International journal of physiology, pathophysiology and pharmacology最新文献_第2页

Evaluation of sleep quality in faculty members of Isfahan university of medical sciences. 伊斯法罕医学科学大学教员睡眠质量评估。

International journal of physiology, pathophysiology and pharmacology Pub Date : 2023-08-15 eCollection Date: 2023-01-01

Zohre Naderi, Babak Amra, Fatemeh Ahmadi, Mohammad Emami Ardestani

{"title":"Evaluation of sleep quality in faculty members of Isfahan university of medical sciences.","authors":"Zohre Naderi, Babak Amra, Fatemeh Ahmadi, Mohammad Emami Ardestani","doi":"","DOIUrl":"","url":null,"abstract":"Background: Sleep disorders can significantly impair the quality of life and daily functions. Evaluating sleep quality can provide valuable information about working conditions. This study aims to evaluate the sleep quality of faculty members at Isfahan University of Medical Sciences (IUMS).Methods: This descriptive-analytic study was conducted from 2020 to 2021, involving 106 faculty members from the medical school. A questionnaire collected demographic information, including age, sex, height, weight, body mass index (BMI), level of education, history of faculty membership, major, working hours during the day and night, residency place, and medical history. The Pittsburgh Sleep Quality Index (PSQI) and Symptom Checklist-25 (SCL-25) questionnaire were used to assess participants' sleep quality. Data were compared between clinicians and basic science faculty members.Results: PSQI subtypes were examined among the participants. The total PSQI score was 6.20±3.4. A comparison of PSQI scores and subtypes based on age categories did not show any significant differences (P > 0.05 for all). Clinicians had significantly lower total PSQI scores (P=0.044), sleep latency (P=0.024), sleep disturbances (P=0.012), and daytime dysfunction (P=0.022). Additionally, clinicians had a lower severity of sleep latency (P=0.024), sleep disturbances (P=0.012), and total PSQI score (P=0.044). However, clinicians exhibited a higher intensity of daytime dysfunction (P=0.022).Conclusion: Faculty members exhibited a high prevalence of sleep disorders, with the most common disorders being sleep disturbance and high sleep latency. The prevalence of sleep disorders was higher among basic science faculty members compared to clinicians.","PeriodicalId":94056,"journal":{"name":"International journal of physiology, pathophysiology and pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509560/pdf/ijppp0015-0125.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41163497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstructive sleep apnea and epilepsy: understanding the pathophysiology of the comorbidity. 阻塞性睡眠呼吸暂停和癫痫：了解合并症的病理生理学。

International journal of physiology, pathophysiology and pharmacology Pub Date : 2023-08-15 eCollection Date: 2023-01-01

Manish Goyal, Priyadarshini Mishra, Harinder Jaseja

{"title":"Obstructive sleep apnea and epilepsy: understanding the pathophysiology of the comorbidity.","authors":"Manish Goyal, Priyadarshini Mishra, Harinder Jaseja","doi":"","DOIUrl":"","url":null,"abstract":"Obstructive sleep apnea (OSA) is a sleep disorder of significant health concern with a high prevalence in the general population. It has been found to exhibit a high incidence of comorbidity with epilepsy, the exact underlying pathophysiology of which still remains poorly understood. OSA is characterized by apnea/hypopnea spells and arousals, leading to intermittent hypoxemia and sleep deprivation. Both sleep deprivation and hypoxemia adversely affect the cortical excitability and favor epileptogenesis and worsening of pre-existing epilepsy, if any. In patients with OSA, deprivation of rapid eye movement sleep (REMS) phase (known for its strong antiepileptic influence) is relatively more than that non rapid eye movement sleep phase leading to postulation of REMS deprivation as a significant factor in the development of epilepsy as a comorbidity in patients with OSA. Furthermore, OSA and epilepsy both have shown to exercise a bidirectional influence on one another and are also likely to exacerbate each other through a positive feedback mechanism. This is especially based on the reports of improved control of epilepsy upon treatment of comorbid OSA. This brief paper attempts to present an underlying pathophysiological basis of the comorbidity of OSA and epilepsy based upon sleep deprivation and hypoxemia that are characteristic features observed in patients with OSA.","PeriodicalId":94056,"journal":{"name":"International journal of physiology, pathophysiology and pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509561/pdf/ijppp0015-0105.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41176450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nitric oxide represses the proliferation of Caco-2 cells by inducing S-G₂/M cell cycle arrest. 一氧化氮通过诱导 S-G2/M 细胞周期停滞来抑制 Caco-2 细胞的增殖。

