Journal of cardiovascular computed tomography最新文献

{"title":"Cardiac computed tomography in a case of hypoattenuated leaflet thickening after transcatheter tricuspid valve replacement.","authors":"Marcos Ferrandez-Escarabajal, Stamatios Lerakis, Lucy M Safi, Stephanie Jou, Sahil Khera, Gilbert H L Tang, Gina LaRocca","doi":"10.1016/j.jcct.2025.05.232","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.05.232","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT derived fractional flow reserve: Part 2 - Critical appraisal of the literature.","authors":"Patricia F Rodriguez-Lozano, Anam Waheed, Sotirios Evangelou, Márton Kolossváry, Kashif Shaikh, Saira Siddiqui, Lauren Stipp, Suvasini Lakshmanan, En-Haw Wu, Nick S Nurmohamed, Ady Orbach, Vinit Baliyan, Joao Francisco Ribeiro Gavina de Matos, Siddharth J Trivedi, Nidhi Madan, Todd C Villines, Abdul Rahman Ihdayhid","doi":"10.1016/j.jcct.2025.05.241","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.05.241","url":null,"abstract":"<p><p>The integration of computed tomography-derived fractional flow reserve (CT-FFR), utilizing computational fluid dynamics and artificial intelligence (AI) in routine coronary computed tomographic angiography (CCTA), presents a promising approach to enhance evaluations of functional lesion severity. Extensive evidence underscores the diagnostic accuracy, prognostic significance, and clinical relevance of CT-FFR, prompting recent clinical guidelines to recommend its combined use with CCTA for selected individuals with with intermediate stenosis on CCTA and stable or acute chest pain. This manuscript critically examines the existing clinical evidence, evaluates the diagnostic performance, and outlines future perspectives for integrating noninvasive assessments of coronary anatomy and physiology. Furthermore, it serves as a practical guide for medical imaging professionals by addressing common pitfalls and challenges associated with CT-FFR while proposing potential solutions to facilitate its successful implementation in clinical practice.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective evaluation of computed tomography imaging for left atrial appendage exclusion using AtriClip: Impact on device sizing and imaging outcomes.","authors":"Atsushi Okada, Erik Beckmann, Miho Fukui, Asa Phichaphop, John R Lesser, Rizwan Q Attia, Sarah M Schwager, Kiahltone R Thao, Evan Walser-Kuntz, Larissa I Stanberry, João L Cavalcante, Sebastian Iturra, Vinayak N Bapat","doi":"10.1016/j.jcct.2025.05.233","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.05.233","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of plaque burden assessed by coronary CT angiography in known coronary artery disease.","authors":"Sung Woo Cho, Tina Torbati, Su Nam Lee, Heidi Gransar, Damini Dey, Piotr Slomka, Sean W Hayes, John D Friedman, Louise E J Thomson, Alan Rozanski, Rebekah Park, Daniel S Berman, Donghee Han","doi":"10.1016/j.jcct.2025.05.239","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.05.239","url":null,"abstract":"<p><strong>Background: </strong>We aimed to investigate in patients with known coronary artery disease (CAD) whether plaque burden assessed by coronary computed tomography angiography (CCTA) can predict subsequent all-cause mortality (ACM).</p><p><strong>Methods: </strong>Consecutive patients with known CAD who underwent CCTA and coronary artery calcium (CAC) scans for CAD evaluation were enrolled. Known CAD was defined as history of myocardial infarction (MI) or percutaneous coronary intervention (PCI). Plaque burden was assessed by CAC (categorized as 0-100, 101-300, 301-999, ≥1000), degree of stenosis (DS) (0-24 ​%, 25-49 ​%, 50-69 ​%, and ≥70 ​%) and segmental involvement score (SIS) (≤2, 3-4, 5-7, and ≥8) on CCTA. Multivariable Cox regression analysis was used to determine the association between plaque burden and ACM.</p><p><strong>Results: </strong>963 patients were included (age 66.1 ​± ​11.5, 72.0 ​% male) of whom 707 had PCI, 586 had MI, and 330 had both. During median follow-up of 3.0 years (interquartile range 1.0-6.5), 91 patients (9.4 ​%) died. By Kaplan-Meier analysis, higher CAC score was associated with a higher risk of ACM (p ​< ​0.001), but DS and SIS were not. In multivariable Cox regression analysis, CAC scores 301-999 (HR:3.10, 95%CI:1.23-7.80, p ​= ​0.017) and ≥1000 (HR:5.81, 95%CI:2.25-15.04, p ​< ​0.001) along with age, current smoking, and aspirin use were independently associated with increased risk of ACM, but DS and SIS were not.