Frontiers in medical technology最新文献

{"title":"Corrigendum: Modeling flow in an <i>in vitro</i> anatomical cerebrovascular model with experimental validation.","authors":"Saurabh Bhardwaj, Brent A Craven, Jacob E Sever, Francesco Costanzo, Scott D Simon, Keefe B Manning","doi":"10.3389/fmedt.2024.1533412","DOIUrl":"https://doi.org/10.3389/fmedt.2024.1533412","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fmedt.2023.1130201.].</p>","PeriodicalId":94015,"journal":{"name":"Frontiers in medical technology","volume":"6 ","pages":"1533412"},"PeriodicalIF":2.7,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11738945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"US regulatory compliance for medical combination products: an overview.","authors":"Manav V Singh, Prafulla Apshingekar, Sanyam Gandhi, Om V Singh","doi":"10.3389/fmedt.2024.1486318","DOIUrl":"10.3389/fmedt.2024.1486318","url":null,"abstract":"<p><p>This article provides a high-level overview of US regulatory review and approval processes for the growing field of medical combination products (CPs; those merging drugs with devices and/or biological products). US law defines drugs, medical devices, and CPs in specific ways, and the components of a CP are still subject to their respective regulations while combined. The Food and Drug Administration's Office of Combination Products (OCP) oversees the review and classification of CPs, which is based on their primary mode of action. When a manufacturer submits a Request for Designation for a new CP, the OCP conducts a technical and clinical evaluation to identify risks and verify modes of action and therapeutic benefits. Evaluating the safety and efficacy of CPs and their constituent parts can be challenging due to the many potential interactions. However, as innovation continues in the health care landscape and the variety of CPs on the market increases, manufacturers must stay proactive in complying with regulatory standards and keeping their products safe.</p>","PeriodicalId":94015,"journal":{"name":"Frontiers in medical technology","volume":"6 ","pages":"1486318"},"PeriodicalIF":2.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing gait data measured by wearable cyborg hybrid assistive limb during assisted walking: gait pattern clustering.","authors":"Yasuko Namikawa, Hiroaki Kawamoto, Akira Uehara, Yoshiyuki Sankai","doi":"10.3389/fmedt.2024.1448317","DOIUrl":"10.3389/fmedt.2024.1448317","url":null,"abstract":"<p><strong>Introduction: </strong>The wearable cyborg Hybrid Assistive Limb (HAL) is a therapeutic exoskeletal device that provides voluntary gait assistance using kinematic/kinetic gait data and bioelectrical signals. By utilizing the gait data automatically measured by HAL, we are developing a system to analyze the wearer's gait during the intervention, unlike conventional evaluations that compare pre- and post-treatment gait test results. Despite the potential use of the gait data from the HAL's sensor information, there is still a lack of analysis using such gait data and knowledge of gait patterns during HAL use. This study aimed to cluster gait patterns into subgroups based on the gait data that the HAL automatically collected during treatment and to investigate their characteristics.</p><p><strong>Methods: </strong>Gait data acquired by HAL, including ground reaction forces, joint angles, trunk angles, and HAL joint torques, were analyzed in individuals with progressive neuromuscular diseases. For each measured item, principal component analysis was applied to the gait time-series data to extract the features of the gait patterns, followed by hierarchical cluster analysis to generate subgroups based on the principal component scores. Bayesian regression analysis was conducted to identify the influence of the wearer's attributes on the clustered gait patterns.</p><p><strong>Results: </strong>The gait patterns of 13,710 gait cycles from 457 treatments among 48 individuals were divided into 5-10 clusters for each measured item. The clusters revealed a variety of gait patterns when wearing the HAL and identified the characteristics of multiple sub-group types. Bayesian regression models explained the influence of the wearer's disease type and gait ability on the distribution of gait patterns to subgroups.</p><p><strong>Discussion: </strong>These results revealed key differences in gait patterns related to the wearer's condition, demonstrating the importance of monitoring HAL-assisted walking to provide appropriate interventions. Furthermore, our approach highlights the usefulness of the gait data that HAL automatically measures during the intervention. We anticipate that the HAL, designed as a therapeutic device, will expand its role as a data measurement device for analysis and evaluation that provides gait data simultaneously with interventions, creating a novel cybernics treatment system that facilitates a multi-faceted understanding of the wearer's gait.</p>","PeriodicalId":94015,"journal":{"name":"Frontiers in medical technology","volume":"6 ","pages":"1448317"},"PeriodicalIF":2.