International journal of physiology, pathophysiology and pharmacology Pub Date : 2019-10-15 eCollection Date: 2019-01-01

Satoru Sakuma, Yukino Ikeda, Itsumi Inoue, Kanna Yamaguchi, Shohko Honkawa, Tetsuya Kohda, Saaya Minamino, Yohko Fujimoto

{"title":"Nitric oxide represses the proliferation of Caco-2 cells by inducing S-G2/M cell cycle arrest.","authors":"Satoru Sakuma, Yukino Ikeda, Itsumi Inoue, Kanna Yamaguchi, Shohko Honkawa, Tetsuya Kohda, Saaya Minamino, Yohko Fujimoto","doi":"","DOIUrl":"","url":null,"abstract":"There is conflicting data regarding the ability of nitric oxide (NO) to promote or inhibit colorectal cancer cell proliferation. Furthermore, NO reacts rapidly with endogenous superoxide at a diffusion-controlled rate to give peroxynitrite (ONOO-), a strong oxidant and nitrating agent. The aim of this study was to assess the effects of exogenous NO and ONOO- on the proliferation of the colorectal cancer cell line Caco-2. NOR5 and SIN-1 were used as NO and ONOO- donors, respectively. Both NOR5 and SIN-1 inhibited the proliferation of the Caco-2 cells; however, the effect of NOR5 was slightly stronger than that of SIN-1. The results also indicated that NO plays a major role in the inhibition of SIN-1-induced proliferation of Caco-2 cells. The results of a terminal deoxynucleotidyl transferase dUTP nick end labeling assay, cell cycle analysis, and p21 protein expression measurement further indicated that NO induced S-G2/M phase arrest, but not apoptosis, in the Caco-2 cells. The results suggest that NO, rather than ONOO-, has the potential to repress the proliferation of Caco-2 cells by inducing S-G2/M cell cycle arrest.","PeriodicalId":94056,"journal":{"name":"International journal of physiology, pathophysiology and pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences between male and female rats in alcohol drinking, negative affects and neuronal activity after acute and prolonged abstinence. 急性和长期戒酒后雌雄大鼠在饮酒、负面影响和神经元活动方面的差异。

International journal of physiology, pathophysiology and pharmacology Pub Date : 2019-08-25 eCollection Date: 2019-01-01

Jing Li, Pei Chen, Xiao Han, Wanhong Zuo, Qinghua Mei, Emily Yao Bian, Jennifer Umeugo, Jianghong Ye

