International journal of oral and maxillofacial surgery最新文献_第9页

SRY-box transcription factor 9 and insulin-like growth factor 1 as potential regulators in the pathogenesis of unilateral condylar hyperplasia: a pilot study. SRY-box转录因子9和胰岛素样生长因子1在单侧髁突增生发病机制中的潜在调节作用：一项初步研究

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-02-19 DOI: 10.1016/j.ijom.2026.02.003

J Chaurand, P Mondragón-Terán, J J Magaña-Quiñones, M Godínez-Victoria

{"title":"SRY-box transcription factor 9 and insulin-like growth factor 1 as potential regulators in the pathogenesis of unilateral condylar hyperplasia: a pilot study.","authors":"J Chaurand, P Mondragón-Terán, J J Magaña-Quiñones, M Godínez-Victoria","doi":"10.1016/j.ijom.2026.02.003","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.02.003","url":null,"abstract":"Unilateral condylar hyperplasia (UCH) is a rare growth disorder characterized by progressive mandibular asymmetry. The imbalance in bone activity within the mandibular condyles can lead to masticatory dysfunction and esthetic concerns. Although several associated factors have been proposed, the precise etiology of UCH remains unknown. In this prospective study, we analyzed the expression patterns of SRY-box transcription factor 9 (SOX9) and insulin-like growth factor 1 (IGF-1) in condylar tissues from 11 patients with UCH treated by proportional condylectomy and compared them to condylar samples from five control patients with other mandibular requiring normal condyles to be included in a mandibular resection benign pathology. Resected condyles were demineralized, paraffin-embedded, and subjected to histological and immunohistochemical analysis. Results demonstrated a marked overexpression of SOX9 (P = 0.0080) and IGF-1 (P = 0.0009) in UCH specimens compared to controls, and a significant association with histopathological type according Slootweg classification (r = 0.9017, P = 0.0014 for SOX9 and r = 0.6549, P = 0.0471 for IGF-1). These findings suggest that SOX9 and IGF-1 may be key players in the signaling pathways underlying UCH, providing new insights into its pathophysiology and offering potential targets for future therapeutic strategies in skeletal growth disorders.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical treatment outcomes and prognostic factors in mandibular medication-related osteonecrosis of the jaw. 下颌骨药物相关性骨坏死的手术治疗结果及预后因素。

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-02-18 DOI: 10.1016/j.ijom.2026.02.001

J Chen, K Jia, X Lyu, J An

{"title":"Surgical treatment outcomes and prognostic factors in mandibular medication-related osteonecrosis of the jaw.","authors":"J Chen, K Jia, X Lyu, J An","doi":"10.1016/j.ijom.2026.02.001","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.02.001","url":null,"abstract":"Medication-related osteonecrosis of the jaw is a severe complication of anti-resorptive and anti-angiogenic therapies, with the mandible being particularly susceptible due to its limited vascularity. This retrospective study evaluated surgical outcomes and prognostic factors in 197 patients with advanced mandibular disease who underwent radical surgery (≥ 6-month follow-up). Surgical procedures included marginal resection with local mucoperiosteal flap closure, segmental resection with direct closure, and segmental resection with various reconstruction methods, including fibula free flap, reconstruction plate with submental island flap, or submandibular gland translocation. The overall success rate was 67.0%. Segmental resection demonstrated significantly higher success than marginal resection (78.6% vs 54.3%, P < 0.001). Among reconstruction methods, fibula free flap achieved the highest success rate at 93.8%. Multivariate analysis identified normal preoperative hemoglobin and serum calcium levels, and the presence of purulent discharge, as protective factors, while bilateral involvement and preoperative pain were associated with poorer outcomes. Although surgical outcomes improved over time with technical advances, success was constrained by patients' compromised systemic conditions. This study confirms that tailored radical surgery, combined with complete lesion removal, appropriate reconstruction, and optimization of modifiable systemic factors, remains an effective strategy for advanced mandibular medication-related osteonecrosis of the jaw.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does simultaneous alloplastic temporomandibular joint reconstruction affect the accuracy of Le Fort I osteotomy? 同时同种异体颞下颌关节重建会影响Le Fort I型截骨术的准确性吗？