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11682894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating regulatory and policy challenges for AI enabled combination devices.","authors":"Snigdha Santra, Preet Kukreja, Kinshuk Saxena, Sanyam Gandhi, Om V Singh","doi":"10.3389/fmedt.2024.1473350","DOIUrl":"10.3389/fmedt.2024.1473350","url":null,"abstract":"<p><p>In recent years, the Artificial Intelligence (AI) has enabled conventional Combination Devices (CDs) to innovate in healthcare merging with technology sectors. However, the challenges like reliance on predicate devices in US Food and Drug Administration (FDA's 510(k) pathway, especially for perpetually updating AI are stressed. Though the European Union (EU's new Medical Device Regulations address software and AI, fitting adaptive algorithms into conformity assessments remains difficult. The urgent need for frameworks cognizant of AI risks like model degradation and data biases is emphasized. Insights from recalled devices and case studies elucidate challenges in regulatory navigation for manufacturers. Adaptive policy frameworks balancing patient safeguards and rapid innovation are proposed. Recommendations target regulators and policy makers, advocating global standards to enable safe, effective and equitable AI adoption. This article aims to examine AI-enabled combination device regulation, inspecting US and EU strategies as well as obstacles for manufacturers and regulators.</p>","PeriodicalId":94015,"journal":{"name":"Frontiers in medical technology","volume":"6 ","pages":"1473350"},"PeriodicalIF":2.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myeloperoxidase enzyme-catalyzed breakdown of zero-dimension carbon quantum dots.","authors":"Pooja Singh, Lalit Kumar Singh","doi":"10.3389/fmedt.2024.1493288","DOIUrl":"10.3389/fmedt.2024.1493288","url":null,"abstract":"<p><p>Carbon quantum dots (CQDs) have shown considerable interest in multiple fields including bioimaging, biosensing, photocatalysis, ion sensing, heavy metal detection, and therapy due to highly tunable photoluminescence and good photostability. Apart from having optical properties CQDs offer several advantages such as low toxicity, environmental friendliness, affordability, and simple synthesis methods. Furthermore, by modifying their surface and functionality, it's possible to precisely control their physical and chemical characteristics. Nevertheless, the growing utilization of carbon-based nanomaterials (CNMs) requires thorough examination of their potential toxicity and long-term impacts on human health and biological systems. In this study, carbon quantum dots (CQDs) were synthesized via a microwave-assisted method using citric acid and urea as precursors, resulting in an average particle diameter of 10.73 nm. The CQDs were further characterized using SEM and FTIR analysis. The CQDs exhibited an excitation wavelength of 320 nm, displaying an emission peak at 430 nm. The enzymatic biodegradation of CQDs by human myeloperoxidase enzyme has been thoroughly investigated here. It is very crucial to understand how these carbon quantum dots interact with the innate immune system that plays a vital role in recognizing and clearing foreign particles. Human myeloperoxidase (MPO), a key enzyme highly expressed in neutrophil granulocytes during inflammatory responses, has been shown to facilitate the biodegradation of carbon quantum dots and various carbon-based nanomaterials through oxidative processes. As a member of the peroxidase family, MPO produces hypochlorous acid (HOCl) and a range of reactive intermediates to eliminate pathogens. Consequently, the study of the biodegradability of CQDs within biological systems is essential for accelerating technological advancements. Here, we have assessed breakdown of CQDs through an oxidative process facilitated by a myeloperoxidase (MPO)-based peroxide system. The human MPO enzyme acted as a catalyst for the CQD degradation, and the addition of hydrogen peroxide (H₂O₂) and sodium chloride (NaCl) was found to accelerate the reaction.</p>","PeriodicalId":94015,"journal":{"name":"Frontiers in medical technology","volume":"6 ","pages":"1493288"},"PeriodicalIF":2.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflexive eye saccadic parameters in Parkinson's disease.","authors":"Nemuel D Pah, Quoc C Ngo, Nicole McConnell, Barbara Polus, Peter Kempster, Arup Bhattacharya, Sanjay Raghav, Dinesh K Kumar","doi":"10.3389/fmedt.2024.1477502","DOIUrl":"10.3389/fmedt.2024.1477502","url":null,"abstract":"<p><strong>Introduction: </strong>Abnormal reactive saccade, with reduced saccadic gain, impaired smooth pursuit, and unwarranted reactions are clinically used to assess people with Parkinson's disease (PwPD). However, there are inconsistent findings related to other saccade parameters such as latency and transition times. This study aimed to identify differences in the reflexive saccade parameters of early stage PwPD and aged-matched control (AMC).</p><p><strong>Methods: </strong>In this observational study, the reactive eye-gaze was recorded for 70 participants (42 PwPD) and parameters of reflexive saccades and eye-gaze fluctuations were extracted. These parameters were then statistically analyzed using the Mann-Whitney <math><mi>U</mi></math> -test.