{"title":"Differences between male and female rats in alcohol drinking, negative affects and neuronal activity after acute and prolonged abstinence.","authors":"Jing Li, Pei Chen, Xiao Han, Wanhong Zuo, Qinghua Mei, Emily Yao Bian, Jennifer Umeugo, Jianghong Ye","doi":"","DOIUrl":"","url":null,"abstract":"Alcohol consumption afflicts men and women differently. However, the underlying neuronal mechanisms that contribute to the difference are mostly unexplored. Although more men suffer from alcohol use disorders (AUD), women more frequently accelerate to dependence and develop adverse consequences of alcoholism sooner than men. Women also exhibit more significant negative emotions that cues more reactivity and alcohol-craving than men. Despite ample evidence that women are vulnerable to AUD, results of preclinical studies on sex differences in alcohol consumption and withdrawal-related behaviors are inconclusive. In this study, we trained adult male and female Sprague-Dawley rats to drink alcohol in the intermittent access to 20% ethanol two-bottle free-choice paradigm for two months. Their behaviors and Fos expression in related brain regions were measured at acute (24 h) and after prolonged (28 days) abstinence. We found that female rats drank more alcohol than males. After acute abstinence, rats of both sexes showed higher sensitivity to depressive, thermal, and mechanical stimuli. Females also displayed higher anxiety levels. After prolonged abstinence, rats of both sexes displayed depressive-like behaviors; the males displayed allodynia; the females showed higher anxiety levels and drank more alcohol upon reaccess to alcohol. Furthermore, during acute withdrawal, Fos-positive nuclei were increased in the prefrontal cortex, anterior cingulate cortex (ACC), nucleus accumbens (NAc), amygdala and lateral habenula (LHb) in the females, versus only in the ACC, amygdala, and LHb in the males. Conversely, after prolonged abstinence, Fos-positive nuclei were decreased in the prefrontal cortex, ACC, and NAc in the females, but fell in the ACC, NAc, and LHb of the males. Thus, adaptations in diverse brain regions may contribute to the sex differences in behaviors in ethanol-withdrawn rats.","PeriodicalId":94056,"journal":{"name":"International journal of physiology, pathophysiology and pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism and adverse effects of multiple sclerosis drugs: a review article. Part 2. 多发性硬化症药物的机制和不良反应：综述文章。第 2 部分。

International journal of physiology, pathophysiology and pharmacology Pub Date : 2019-08-15 eCollection Date: 2019-01-01

Aryan Rafiee Zadeh, Keyvan Ghadimi, Akram Ataei, Mozhde Askari, Neda Sheikhinia, Nooshin Tavoosi, Masih Falahatian

引用次数: 0

Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links. 2型糖尿病、氧化应激和炎症：研究它们之间的联系。

International journal of physiology, pathophysiology and pharmacology Pub Date : 2019-06-15 eCollection Date: 2019-01-01

Oluwafemi Omoniyi Oguntibeju

{"title":"Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links.","authors":"Oluwafemi Omoniyi Oguntibeju","doi":"","DOIUrl":"","url":null,"abstract":"Diabetes mellitus has been recognised as one of the four major non-communicable diseases that demands urgent attention from all key shareholders globally in an effort to address its prevalence and associated complications. It is considered as a top 10 cause of death globally, killing about 1.6 million people worldwide and is seen as the third highest risk factor for worldwide premature mortality due to hyperglycaemia and hyperglycaemic-induced oxidative stress and inflammation. There is a strong link between hyperglycaemia, hyperglycaemic-induced oxidative stress, inflammation and the development and progression of type 2 diabetes mellitus. Various reports have shown that chronic low-grade inflammation is associated with the risk of developing type 2 diabetes and that sub-clinical inflammation contributes to insulin resistance and is linked to the characteristics of metabolic syndrome which include hyperglycaemia. Oxidative stress stimulates the generation of inflammatory mediators and inflammation in turn enhances the production of reactive oxygen species. This interaction between diabetes, oxidative stress and inflammation is the primary motivation for the compilation of this review. Based on previous studies, the review examines the interaction between diabetes, oxidative stress and inflammation, factors promoting prevalence of diabetes mellitus, mechanisms involved in hyperglycaemia-induced oxidative stress with particular focus on type 2 diabetes and selected diabetic complications.","PeriodicalId":94056,"journal":{"name":"International journal of physiology, pathophysiology and pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628012/pdf/ijppp0011-0045.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positive effects of systemic sodium benzoate and olanzapine treatment on activities of daily life, spatial learning and working memory in ketamine-induced rat model of schizophrenia. 全身苯甲酸钠和奥氮平治疗对氯胺酮诱导的精神分裂症大鼠日常生活活动、空间学习和工作记忆的积极影响。

