Journal of cardiovascular computed tomography最新文献

{"title":"Right atrial-to-pulmonary vein fenestration causing partial unroofing of right superior pulmonary vein: Findings on virtual dissection.","authors":"Damandeep Singh, Niraj Nirmal Pandey, Aprateem Mukherjee, Saurabh Kumar Gupta","doi":"10.1016/j.jcct.2025.05.001","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.05.001","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic utility of unrequested non-gated chest computed tomography in patients with suspected coronary artery disease: A comparative analysis with SPECT-MPI and invasive coronary angiography.","authors":"Hoang Lai, Sina Bagheri, Francesca Calicchio, Abraham Fatah, Fariha Raoufi, Chibuike Agwuegbo, Waqqas Mirza, Jenny Tran, Evelyn Gandhi, Benjamin Szumowski, Akanksha Maurya, Armin Hojjat","doi":"10.1016/j.jcct.2025.04.014","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.04.014","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor-referencing JCCT-D-25-00140- Racial referral bias in cardiac computed tomography: Differences, disparities or discrimination?","authors":"Aun-Yeong Chong, Benjamin Chow","doi":"10.1016/j.jcct.2025.05.004","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.05.004","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of diabetes on plaque, stenosis, and coronary artery calcium score.","authors":"Jonathan P Phan, April Kinninger, Sion K Roy, Mrinal Bhandari, Matthew J Budoff","doi":"10.1016/j.jcct.2025.04.013","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.04.013","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary trends in utilization of pediatric cardiac imaging in children's hospitals.","authors":"Karina Javalkar, Yuanyuan Fu, Stuart Lipsitz, Ashwin Prakash, Rebecca Beroukhim, Sunil J Ghelani","doi":"10.1016/j.jcct.2025.04.011","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.04.011","url":null,"abstract":"<p><strong>Background: </strong>There has been an increase in availability and utilization of cardiac CT (CCT) and magnetic resonance (CMR) imaging in pediatric cardiology. Understanding trends in their utilization can provide foundational data for defining appropriate use of these tests in pediatrics, and guide resource distribution enhance access to these modalities.</p><p><strong>Methods: </strong>This retrospective observational study utilized data from the Pediatric Health Information Systems (PHIS) database, a clinical and billing database including 49 children's hospitals. Encounters between 2010 and 2023 that had a code for any cardiac imaging test (echocardiography, CCT, or CMR) were included. The proportion of encounters utilizing each cardiac imaging test per year was calculated, and the primary outcome was the change in this proportion.</p><p><strong>Results: </strong>A total of 95,021,317 hospital-based encounters were queried, of which 1,442,094 had at least one of the 3 tests performed. The total number of encounters utilizing any cardiac imaging test increased over the study period. The proportion of encounters with echocardiography decreased (by 6.5 ​%) while those with CMR and CCT increased (70 ​% and 200 ​% respectively) over the study period. There was variation in imaging utilization by geographic region and diagnosis.</p><p><strong>Conclusion: </strong>This study highlights a marked increase in CCT use in pediatric cardiac imaging, accompanied by regional disparities in utilization. The growing role of CCT underscores the need for tailored training programs for pediatric cardiologists and increased resource allocation to meet rising demand. Future research should explore the drivers of regional variation and investigate the impact of modality choice on patient outcomes and care efficiency.