Journal of cardiovascular computed tomography最新文献

{"title":"Key takeaways from the 2025 expert consensus document on cardiac computed tomography for prosthetic heart valve assessment.","authors":"Nisha Hosadurg, Sotirios Evangelou, João L Cavalcante","doi":"10.1016/j.jcct.2025.07.005","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.07.005","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT derived fractional flow reserve: Part 1 - Comprehensive review of methodologies.","authors":"Kashif Shaikh, Patricia Rodriguez Lozano, Sotirios Evangelou, En-Haw Wu, Nick S Nurmohamed, Nidhi Madan, Dhiran Verghese, Chandana Shekar, Anam Waheed, Saira Siddiqui, Márton Kolossváry, Shone Almeida, Tyler Coombes, Dominika Suchá, Siddharth J Trivedi, Abdul Rahman Ihdayhid","doi":"10.1016/j.jcct.2025.07.001","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.07.001","url":null,"abstract":"<p><p>Advancements in cardiac computed tomography angiography (CCTA) have enabled the extraction of physiological data from an anatomy-based imaging modality. This review outlines the key methodologies for deriving fractional flow reserve (FFR) from CCTA, with a focus on two primary methods: 1) computational fluid dynamics-based FFR (CT-FFR) and 2) plaque-derived ischemia assessment using artificial intelligence and quantitative plaque metrics. These techniques have expanded the role of CCTA beyond anatomical assessment, allowing for concurrent evaluation of coronary physiology without the need for invasive testing. This review provides an overview of the principles, workflows, and limitations of each technique and aims to inform on the current state and future direction of non-invasive coronary physiology assessment.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CCTA and CACS for preoperative cardiovascular risk stratification in patients undergoing noncardiac surgery: A systematic review and meta-analysis.","authors":"Ioannis Kyriakoulis, Konstantinos G Kyriakoulis, Konstantinos Aznaouridis, Sriram Sunil Kumar, Dimitrios Schizas, Damianos G Kokkinidis","doi":"10.1016/j.jcct.2025.06.007","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.06.007","url":null,"abstract":"<p><strong>Background: </strong>Major Adverse Cardiovascular Events (MACE) is a common cause of perioperative and long-term morbidity and mortality following noncardiac surgery. Patients who require preoperative cardiovascular risk stratification, traditionally undergo noninvasive cardiac imaging using myocardial perfusion imaging or stress echocardiography. Coronary Computed Tomography Angiography (CCTA) and Coronary Artery Calcium Score (CACS) have demonstrated prognostic value in predicting postoperative MACE and effectively risk stratifying patients undergoing noncardiac surgery.</p><p><strong>Methods: </strong>We performed a systematic search in MEDLINE and Scopus for studies reporting data on preoperative CCTA and CACS results and postoperative short- and long-term MACE in patients undergoing noncardiac surgery. A random-effect model (DerSimonian-Laird approach) was used to estimate the pooled Odds Ratios for MACE according to different CCTA and CACS results. A bivariate random-effects meta-analysis model was employed to assess pooled sensitivity and specificity of CCTA and CACS for MACE, and meta-analyses of proportions were performed to assess pooled positive predictive value (PPV), negative predictive value (NPV), and accuracy estimates.</p><p><strong>Results: </strong>Out of 1,009 studies identified from the literature search, fourteen studies were included in the meta-analysis. Obstructive stenosis (stenosis ≥50 ​%) on CCTA demonstrated increased odds for MACE compared to nonobstructive stenosis or normal findings, both in short- and long-term postoperative period (OR: 3.94, 95 ​% CI: 1.63-9.54 and OR: 8.95, 95 ​% CI: 4.48-17.87, respectively). Similar outcomes were observed when comparing patients with severe CACS (CACS ≥400) (OR: 2.29, 95 ​% CI: 1.35-3.86 and OR: 5.45, 95 ​% CI: 3.49-8.51 for short- and long-term postoperative MACE, respectively). In terms of prognostic performance CCTA and CACS demonstrated high NPV but moderate PPV for short- and long-term postoperative MACE.</p><p><strong>Conclusion: </strong>Obstructive stenosis on CCTA as well as severe CACS (CACS ≥400) can reliably risk stratify patients undergoing noncardiac surgery.</p><p><strong>Protocol registration: </strong>CRD42024600216.