</p><p><strong>Conclusion: </strong>In patients with known CAD undergoing CCTA, CAC score>300 was an independent predictor of ACM. CAC may provide additional guidance for the intensity of secondary preventive treatments than the degree of residual stenosis or the number of segments with CAD.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative computed tomography assessment of right ventricular remodeling after right ventricular outflow tract reconstruction using a conduit in patients with pulmonary atresia and ventricular septal defect: Correlations with echocardiographic parameters.","authors":"Hyun Woo Goo","doi":"10.1016/j.jcct.2025.05.236","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.05.236","url":null,"abstract":"<p><strong>Background: </strong>This retrospective study aimed to assess computed tomography (CT)-derived quantitative right ventricular (RV) remodeling patterns after RV outflow tract reconstruction using a conduit in patients with pulmonary atresia and ventricular septal defect and correlate them with echocardiographic parameters.</p><p><strong>Methods: </strong>A total of 61 patients (90 CT volumetry studies, age: 16.2 ​± ​6.5 years) were retrospectively evaluated. Ventricular volume, myocardial mass, ejection fraction, stroke volume (SV), and SV difference were compared between the valveless and valved conduit groups; they were analyzed according to echocardiography-derived RV outflow tract pressure gradient and RV systolic pressure.</p><p><strong>Results: </strong>The valveless conduit group had smaller indexed left ventricular (LV) end-diastolic volume (83.4 ​± ​14.9 ​mL/m² [mean ​± ​standard deviation] vs. 90.6 ​± ​17.6 ​mL/m²; p ​< ​0.039) and indexed LV SV (43.0 ​± ​8.0 ​mL/m² vs. 48.0 ​± ​8.9 ​mL/m²; p ​< ​0.006), larger indexed RV end-diastolic volume (118.0 ​± ​26.1 ​mL/m² vs. 98.1 [84.6-114.2] mL/m² [median {interquartile range}]; p ​= ​0.010), indexed RV SV (62.5 ​± ​13.8 ​mL/m² vs. 49.3 ​± ​13.7 ​mL/m²; p ​< ​0.001), and indexed SV difference (19.5 ​± ​12.3 ​mL/m² vs. -2.2 [-6.5-4.8] mL/m²; p ​< ​0.001), and higher RV ejection fraction (53.2 ​± ​7.9 ​% vs. 48.7 [42.5-54.8]%; p ​= ​0.018) than the valved conduit group. The moderate or severe pulmonary stenosis group had higher indexed RV myocardial mass (54.03 ​± ​15.1 ​g/m² vs. 43.8 [34.4-52.2] g/m²; p ​= ​0.012); the moderately or severely elevated RV systolic pressure group had smaller indexed RV SV (53.4 ​± ​16.5 ​mL/m² vs. 62.8 ​± ​15.1 ​mL/m²; p ​< ​0.032) and indexed SV difference (7.0 ​± ​14.7 ​mL/m² vs. 18.8 ​± ​14.7 ​mL/m²; p ​< ​0.005) and larger indexed RV myocardial mass (58.2 [47.4-63.1] g/m² vs. 46.0 ​± ​12.9 ​g/m²; p ​= ​0.013).</p><p><strong>Conclusion: </strong>Cardiac CT can be used to quantitatively evaluate RV remodeling after RV outflow tract reconstruction using a conduit patterns in patients with pulmonary atresia and ventricular septal defect. Echocardiography-derived pulmonary stenosis and elevated RV systolic pressure demonstrate significant correlations with the CT-derived parameters.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative assessment of CAC and SIS plaque burden categories via AI-guided quantitative CT analysis.","authors":"Beshoy Iskander, Keishi Ichikawa, Natdanai Punnanithinont, Soumya Kambalapalli, April Kinninger, Srikanth Krishnan, Suvasini Lakshmanan, Sion Roy, Matthew J Budoff","doi":"10.1016/j.jcct.2025.05.234","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.05.234","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple-vessel coronary cameral fistula as a cause of diffuse coronary artery ectasia: Diagnostic insights from coronary CT angiography.","authors":"Ahmed Aldajani, Yoshito Kadoya, Gary Small, Benjamin J W Chow","doi":"10.1016/j.jcct.2025.05.238","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.05.238","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plaque quantification from coronary computed tomography angiography in predicting cardiovascular events: A systematic review and meta-analysis.","authors":"Jack S Bell, Jonathan Weir-McCall, Edward Nicol, Gregory Y H Lip, Bjarne L Nørgaard, Timothy A Fairbairn","doi":"10.1016/j.jcct.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.05.003","url":null,"abstract":"<p><strong>Background: </strong>Plaque volumes quantified from coronary computed tomography angiography (CCTA) may offer improved risk prediction for future major adverse cardiovascular events (MACE) above current standards of care. This systematic review and meta-analysis examines the association between CCTA-derived plaque volumes and future MACE in stable coronary artery disease (CAD).</p><p><strong>Methods: </strong>A systematic literature search was undertaken using PubMed, Web of Science and Cochrane Library databases. 