Cancer Cytopathology最新文献

{"title":"Risks of malignancy in the major nongynecologic cytopathology reporting systems: Critiques and discussions","authors":"Marc P. Pusztaszeri MD, PhD,&nbsp;Mauro Saieg MD, PhD,&nbsp;Zubair W. Baloch MD, PhD","doi":"10.1002/cncy.22809","DOIUrl":"10.1002/cncy.22809","url":null,"abstract":"<p>The ever-increasing popularity of standardized systems for reporting cytopathology has led in part to much attention to and importance of the risk stratification schemes, especially the risks of malignancy (ROMs), which are associated with the different diagnostic categories and upon which recommendations for clinical management are based. However, it is well known that the ROM calculations are based on retrospective reviews of the existing literature, representing a heterogeneous patient population, and are plagued by significant biases and variations. Statistically, the ROM represents the post-test probability of malignancy, which changes with the test result and with the prevalence of malignancy (or pretest probability) in an individual practice setting and individual patient presentation. Therefore, the clinical utility of the ROM is questioned and likely needs a second look in the nongynecologic cytopathology reporting systems. In this communication, the authors discuss the status of the ROM estimates according to the most commonly used nongynecologic reporting systems, including for thyroid, salivary glands, and others, highlighting similarities and differences with a focus on the limitations of ROM estimates and their application in clinical practice.</p>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 8","pages":"467-480"},"PeriodicalIF":2.6,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cncy.22809","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140325041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The updated College of American Pathologists principles of analytic validation of immunohistochemical assays: A step forward for cytopathology","authors":"Sinchita Roy-Chowdhuri MD, PhD","doi":"10.1002/cncy.22818","DOIUrl":"10.1002/cncy.22818","url":null,"abstract":"","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 9","pages":"547-548"},"PeriodicalIF":2.6,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140292969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive evaluation of cytomorphologic, histologic, and molecular features of DICER1-altered thyroid lesions on FNA: A multipractice experience","authors":"Krisztina Lengyel MD,&nbsp;Daniel J. Lubin MD,&nbsp;Wen-Yu Hsiao MD,&nbsp;Sam Sirotnikov DO,&nbsp;Guangju Luo MD,&nbsp;James W. Roberts MD,&nbsp;Qiuying Shi MD MS,&nbsp;Kelly Magliocca DMD,&nbsp;Melinda M. Lewis MD,&nbsp;Donald L. Sears MD,&nbsp;Ghulam Ilyas MD,&nbsp;Beverly B. Rogers MD,&nbsp;Kartik Viswanathan MD PhD","doi":"10.1002/cncy.22805","DOIUrl":"10.1002/cncy.22805","url":null,"abstract":"<p>A comprehensive multipractice cytologic-histologic-molecular correlation of a <i>DICER1</i>-altered thyroid lesion cohort, comprising one of the largest to date.</p>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 6","pages":"359-369"},"PeriodicalIF":3.4,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporation of DNA methylation profiling into the cytopathology laboratory","authors":"Gloria H. Sura MD,&nbsp;Leomar Y. Ballester MD, PhD","doi":"10.1002/cncy.22810","DOIUrl":"10.1002/cncy.22810","url":null,"abstract":"","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 9","pages":"543-546"},"PeriodicalIF":2.6,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140130724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growing threats of a mass exodus in governmental public health","authors":"Bryn Nelson PhD,&nbsp;William Faquin MD, PhD","doi":"10.1002/cncy.22804","DOIUrl":"10.1002/cncy.22804","url":null,"abstract":"&lt;p&gt;The backbone of the nation’s public health workforce is buckling.&lt;/p&gt;&lt;p&gt;A recent study has raised alarms with its dire prediction of a mass exodus of governmental public health workers—considered the “backbone” of public health efforts in the United States—if current trends hold.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; “In our analytic sample, nearly half of all employees in state and local public health agencies left between 2017 and 2021, a proportion that rose to three-quarters for those ages 35 and younger or with shorter tenures,” the study’s authors wrote. “If separation trends continue, by 2025 this would represent more than 100,000 staff leaving their organizations, or as much as half of the governmental public health workforce in total.”&lt;/p&gt;&lt;p&gt;Based on data from the Public Health Workforce Interests and Needs Surveys in 2017 and 2021, the study has raised troubling questions about the country’s health priorities and the ability of local and state governments to recruit and retain new talent to help fill a yawning gap. “If you saw half or three quarters of firefighters or police indicating that they were planning to quit, much less retire, I think that would be pretty concerning. That’s kind of where we are right now in public health,” says lead author Jonathon Leider, PhD, an associate professor of public health and the director of the Center for Public Health Systems at the University of Minnesota in Minneapolis.