Hand surgery & rehabilitation最新文献

{"title":"Ultrasound-guided percutaneous release of the ulnar nerve at the elbow.","authors":"Olivier Marès, Javier Ferreira, Berenice Moutinot, Vincent Martinel, Pascal Kouyoumdjian, Thomas Apard","doi":"10.1016/j.hansur.2024.102071","DOIUrl":"10.1016/j.hansur.2024.102071","url":null,"abstract":"<p><strong>Introduction: </strong>Surgical treatment of ulnar tunnel syndrome is controversial, with no consensus on the ideal procedure. Nevertheless, in-situ decompression seems to provide faster recovery with less morbidity than neurolysis-transposition. The aim of this retrospective study was to validate a new percutaneous technique using ultrasonography.</p><p><strong>Methods: </strong>A retrospective 2-center study included 40 patients with McGowan stage 1 or 2 ulnar nerve entrapment at the elbow treated by a new limited ultrasound-guided percutaneous technique. Patients with McGowan stage 3, osteoarthritis at the elbow or instability were excluded. The study endpoint was clinical success of the percutaneous technique using ultrasonography for release of ulnar nerve entrapment at the elbow. The secondary endpoint was time to recovery.</p><p><strong>Results: </strong>All 40 patients showed clinical improvement, with the resolution of acroparesthesia symptoms. No recurrences were observed at 13 months' follow-up. There were no cases of neurological complications, ulnar nerve instability or infection. Patients were able to return to work rapidly, with an average absence of 3.5 weeks.</p><p><strong>Discussion: </strong>Numerous studies questioned the value of ulnar nerve transposition associated with release in the early stages. No significant difference was found between in-situ decompression and transposition; however, more complications were observed in patients with transposition.</p><p><strong>Conclusion: </strong>Overall, this new ultrasound-guided percutaneous technique for ulnar nerve entrapment was safe. It allowed rapid recovery with effective symptom relief while limiting the risk of complications and time off work.</p>","PeriodicalId":94023,"journal":{"name":"Hand surgery & rehabilitation","volume":" ","pages":"102071"},"PeriodicalIF":0.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential CpG methylation at <i>Nnat</i> in the early establishment of beta cell heterogeneity.","authors":"Vanessa Yu, Fiona Yong, Angellica Marta, Sanjay Khadayate, Adrien Osakwe, Supriyo Bhattacharya, Sneha S Varghese, Pauline Chabosseau, Sayed M Tabibi, Keran Chen, Eleni Georgiadou, Nazia Parveen, Mara Suleiman, Zoe Stamoulis, Lorella Marselli, Carmela De Luca, Marta Tesi, Giada Ostinelli, Luis Delgadillo-Silva, Xiwei Wu, Yuki Hatanaka, Alex Montoya, James Elliott, Bhavik Patel, Nikita Demchenko, Chad Whilding, Petra Hajkova, Pavel Shliaha, Holger Kramer, Yusuf Ali, Piero Marchetti, Robert Sladek, Sangeeta Dhawan, Dominic J Withers, Guy A Rutter, Steven J Millership","doi":"10.1101/2023.02.04.527050","DOIUrl":"10.1101/2023.02.04.527050","url":null,"abstract":"<p><strong>Aims/hypothesis: </strong>Beta cells within the pancreatic islet represent a heterogenous population wherein individual sub-groups of cells make distinct contributions to the overall control of insulin secretion. These include a subpopulation of highly-connected 'hub' cells, important for the propagation of intercellular Ca²⁺ waves. Functional subpopulations have also been demonstrated in human beta cells, with an altered subtype distribution apparent in type 2 diabetes. At present, the molecular mechanisms through which beta cell hierarchy is established are poorly understood. Changes at the level of the epigenome provide one such possibility which we explore here by focussing on the imprinted gene neuronatin (<i>Nnat</i>), which is required for normal insulin synthesis and secretion.</p><p><strong>Methods: </strong>Single cell RNA-seq datasets were examined using Seurat 4.0 and ClusterProfiler running under R. Transgenic mice expressing eGFP under the control of the <i>Nnat</i> enhancer/promoter regions were generated for fluorescence-activated cell (FAC) sorting of beta cells and downstream analysis of CpG methylation by bisulphite and RNA sequencing, respectively. Animals deleted for the de novo methyltransferase, DNMT3A from the pancreatic progenitor stage were used to explore control of promoter methylation. Proteomics was performed using affinity purification mass spectrometry and Ca²⁺ dynamics explored by rapid confocal imaging of Cal-520 and Cal-590. Insulin secretion was measured using Homogeneous Time Resolved Fluorescence Imaging.</p><p><strong>Results: </strong><i>Nnat</i> mRNA was differentially expressed in a discrete beta cell population in a developmental stage- and DNA methylation (DNMT3A)-dependent manner. Thus, pseudo-time analysis of embryonic data sets demonstrated the early establishment of <i>Nnat</i>-positive and negative subpopulations during embryogenesis. NNAT expression is also restricted to a subset of beta cells across the human islet that is maintained throughout adult life. NNAT⁺ beta cells also displayed a discrete transcriptome at adult stages, representing a sub-population specialised for insulin production, reminiscent of recently-described \"β_HI\" cells and were diminished in <i>db/db</i> mice. 