecanemab and donanemab, has proven efficacy in slowing cognitive decline in early-stage AD. These therapies mark a change in thinking in AD management, emphasizing the importance of early diagnosis and intervention. Cholinesterase inhibitors and memantine remain the standard treatments for mild, moderate to severe dementia, providing symptomatic relief and functional stabilization. Additionally, emerging strategies targeting tau pathology and neuroinflammation are under investigation, offering hope for future breakthroughs. Beyond pharmacotherapy, this review highlights the importance of personalized, multimodal treatment approaches that integrate lifestyle modifications, cognitive training, and caregiver support. The updated diagnostic framework, incorporating fluid and imaging biomarkers, enables more precise staging and individualized treatment plans. Despite these advances, challenges still lie in refining patient selection, addressing treatment-related side effects, and ensuring accessibility to appropriate therapies. As the field moves forward, ongoing clinical trials and real-world evidence will further refine treatment strategies. A proactive approach, combining early detection with disease-modifying and symptomatic therapies, is essential for improving patient outcomes and quality of life. This article synthesizes current knowledge and provides a roadmap for clinicians and researchers navigating the evolving landscape of AD treatment.</p>","PeriodicalId":94115,"journal":{"name":"Journal of the Chinese Medical Association : JCMA","volume":" ","pages":"495-502"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circular RNA LDLRAD3 promotes gastric cancer progression by upregulating COL4A5 through sponging miR-137: Erratum.","authors":"Chenghui Li, Xiao Xing, Sinian Huang, Ting Zhu, Bin Yan","doi":"10.1097/JCMA.0000000000001247","DOIUrl":"10.1097/JCMA.0000000000001247","url":null,"abstract":"","PeriodicalId":94115,"journal":{"name":"Journal of the Chinese Medical Association : JCMA","volume":" ","pages":"578"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of Chinese herbal enema combined with Mesalazine versus Mesalazine alone in the treatment of ulcerative colitis: A randomized controlled trial.","authors":"Jiao Zhang, Bin Shi, Da Li, Yan Du, Shujiang Gu, Haiying Yao, Dongxuan Zhang, Yuan Tao","doi":"10.1097/JCMA.0000000000001259","DOIUrl":"https://doi.org/10.1097/JCMA.0000000000001259","url":null,"abstract":"<p><strong>Background: </strong>Mesalazine is a standard treatment for ulcerative colitis (UC). However, it is unclear whether the efficacy of mesalazine combined with traditional Chinese medicine (TCM) enemas is superior to that of mesalazine alone. Therefore, this study aimed to evaluate the clinical effectiveness of TCM enema hydrotherapy combined with mesalazine for active UC.</p><p><strong>Methods: </strong>Patients with active UC were randomly assigned to two treatment groups: a combination of mesalazine and TCM enemas and mesalazine alone. Outcome measures included TCM symptom scores, levels of inflammatory markerss [interleukin-8 (IL-8), tumor necrosis factor α (TNF-α), high-sensitivity C-reactive protein (hs-CRP)], colonoscopy scores (Baron score), disease activity indices [Sutherland Disease Activity Index (DAI), modified Mayo score], and recurrence rates.</p><p><strong>Results: </strong>A total of 80 patients were included in the study. Regarding the primary outcomes, the total effective rate in the combination group was 95%, which was significantly higher than the 75% observed in the mesalazine group (p < 0.05). The recurrence rate was lower in the combined group (2.5%) than in the mesalazine group (17.5%) (p < 0.05). Regarding secondary outcomes, the combination group showed higher reductions in TCM symptom scores than the mesalazine group, particularly in the areas of bloody stool, diarrhea, and abdominal pain (p < 0.05). The combined group also showed significantly lower inflammatory markers (IL-8, TNF-α, hs-CRP) and disease activity scores (Baron score, DAI, modified Mayo score) compared to the mesalazine group (p < 0.05).</p><p><strong>Conclusion: </strong>The combination of TCM enema hydrotherapy and mesalazine therapy led to significant clinical improvement with lower inflammatory responses and reduced recurrence rates in patients with active UC. The combination treatment may be more effective than mesalazine alone and shows promise as a management option for UC.