Journal of the American Geriatrics Society最新文献

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Cost-Effectiveness of the Geriatrician-Led Comprehensive Geriatric Assessment in Different Healthcare Settings: An Economic Evaluation. 在不同的医疗环境中,老年医生主导的综合老年评估的成本效益:一项经济评估。
Journal of the American Geriatrics Society Pub Date : 2025-03-26 DOI: 10.1111/jgs.19448
Eric Kai-Chung Wong, Wanrudee Isaranuwatchai, Joanna E M Sale, Andrea C Tricco, Sharon E Straus, David M J Naimark
{"title":"Cost-Effectiveness of the Geriatrician-Led Comprehensive Geriatric Assessment in Different Healthcare Settings: An Economic Evaluation.","authors":"Eric Kai-Chung Wong, Wanrudee Isaranuwatchai, Joanna E M Sale, Andrea C Tricco, Sharon E Straus, David M J Naimark","doi":"10.1111/jgs.19448","DOIUrl":"https://doi.org/10.1111/jgs.19448","url":null,"abstract":"<p><strong>Background: </strong>With a shortage of geriatricians, the appropriate distribution of geriatricians across healthcare settings (e.g., acute care, rehabilitation, or community clinics) is unknown. Our objective was to determine which setting(s) geriatricians should preferentially staff to be most economically attractive for the Canadian healthcare system.</p><p><strong>Methods: </strong>We conducted a cost-effectiveness analysis using a two-dimensional microsimulation model. The model simulated a population of frail adults aged ≥ 65 years. The simulation was done over a lifetime horizon from the Ontario public payer perspective. Strategies included (1) usual care (baseline proportions of geriatrician CGAs in each setting), (2) acute care only (100% receive CGA in acute care), (3) community care only, (4) rehabilitation only, (5) acute care and community combined, (6) acute care and rehabilitation combined, (7) community and rehabilitation combined, and (8) acute care, community, and rehabilitation combined. Primary model outputs included quality-adjusted life months (QALMs), lifetime costs, and incremental cost-effectiveness ratios (ICERs).</p><p><strong>Results: </strong>The acute care and rehabilitation combined strategy was undominated at a lifetime cost of C$139,987 and with an effectiveness of 42.09 QALM. At an ICER of C$1203 per QALM, the combination strategy of acute care, rehabilitation, and community clinics was cost-effective relative to acute care and rehabilitation, assuming a cost-effectiveness threshold of C$4167 per QALM (equivalent to C$50,000 per quality-adjusted life year). The other six strategies were dominated. When individually compared to usual care, all of the strategies were dominant or cost-effective.</p><p><strong>Conclusions: </strong>An undominated strategy of staffing geriatricians was in the acute care and rehabilitation settings, with the option of adding community clinics if cost and resources permit.</p>","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive Versus Conservative Treatment Strategy in Older Patients With Non-ST Segment Elevation Acute Coronary Syndromes: A Meta-Analysis of Randomized Controlled Trials. 老年非st段抬高急性冠状动脉综合征患者有创与保守治疗策略:一项随机对照试验的荟萃分析
Journal of the American Geriatrics Society Pub Date : 2025-03-26 DOI: 10.1111/jgs.19447
Mushood Ahmed, Areeba Ahsan, Aimen Shafiq, Tallal Mushtaq Hashmi, Raheel Ahmed, Mahboob Alam, Farhan Shahid, Jamal S Rana, Mamas A Mamas, Gregg C Fonarow
{"title":"Invasive Versus Conservative Treatment Strategy in Older Patients With Non-ST Segment Elevation Acute Coronary Syndromes: A Meta-Analysis of Randomized Controlled Trials.","authors":"Mushood Ahmed, Areeba Ahsan, Aimen Shafiq, Tallal Mushtaq Hashmi, Raheel Ahmed, Mahboob Alam, Farhan Shahid, Jamal S Rana, Mamas A Mamas, Gregg C Fonarow","doi":"10.1111/jgs.19447","DOIUrl":"https://doi.org/10.1111/jgs.19447","url":null,"abstract":"<p><strong>Background: </strong>Non-ST segment elevation acute coronary syndromes (NSTE-ACS) are a common cause of hospital admission in older patients. Our study aims to synthesize the available evidence from randomized controlled trials (RCTs) to compare clinical outcomes with invasive versus conservative medical management in this population.