International journal of physiology, pathophysiology and pharmacology Pub Date : 2019-04-15 eCollection Date: 2019-01-01

Ghada S Mahmoud, Sally A Sayed, Shehabeldin N Abdelmawla, Mohamed A Amer

{"title":"Positive effects of systemic sodium benzoate and olanzapine treatment on activities of daily life, spatial learning and working memory in ketamine-induced rat model of schizophrenia.","authors":"Ghada S Mahmoud, Sally A Sayed, Shehabeldin N Abdelmawla, Mohamed A Amer","doi":"","DOIUrl":"","url":null,"abstract":"Background: Sodium Benzoate (SB) significantly improved positive, negative, and cognitive symptoms as add on treatment in schizophrenia. Olanzapine (Ola), the most effective atypical antipsychotic drug, has been linked to hepatic steatosis, acute kidney injury, reproductive side effects and poor effect on negative symptoms in some patients.Goals: is to compare the efficacy and check the safety of long-term monotherapy with SB 0.01 mg/Kg versus Ola on male cognitive, memory, hepatic, renal and testicular functions in rat model of schizophrenia.Methods: 48 young adult male rats were divided into 6 groups; C: control; O: received Ola; SB: received SB; K: received single IP ketamine (Ket) injection; K+O: received Ola and Ket and K+SB: received SB and Ket. Ola and SB given orally for 3 or 10 weeks for behavioral or serological studies respectively. We measured activities of daily life (ADL), spatial learning and memory in radial arm water maze (RAWM), serum parameters of hepatic, renal and testicular functions.Results: Both Ola and SB significantly improved hoarding and burrowing, caused significant decrease in time to reach target (TRT), working memory errors (WME) in K+O and K+SB groups compared to K group. Ola caused significant increase in ALT, AST and creatinine and decrease in serum LH, testosterone compared to controls. SB caused significant rise in serum LH, ALT, AST and decrease in protein and albumin compared to both C and O groups.Conclusion: Both Ola and SB improved ADL, cognitive and memory functions. Although SB saved testicular and renal functions, it worsened liver function compared to Ola.","PeriodicalId":94056,"journal":{"name":"International journal of physiology, pathophysiology and pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526385/pdf/ijppp0011-0021.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of lunasin from Indonesian soybean extract on histopatologic examination and cox-2 expression in dextran sodium sulfate-induced mice colon. 印尼大豆提取物lunasin对右旋糖酐硫酸钠诱导的小鼠结肠组织病理学检查和cox-2表达的影响。

International journal of physiology, pathophysiology and pharmacology Pub Date : 2018-12-25 eCollection Date: 2018-01-01

Kusmardi Kusmardi, Nessa Nessa, Ari Estuningtyas, Aryo Tedjo

{"title":"The effect of lunasin from Indonesian soybean extract on histopatologic examination and cox-2 expression in dextran sodium sulfate-induced mice colon.","authors":"Kusmardi Kusmardi, Nessa Nessa, Ari Estuningtyas, Aryo Tedjo","doi":"","DOIUrl":"","url":null,"abstract":"Inflammatory bowel disease (IBD) is a condition describing chronic gastrointestinal inflammation. Chronic inflammation in colon can develop into colon cancer. Lunasin has been known to inhibit inflammatory reactions induced by lipopolysaccharide in vitro. The effect of lunasin to inhibit inflammation in vivo is not widely known. In this study, we analyzed the effect of lunasin from soybean to decrease the risk of inflammation by analyzing histopathologic feature and the expression of COX-2. 30 mice are divided into 6 groups. Normal group was not induced by dextran sodium sulfate (DSS). The other groups were induced by 2% DSS through drinking water for 9 days. After 9 days, negative control group did not receive any treatment. The other groups received treatment given lunasin dose 20 mg/kg body weight (BW) and 40 mg/kg BW, commercial lunasin and positive control given aspirin. Treatment was performed for 5 weeks. Inflammatory colon histopathologic examination and immunohistochemical score of COX-2 proteins were analyzed using statistical tests. Lunasin dose 20 mg/kg BW and 40 mg/kg BW were able to significantly reduce inflammation (P<0.05) performed by histopathologic feature with an average score of 2.52 and 2.16 COX-2 expression decreased significantly (P<0.05) with an average score of 43.674 and 33.349. Lunasin dose 20 mg/kg BW and 40 mg/kg BW were able to inhibit inflammation and decrease the expression of COX-2 in colon induced by DSS.","PeriodicalId":94056,"journal":{"name":"International journal of physiology, pathophysiology and pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334218/pdf/ijppp0010-0154.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41167952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New insights and new hope for pulmonary arterial hypertension: natriuretic peptides clearance receptor as a novel therapeutic target for a complex disease. 肺动脉高压的新见解和新希望：利钠肽清除受体作为一种复杂疾病的新治疗靶点。