</p><p><strong>Results: </strong>Results showed that PwPD had significantly shorter latency than AMC for reflexive saccadic movement away from the center of the screen. The overshoot as a fraction of the screen width, a measure of the inaccuracy in reaching the target, was also significantly higher for PwPD. PwPD had greater horizontal and vertical eye gaze fluctuation with a steady target. The numbers of invalid saccades, i.e., when the gaze goes in the opposite direction from the target movement or is considered anticipatory, were similar for both groups; PwPD with 33.43% and AMC with 25.71%.</p><p><strong>Discussion: </strong>This study shows that there are significant differences in the reflexive saccade of PwPD and AMC measured using an inexpensive eye-tracking device. The presence of invalid saccade trials, and differences between towards and away from screen center, both of which were not considered in earlier studies, may explain the discrepancies between earlier studies. The outcome of this study has the potential to be made a device that would assist neurologists in the assessment of PwPD.</p>","PeriodicalId":94015,"journal":{"name":"Frontiers in medical technology","volume":"6 ","pages":"1477502"},"PeriodicalIF":2.7,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in aspiration catheter tip design for thrombectomy: a comprehensive patent review.","authors":"Vera G Kortman, Yinte Verberne, Mostafa A Atalla, Aimée Sakes","doi":"10.3389/fmedt.2024.1388638","DOIUrl":"10.3389/fmedt.2024.1388638","url":null,"abstract":"<p><p>Thrombus removal from the human body is facilitated through the utilization of aspiration catheters during minimally invasive thrombectomy procedures, where a pressure differential guides the targeted tissue through a flexible tubular medical instrument. In this paper, we present a patent analysis of thrombectomy aspiration catheter tip designs sourced from the EspaceNet database. Our findings reveal that enhancing the operability of aspiration catheters can be achieved by improving ease of positioning or suction capacity, whether through active or passive means. In terms of the former, both tip shape and flexibility play pivotal roles in maneuvering the distal end effectively. Variations in aspiration port characteristics, either distal-oriented or sideways-oriented, have the potential to enhance suction efficiency. In the active approach, aspects of positioning and suctioning are integrated into a single design, allowing for seamless transitions between configurations. While numerous design characteristics can coexist in a thrombectomy aspiration tip, a balance between flexibility and buckling resistance, as well as between maximizing aspiration lumen diameter and minimizing tip diameter, must be struck. This paper offers an insightful overview of existing thrombectomy aspiration tip designs, providing valuable inspiration for future innovations in this field.</p>","PeriodicalId":94015,"journal":{"name":"Frontiers in medical technology","volume":"6 ","pages":"1388638"},"PeriodicalIF":2.7,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effective track and trace technology for poor-quality chemotherapeutic pharmaceuticals in resource-limited countries: a review of the Chemotherapeutic Paper Analytical Device.","authors":"Minichil Chanie Worku, Liknew Workie Limenh, Biset Asrade Mekonnen, Yeniewa Kerie Anagaw","doi":"10.3389/fmedt.2024.1436614","DOIUrl":"10.3389/fmedt.2024.1436614","url":null,"abstract":"<p><p>Poor-quality medicines (substandard or counterfeit) can lead to treatment failure. There is a vast global imbalance in cancer treatment outcomes due to the difficulty of accessing quality chemotherapeutic products. Early diagnosis of cancer brings more hope for curative treatment of cancer and increases the demand for chemotherapeutic products. Consequently, it creates opportunities for unethical manufacturers and suppliers to develop substandard and/or counterfeit products. An ongoing review of cost-effective analytical methods is therefore paramount to tracking and tracing poor chemotherapeutic pharmaceutical products. Low- and middle-income country (LMIC) regulators lack safety equipment and standard operating procedures to handle chemotherapeutic products safely in the drug analysis laboratory and have limited capacity to perform post-marketing surveillance on these products. This review aimed to provide a compressive review of the Chemotherapeutic Paper Analytical Device (ChemoPAD). ChemoPAD is an important tool for quality screening of commonly used chemotherapeutic products in LMIC settings. It is an efficient, fast, simple, accessible, cost-effective, and transferable analytical method for verifying substandard and/or counterfeit chemotherapeutic products. Designed as a complete paper-based laboratory the size of a playing card, the ChemoPAD provides a promising solution for healthcare providers, patients, and other parties involved in post-marketing surveillance of chemotherapeutic products. Thus, in the near future, scientists could probably witness the use of the ChemoPAD technology platform to trace and track substandard and/or counterfeit chemotherapeutic products.</p>","PeriodicalId":94015,"journal":{"name":"Frontiers in medical technology","volume":"6 ","pages":"1436614"},"PeriodicalIF":2.