Foot & ankle international最新文献

{"title":"Patient-Reported Outcomes and Revision Risk Following Total Ankle Replacement With and Without Ipsilateral Hindfoot Fusion.","authors":"Emily Teehan, Allison L Boden, Agnes Jones, Jensen Henry, Constantine Demetracopoulos","doi":"10.1177/10711007251341316","DOIUrl":"10.1177/10711007251341316","url":null,"abstract":"<p><strong>Background: </strong>Hindfoot (subtalar, talonavicular, and/or calcaneocuboid) fusion is commonly used to treat arthritis and/or deformity. Some patients undergoing total ankle replacement (TAR) have a history of hindfoot fusion or undergo it concomitantly. This study aims to evaluate Patient-Reported Outcomes Measurement Information System (PROMIS)-based clinical outcomes, revision rates, and radiographic findings of primary TAR with ipsilateral hindfoot fusion at a minimum 2-year follow-up from primary TAR. We hypothesized that TAR patients with ipsilateral hindfoot fusion would have worse patient-reported outcomes and clinical outcomes than TAR-only patients.</p><p><strong>Methods: </strong>A retrospective review of 400 primary TAR patients with or without prior/concomitant ipsilateral hindfoot fusion was conducted. PROMIS domains, radiographs, complications, and revisions were analyzed. Multivariate linear regression models were used to evaluate the associations between hindfoot fusion and 2-year postoperative PROMIS scores. We compared proportions meeting minimal clinically important difference (MCID) and patient-acceptable symptom state (PASS) thresholds.</p><p><strong>Results: </strong>Of 400 ankles, 49 (12.3%) had ipsilateral hindfoot fusion. On multivariate analysis, hindfoot fusion was associated with worse 2-year PROMIS scores in most domains, including Physical Function, Pain Interference, and Global Mental Health. However, rates of achieving MCID and PASS were largely similar between groups. At 2 years, hindfoot fusion patients were equally likely to achieve MCID in Physical Function, Pain Interference, and Depression, and to meet PASS thresholds for Pain Interference, Pain Intensity, and Physical Function. They were significantly less likely to achieve MCID for Pain Intensity (<i>P</i> = .012) and PASS for Global Mental Health (<i>P</i> = .015) and Depression (<i>P</i> = .024). Revision rate was higher in the hindfoot fusion group (10.2% vs. 2.6%, <i>P</i> = .038).</p><p><strong>Conclusion: </strong>Although patients undergoing TAR with ipsilateral hindfoot fusion report lower absolute PROMIS scores in several domains, they appear equally likely to perceive meaningful clinical improvement and reach acceptable postoperative states in pain and function. These patients may still experience more persistent mental health burden and slightly less improvement in pain intensity.</p>","PeriodicalId":94011,"journal":{"name":"Foot & ankle international","volume":" ","pages":"845-854"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making PROMs Work for Patients-and for Us.","authors":"Charles L Saltzman, Robert B Anderson, Brad D Blankenhorn, John T Campbell, Christopher P Chiodo, Timothy R Daniels, George B Holmes, Ellie Pinsker, Stefan Rammelt, Robert A Vander Griend","doi":"10.1177/10711007251355824","DOIUrl":"10.1177/10711007251355824","url":null,"abstract":"","PeriodicalId":94011,"journal":{"name":"Foot & ankle international","volume":"46 8","pages":"811-812"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Short Primer on the Reporting of Patient-Reported Outcome Measures in Clinical Studies.","authors":"Ellie Pinsker, Richard Sloane, Robert A Vander Griend, Christopher P Chiodo, Timothy R Daniels, Charles L Saltzman","doi":"10.1177/10711007251355848","DOIUrl":"10.1177/10711007251355848","url":null,"abstract":"","PeriodicalId":94011,"journal":{"name":"Foot & ankle international","volume":"46 8","pages":"813-815"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Preoperative X/Y Ratio on Clinical Outcomes following Percutaneous Zadek Osteotomy for Insertional Achilles Tendinopathy.","authors":"Sarah Hall Kiriluk, Anne Holly Johnson, Jonathan R M Kaplan, Ettore Vulcano, Thomas Lewis, Peter Lam, Oliver Schipper, J Benjamin Jackson, Tyler A Gonzalez","doi":"10.1177/10711007251341890","DOIUrl":"10.1177/10711007251341890","url":null,"abstract":"<p><strong>Background: </strong>The percutaneous dorsal closing wedge calcaneal Zadek osteotomy (ZO) is an effective treatment for patients with insertional Achilles tendinopathy (IAT), although consensus is lacking on ideal patient selection. Tourné et al proposed that a preoperative calcaneal X/Y ratio <2.5 defines surgical candidacy, but this criterion remains controversial. This study evaluated whether patients with IAT benefit from percutaneous ZO regardless of preoperative X/Y ratio.