'Hub' cells were less abundant in the NNAT⁺ population, consistent with epigenetic control of this functional specialization.</p><p><strong>Conclusions/interpretation: </strong>These findings demonstrate that differential DNA methylation at <i>Nnat</i> represents a novel means through which beta cell heterogeneity is established during development. We therefore hypothesise that changes in methylation at this locus may thus contribute to a loss of beta cell hierarchy and connectivity, potentially contributing to defective insulin secretion in some forms of diabetes.</p>","PeriodicalId":94023,"journal":{"name":"Hand surgery & rehabilitation","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10705251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82487063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical treatment of the mallet fracture: Open or percutaneous procedure?","authors":"G. Caruso, Laura Martini, S. Sargenti, A. Vitali","doi":"10.1016/j.hansur.2022.09.102","DOIUrl":"https://doi.org/10.1016/j.hansur.2022.09.102","url":null,"abstract":"","PeriodicalId":94023,"journal":{"name":"Hand surgery & rehabilitation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43226124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intérêt de l’arthroscopie du poignet dans la prise en charge du syndrome d’Essex Lopresti au stade aigu","authors":"G. Herzberg, M. Burnier, Lyliane Ly","doi":"10.1016/j.hansur.2022.09.110","DOIUrl":"https://doi.org/10.1016/j.hansur.2022.09.110","url":null,"abstract":"","PeriodicalId":94023,"journal":{"name":"Hand surgery & rehabilitation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41610827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conception d’une prothèse de pouce mixte, thermoformée et impression 3D pour les patients amputés","authors":"V. Oca, Maxime Debailleul, Charles Hustin, P. Duriez, d’Almeida Marc-Antoine, P. Laronde","doi":"10.1016/j.hansur.2022.09.233","DOIUrl":"https://doi.org/10.1016/j.hansur.2022.09.233","url":null,"abstract":"","PeriodicalId":94023,"journal":{"name":"Hand surgery & rehabilitation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45250410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparaison de l’auto-évaluation et évaluation dans l’apprentissage de la microchirurgie: Une étude rétrospective comparative dans une cohorte d’étudiants en microchirurgie","authors":"J. Brunet, A. Petit, J. Jeudy, E. Maugendre, Y. S. Cast, N. Bigorre","doi":"10.1016/j.hansur.2022.09.152","DOIUrl":"https://doi.org/10.1016/j.hansur.2022.09.152","url":null,"abstract":"","PeriodicalId":94023,"journal":{"name":"Hand surgery & rehabilitation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48023535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enucléation antéro-médiale du scaphoïde carpien sur une fracture luxation trans stylo-rétrolunaire: A propos d’un cas","authors":"M. Boukredera, M. Khenfri, A. Benhabiles","doi":"10.1016/j.hansur.2022.09.185","DOIUrl":"https://doi.org/10.1016/j.hansur.2022.09.185","url":null,"abstract":"","PeriodicalId":94023,"journal":{"name":"Hand surgery & rehabilitation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47138673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal split tear with intratendinous gap of the extensor digiti minimi","authors":"Romain Baillot, S. Durand","doi":"10.1016/j.hansur.2022.09.149","DOIUrl":"https://doi.org/10.1016/j.hansur.2022.09.149","url":null,"abstract":"","PeriodicalId":94023,"journal":{"name":"Hand surgery & rehabilitation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44280903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etude préliminaire: Orthèse courte suite à lésions de fléchisseurs","authors":"J. Rouzaud","doi":"10.1016/j.hansur.2022.09.238","DOIUrl":"https://doi.org/10.1016/j.hansur.2022.09.238","url":null,"abstract":"","PeriodicalId":94023,"journal":{"name":"Hand surgery & rehabilitation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45972238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La greffe vascularisée du condyle fémoral médial pour le traitement de la pseudarthrose et de la nécrose osseuse du membre supérieur: Notre expérience sur 28 cas","authors":"Pierluigi Tos, Alessandro Crosio, Maro Magnani, E. Barberini, Letizia Marenghi, Sergio De Santis, Simona Odella","doi":"10.1016/j.hansur.2022.09.150","DOIUrl":"https://doi.org/10.1016/j.hansur.2022.09.150","url":null,"abstract":"","PeriodicalId":94023,"journal":{"name":"Hand surgery & rehabilitation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46121485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}