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in Pre-TAVR coronary evaluation: A step forward.","authors":"Ahmed Aldajani, Pascal Thériault-Lauzier","doi":"10.1016/j.jcct.2025.07.002","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.07.002","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flow dynamic differences between Kawasaki Disease patients with coronary artery aneurysms and ectasia.","authors":"Brennan J Vogl, Joseph Chibuike Nwokeafor, Emily Hyatt, Emily Vitale, Ahmad Bshennaty, Simon Lee, John Kovalchin, James Gaensbauer, Guy Hembroff, Hoda Hatoum","doi":"10.1016/j.jcct.2025.07.003","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.07.003","url":null,"abstract":"<p><strong>Background: </strong>Untreated Kawasaki Disease (KD) can lead to coronary artery (CA) dilations, such as CA aneurysms (CAA), CA ectasia (CAE), or both (CAA ​+ ​CAE). Currently, therapeutic decisions rely solely on geometric measurements, which have limitations. This study aims to correlate differences in flow dynamics between CAA, CAE, and CAA ​+ ​CAE with clinical outcomes and thrombotic potential.</p><p><strong>Methods: </strong>A multicenter retrospective study was performed using a total of 50 dilation models from patients with KD. Dilations were categorized as either CAA (n ​= ​30), CAE (n ​= ​14), or CAA ​+ ​CAE (n ​= ​6). Patient-specific 3D digital models of the CAs were created for each patient. Geometric measurements of each CA were recorded. Flow simulations were conducted and hemodynamic metrics such as time average wall shear stress (TAWSS), oscillatory shear index (OSI), relative residence time (RRT), and normalized average wall shear stress divergence (AWSS) were calculated.</p><p><strong>Results: </strong>CAAs had the largest dilations and entrance diameters. The dilation length and aspect ratio were higher for CAEs. CAAs exhibited consistently low velocity and low TAWSS with extensive regions of co-localized high RRT and OSI, and AWSS source points. CAEs showed elevated RRT in some cases but minimal OSI with little spatial overlap between metrics. CAA+CAEs showed variable and diffuse flow patterns with limited co-localization.</p><p><strong>Conclusion: </strong>Flow dynamics vary significantly across dilation morphologies in KD. Patients with only CAAs present hemodynamic data associated with the highest likelihood of thrombosis. Hemodynamic metrics may serve as mechanistic markers for thrombogenic potential and should be considered alongside anatomical measurements in future risk stratification efforts.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central and peripheral artery stiffness: Key players in cardiovascular disease risk.","authors":"Gisele J Bentley, Alice M Barrell, Carmel M McEniery","doi":"10.1016/j.jcct.2025.06.013","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.06.013","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrete non-calcified plaque is associated with increased major adverse cardiovascular events in a high cardiovascular risk population with low coronary artery calcium scores (0-100).","authors":"Tyler C Miller, Emily Hendricks, Seher Berzingi, Helen Watson, Samuel Mensah, Syed Ahmad, Nicholas Borkowski, Juan Carlo Avalon, Rida Laeeq, Daniel Brito Guzman, Sudarshan Balla, Kristen Bell, Ruby Havistin, Irfan Zeb, Lakshmi Muthukumar, Yasmin S Hamirani, James D Mills","doi":"10.1016/j.jcct.2025.06.014","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.06.014","url":null,"abstract":"<p><strong>Background: </strong>Patients with coronary artery calcium (CAC) scores of 0-100 and non-calcified plaque (NCP) on coronary computed tomography angiography (CCTA) have traditionally been considered low risk for obstructive coronary artery disease (CAD) and future adverse cardiovascular events (CVEs). In regions with high pre-test probability for CAD and negative social determinants of health, rates of adverse CVEs remain higher than in lower-risk populations.</p><p><strong>Methods: </strong>A retrospective review from January 2019 to May 2022 of 1050 symptomatic patients without known CAD and a CAC score of 0-100 identified 385 patients (37 ​%) with discrete NCP and 665 patients (63 ​%) without NCP on CCTA. The study's primary endpoint was to identify predictors of discrete NCP presence and future adverse CVEs (death, non-ST and ST-elevation myocardial infarction, or cerebrovascular accident) within two years.