</p><p><strong>Methods: </strong>A literature search of online databases including PubMed/MEDLINE, Embase, and the Cochrane Library was conducted from inception to September 1, 2024. The search aimed to identify RCTs that reported clinical outcomes with invasive versus conservative strategies in older patients (≥ 70 years) with NSTE-ACS. The risk ratios (RRs) were used as summary estimates.</p><p><strong>Results: </strong>Seven RCTs with 2998 patients were included; 1490 patients in the invasive group and 1508 patients in the conservatively managed group. The pooled analysis demonstrated no statistically significant difference between the two strategies for the risk of all-cause death (RR: 1.03, 95% CI: 0.92-1.15), cardiovascular death (RR: 1.04, 95% CI: 0.82-1.33), stroke (RR: 0.78, 95% CI: 0.53-1.15), and major bleeding (RR: 1.23, 95% CI: 0.90-1.69). However, the invasive strategy was associated with a significantly reduced risk of myocardial infarction (RR: 0.74, 95% CI: 0.57-0.96) and unplanned revascularization (RR: 0.29, 95% CI: 0.21-0.40) compared to the conservative strategy.</p><p><strong>Conclusion: </strong>In older patients with NSTE-ACS, an invasive strategy reduces the risk of repeat myocardial infarction and unplanned revascularization without a significant increase in stroke or major bleeding. There was no associated reduction in all-cause or cardiovascular mortality with the invasive strategy compared to conservative management.</p>","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Change in Fall Status of Older People With Dementia and Caregiving Difficulties: Moderation Effects of Living Arrangements. 老年痴呆及照顾困难患者跌倒状况的变化:生活安排的调节作用。
Journal of the American Geriatrics Society Pub Date : 2025-03-24 DOI: 10.1111/jgs.19442
Yuanjin Zhou, Kylie Meyer, Ellliane Irani, Xiao Liu, Namkee Choi
{"title":"Change in Fall Status of Older People With Dementia and Caregiving Difficulties: Moderation Effects of Living Arrangements.","authors":"Yuanjin Zhou, Kylie Meyer, Ellliane Irani, Xiao Liu, Namkee Choi","doi":"10.1111/jgs.19442","DOIUrl":"https://doi.org/10.1111/jgs.19442","url":null,"abstract":"<p><strong>Objectives: </strong>We aim to investigate the associations between 2-year fall status among community-dwelling older people with dementia and care partners' emotional, physical, and financial difficulties, with living arrangements (co-residence vs. separate residence) as a moderator.</p><p><strong>Method: </strong>We used the 2015-2017 National Health and Aging Trends Study and the linked survey 2017 National Study of Caregiving (935 care partners for 567 community-dwelling older people with dementia). We employed multilevel generalized linear regression models to examine the associations of fall status between 2015 and 2017 with caregiving difficulties in 2017 for co-residing and non-co-residing care partners. We then evaluated the moderation effect of care partners' living arrangements.</p><p><strong>Results: </strong>For co-residing care partners, high (p = 0.001), increased (p = 0.001), and decreased (p = 0.001) fall frequency over 2 years was significantly associated with emotional difficulties. For non-co-residing care partners, high (p < 0.001), increased (p = 0.001), and decreased (p = 0.002) fall frequency was significantly associated with their physical difficulties. Compared to co-residing care partners, those who lived apart experienced greater physical difficulties when the fall frequency increased over 2 years (p < 0.05), but this effect became non-significant after the Bonferroni correction. High fall frequency was significantly associated with financial difficulties for co-residing (p = 0.009) and non-co-residing (p = 0.003) care partners, and decreased fall frequency was only significantly associated with financial difficulties for non-co-residing care partners (p = 0.018). All findings for financial difficulties became non-significant after the Bonferroni correction.</p><p><strong>Discussion: </strong>This study found differential associations between fall status over 2 years and care-related difficulties by care partners' living arrangements. Preventing falls for this population can potentially reduce the informal caregiving burden, especially the emotional difficulties for co-residing care partners and the physical difficulties of non-co-residing caregivers. Tailored interventions to manage fall risk among older people with dementia and support care partners with different living arrangements are crucial to improving their well-being.</p>","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Hearing Intervention on Physical Activity Measured by Accelerometry: A Secondary Analysis of the ACHIEVE Study. 听力干预对加速度计测量的身体活动的影响:对ACHIEVE研究的二次分析。