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-02-17 DOI: 10.1016/j.ijom.2026.02.006

M D Han, L G Mercuri, M Miloro, M Caminiti

{"title":"Does simultaneous alloplastic temporomandibular joint reconstruction affect the accuracy of Le Fort I osteotomy?","authors":"M D Han, L G Mercuri, M Miloro, M Caminiti","doi":"10.1016/j.ijom.2026.02.006","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.02.006","url":null,"abstract":"Simultaneous alloplastic temporomandibular joint reconstruction (ATMJR) with Le Fort I osteotomy (LFI) may be indicated when significant temporomandibular joint (TMJ) pathology accompanies dentofacial deformities. Currently, the impact of concomitant ATMJR on LFI accuracy is not known. The purpose of this study was to assess the influence of patient-fitted ATMJR on the accuracy of simultaneous LFI. In this retrospective cohort study, patients undergoing LFI with and without ATMJR were enrolled. Preoperative and postoperative cone-beam computed tomography was analyzed using regional voxel-based registration. The primary predictor variable was use of ATMJR, and others included impaction at the maxillary central incisor (U1), age, and sex. The primary outcome variable was the mediolateral/superoinferior/anteroposterior absolute linear surgical error at U1 (U1AE). The secondary outcome variable was the three-dimensional surgical error at U1. In 20 subjects (eight ATMJR, 12 non-ATMJR), median U1AE ranged from 0.50 to 1.30 mm and median three-dimensional surgical error from 1.37 to 2.17 mm. ATMJR was associated with higher anteroposterior U1AE (median difference 0.8 mm, P = 0.012) and under-impaction (mean 0.86 mm, P = 0.036). Simultaneous ATMJR is associated with greater anteroposterior surgical error and a tendency towards under-impaction. Appropriate case selection and planning modifications should be considered as appropriate.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do cortical and medullary bone volume, and retromolar and ramus thickness, influence the sagittal split pattern? A retrospective analysis. 皮质和髓质骨体积、臼齿后和支的厚度是否影响矢状面分裂模式？回顾性分析。

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-02-16 DOI: 10.1016/j.ijom.2026.01.006

G Cunha, J Husarek, M Maintz, M A C Gabrielli, F S Halbeisen, F S Salmen, N Sharma, F M Thieringer

{"title":"Do cortical and medullary bone volume, and retromolar and ramus thickness, influence the sagittal split pattern? A retrospective analysis.","authors":"G Cunha, J Husarek, M Maintz, M A C Gabrielli, F S Halbeisen, F S Salmen, N Sharma, F M Thieringer","doi":"10.1016/j.ijom.2026.01.006","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.01.006","url":null,"abstract":"Sagittal split osteotomy (SSO) is a well-established technique for mandibular repositioning, although unfavourable split patterns remain a relevant intraoperative concern. This retrospective study evaluated anatomical factors influencing split morphology, including cortical and medullary bone volumes and mandibular ramus thickness. Pre- and postoperative imaging from 94 SSOs were analysed, and split patterns were classified using the adapted Plooij Lingual Split Scale (LSS). Associations were assessed with the Kruskal-Wallis test, with the Wilcoxon rank sum and Fisher's exact tests used to compare Angle malocclusion classes. Ideal splits (LSS 1) occurred in 68.1% of cases, followed by splits over the canal (LSS 3) in 22.3%, posterior ramus border splits (LSS 2) in 5.3%, and bad splits (LSS 4) in 4.3%. LSS 1 cases showed significantly greater cortical bone volume (P = 0.005) and increased ramus thickness at all measured levels (P < 0.001, P < 0.001, P = 0.0039). Angle class II patients had greater ramus thickness (P = 0.045) and lower medullary bone volume than class III patients. Greater bone volume and ramus thickness were associated with more favourable split outcomes. Further prospective studies are needed to confirm these findings.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adjuvant high-dose-rate brachytherapy for recurrent orbital solitary fibrous tumour: case report and review of the literature. 高剂量率近距离辅助治疗复发性眼眶孤立性纤维瘤：病例报告及文献复习。