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semiquantitative metrics of coronary artery disease burden: Intra-individual comparison between ultrahigh-resolution photon-counting detector CT and energy-integrating detector CT.","authors":"Giuseppe Tremamunno, Akos Varga-Szemes, U Joseph Schoepf, Dmitrij Kravchenko, Muhammad Taha Hagar, Chiara Gnasso, Emese Zsarnóczay, Jim O'Doherty, Damiano Caruso, Andrea Laghi, Bálint Szilveszter, Borbála Vattay, Pál Maurovich-Horvat, Ismail Mikdat Kabakus, Pal Spruill Suranyi, Tilman Emrich, Milan Vecsey-Nagy","doi":"10.1016/j.jcct.2025.04.012","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.04.012","url":null,"abstract":"<p><strong>Background: </strong>Quantitative coronary stenosis and plaque volumes have demonstrated intra-individual differences between ultrahigh-resolution (UHR) photon-counting detector (PCD)-CT and energy-integrating detector (EID)-CT. This study aimed to assess the impact of UHR PCD-CT on semiquantitative scores of coronary artery disease (CAD) burden compared with EID-CT.</p><p><strong>Methods: </strong>Patients undergoing coronary CT angiography (CCTA) on an EID-CT system for stable chest pain or pre-transcatheter aortic valve replacement evaluation were prospectively enrolled for UHR PCD-CT scan within 30 days. Both datasets were visually evaluated using five established semiquantitative scores: Segment Involvement Score (SIS), Segment Stenosis Score (SSS), Multivessel Aggregate Stenosis Score (MVAS), CCTA-adapted Leaman score (CT-LeSc), and Coronary Artery Disease Reporting and Data System (CAD-RADS). Additionally, the total number of detected plaques and high-risk features were reported (positive remodeling, spotty calcification, low-attenuation, and napkin-ring sign).</p><p><strong>Results: </strong>The cohort comprised 46 patients (37 men, 68.4 ​± ​6.9 years). When assessing stenosis severity, PCD-CT showed lower SSS (3.5 [1.3-5.0] vs 6.5 [3.0-9.8], p ​< ​0.001), MVAS (5.5 [4.0-7.0] vs 7.0 [5.0-9.0], p ​< ​0.001), and CT-LeSc (10.4 [8.5-13.9] vs 11.2 [8.8-15.4], p ​= ​0.032). Furthermore, 52 ​% (24/46) of patients were reclassified to a lower CAD-RADS category compared to EID-CT. In terms of CAD extent, PCD-CT demonstrated higher SIS (8.0 [6.0-9.0] vs 7.0 [6.0-8.8], p ​= ​0.018) and plaque count (9.0 [7.0-13.8] vs 7.0 [7.0-9.8] p ​< ​0.001). Positive remodeling was less frequent in PCD-CT datasets (2.0 [1.0-4.3] vs 1.0 [0.0-3.0], p ​= ​0.012), with no significant differences in other high-risk features.</p><p><strong>Conclusion: </strong>The use of UHR PCD-CT detects less severe, but more extensive CAD compared to EID-CT. The effect of such CCTA-based differences on individual risk stratification needs further investigation.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between peripheral medial and intimal arterial calcification patterns with central arterial stiffness in individuals with type 2 diabetes mellitus: The cross-sectional Early-HFpEF study.","authors":"R Meer, I Oughzou, A G Hoek, E Dal Canto, M T Blom, T Doesburg, P A de Jong, P J M Elders, J W J Beulens","doi":"10.1016/j.jcct.2025.04.005","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.04.005","url":null,"abstract":"<p><strong>Background: </strong>Animal studies suggest that medial arterial calcification (MAC) increases arterial stiffness, which in turn could lead to cardiovascular disease (CVD), but human studies are lacking. We evaluated the associations of peripheral arterial calcification pattern and quantity with arterial stiffness in individuals with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>Cross-sectional data was used of 774 individuals (64 ​% men, 67 [63-71] years) with T2DM who underwent carotid-femoral pulse wave velocity measurements (cfPWV) and CT-scans of the lower-extremities. Femoral and crural dominant arterial calcification patterns (MAC, intimal (IAC), absent/indistinguishable) were determined via a histologically-validated scoring algorithm. Calcification Agatston scores were categorized into zero (reference category) and tertiles>0. Multivariable-adjusted linear regression was used.