Journal of the American Geriatrics Society Pub Date : 2025-03-24 DOI: 10.1111/jgs.19435
Jennifer A Schrack, Amal A Wanigatunga, Nancy W Glynn, Michelle L Arnold, Sheila Burgard, Theresa H Chisolm, David Couper, Jennifer A Deal, Theresa Gmelin, Adele M Goman, Alison R Huang, Lisa Gravens-Mueller, Kathleen M Hayden, Pablo Martinez-Amezcua, Christine M Mitchell, James S Pankow, James R Pike, Nicholas S Reed, Victoria A Sanchez, Kevin J Sullivan, Josef Coresh, Frank R Lin
{"title":"Effects of Hearing Intervention on Physical Activity Measured by Accelerometry: A Secondary Analysis of the ACHIEVE Study.","authors":"Jennifer A Schrack, Amal A Wanigatunga, Nancy W Glynn, Michelle L Arnold, Sheila Burgard, Theresa H Chisolm, David Couper, Jennifer A Deal, Theresa Gmelin, Adele M Goman, Alison R Huang, Lisa Gravens-Mueller, Kathleen M Hayden, Pablo Martinez-Amezcua, Christine M Mitchell, James S Pankow, James R Pike, Nicholas S Reed, Victoria A Sanchez, Kevin J Sullivan, Josef Coresh, Frank R Lin","doi":"10.1111/jgs.19435","DOIUrl":"10.1111/jgs.19435","url":null,"abstract":"<p><strong>Background: </strong>Hearing loss is prevalent in older adults and is associated with reduced daily physical activity, but whether hearing intervention attenuates declines in physical activity is unknown. We investigated the 3-year effect of a hearing intervention versus a health education control on accelerometer-measured physical activity in older adults with hearing loss.</p><p><strong>Methods: </strong>This secondary analysis of the ACHIEVE randomized controlled trial included 977 adults aged 70-84 years with hearing loss. Participants were randomized to either a hearing intervention group or a health education control group. Physical activity was measured using wrist-worn accelerometers at baseline, 1, 2, and 3 years. Linear mixed models assessed the impact of the intervention on changes in total activity counts, active minutes per day, and activity fragmentation.</p><p><strong>Results: </strong>Among 847 participants in the final analysis (mean age 76.2 years; 440 [52%] women; 87 [10%] Black; 5 [0.8%] Hispanic), total activity counts declined by 2.7% annually, and active minutes/day declined by 2.1% annually over 3 years in both intervention and control groups. Activity patterns also became more fragmented over time. No appreciable differences were observed between hearing intervention and health education control in the 3-year change in accelerometry-measured physical activity measures.</p><p><strong>Conclusions: </strong>Hearing intervention did not appreciably attenuate 3-year declines in physical activity compared to health education control in older adults with hearing loss. Alternative strategies beyond hearing treatment may be needed to enhance physical activity among older adults with hearing loss.</p>","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prescribing Patterns and Impact of Sedatives in Hospitalized Older Adults: A Secondary Analysis of the MedSafer Study. 住院老年人镇静剂的处方模式和影响:MedSafer研究的二次分析
Journal of the American Geriatrics Society Pub Date : 2025-03-23 DOI: 10.1111/jgs.19437
Bennet Desormeau, Allen Huang, James Downar, Peter E Wu, Emilie Bortolussi-Courval, Sydney B Ross, Kiran Battu, Louise Papillon-Ferland, Finlay A McAlister, Sarah Elsayed, Marnie Goodwin Wilson, Rodrigo B Cavalcanti, Emily G McDonald, Todd C Lee
