Journal of nuclear medicine : official publication, Society of Nuclear Medicine最新文献

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68Ga-FAPI-04 PET/CT Imaging for Assessing Renal Tubulointerstitial Fibrosis in Lupus Nephritis. 68Ga-FAPI-04 PET/CT成像评估狼疮性肾炎肾小管间质纤维化
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-03-03 DOI: 10.2967/jnumed.124.268643
Shuyi Yu, Zhixia Yang, Zetao Ding, Yingqi Jia, Liyan Wan, Lei Li, Jing Lv, Haoyu Pan, Jinyi Qian, Xiaohan Wei, Yue Yang, Yunlong Zan, Jialin Teng, Biao Li, Chengde Yang, Jing Xu, Luan Xue, Hui Shi, Min Zhang
{"title":"<sup>68</sup>Ga-FAPI-04 PET/CT Imaging for Assessing Renal Tubulointerstitial Fibrosis in Lupus Nephritis.","authors":"Shuyi Yu, Zhixia Yang, Zetao Ding, Yingqi Jia, Liyan Wan, Lei Li, Jing Lv, Haoyu Pan, Jinyi Qian, Xiaohan Wei, Yue Yang, Yunlong Zan, Jialin Teng, Biao Li, Chengde Yang, Jing Xu, Luan Xue, Hui Shi, Min Zhang","doi":"10.2967/jnumed.124.268643","DOIUrl":"10.2967/jnumed.124.268643","url":null,"abstract":"<p><p>The objective of this study was to evaluate the feasibility of using <sup>68</sup>Ga-labeled fibroblast activation protein inhibitor-04 (<sup>68</sup>Ga-FAPI-04) PET/CT imaging as a molecular tracer and noninvasive tool for assessing active renal tubulointerstitial fibrosis in patients with lupus nephritis (LN). <b>Methods:</b> The study included 29 LN patients who underwent <sup>68</sup>Ga-FAPI-04 PET/CT scanning to quantify <sup>68</sup>Ga-FAPI-04 uptake. Renal biopsies were performed within a week of scanning. Renal fibrosis levels in biopsy samples were assessed by Masson staining. Immunofluorescence analysis identified the expression of fibroblast activation protein (FAP), E-cadherin, and α-smooth muscle actin in the renal biopsy specimens. FAP expression of healthy controls, LN patients, and patients with minimal change of disease at the messenger RNA level and its association with interferon levels were explored using microarray data from the Gene Expression Omnibus database. Additionally, quantitative polymerase chain reaction and Western blot analyses quantified FAP messenger RNA and protein expression in renal tubular epithelial cells (RTEC) after stimulation with interferon-α in vitro. <b>Results:</b> The study revealed significantly increased renal <sup>68</sup>Ga-FAPI-04 uptake in LN patients (<i>n</i> = 29) compared with healthy controls (<i>n</i> = 26). Normalized renal <sup>68</sup>Ga-FAPI-04 uptake positively correlated with disease duration, creatinine levels, chronicity index, and renal tubulointerstitial fibrosis levels. Patients with a chronicity index exceeding 4, indicative of a poorer prognosis, showed markedly higher renal <sup>68</sup>Ga-FAPI-04 uptake. FAP expression was predominantly localized in RTEC, where increased FAP expression corresponded to reduced E-cadherin expression. Gene set enrichment analysis of GSE112943 and GSE60861 datasets showed positive enrichment of type I interferon signaling gene sets (<i>P</i> < 0.01). Correlation analysis of interferon-α and interferon-γ pathways with FAP expression in these datasets was significant (<i>P</i> < 0.01). In vitro experiments, with interferon-α-stimulated RTEC showed elevated FAP expression. <b>Conclusion:</b> This study demonstrates the feasibility of using <sup>68</sup>Ga-FAPI-04 PET/CT imaging for noninvasive assessment of active lupus renal tubulointerstitial fibrosis. Elevated FAP expression in LN is primarily expressed by RTEC and contributes to the development of interstitial fibrosis. Type I interferon appears to induce FAP expression. These findings provide insights into the molecular mechanisms underlying renal tubulointerstitial fibrosis in LN and offer a valuable tool for assessing kidney status in lupus.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"418-424"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Side-by-Side Comparison of the In Vivo Performance of [212Pb]Pb-DOTAMTATE and Other SSTR2-Targeting Compounds. [212Pb]Pb-DOTAMTATE与其他sstr2靶向化合物体内性能的对比研究
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-03-03 DOI: 10.2967/jnumed.124.268345
Amal Saidi, Tania A Stallons, Amy G Wong, Aaron T Schatzmann, Ugur Soysal, Julien J Torgue