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11617187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An approach to reduce inhaler errors using Donabedian's triad.","authors":"Dorothy May Isip Cruz, Manjush Karthika, Ashraf Alzaabi","doi":"10.3389/fmedt.2024.1494089","DOIUrl":"10.3389/fmedt.2024.1494089","url":null,"abstract":"<p><p>Inhaler errors inversely affect the outcome of respiratory diseases. Inhaler devices, such as the metered-dose inhalers (MDI) and dry powder inhalers (DPI), are commonly used in treating respiratory diseases like asthma and chronic obstructive pulmonary disease (COPD), and incorrect use of these devices can result in suboptimal treatment outcomes, increased probabilities of hospitalizations or admissions, and poorer quality of life. Patient related factors to inhaler errors include age, cognitive and physical abilities, education, language barriers, and preferences. Device-related factors such as inhaler design and operational complexity can also lead to errors. Finally, factors related to healthcare professionals (HCP) such as competency, level of knowledge in disease and inhaler device and availability to educate patients, can play a role in inhaler error. Quality management is a potential solution to this problem. Quality improvement strategies towards addressing inhaler misuse can increase patient satisfaction and improve patient outcomes. Donabedian's triad, which includes structure, process, and outcome can be utilized in developing a framework for reducing inhaler errors. Institutional solutions are more towards the structural and process changes in the triad, such as HCP training, checklists on training efficacy, provision of action plans, and availability of staff to educate and train patients. Patient-centered solutions focus more on process and outcome domains, such as improvement in lung functions, patient education, re-assessment and re-education of inhaler techniques, and adherence to treatment regimen. By focusing on structural and process domains, the quality of care can be enhanced, resulting in improved outcomes.</p>","PeriodicalId":94015,"journal":{"name":"Frontiers in medical technology","volume":"6 ","pages":"1494089"},"PeriodicalIF":2.7,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open-loop narrowband magnetic particle imaging based on mixed-frequency harmonic magnetization response.","authors":"Hongli Yu, Ping Huang, Xiting Peng, Zheyan Wang, Zhichuan Qiu, Kewen Li, Tianshu Li, Zhiyao Liu, Hao Cui, Shi Bai","doi":"10.3389/fmedt.2024.1464780","DOIUrl":"10.3389/fmedt.2024.1464780","url":null,"abstract":"<p><strong>Introduction: </strong>Magnetic particle imaging (MPI), a radiation-free, dynamic, and targeted imaging technique, has gained significant traction in both research and clinical settings worldwide. Signal-to-noise ratio (SNR) is a crucial factor influencing MPI image quality and detection sensitivity, and it is affected by ambient noise, system thermal noise, and the magnetization response of superparamagnetic nanoparticles. Therefore to address the high amplitude system and inherent thermal noise present in conventional MPI systems is essential to improve detection sensitivity and imaging resolution.</p><p><strong>Method: </strong>This study introduces a novel open-loop, narrow-band MPI signal acquisition system based on mixed-frequency harmonic magnetization response. Allowing superparamagnetic nanoparticles to be excited by low frequency, high amplitude magnetic fields and high frequency, low amplitude magnetic fields, the excitation coil generates a mixed excitation magnetic field at a mixed frequency of 8.664 kHz (<i>f</i> _<i>H</i>  + 2<i>f</i> _<i>L</i> ), and the tracer of superparamagnetic nanoparticles can generate a locatable superparamagnetic magnetization signal with rich harmonic components in the mixed excitation magnetic field and positioning magnetic field. The third harmonic signal is detected by a Gradiometer coil with high signal-to-noise ratio, and the voltage cloud image is formed.</p><p><strong>Result: </strong>The experimental results show that the external noise caused by the excitation coil can be effectively reduced from 12 to about 1.5 μV in the imaging area of 30 mm × 30 mm, which improves the stability of the detection signal of the Gradiometer coil, realizes the detection of high SNR, and makes the detection sensitivity reach 10 μg Fe. By mixing excitation, the total intensity of the excitation field is reduced, resulting in a slight improvement of the resolution under the same gradient field, and the spatial resolution of the image reconstruction is increased from 2 mm under the single frequency excitation (20.7 kHz) in the previous experiment to 1.5 mm under the mixed excitation (8.664 kHz).</p><p><strong>Conclusions: </strong>These experimental results highlight the effectiveness of the proposed open-loop narrowband MPI technique in improving signal detection sensitivity, achieving high signal-to-noise ratio detection and improving the quality of reconstructed images by changing the excitation magnetic field frequency of the excitation coil, providing novel design ideas and technical pathways for future MPI systems.</p>","PeriodicalId":94015,"journal":{"name":"Frontiers in medical technology","volume":"6 ","pages":"1464780"},"PeriodicalIF":2.7,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11537903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}