{"title":"Prescribing Patterns and Impact of Sedatives in Hospitalized Older Adults: A Secondary Analysis of the MedSafer Study.","authors":"Bennet Desormeau, Allen Huang, James Downar, Peter E Wu, Emilie Bortolussi-Courval, Sydney B Ross, Kiran Battu, Louise Papillon-Ferland, Finlay A McAlister, Sarah Elsayed, Marnie Goodwin Wilson, Rodrigo B Cavalcanti, Emily G McDonald, Todd C Lee","doi":"10.1111/jgs.19437","DOIUrl":"https://doi.org/10.1111/jgs.19437","url":null,"abstract":"<p><strong>Background: </strong>We aimed to examine the impact of sedative prescription patterns in hospitalized older adults on post-discharge adverse drug events (ADEs), falls, and sleep.</p><p><strong>Methods: </strong>We conducted a secondary analysis of the MedSafer randomized controlled trial (RCT; NCT03272607) which included hospitalized adults ≥ 65 years of age who were taking ≥ 5 medications. We identified patients who completed follow-up at 30 days post-discharge and provided patient-reported outcomes for sleep disturbance (PROMIS SD 4a). We grouped patients based on sedative use as follows: nonusers, continued home use (pre- and post-hospitalization), deprescribed home use, and new use at discharge. Using multivariable logistic regression, we compared the odds of patients having experienced ≥ 1 ADE (not necessarily ascribed to sedatives), a fall, or any adverse event within 30 days post-discharge. We also used ordinal logistic regression and a minimal important difference approach to compare the change in sleep disturbance at 30 days post-discharge.</p><p><strong>Results: </strong>The cohort comprised 3630 patients with a median age of 78. A total of 2810 (77.4%) were categorized as nonusers; 475 (13.1%) continued home use; 293 (8.1%) deprescribed home use; and 52 (1.4%) new users at discharge. Compared to the continued home use group, the deprescribed group was substantially less likely to experience an ADE post-discharge (adjusted odds ratio [aOR], 0.39 [95% CI, 0.16-0.97]). Correspondingly, new users at discharge had substantially higher odds of falls (aOR, 2.51 [95% CI, 1.13-5.61]). Favorable changes in sleep disturbance were more likely among nonusers (aOR, 1.29 [95% CI, 1.05-1.58]) and deprescribed users (aOR, 1.11 [95% CI, 0.82-1.50]) when compared to continued users.</p><p><strong>Conclusions: </strong>In this cohort, patients who had their sedatives deprescribed were 61% less likely than continued users to have a post-discharge ADE, and new sedative use at discharge was associated with appreciable risk of falls. Hospitalization likely represents a window of opportunity to improve care by promoting sedative deprescription and avoiding new starts.</p>","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serious Illness Communication in a Randomized Trial of a Nurse and Social Worker Palliative Telecare Team. 一个护士和社工姑息治疗远程团队的随机试验中的重病沟通。
Journal of the American Geriatrics Society Pub Date : 2025-03-22 DOI: 10.1111/jgs.19445
Allison V Lange, William J Feser, Edward Hess, Anna E Barón, Jessica E Ma, David B Bekelman
{"title":"Serious Illness Communication in a Randomized Trial of a Nurse and Social Worker Palliative Telecare Team.","authors":"Allison V Lange, William J Feser, Edward Hess, Anna E Barón, Jessica E Ma, David B Bekelman","doi":"10.1111/jgs.19445","DOIUrl":"https://doi.org/10.1111/jgs.19445","url":null,"abstract":"<p><strong>Background: </strong>Early serious illness communication (SIC) has numerous benefits for patients with cardiopulmonary illnesses, yet engaging patients in this complex, iterative communication process is challenging due to constraints on clinician time, limited clinician training in these conversations, and a lack of patient readiness. This study reports secondary SIC outcomes of a previously reported clinical trial.</p><p><strong>Methods: </strong>In a randomized clinical trial of a nurse and social worker palliative telecare team, one visit with the nurse and/or social worker focused on SIC using a protocolized guide. Participants were at high risk of hospitalization or death, had poor health status, and chronic obstructive pulmonary disease and/or heart failure or interstitial lung disease. Documented SIC, advance directive (AD) completion, and the four-item readiness to engage in advance care planning scale (ACP-4) were measured at baseline and 6 months. Differences in change between intervention and usual care were analyzed using linear models and linear mixed models.