{"title":"Side-by-Side Comparison of the In Vivo Performance of [<sup>212</sup>Pb]Pb-DOTAMTATE and Other SSTR2-Targeting Compounds.","authors":"Amal Saidi, Tania A Stallons, Amy G Wong, Aaron T Schatzmann, Ugur Soysal, Julien J Torgue","doi":"10.2967/jnumed.124.268345","DOIUrl":"10.2967/jnumed.124.268345","url":null,"abstract":"<p><p>There are numerous versions of octreotide and octreotate, including DOTAMTATE, DOTATATE, JR11, and lead-specific chelator (PSC)-PEG2-TOC. These peptides, which can be either analogs or antagonists, are used in nuclear medicine for diagnostic imaging or targeted radionuclide therapy of neuroendocrine tumors that are positive for somatostatin receptors (SSTRs). Despite their structural and targeting similarities, they have distinct properties and clinical uses. We aimed to perform an extensive preclinical comparison of all these somatostatin analogs with <sup>212</sup>Pb, directly studying their pharmacokinetic properties in tumors overexpressing SSTR2. <b>Methods:</b> All SSTR2 analogs were manufactured with the DOTAM, PSC, or DOTA chelators for appropriate comparison after radiolabeling with <sup>212</sup>Pb. Chelation, quantification, and pharmacokinetics were compared side by side in AR42J-tumor-bearing animals. <b>Results:</b> These findings highlight the superior chelation efficiency and faster kinetics of DOTAM and then DOTA compared with the PSC. We also discovered a superior tumor-to-kidney area under the curve ratio for [<sup>212</sup>Pb]Pb-DOTAMTATE over other SSTR2-targeting peptides when radiolabeled with <sup>212</sup>Pb. <b>Conclusion:</b> Taken together, the results indicates that [<sup>212</sup>Pb]Pb-DOTAMTATE has favorable tumor retention and a more favorable dosimetry profile, which is crucial for targeted α-therapy in treating SSTR2-positive neuroendocrine tumors.</p>","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"391-397"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SPECT Deserves RESPECT: The Potential of SPECT/CT to Optimize Patient Outcomes with Theranostics Therapy. SPECT值得尊重:SPECT/CT在治疗治疗中优化患者预后的潜力。
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-03-03 DOI: 10.2967/jnumed.124.268325
Louise Emmett
{"title":"SPECT Deserves RESPECT: The Potential of SPECT/CT to Optimize Patient Outcomes with Theranostics Therapy.","authors":"Louise Emmett","doi":"10.2967/jnumed.124.268325","DOIUrl":"10.2967/jnumed.124.268325","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"349-350"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reflections on the Demand for PSMA- and SSTR-Targeted Radiopharmaceutical Therapies: Why We Were Wrong (and Why We Will Be Right Eventually). 对以PSMA和sstr为目标的放射性药物治疗需求的反思:为什么我们错了(为什么我们最终将是正确的)。
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-03-03 DOI: 10.2967/jnumed.124.269401
Johannes Czernin, Lisa Bodei, Irvin Modlin, Jeremie Calais
{"title":"Reflections on the Demand for PSMA- and SSTR-Targeted Radiopharmaceutical Therapies: Why We Were Wrong (and Why We Will Be Right Eventually).","authors":"Johannes Czernin, Lisa Bodei, Irvin Modlin, Jeremie Calais","doi":"10.2967/jnumed.124.269401","DOIUrl":"10.2967/jnumed.124.269401","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"333-336"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Summary: EANM/SNMMI Release Joint Guideline/Procedure Standard for [18F]FDG Hybrid PET Use in Infection and Inflammation in Adults, Version 2.0. 摘要:EANM/SNMMI发布了[18F]FDG混合PET在成人感染和炎症中的使用联合指南/程序标准,2.0版。
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-03-03 DOI: 10.2967/jnumed.125.269538
Olivier Gheysens, Matthieu Pelletier-Galarneau, Giorgio Treglia, Ora Israel, Francois Jamar, Gad Abikhzer
{"title":"Summary: EANM/SNMMI Release Joint Guideline/Procedure Standard for [<sup>18</sup>F]FDG Hybrid PET Use in Infection and Inflammation in Adults, Version 2.0.","authors":"Olivier Gheysens, Matthieu Pelletier-Galarneau, Giorgio Treglia, Ora Israel, Francois Jamar, Gad Abikhzer","doi":"10.2967/jnumed.125.269538","DOIUrl":"10.2967/jnumed.125.269538","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"480-481"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Radiopharmaceuticals: A Sustainable Path to the Improvement of Patient Care. 诊断性放射性药物:改善病人护理的可持续途径。