</p><p><strong>Results: </strong>MAC and IAC were dominant in 38% and 24% of femoral arteries versus 29% and 15% of crural arteries, respectively. Femoral and crural MAC were associated with higher cfPWV (0.64 ​m/s [0.26-1.03]; 0.76 [0.37-1.14], respectively). Crural but not femoral IAC was associated with higher cfPWV (0.58 [0.10-1.06]; 0.25 [-0.20-0.69], respectively). Adjusted for calcification quantity, only crural MAC remained significantly associated with higher cfPWV. cfPWV was higher in individuals with MAC versus IAC, but not statistically significant (femoral p ​= ​0.066; crural p ​= ​0.490). Femoral and crural calcification scores in the highest tertile were associated with higher cfPWV (0.86 [0.34-1.39]; 0.78 [0.29-1.27], respectively).</p><p><strong>Conclusion: </strong>Crural MAC was independently associated with increased arterial stiffness. Arterial stiffness was higher in MAC versus IAC. Crural and femoral arterial calcification quantity were associated with increased arterial stiffness. Peripheral arterial calcification, specifically MAC, may lead to CVD via increased arterial stiffness in T2DM.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low endothelial shear stress is associated with increased coronary atherosclerotic plaque activity in patients that presented with acute coronary syndrome.","authors":"Jonathan K Tapley, Barry J Doyle, Jamie W Bellinge, Harrison T Caddy, Dirk C Blom, Thomas Churack, David E Newby, Carl J Schultz, Lachlan J Kelsey","doi":"10.1016/j.jcct.2025.04.003","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.04.003","url":null,"abstract":"<p><strong>Background: </strong>Both coronary atherosclerotic plaque activity and low endothelial shear stress (ESS) are predictive of adverse cardiovascular events. We aimed to investigate their association and relationship with high-risk plaque features.</p><p><strong>Methods: </strong>Coronary computed tomography angiography (CCTA) based flow simulations were used to compute ESS in patients presenting with acute coronary syndrome proceeding percutaneous coronary intervention. Associations between ESS, CCTA plaque features and coronary plaque activity, measured by ¹⁸F-sodium fluoride (¹⁸F-NaF) positron emission tomography (PET), were investigated at the coronary segment and vessel level.</p><p><strong>Results: </strong>ESS and coronary plaque activity were both analyzed in 330 coronary segments and 123 vessels. The area of low ESS (<0.4 ​Pa), termed low shear area (LSA), was larger in ¹⁸F-NaF positive regions increasing from median 11.7 ​mm² (IQR: 4.6-27.4) to 29.0 ​mm² (IQR: 14.1-55.2) at the segment level (P ​< ​0.0001) and from median 27.3 ​mm² (IQR: 8.6-65.3) to 57.8 ​mm² (26.6-108.2) at the vessel level (P ​= ​0.0049). The maximum tissue-to-background ratio of ¹⁸F-NaF activity positively correlated with LSA at the segment level (r_s ​= ​0.27; P ​< ​0.0001) and at the vessel level (r_s ​= ​0.38; P ​< ​0.0001). LSA was associated with spotty calcification at both the segment (P <0.0001) and vessel level (P ​= ​0.0042) and positive remodeling at the vessel level (P ​= ​0.025).</p><p><strong>Conclusions: </strong>In patients with acute coronary syndrome, LSA is associated with increased coronary atherosclerotic plaque activity, as measured by ¹⁸F-NaF PET.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative feasibility of aortic-valve agatston score derived from 5 ​mm-thick non-electrocardiography-gated noncontrast body computed tomography for evaluating severe aortic stenosis.","authors":"Masaya Kisohara, Toshihide Itoh, Tatsuya Kawai, Haruna Sagoh, Tsuyoshi Ito, Kazuma Murai, Nobuo Kitera, Seita Watanabe, Akio Hiwatashi","doi":"10.1016/j.jcct.2025.03.008","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.03.008","url":null,"abstract":"<p><strong>Background: </strong>The aortic-valve Agatston score (AVAS) is valuable for evaluating severe aortic stenosis (AS). While visual assessment of AS using chest computed tomography (CT) during lung cancer screening facilitates qualitative evaluation, it remains unclear whether AVAS derived from body CT that are neither electrocardiography (ECG)-triggered nor ECG-gated can quantitatively evaluate severe AS. This study aims to investigate the quantitative feasibility of AVAS derived from the 5 ​mm-thick noncontrast body CT for evaluating severe AS.