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-01-30 DOI: 10.1016/j.ijom.2026.01.017

R García-Risco, D Oliver-Gutierrez, J Oliveres, T Alonso

{"title":"Adjuvant high-dose-rate brachytherapy for recurrent orbital solitary fibrous tumour: case report and review of the literature.","authors":"R García-Risco, D Oliver-Gutierrez, J Oliveres, T Alonso","doi":"10.1016/j.ijom.2026.01.017","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.01.017","url":null,"abstract":"Orbital solitary fibrous tumour (SFT) is a rare, typically benign neoplasm that presents a challenge to management due to its tendency to recur and the potential complications associated with surgical treatment. Complete surgical excision is the standard treatment, with adjuvant therapies considered in high-risk cases, although evidence remains limited. The case of a 56-year-old man with an orbital SFT exhibiting a high rate of recurrence, resulting in 13 surgical interventions over a 20-year period, is reported here. After multiple surgical approaches and radiotherapy following incomplete resections, the tumour recurred intra- and extraorbitally. Following tumour progression and reclassification as World Health Organization grade 2, an anterosuperior orbitotomy was performed, and five flexible catheters were placed for high-dose-rate (HDR) brachytherapy. The patient received 32 Gy over 8 days, with no recurrence at the 2-year follow-up. This case report describes a novel use of intraorbital HDR brachytherapy for orbital SFT. The clinical course, treatment strategy, and outcomes are presented, suggesting HDR brachytherapy as a promising adjuvant therapy for selected recurrent cases.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subcutaneous anesthetic technique to the auriculotemporal nerve for minimally invasive procedures in the temporomandibular joint. 用于颞下颌关节微创手术的耳颞神经皮下麻醉技术。

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-01-30 DOI: 10.1016/j.ijom.2025.12.011

A Rosa, P Espinoza-Mellado, J Saldivia, C Alvarez-Pina

引用次数: 0

Surgical management of mandibular osteoradionecrosis: risk factors, timeline and surgical outcomes. 下颌骨放射性骨坏死的外科治疗：危险因素、时间和手术结果。

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-01-30 DOI: 10.1016/j.ijom.2026.01.010

R Y Kagan, A Ramakrishnan, A Mayer, T A Iseli

{"title":"Surgical management of mandibular osteoradionecrosis: risk factors, timeline and surgical outcomes.","authors":"R Y Kagan, A Ramakrishnan, A Mayer, T A Iseli","doi":"10.1016/j.ijom.2026.01.010","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.01.010","url":null,"abstract":"Surgery is the preferred treatment option for those with severe or refractory osteoradionecrosis (ORN). This retrospective cohort study evaluated surgical management outcomes for mandibular ORN in 36 patients treated at The Royal Melbourne Hospital between 2017 and 2024. Most patients were male (mean age 67.9 years) with Notani Stage III ORN (81%). Common risk factors included radiation >60 Gy (83.6%), smoking (66.6%), and alcohol use (77.8%). A total of 59 surgeries were performed: 46 debridement and 13 segmental mandibulectomies. ORN was associated with high morbidity and mortality (19% died during follow up). Debridement gave long-term relief in 13% of patients, delaying second and third surgeries by 10 and 23 months, respectively. Segmental resections were significantly associated with ORN healing (odds ratio = 10.7, P < 0.001). Segmental mandibulectomy provided sustained relief in 62% and was 10 times more effective than debridement in achieving healed ORN. Debridement and segmental mandibulectomy both have a role in management of mandibular ORN. Debridement provides more time for tissues to recover post-radiotherapy, to exit the high-risk period for cancer recurrence and to allow medical interventions, e.g., smoking cessation.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does preoperative joint space affect accuracy in splint-based Le Fort I osteotomy? 术前关节间隙是否影响夹板Le Fort I型截骨术的准确性？