&lt;/p&gt;&lt;p&gt;Many of the public health jobs lost during the Great Recession of 2008–2009 never returned and left governments with a workforce deficit, Dr Leider says. Then, older employees who had delayed retirement during the recession started to leave during the economic recovery. Their departure was compounded by what some demographers have dubbed the “silver tsunami,” or the wave of baby boomers reaching retirement age.&lt;/p&gt;&lt;p&gt;“We’ve been investing in this short-age for a long time,” adds study coauthor Brian Castrucci, DrPH, MA, president and chief executive officer of the de Beaumont Foundation in Bethesda, Maryland, which focuses on improving community health and public health systems. By the start of the COVID-19 pandemic, he notes, a lack of attention to filling the available positions and increasing low pay rates had already contributed to a shortage of 80,000 full-time equivalents.&lt;/p&gt;&lt;p&gt;The pandemic then led to “unprecedented levels of bullying, politicization, and political attacks on the public health workforce,” he charges. Amid that hostile environment, employees were pulled from other health department divisions to bolster short-staffed pandemic response teams, which added to the stress. “This is just a recipe for burnout,” he says. “The pandemic was an accelerant, but the fire was already burning.”&lt;/p&gt;&lt;p&gt;Emily Burke, EdD, MPH, senior director of workforce development and applied practice at the Association of Schools and Programs of Public Health in Washington, DC, says that a continuation of the alarming exodus could have major ","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 3","pages":"134-135"},"PeriodicalIF":3.4,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cncy.22804","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140048806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving diagnostic yield of pancreatic serous cystadenoma with cyst fluid ancillary testing, adjunct immunohistochemistry, and additional fine-needle biopsy sampling","authors":"Xi Wang MD, PhD,&nbsp;Xuchen Zhang MD, PhD,&nbsp;Pei Hui MD, PhD,&nbsp;Guoping Cai MD","doi":"10.1002/cncy.22808","DOIUrl":"10.1002/cncy.22808","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Fine-needle aspiration (FNA) diagnosis of pancreatic serous cystadenoma (SCA) remains challenging. This retrospective study aimed to evaluate the roles of cyst fluid ancillary testing and combined fine-needle biopsy (FNB) in improving the diagnostic yield.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The authors retrospectively reviewed cytology cases that were histologically confirmed SCAs. Clinical features and FNA cyst fluid biochemical and molecular analysis results along FNB findings were reviewed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study cohort included 31 cases from 13 male and 18 female patients with a mean age of 65. The original cytologic diagnoses were nondiagnostic (<i>n</i> = 6, 19%), negative for malignant cells/cyst contents (<i>n</i> = 7, 23%), atypical cells (<i>n</i> = 3, 10%), nonmucinous cyst (<i>n</i> = 11, 35%), and serous cystadenoma (<i>n</i> = 4, 13%). Cyst fluid carcinoembryonic antigen (CEA) analysis was performed in 17 cases, all of which showed a low CEA level (&lt;192 ng/mL). All 14 cases with molecular testing showed a wild-type <i>KRAS</i>. Inhibin immunohistochemistry was retrospectively performed on the FNA cell blocks, inhibin was positive in six of seven cases tested. In 15 cases with concurrent FNA and FNB biopsies, the diagnosis of SCA was seen in only one FNA case (7%) but 13 FNB cases (87%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study suggests that FNA diagnosis of SCA remains challenging even with ancillary testing including cyst fluid CEA level and <i>KRAS</i> mutation analysis. Adjunct inhibin immunostaining may help improve the cytologic diagnosis of selective SCA cases. FNB appears superior to FNA for a definite diagnosis of SCA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 7","pages":"425-434"},"PeriodicalIF":2.6,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140048852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interobserver agreement in the interpretation of anal cytology","authors":"Maria Benevolo PhD,&nbsp;Francesca Rollo PhD,&nbsp;Alessandra Latini MD,&nbsp;Massimo Giuliani DSc,&nbsp;Amalia Giglio MD,&nbsp;Eugenia Giuliani PhD,&nbsp;Maria Gabriella Donà PhD","doi":"10.1002/cncy.22807","DOIUrl":"10.1002/cncy.22807","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Anal cytology represents a tool for anal cancer screening in high-risk populations. In addition to accuracy, the reproducibility of the interpretation is of key importance. The authors evaluated the agreement of anal cytologic interpretation between two cytopathologists.