</p><p><strong>Results: </strong>The 306 participants were on average 68.9 years, 90.2% male, 80.1% White, with multiple comorbidities (mean of 7.6). All outcomes were similar at baseline. ACP-4 increased more in the intervention group at 6 months compared to usual care (difference in change scores: 0.49; 95% CI 0.22-0.66, p < 0.001). Documented SIC at 6 months was higher in the intervention group compared to usual care (122/154, 79.2% vs. 7/152, 4.6%); adjusted difference in proportions 74.6% (95% CI 67.3-81.9, p < 0.001). The difference in proportion of participants with an AD at 6 months was not significant; adjusted difference in proportions, 0.01%, (95% CI -0.04-0.07, p = 0.64).</p><p><strong>Conclusions: </strong>After participation in a telephonic, protocolized SIC intervention, documented SIC increased, and readiness to engage in ACP increased. Future research should evaluate how documented SIC is used and the effect of SIC on downstream outcomes of healthcare decisions and patient well-being.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov NCT02713347, https://clinicaltrials.gov/ct2/show/NCT02713347.</p>","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association of Dementia and Mild Cognitive Impairment With Outpatient Ambulatory Care Utilization in the Community. 痴呆和轻度认知障碍与社区门诊护理利用的关系。
Journal of the American Geriatrics Society Pub Date : 2025-03-22 DOI: 10.1111/jgs.19446
Yi Chen, Bryan D James, Ana W Capuano, Mousumi Banerjee, Mellanie V Springer, Brittney S Lange-Maia, Lisa L Barnes, David A Bennett, Julie P W Bynum, Francine Grodstein
{"title":"The Association of Dementia and Mild Cognitive Impairment With Outpatient Ambulatory Care Utilization in the Community.","authors":"Yi Chen, Bryan D James, Ana W Capuano, Mousumi Banerjee, Mellanie V Springer, Brittney S Lange-Maia, Lisa L Barnes, David A Bennett, Julie P W Bynum, Francine Grodstein","doi":"10.1111/jgs.19446","DOIUrl":"10.1111/jgs.19446","url":null,"abstract":"<p><strong>Background: </strong>Ambulatory care is critical in delivering interventions for dementia and mild cognitive impairment (MCI), from basic services to novel therapeutics. Yet, little is known regarding how community-dwelling persons with dementia/MCI interact with clinicians in outpatient ambulatory settings. We assessed associations of dementia/MCI with outpatient ambulatory evaluation and management (E&M) visits.</p><p><strong>Methods: </strong>We included 2116 community-dwelling participants in Rush Alzheimer's Disease Center cohorts, with linked fee-for-service Medicare claims. Annually from 2011 to 2019, cohort neuropsychologic evaluations classified participants as dementia, MCI, or no cognitive impairment (NCI). Across groups, we compared annual probability of visiting providers and number of E&M visits, using repeated measures logistic or generalized Poisson mixed effects models.</p><p><strong>Results: </strong>Across 8672 person-years (PY) of follow-up, the mean age was 82 (SD 7.6) years; 77% of PYs were among females and 24% among Black participants. Controlling for demographics and comorbidity, the annual predicted probability of primary care visits was high in all groups (86%-92%). Although there were few visits with dementia-related specialists, we found a higher probability of these visits among those with dementia (15%) and MCI (17%) than NCI (12%; p = 0.009, dementia vs. NCI; p < 0.001, MCI vs. NCI). There were striking differences in visits to other medical specialties: the mean number of annual visits was 40% lower for those with dementia (p < 0.001) and 10% lower for MCI (p < 0.001) than NCI. Overall, dementia and MCI were associated with 19% (p < 0.001) and 4% (p = 0.005) fewer E&M visits, respectively, compared to NCI.</p><p><strong>Conclusions: </strong>Older adults with dementia and MCI interact with primary care providers regularly and are more likely to use dementia-related specialists than those with NCI. Yet, we found lower utilization of other medical specialties, without compensatory increases in primary care, leading to fewer overall E&M visits, even in MCI. Together, the findings may suggest lost opportunities to address the scope of health issues in vulnerable groups.</p>","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Efficacy and Safety of Canagliflozin by Frailty Status in Participants of the CANVAS and CREDENCE Trials. canag列净在CANVAS和CREDENCE试验参与者中衰弱状态的有效性和安全性。
