Journal of cardiovascular computed tomography最新文献

{"title":"Rational and design of the FAMILY study - High-risk coronary atherosclerosis among asymptomatic subjects with family history of myocardial infarction.","authors":"Edoardo Conte, Chiara Di Resta, Laura Pandolfi, Davide Marchetti, Eleonora Melotti, Andrea Provera, Daniela Lakuria, Angelo Ratti, Blanca Prestini, Maria Clara Alessandrello, Andrea Savastano, Alessandro Masini, Michela Righetto, Elena De Vecchi, Luca Yamen Samman, Giovanni Mauri, Luigi Pedone, Giuseppe Banfi, Antonio L Bartorelli, Luca Sconfienza, Daniele Andreini","doi":"10.1016/j.jcct.2026.08.008","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.08.008","url":null,"abstract":"<p><strong>Introduction: </strong>A family history (FH) of premature coronary artery disease (CAD) is a major cardiovascular risk factor often underestimated by traditional scoring systems like SCORE2, which do not incorporate FH. The FAMILY trial (NCT07352111) is a prospective study investigating the role of cardiac CT (CCT) in identifying high-risk atherosclerosis in this specific population.</p><p><strong>Rational and objectives: </strong>To enable personalized primary prevention, this study integrates genotypic and bio-humoral profiling with CCT plaque imaging in asymptomatic individuals with an FH of CAD. The primary objective of the study is to determine the prevalence of high-risk atherosclerosis in this specific cohort.</p><p><strong>Methods: </strong>and Preliminary Data: We are prospectively enrolling asymptomatic first-degree relatives of patients with early-onset myocardial infarction (males <55, females <60 years). Participants undergo clinical evaluation, SCORE2 risk calculation, and advanced 256-slice CCT. High-risk atherosclerosis is defined by the presence of at least two high-risk plaque features and/or elevated volumes of low-attenuation/non-calcified plaque. A nested cohort (10-20%) of risk-reclassified patients will undergo comprehensive genetic profiling. Preliminary, data on the first 16 subjects enrolled (mean age 54 ± 6 years) were collected and analysed supporting the feasibility of the study.</p><p><strong>Conclusion: </strong>Traditional risk scores often underestimate CAD risk in individuals with a strong family history. By utilizing advanced CCT to detect high-risk atherosclerosis, the FAMILY trial aims to accurately reclassify patient risk and, potentially, guide early, targeted prevention. Feasibility data are presented but, given the limited size of this preliminary cohort, definitive conclusions await full enrolment.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148858014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple rule-out CT: An old idea meets a new detector.","authors":"Lili Szaraz, Pal Maurovich-Horvat","doi":"10.1016/j.jcct.2026.08.011","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.08.011","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148852080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to <'biomarkers for identification of high-risk coronary artery plaques in patients with suspected coronary artery disease'> <[ journal of cardiovascular computed tomography 18 (2024) 467-475]>.","authors":"Gitte Pedersen, Jonathan Nørtoft Dahl, Laust Dupont Rasmussen, Anne-Birgitte Garm Blavnsfeldt, Sidsel Hauge Bottcher, Matias Hauge Bottcher, Mette Nyegaard, Louise Nissen, Simon Winther","doi":"10.1016/j.jcct.2026.08.012","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.08.012","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148835816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term prognosis of coronary artery calcium scoring on top of cardiac SPECT in stable symptomatic patients.","authors":"Mandy Kamerman, Joris D van Dijk, Jorik R Timmer, Jan Paul Ottervanger, Siert Knollema, Grigory Sidorenkov, Rozemarijn Vliegenthart, Mohamed Mouden","doi":"10.1016/j.jcct.2026.07.011","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.07.011","url":null,"abstract":"<p><strong>Background: </strong>The coronary artery calcium score (CACS) has strong prognostic value in stable chest pain patients. However, studies with follow-up beyond 5 years are scarce. We studied the long-term prognosis of CACS beyond pre-test probability (PTP) and single-photon emission computed tomography (SPECT) results for major adverse cardiac events (MACE).</p><p><strong>Methods: </strong>We performed a retrospective cohort study among 6059 patients with non-acute chest pain, suspected of obstructive coronary artery disease who underwent clinically indicated SPECT/CT imaging with simultaneous CACS. Data on MACE, defined as cardiac death and non-fatal myocardial infarction, were collected during follow-up. The value of CACS in addition to PTP categories and SPECT results was studied using multivariable Cox analysis.</p><p><strong>Results: </strong>During a median follow-up of 9.1 years (IQR 7.8-10.4), 6.1% (N = 365) of patients suffered from MACE. In CACS 0 (27% of all) annual MACE rates were 0.2-0.3% across PTP categories, and 0.2-0.6% across SPECT results. In CACS >1000 (10 % of all) annual MACE rates were 2.5-2.5% across PTP categories and 2.2-3.0% across SPECT results. High CACS (>1000 vs. 0, HR 4.14; 95%CI, 2.64-6.53) and abnormal SPECT (>10% ischemia vs. normal, HR 1.78; 95%CI, 1.27-2.46) predicted MACE. Compared to a model of PTP and cardiovascular risk factors (area under the ROC curve 0.72), adding SPECT improved discriminatory ability (0.73; p = 0.003), and adding CACS on top of SPECT improved performance further (0.75; p < 0.001).