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Liquid-based cytologic slides from human immunodeficiency virus (HIV)-negative men who have sex with men (MSM) were evaluated by two readers with at least 10 years of expertise in cervical cytology. Cases with a discordant interpretation were reviewed, and a consensus was reached. Human papillomavirus (HPV) genotyping was performed using a proprietary HPV genotyping test. Unweighted and weighted Cohen kappa and 95% confidence interval (CI) values were calculated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 713 slides that were adequate for interpretation were evaluated (MSM: median age, 33 years). An HPV test was performed on 620 samples (87.0%). Considering a dichotomous interpretation (negative for intraepithelial lesion or malignancy vs. atypical squamous cells of undetermined significance or worse), the crude agreement between the two readers was 93.3% (kappa = 0.82; 95% CI, 0.77–0.87). Once a consensus for discordant cases was reached, the best agreement was found for the negative for intraepithelial lesion or malignancy category (511 of 528 samples; 96.8%), whereas the atypical squamous cells of undetermined significance category showed the lowest agreement (90 of 117 samples, 76.9%). Considering the individual cytologic categories, overall agreement was 92.1% (kappa = 0.85; 95% CI, 0.81–0.89). The discordant interpretations were not associated with high-risk HPV infection, HPV16 infection, or MSM age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The results indicating excellent interobserver agreement in this study substantiate the use of anal cytology in the setting of human immunodeficiency virus-negative MSM.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 7","pages":"419-424"},"PeriodicalIF":2.6,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cncy.22807","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140048805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging archival cerebrospinal fluid samples for genetic insights from cell-free DNA","authors":"Alexandra M. Miller MD, PhD,&nbsp;Tejus A. Bale MD, PhD","doi":"10.1002/cncy.22794","DOIUrl":"10.1002/cncy.22794","url":null,"abstract":"<p>Cerebrospinal fluid (CSF) samples are often a rich source of tumor-derived cell-free DNA (cfDNA), a high degree of success in detecting tumor mutations can even be achieved with archival CSF samples.</p>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 4","pages":"212-213"},"PeriodicalIF":3.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139995655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interobserver agreement and risk of malignancy using the International Academy of Cytology Yokohama System for reporting breast FNA biopsy in a liquid-based exclusive cohort","authors":"Olawunmi Folarin MD,&nbsp;David Kim MD,&nbsp;Hamza N. Gokozan MD,&nbsp;Jonas J. Heymann MD,&nbsp;Jose V. Scarpa Carniello MD,&nbsp;Lucelina Rosado CT(ASCP),&nbsp;Momin T. Siddiqui MD,&nbsp;Ami Patel MD","doi":"10.1002/cncy.22798","DOIUrl":"10.1002/cncy.22798","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Per the College of American Pathologist’s National Breast Fine Needle Aspiration Biopsy (FNAB) Practice Survey, ∼40% of laboratories use liquid-based cytology (LBC) for breast FNAB. The reproducibility of the International Academy of Cytology Yokohama System (YS) for reporting breast FNAB on LBC was explored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Breast FNAB specimens submitted as LBC only (all ThinPrep) between January 2017 and January 2021 were retrieved. Cases without histopathologic follow-up were excluded. Clinical and radiologic information was collected. One cytologist and six cytopathologists rendered diagnoses per YS. All reviewers were blinded to the original diagnosis and histopathologic follow-up. The risk of malignancy was calculated. Concordance rates were calculated by a weighted Cohen Kappa score (κ).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Review of 110 cases demonstrated substantial to near-perfect agreement between each reviewer (κ = 0.73–0.91) and follow-up histopathology (κ = 0.66–0.85). The agreement was lowest in the inadequate (κ = 0.05) and atypical (κ = 0.04) categories. The lack of concordance in the atypical category was common in cases with low cellularity or incomplete structural features. The risk of malignancy for inadequate, benign, atypical, suspicious for malignancy, and malignant categories were 12.5% (2/16), 3% (2/65), 67%, (8/12) 100% (1/1), and 100% (16/16).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Interobserver agreement is excellent using the five YS categories in LBC. Lack of cellularity and incomplete architectural features were barriers to perfect agreement. Established pitfalls in the interpretation of LBC were cause for atypical diagnoses. Continuous training and education are recommended to avoid misdiagnosis because of the nonconventional cytomorphologic features of LBC and to improve inadequate and atypical rates within YS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 5","pages":"320-326"},"PeriodicalIF":3.4,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of cytology and high-risk HPV testing in 1067 endocervical adenocarcinomas and precursor lesions","authors":"Lei Ye,&nbsp;Meifu Gan,&nbsp;Yeli Yao,&nbsp;Bingjian Lu","doi":"10.1002/cncy.22802","DOIUrl":"10.1002/cncy.22802","url":null,"abstract":"<p>The detection efficacy of cytology and high-risk human papillomavirus (hrHPV) cotesting has been analyzed in a large cohort of patients with cervical glandular lesions. Cotesting can maximize the detection effect for adenocarcinoma in situ and HPV-associated adenocarcinoma; however, cytology and hrHPV cotesting is not optimal for HPV-independent adenocarcinoma.</p>","PeriodicalId":9410,"journal":{"name":"Cancer Cytopathology","volume":"132 6","pages":"340-347"},"PeriodicalIF":3.4,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139905078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}