504 publications were screened, identifying 38 studies for inclusion in the systematic review. 15 studies were eligible for meta-analysis. Separate meta-analyses were conducted for the most frequently investigated plaque volume variables.</p><p><strong>Results: </strong>35 out of 38 included studies showed an association between quantified plaque volumes and MACE. Low attenuation plaque (LAP) volume and total plaque volume (TPV) were most frequently independently associated with MACE. On meta-analysis, there was a significant association between MACE and TPV (pooled HR 3.93, 95 ​% CI 2.10-7.34, p ​< ​0.0001), LAP volume (pooled HR 2.81, 95 ​% CI 2.01-3.93, p ​< ​0.0001), calcified plaque volume (pooled HR 2.21, 95 ​% 1.5-3.24, p ​< ​0.0001), non-calcified plaque volume (pooled HR 2.55, 95 ​% CI 1.30-4.98, p ​= ​0.006), LAP burden (pooled HR 3.22, 95 ​% CI 2.12-4.87, p ​< ​0.0001), calcified plaque burden (pooled HR 2.25, 95 ​% 1.56-3.24, p ​< ​0.0001) and non-calcified plaque burden (pooled HR 3.42, 95 ​% CI 1.49-7.81, p ​= ​0.004). Total plaque burden was significantly associated with MACE after exclusion of a small study driving considerable heterogeneity (pooled HR 3.81, 95 ​% CI 2.45-5.94, p ​< ​0.0001).</p><p><strong>Conclusion: </strong>Quantified plaque volumes are associated with MACE in patients undergoing CCTA for stable CAD. Future work is required in diverse populations with standardised methods to determine the clinical utility of plaque quantification in real world practice.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomically indexed aortic valve calcium score more accurately predicts transaortic peak velocities and gradients compared to radiomics features in patients with severe aortic stenosis.","authors":"James W Goldfarb, Lin Wang, Lu Chen, Jaffar M Khan, Ziad A Ali, Omar K Khalique","doi":"10.1016/j.jcct.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.05.005","url":null,"abstract":"<p><strong>Background: </strong>This study examines the use of computed tomography (CT)-derived calcified and non-calcified aortic valve (AV) features, including radiomics-based quantitative imaging biomarkers, for predicting aortic stenosis (AS) severity and evaluating sex-specific differences.</p><p><strong>Methods: </strong>In this retrospective, single-center study, 270 patients (50 ​% female) with severe AS and preserved left ventricular ejection fraction were assessed in the primary-cohort using both echocardiography and CT angiography. Correlation-based feature selection and Lasso regression were employed to refine the most predictive features. Logistic regression models were developed for the overall-, male-, and female-cohorts, evaluating the predictive power of calcified and non-calcified AV features for identification of peak aortic valve jet velocity (PAV) ​≥ ​4 ​m/s and mean pressure gradient (MPG) ​≥ ​40 ​mmHg.</p><p><strong>Results: </strong>Statistical methods reduced the initial 44 CT variables to 13 in overall-cohort models, 10 in male-cohort models, and 12 in female-cohort models. The inclusion of these additional features significantly improved model performance compared to using the AV calcium score (AVCS) alone or its indexed variants. Indexing the AVCS to anatomical features resulted in modest improvements, with ROC-AUC values increasing from 0.71 (non-indexed Agatston) to 0.78 (indexed to sinus-of-Valsalva (SOV) volume) for PAV prediction in overall-cohort models. However, incorporating the full set of selected features further enhanced predictive accuracy, raising the ROC-AUC to 0.80. Similar trends were observed for MPG, with the best-performing models achieving a ROC-AUC of 0.84 compared to 0.73 using the non-indexed AVCS score alone. The male- and female-cohort models demonstrated similar improvements, with sex-specific feature sets significantly enhancing performance beyond indexed AVCSs.</p><p><strong>Conclusions: </strong>Indexing the AVCS to SOV volume and aortic annulus area enhances the predictive power of AS severity models, though incorporating a broader set of calcified and non-calcified CT features provides the greatest improvement. These findings underscore the importance of considering anatomical and sex-specific differences in the assessment of AS.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAC progression in men and women: Is there an inflection at menopause?","authors":"Ella C Ishaaya, April Kinninger, Logan Schwarzman, Sion K Roy, Matthew J Budoff","doi":"10.1016/j.jcct.2025.05.002","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.05.002","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}