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-01-30 DOI: 10.1016/j.ijom.2026.01.018

M D Han, A Tavasoli, R Malaki, M Miloro

{"title":"Does preoperative joint space affect accuracy in splint-based Le Fort I osteotomy?","authors":"M D Han, A Tavasoli, R Malaki, M Miloro","doi":"10.1016/j.ijom.2026.01.018","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.01.018","url":null,"abstract":"In splint-based Le Fort I osteotomy (LFI), variations in condyle-fossa relationship can influence surgical accuracy. The aim of this study was to investigate the impact of the preoperative joint space (JS) on surgical errors. This retrospective study included patients status post splint-based maxilla-first LFI at a single institution in a 7-month period. Preoperative JS was measured on preoperative cone-beam computed tomography (CBCT), while angular and linear surgical movements at the maxillary dental midline (U1) were measured using regional voxel-based registration. In 26 eligible subjects, the mean absolute linear and angular errors were 0.82-1.18 mm and 0.87-1.21°, respectively. The greatest superior and posterior preoperative JS correlated with mediolateral (P = 0.020) and anteroposterior (P = 0.019) error, respectively. JS was not associated with angular errors (P > 0.05). Laterality of the greater posterior preoperative JS was associated with the mediolateral linear error (P = 0.026). Regression analysis showed that 3.92 mm posterior preoperative JS resulted in 1 mm anteroposterior error, and a left-to-right posterior preoperative JS differential of 1.35 mm resulted in 1 mm mediolateral error. Vertical and anteroposterior preoperative JS can affect accuracy in maxilla-first splint-based LFI. Routine preoperative evaluation can help identify at-risk cases.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconstruction of the atrophic maxilla combining Le Fort I osteotomy, sinus augmentation and titanium mesh guided bone regeneration: a technical note. Le Fort I型截骨术、鼻窦增强术和钛网引导骨再生联合重建萎缩性上颌骨：技术说明。

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-01-28 DOI: 10.1016/j.ijom.2026.01.008

F Riehl, V Romao, R Lan, E Masson Regnault

引用次数: 0

Genial swing orthomorphic osteotomy: a novel technique for retrogenia-associated obstructive sleep apnoea. 温和摆动正形截骨术：一种治疗肾后性阻塞性睡眠呼吸暂停的新技术。

IF 2.7

International journal of oral and maxillofacial surgery Pub Date : 2026-01-26 DOI: 10.1016/j.ijom.2026.01.007

P C Salins, P L Monis, S Shetty, S Panwar

{"title":"Genial swing orthomorphic osteotomy: a novel technique for retrogenia-associated obstructive sleep apnoea.","authors":"P C Salins, P L Monis, S Shetty, S Panwar","doi":"10.1016/j.ijom.2026.01.007","DOIUrl":"https://doi.org/10.1016/j.ijom.2026.01.007","url":null,"abstract":"Retrogenia, despite its anatomical significance, remains under-recognized as a contributing factor in obstructive sleep apnoea (OSA). While retrognathia and micrognathia are well-documented, retrogenia as an isolated morphological variant has received limited attention in the context of OSA. This technical note introduces the genial swing orthomorphic osteotomy (GSOO), a novel orthomorphic surgical technique specifically designed to address dysmorphology associated with retrogenia. The procedure repositions the genial segment to enhance posterior airway space, while also achieving favourable facial aesthetics. The surgical technique is described in detail, highlighting key anatomical considerations, planning steps, and intra-operative execution. Preliminary application in two patients with OSA secondary to retrogenia demonstrated improvements in airway dimensions, apnoea-hypopnoea index (AHI), and facial profile as well as significant improvement across all eight symptoms domains of the OSA QoL (Quality of Life) questionnaire. The technique presents as a promising intervention for selected patients with OSA linked to retrogenia, warranting further clinical evaluation.","PeriodicalId":94053,"journal":{"name":"International journal of oral and maxillofacial surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146069323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0