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-02-03 DOI: 10.2967/jnumed.124.268608
Andrei Gafita, Andrew R Menard, Lilja B Solnes
{"title":"Diagnostic Radiopharmaceuticals: A Sustainable Path to the Improvement of Patient Care.","authors":"Andrei Gafita, Andrew R Menard, Lilja B Solnes","doi":"10.2967/jnumed.124.268608","DOIUrl":"10.2967/jnumed.124.268608","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"186"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maintaining the Evidence for In Vivo Brain Estrogen Receptor Density by Neuroendocrine Aging and Relationships with Cognition and Symptomatology. 神经内分泌老化维持体内脑雌激素受体密度的证据及其与认知和症状学的关系。
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-02-03 DOI: 10.2967/jnumed.124.269268
Lisa Mosconi, Matilde Nerattini, Valentina Berti, Dawn C Matthews, Caroline Andy, Schantel Williams, Matthew Fink, Alberto Pupi, Roberta Diaz Brinton
{"title":"Maintaining the Evidence for In Vivo Brain Estrogen Receptor Density by Neuroendocrine Aging and Relationships with Cognition and Symptomatology.","authors":"Lisa Mosconi, Matilde Nerattini, Valentina Berti, Dawn C Matthews, Caroline Andy, Schantel Williams, Matthew Fink, Alberto Pupi, Roberta Diaz Brinton","doi":"10.2967/jnumed.124.269268","DOIUrl":"10.2967/jnumed.124.269268","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"331-332"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastrin-Releasing Peptide Receptor Imaging and Therapy in the Era of Personalized Medicine. 个性化医疗时代胃泌素释放肽受体成像与治疗。
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-02-03 DOI: 10.2967/jnumed.124.268861
Clément Morgat, Andrei Iagaru, Elif Hindié
{"title":"Gastrin-Releasing Peptide Receptor Imaging and Therapy in the Era of Personalized Medicine.","authors":"Clément Morgat, Andrei Iagaru, Elif Hindié","doi":"10.2967/jnumed.124.268861","DOIUrl":"10.2967/jnumed.124.268861","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"207-208"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is the Clinical Implementation of In-House Artificial Intelligence-Developed Algorithms Happening? 内部人工智能开发算法的临床应用正在发生吗?
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-02-03 DOI: 10.2967/jnumed.124.268156
David Gergely Kovacs, Claes Nøhr Ladefoged, Jacob Bak Rosenkjær, Fatima Mawassi, Line Akiti Hingelberg, Anna Olga Aaskilde Laursen, Barbara Malene Fischer, Flemming Littrup Andersen
{"title":"Is the Clinical Implementation of In-House Artificial Intelligence-Developed Algorithms Happening?","authors":"David Gergely Kovacs, Claes Nøhr Ladefoged, Jacob Bak Rosenkjær, Fatima Mawassi, Line Akiti Hingelberg, Anna Olga Aaskilde Laursen, Barbara Malene Fischer, Flemming Littrup Andersen","doi":"10.2967/jnumed.124.268156","DOIUrl":"10.2967/jnumed.124.268156","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"183-185"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Redifferentiation of a RET-Fusion, Radioiodine-Refractory, Differentiated Thyroid Cancer with Selpercatinib: Flip-Flop Between [18F]FDG PET/CT and 131I Posttreatment Scanning. Selpercatinib治疗ret融合、放射性碘难治性分化甲状腺癌的再分化:[18F]FDG PET/CT和131I治疗后扫描之间的触发器
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Pub Date : 2025-02-03 DOI: 10.2967/jnumed.124.268539
Floriane Barbry, Benjamin Chevalier, Amandine Beron, Georges Lion, Samuel Boury, Camille Marciniak, Clio Baillet, Christine Do Cao, Arnaud Jannin
{"title":"Redifferentiation of a RET-Fusion, Radioiodine-Refractory, Differentiated Thyroid Cancer with Selpercatinib: Flip-Flop Between [<sup>18</sup>F]FDG PET/CT and <sup>131</sup>I Posttreatment Scanning.","authors":"Floriane Barbry, Benjamin Chevalier, Amandine Beron, Georges Lion, Samuel Boury, Camille Marciniak, Clio Baillet, Christine Do Cao, Arnaud Jannin","doi":"10.2967/jnumed.124.268539","DOIUrl":"10.2967/jnumed.124.268539","url":null,"abstract":"","PeriodicalId":94099,"journal":{"name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","volume":" ","pages":"330"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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