International journal of physiology, pathophysiology and pharmacology Pub Date : 2017-03-21 DOI: 10.1016/S0735-1097(17)35291-9

E. Egom, Tiam Feridooni, R. Pharithi, B. Khan, Haaris A. Shiwani, V. Maher, Yassine El Hiani, R. Rose, K. Pasumarthi, Hilaire A Ribama

引用次数: 14

Modulatory influence of Parkia biglobosa protein isolate on testosterone and biomarkers of oxidative stress in brain and testes of streptozotocin-induced diabetic male rats. 大叶朴树蛋白分离物对链脲佐菌素诱导的糖尿病雄性大鼠大脑和睾丸中睾酮和氧化应激生物标志物的调节作用

International journal of physiology, pathophysiology and pharmacology Pub Date : 2016-09-30 eCollection Date: 2016-01-01

Bolajoko Idiat Ogunyinka, Babatunji Emmanuel Oyinloye, Foluso Oluwagbemiga Osunsanmi, Andrew Rowland Opoku, Abidemi Paul Kappo

{"title":"Modulatory influence of Parkia biglobosa protein isolate on testosterone and biomarkers of oxidative stress in brain and testes of streptozotocin-induced diabetic male rats.","authors":"Bolajoko Idiat Ogunyinka, Babatunji Emmanuel Oyinloye, Foluso Oluwagbemiga Osunsanmi, Andrew Rowland Opoku, Abidemi Paul Kappo","doi":"","DOIUrl":"","url":null,"abstract":"Parkia biglobosa seed an important household spice commonly consumed in Nigeria is believed to possess antioxidant activity that may exert modulatory effects in diabetes and diabetic complications. This study investigated the modulatory potential of Parkia biglobosa protein isolate (PBPi) on serum testosterone (sTT) level as well as its influence on biomarkers of oxidative stress in brain and testes of streptozotocin-induced diabetic male rats. Animals were made diabetic by single intraperitoneal administration of streptozotocin (STZ; 60 mg/kg body weight). PBPi (200 or 400 mg/kg body weight) was given orally by gavage or insulin (5 U/kg, i.p.) was administered daily to STZ-induced diabetic rats for 28 days. The results revealed a significant elevation in thiobarbituric acid reactive substances (TBARS) levels in the brain and testes of diabetic rats. This was closely associated with a concomitant reduction in levels of sTT and reduced testes weight, a noticeable decline in the glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) as well as total glutathione (Total GSH) level in the brain and testes of diabetic rats. Interestingly, treatment with PBPi efficiently prevented the alterations witnessed in the serum sTT and also ameliorated various alterations in the biomarkers of oxidative stress (TBARS, Total GSH, GST, SOD and CAT) in brain and testes of diabetic rats. These results provide evidence that PBPi could protect the brain and testicular tissues against oxidative stress induced by STZ, via modulation of serum testosterone concentration and also by enhancing antioxidant defence system in STZ-diabetic rats.","PeriodicalId":94056,"journal":{"name":"International journal of physiology, pathophysiology and pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140290062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0