</p>","PeriodicalId":94115,"journal":{"name":"Journal of the Chinese Medical Association : JCMA","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased serum APOC3 in patients with syphilis can predict the absence of Jarisch-Herxheimer reaction after benzathine penicillin treatment.","authors":"Hung-Chin Tsai, Pei-Yun Chou, Hui-Min Chang, Susan Shin-Jung Lee, Yao-Shen Chen","doi":"10.1097/JCMA.0000000000001238","DOIUrl":"10.1097/JCMA.0000000000001238","url":null,"abstract":"<p><strong>Background: </strong>Apolipoprotein C3 (APOC3) was found to induce inflammation in human monocytes. Jarisch-Herxheimer reaction (JHR) was perceived to be caused by immune reactions of dividing spirochaetes to penicillin treatment. The aim of this study was to investigate the role of APOC3 in patients with syphilis and JHR.</p><p><strong>Methods: </strong>This prospective cohort study enrolled adult patients with active syphilis with/without JHR. Serum samples were collected before and after administration of the first dose of benzathine penicillin and the serum levels of APOC3 were determined by enzyme-linked immunosorbent assay (ELISA). The APOC3 level and changes in APOC3 level before and after benzathine penicillin treatment in different groups were compared with the Mann-Whitney U test or Kruskal-Wallis test.</p><p><strong>Results: </strong>Forty adult patients with syphilis and 32 controls were enrolled. All 40 patients with syphilis were men who have sex with men, and 30 (75%) were people living with human immunodeficiency virus (HIV). Overall, 19 patients (47%) developed JHR. The active syphilis group had a significantly higher serum APOC3 level (median 38.3 µg/mL, interquartile range [IQR]: 34.5-48.0 µg/mL) than the controls ( p = 0.020). The serum levels of APOC3 were higher in the 21 patients without JHR before and after benzathine penicillin treatment compared with the controls (38.9 µg/mL [IQR: 34.5-66.7 µg/mL] and 39.4 µg/mL [IQR: 33.7-62.9] µg/mL vs 31.8 µg/mL [IQR: 27.5-42.2 µg/mL]). Receiving operating characteristic curve analysis showed that the best cutoff value of APOC3 to predict the absence of JHR before benzathine penicillin therapy compared to the controls was 34.2 µg/mL (area under the curve 0.695, p = 0.017, CI = 0.544-0.846, sensitivity = 0.81, specificity = 0.406).</p><p><strong>Conclusion: </strong>A high baseline serum APOC3 level can predict the absence of JHR in patients with syphilis treated with the first dose of benzathine penicillin.</p>","PeriodicalId":94115,"journal":{"name":"Journal of the Chinese Medical Association : JCMA","volume":" ","pages":"461-468"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Far-infrared therapy on arteriovenous fistula among hemodialysis patients: A systematic review and meta-analysis.","authors":"Ruhana Che Yusof, Mohd Noor Norhayati, Mohd Yacob Azman","doi":"10.1097/JCMA.0000000000001236","DOIUrl":"10.1097/JCMA.0000000000001236","url":null,"abstract":"<p><strong>Background: </strong>Far-infrared (FIR) is one of the alternative therapies used to improve the performance of arteriovenous fistula (AVF) in hemodialysis patients. This review was done to pool the mean difference of vascular access flow and AVF diameter between the FIR and the control group. It also pooled the risk ratio of 1-year unassisted AVF patency, AVF occlusion, surgical intervention, and AVF malfunction between groups.</p><p><strong>Methods: </strong>The studies were reviewed using a systematic review, meta-analysis, and a search of four databases. The risk of bias in non-randomized studies of interventions (ROBINS-I) and the Revised Cochrane risk-of-bias instrument for randomized trials (RoB-2) were used to assess the data quality. The meta-analysis was performed using the random-effects model by inverse variance to measure the mean difference for continuous data and the Mantel-Haenszel method for dichotomous data.</p><p><strong>Results: </strong>FIR therapy group had a significant difference in risk ratio in 1-year unassisted AVF patency (risk ratio: 1.23 [95% CI, 1.12-1.36]), AVF occlusion (risk ratio: 0.24 [95% CI, 0.08-0.68]), surgical intervention (risk ratio: 0.45 [95% CI, 0.23-0.86]), and AVF malfunction (risk ratio: 0.44 [95% CI, 0.30-0.62]) compared with the control group. However, for vascular access flow and AVF diameter, there was no difference between the groups (mean difference: 68.38 [95% CI, -3.84 to 140.61] and -0.07 [95% CI, -0.31 to 0.17], respectively).</p><p><strong>Conclusion: </strong>The findings showed that the FIR therapy improved AVF performance. However, the limited number of studies primarily from Taiwanese may act differently from others.</p>","PeriodicalId":94115,"journal":{"name":"Journal of the Chinese Medical Association : JCMA","volume":" ","pages":"425-432"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}