Journal of the American Geriatrics Society Pub Date : 2025-03-19 DOI: 10.1111/jgs.19444
Tu N Nguyen, Jie Yu, Vlado Perkovic, Meg Jardine, Kenneth W Mahaffey, Clara K Chow, Clare Arnott, Richard I Lindley
{"title":"The Efficacy and Safety of Canagliflozin by Frailty Status in Participants of the CANVAS and CREDENCE Trials.","authors":"Tu N Nguyen, Jie Yu, Vlado Perkovic, Meg Jardine, Kenneth W Mahaffey, Clara K Chow, Clare Arnott, Richard I Lindley","doi":"10.1111/jgs.19444","DOIUrl":"https://doi.org/10.1111/jgs.19444","url":null,"abstract":"<p><strong>Background: </strong>Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been shown to improve renal and cardiovascular outcomes in patients with type 2 diabetes. Limited evidence exists about the efficacy and safety of SGLT2 inhibitors in patients with frailty.</p><p><strong>Methods: </strong>This was a post hoc pooled, participant-level data analysis of the CANVAS Program (CANVAS and CANVAS-R) and the CREDENCE trial. We examined the effect of canagliflozin on: (1) Major adverse cardiovascular events (MACE), (2) Cardiovascular mortality, (3) all-cause mortality, and (4) key safety outcomes. Frailty was defined by a Frailty Index (FI) based on a deficit accumulation approach (FI > 0.25: frail). Cox proportional-hazard models were used to estimate the efficacy and safety of canagliflozin overall and according to frailty status.</p><p><strong>Results: </strong>There were 14,543 participants (10,142 from the CANVAS Program, 4401 from the CREDENCE trial). Their mean age was 63.2 years; 35.3% were female. Frailty was present in 56% of the study participants. The benefits of canagliflozin were observed in both the frail and non-frail subgroups: HRs for MACE 0.80 (95% CI 0.70-0.90) in the frail versus 0.91 (95% CI 0.75-1.09) in the non-frail (p for interaction = 0.27); HRs for cardiovascular mortality 0.79 (95% CI 0.67-0.95) in the frail versus 0.94 (95% CI 0.70-1.27) in the non-frail (p for interaction = 0.38); HRs for all-cause mortality 0.81 (95% CI 0.70-0.94) in the frail versus 0.93 (95% CI 0.74-1.16) in the non-frail (p for interaction = 0.39). Adverse events were similar among frail and non-frail participants, except for osmotic diuresis (HRs 1.67, 95% CI 1.22-2.28 in the frail vs. 3.05, 95% CI 2.13-4.35 in the non-frail, p for interaction = 0.01).</p><p><strong>Conclusions: </strong>Canagliflozin improved cardiovascular and mortality endpoints in participants with type 2 diabetes irrespective of frailty status, with a similar safety profile. Our findings, in addition to those from other recent studies, provide evidence to support the introduction of SGLT2 inhibitor therapy in patients perceived to be frail.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov CANVAS: NCT01032629; CANVAS-R: NCT01989754; CREDENCE: NCT02065791.</p>","PeriodicalId":94112,"journal":{"name":"Journal of the American Geriatrics Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frailty Matters-Why Isn't It Guiding Clinical Decisions? 虚弱很重要——为什么它不能指导临床决策?
Journal of the American Geriatrics Society Pub Date : 2025-03-19 DOI: 10.1111/jgs.19443
Márlon Juliano Romero Aliberti, Daniel F Arteaga-Vargas, Thiago Junqueira Avelino-Silva
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引用次数: 0
Response to Dr. Ouslander's Editorial on Antipsychotic Use in Nursing Home Residents. 对奥斯兰德博士关于疗养院居民使用抗精神病药物社论的回应。
Journal of the American Geriatrics Society Pub Date : 2025-03-18 DOI: 10.1111/jgs.19404
Jiska Cohen-Mansfield
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引用次数: 0
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