</p><p><strong>Methods: </strong>In this retrospective study, data were collected from participants who underwent both cardiac CT scans that were either ECG-gated or ECG-triggered and noncontrast body CT scans that were neither ECG-triggered nor ECG-gated prior to AS treatment. We quantified AVAS from the body CT scan with a slice thickness of 5 ​mm (body CT AVAS) and AVAS from the cardiac CT scan with a slice thickness of 3 ​mm (cardiac CT AVAS). Regression analysis was performed between body CT AVAS and cardiac CT AVAS. Receiver-operating characteristic (ROC) curve analysis of body CT AVAS was conducted to detect cardiac CT AVAS of ≥2000 and ​≥1300.</p><p><strong>Results: </strong>A total of 265 participants (90 males; median age, 84 years [interquartile range, 80-88 years]) were analyzed. Regression analysis between body CT AVAS and cardiac CT AVAS yielded an R² of 0.92. Body CT AVAS of 2540 and 1440 corresponded to cardiac CT AVAS of 2000 and 1300, respectively. The areas under the ROC curves were 0.99 and 0.98, respectively.</p><p><strong>Conclusion: </strong>Five mm-thick noncontrast body CT AVAS is a quantitatively feasible tool for evaluating severe AS.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of lower noninvasive fractional flow reserve values with high risk anatomic characteristics in pediatric patients with anomalous coronary arteries.","authors":"Kanwal M Farooqi, Sophia Hsien, Yun Zhang, Denis J Donovan, Maroun Yammine, Patricia Moscicki, Jacqueline Contento, Ruskin S Del Mundo, Alexandra Channing, Amee M Shah, Priyanka Asrani, Amara Majeed, Michael P Dilorenzo, Jonathan Kochav, Rachel Weller, Emile A Bacha, Andrew Goldstone, Marlon Rosenbaum, Andrew J Einstein","doi":"10.1016/j.jcct.2025.04.002","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.04.002","url":null,"abstract":"<p><strong>Background: </strong>Although there are data on fractional flow reserve CT (CT-FFR) assessment for anomalous aortic origin of coronary artery (AAOCA) in adults, reports in children are limited.</p><p><strong>Methods: </strong>Cardiac CT angiograms of patients ages 4-21 years with AAOCA performed from 2010 to 2021 ​at a single center were retrospectively identified. Characteristics historically considered high-risk -slit-like ostium, interarterial course, or intramural segment-, symptoms suggestive of ischemia, or positive provocative testing were correlated with reduced CT-FFR values of <0.8 and ​< ​0.9. Distribution of CT-FFR values in patients with and without high-risk characteristics were compared.</p><p><strong>Results: </strong>CTAs for 39 patients, median age 14.3 (interquartile11.4-15.8) were of adequate quality for analysis. In anomalous right (ARCA) patients (n ​= ​30), rates of interarterial course, intramural course and acute takeoff angle were each 83.3 ​%; 80 ​% had slit-like orifice. In anomalous left (ALCA) patients (n ​= ​9), 77.8 ​% had an intramural segment, 77.8 ​% acute takeoff angle, and 66.7 ​% interarterial course; none had slit-like orifice. CT-FFR values were significantly lower in patients with ARCA and high-risk anatomic characteristics. There was no significant correlation between high-risk characteristics or intramural length, and abnormal FFR with cutoff of <0.8. With cutoff <0.9, there was correlation between slit-like orifice and abnormal RCA and circumflex CT-FFR. In patients with ARCA, intramural length correlated negatively with RCA CT-FFR value (rho ​= ​-0.67, p ​< ​0.0001).</p><p><strong>Conclusion: </strong>CT-FFR values are lower in patients with ARCA and anatomic characteristics considered high-risk. A cutoff CT-FFR value of <0.9 correlated with slit-like orifice. Further studies are needed to show utility of CT-FFR in guiding management of AAOCA in children.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}