</p><p><strong>Conclusions: </strong>CACS adds incremental prognostic information to PTP and SPECT in stable chest pain patients. Absence of coronary calcium results in an excellent long-term prognosis regardless of PTP and SPECT result.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148835811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary calcium to rule out obstructive coronary artery disease in patients with non-anginal chest pain.","authors":"Ngoc-Nguyen Thi Nguyen","doi":"10.1016/j.jcct.2026.08.009","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.08.009","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148803744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is nitroglycerin still necessary for coronary CT angiography in the era of photon-counting CT?","authors":"Ismail M Kabakus, Dhruw M Maisuria, Jordan H Chamberlin, Ian L Mencken, Cesar G Lopez Rodriguez, Michael M Sagatelian, Jeremy R Burt, Dhiraj Baruah","doi":"10.1016/j.jcct.2026.08.007","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.08.007","url":null,"abstract":"<p><strong>Background: </strong>Sublingual nitroglycerin is routinely administered before coronary computed tomography angiography (CCTA) to improve coronary artery visualization. However, most supporting evidence originates from older-generation CT systems and focuses on image quality rather than diagnostic accuracy. The impact of nitroglycerin on the diagnostic performance of photon-counting detector CT (PCD-CT) CCTA remains unknown.</p><p><strong>Methods: </strong>In this retrospective single-center study, consecutive patients who underwent photon-counting CCTA between January 2023 and November 2025 and invasive coronary angiography (ICA) within 30 days were identified. The final cohort consisted of 124 patients, including 61 who received sublingual nitroglycerin and 63 who did not. Diagnostic performance for detecting obstructive coronary artery disease was assessed on both a per-patient and per-vessel basis using ICA as the reference standard. Objective image quality was evaluated using coronary attenuation, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR).</p><p><strong>Results: </strong>On per-patient analysis, sensitivity was similar between the nitroglycerin and non-nitroglycerin cohorts (90.3% vs. 90.9%, p = 0.940), as was NPV (86.4% vs. 88.9%, p = 0.780). Non-nitroglycerin cohort demonstrated numerically higher specificity (80.0% vs. 63.3%, p = 0.160), PPV (83.3% vs. 71.8%, p = 0.250), and overall accuracy (85.7% vs. 77.0%, p = 0.220), although these differences were not statistically significant. No significant differences were observed on per-vessel analysis. Nitroglycerin increased coronary attenuation but did not improve SNR or CNR.</p><p><strong>Conclusions: </strong>In patients undergoing photon-counting CCTA, sublingual nitroglycerin administration was not associated with a statistically significant improvement in per-patient or per-vessel diagnostic performance. These findings should be considered hypothesis-generating and require confirmation in larger prospective studies before any conclusions can be drawn regarding the incremental value of routine nitroglycerin administration in photon-counting CCTA.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148803750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cantrell's pentalogy with hypoplastic left heart syndrome: Computed tomography angiographic evaluation.","authors":"Brenna Marques Amorim Tenório Pinto, Lhuanna Maria Barbosa Teixeira, Bruno Lima Moreira, Cintia Acosta Melo","doi":"10.1016/j.jcct.2026.08.005","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.08.005","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148803759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitroglycerin-optimised coronary CT angiography in severe aortic stenosis: Shifting the burden of proof in pre-TAVR coronary assessment.","authors":"Andreas A Giannopoulos, Oliver Gaemperli","doi":"10.1016/j.jcct.2026.08.004","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.08.004","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148803775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of semaglutide on left ventricular mass in patients with type 2 diabetes: A cardiac CT substudy of the STOP trial.","authors":"Ruben Mora, Patrick A Kwaah, Kyvan Irannejad, Venkat Sanjay Manubolu, Keishi Ichikawa, April Kinninger, Suvasini Lakshmanan, Matthew J Budoff","doi":"10.1016/j.jcct.2026.08.010","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.08.010","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148852125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-interval coronary plaque remodeling assessed by serial AI-quantified coronary CTA during intensive plaque-directed therapy.","authors":"Ronald P Karlsberg, Abhinav R Thummala, Francisco X Elisarraras, Ilana S Golub, Geoffrey W Cho","doi":"10.1016/j.jcct.2026.07.007","DOIUrl":"https://doi.org/10.1016/j.jcct.2026.07.007","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148803800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}