</p><p><strong>Results: </strong>A logistic regression analysis showed the presence of discrete NCP in patients with a CAC score of 0-100 was significantly associated with hyperlipidemia (OR 1.556, 95 ​% CI [1.145-2.115], p ​< ​0.005), diabetes mellitus (OR 1.475, 95 ​% CI [1.043-2.085], p ​< ​0.028), tobacco use disorder (OR 1.372, 95 ​% CI [1.028-1.830], p ​< ​0.032), older age (OR 1.035, 95 ​% CI [1.022-1.048], p ​< ​0.001), elevated systolic blood pressure (OR 1.020, 95 ​% CI [1.011-1.028], p ​< ​0.001), and higher total CAC score (OR 1.013 95 ​% CI [1.007-1.020], p ​< ​0.001). Patients with NCP had higher cardiac risk scores (ASCVD and Morise score) and were more likely to live in rural communities (0-5000 people) (p ​< ​0.005). They also had higher rates of coronary angiography, non-ST and ST-elevation myocardial infarctions, and coronary artery bypass grafting at two years (p ​< ​0.001). The presence of discrete NCP remained an independent predictor for future adverse CVEs after adjusting for diabetes mellitus, systolic blood pressure, hyperlipidemia, total CAC score, age, female sex, body mass index, and community population size (aOR 1.882, 95 ​% CI [1.048-3.380], p ​< ​0.034). Patients with discrete NCP had a 5.70 ​% adverse CVE rate.</p><p><strong>Conclusion: </strong>High rates of discrete NCP (37 ​%) and subsequent adverse CVEs were observed in our symptomatic, high cardiovascular risk population with CAC scores of 0-100. The presence of discrete NCP on CCTA was an independent risk factor for future adverse CVEs. Our findings emphasize the need for a more comprehensive approach to cardiovascular risk assessment in these vulnerable groups.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incremental prognostic value of aortic tortuosity index in older patients undergoing transcatheter aortic valve replacement.","authors":"Tuan Hoang Nguyen, Ryota Ando, Kazuyuki Yamaguchi, Takamitsu Nakamura, Tsuyoshi Kobayashi, Manabu Uematsu, Toru Yoshizaki, Takeo Horikoshi, Toshiki Takei, Miu Eguchi, Ryota Yamada, Kazuto Nakamura, Akira Sato","doi":"10.1016/j.jcct.2025.06.012","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.06.012","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of single-source cardiac CT and CMR quantified ventricular volumes and function in congenital heart disease.","authors":"Nikhil Patel, Jennifer Cohen, Hari G Rajagopal, David M Barris, Kenan W D Stern, Nadine F Choueiter, Kali A Hopkins, Gina LaRocca, Adam Jacobi, Barry Love, Robert H Pass, Ali N Zaidi, Son Q Duong","doi":"10.1016/j.jcct.2025.06.009","DOIUrl":"10.1016/j.jcct.2025.06.009","url":null,"abstract":"<p><strong>Background: </strong>Cardiac CT (CCT) is important for anatomic evaluation of congenital heart disease (CHD) prior to pulmonary valve replacement (PVR). However, volumetric and functional criteria for PVR are derived from cardiac MRI (CMR). Systematic differences between CCT and CMR volumes are underexplored in patients with CHD.</p><p><strong>Methods: </strong>Retrospective review of CHD patients with CMR and single-source CCT<180 days apart. Ventricular volumes were recontoured by blinded experts and global agreement was compared. Right ventricular regional differences in contours were assessed. Agreement of CCT with CMR-defined criteria for PVR was reported.</p><p><strong>Results: </strong>Twenty-nine patients (mean age 33 years, 48 ​% tetralogy of Fallot, 24 ​% congenital pulmonary stenosis, 83 ​% evaluated for PVR) had average CMR RVEDVi 152 ​mL/m², RVESVi 80 ​mL/m², RVEF 49 ​%, and RVEDV:LVEDV 1.9:1. CCT measured significantly higher RVEDVi (mean difference (MD) +17 ​mL/m²), RVESVi (MD +17 ​mL/m²), and RVEDV:LVEDV (MD +0.1) with no difference in stroke volume. There was a lower RVEF (MD -5 ​%). CCT had 90-100 ​% sensitivity/NPV to identify CMR-defined RV PVR thresholds, but had lower specificity and PPV. Faster heart rates had higher RVESVi CCT-CMR difference. The basal and mid-inferior RV contours contributed the most to CCT-CMR differences.</p><p><strong>Conclusions: </strong>Single-source CCT measures higher RV volumes and lower EF compared to CMR (i.e. more adversely-remodeled). Mechanisms include inferior stretch due to differences in breathing-instruction, and misidentification of end-systole. CMR-derived PVR thresholds applied to CCT would lead to more proactive intervention. \"Adjusting\" single-source CCT volumes by the observed difference between modalities is a reasonable approach. Single-source CCT-specific volumetric recommendations for PVR are needed.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary atresia with bilateral major aortopulmonary collaterals and ventricular septal defect.","authors":"Yuhan Zhou, Limin Lei, Xiaoxu Guo, Songwei Yue","doi":"10.1016/j.jcct.2025.06.010","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.06.010","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}