</p><p><strong>Methods: </strong>A retrospective comparative study of 27 patients undergoing percutaneous ZO was performed. Patients were stratified into 2 cohorts based on preoperative X/Y ratio (<2.5 vs ≥2.5). Primary outcomes were PROMIS scores for pain, function, and mobility at 3, 6, and 12 months. Secondary outcomes included complication rates and radiographic parameters. Minimal clinically important differences were used to assess clinical significance.</p><p><strong>Results: </strong>Between May 2022 and May 2024, 27 cases were included in the current analyses. Seventeen cases had an X/Y <2.5; 10 had an X/Y ≥2.5. Both cohorts demonstrated significant improvement in PROMIS pain, function, mobility scores (<i>P</i> < .05). Patients with X/Y ≥2.5 demonstrated statistically greater improvement in pain scores than patients with X/Y <2.5 (<i>P</i> = .049) at 1-year follow-up. Ninety-eight percent of patients were satisfied following ZO intervention.</p><p><strong>Conclusion: </strong>Percutaneous ZO demonstrated meaningful improvement in patients' function, pain, and mobility regardless of preoperative X/Y ratio. These findings challenge the use of the <2.5 X/Y threshold as a strict selection criterion. Percutaneous ZO may be a viable option for a broader population of IAT patients than previously considered.</p>","PeriodicalId":94011,"journal":{"name":"Foot & ankle international","volume":" ","pages":"887-894"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Utility of Magnetic Resonance Imaging for Plantar Vein Thrombosis.","authors":"Patrick T Davis, Rachel C Davis, Brennan J Boettcher, Michael D Ringler, Naveen S Murthy","doi":"10.1177/10711007251339481","DOIUrl":"10.1177/10711007251339481","url":null,"abstract":"<p><strong>Background: </strong>Plantar vein thrombosis (PVT) is a rare cause of unilateral plantar foot pain not commonly assessed during sonographic scans for venous thromboembolic evaluation. The present study aims to increase awareness of PVT when evaluating musculoskeletal conditions and to discuss the utility and characteristic imaging findings of PVT on magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>This is a retrospective chart review identifying patients with suspected PVT via search of a single institution's radiology reports. Twelve patients had an available lower extremity MRI. These 12 MRIs were independently reviewed by 2 fellowship-trained musculoskeletal radiologists for common imaging characteristics. Of note, only 7 of the 12 available imaging studies contained MRI findings consistent with PVT as determined by the radiology reviewers. For these 7 patients, clinical characteristics were also recorded.</p><p><strong>Results: </strong>Between both radiology reviewers, there was 100% agreement confirming, localizing, and describing the findings of PVT. Of the 7 cases of MRI-confirmed PVT, 6 of 7 studies were performed without contrast and 1 of 7 was performed with and without contrast. The lateral plantar vein was the predominant vein involved in 85.7% (6/7). All 7 cases showed signs of intraluminal signal change, venous enlargement, and muscle edema. Two cases (28.6%, 2/7) displayed collateralization and/or enlargement of surrounding veins. In the only MRI performed with contrast, perivascular enhancement and a filling defect were noted.</p><p><strong>Conclusion: </strong>In the evaluation of a painful foot, an MRI can be used to diagnose PVT reliably and may have several advantages over compression ultrasonography (US) because of its ability to identify other unsuspected etiologies of a painful foot and elimination of technical limitations of compression US in the plantar foot region.</p>","PeriodicalId":94011,"journal":{"name":"Foot & ankle international","volume":" ","pages":"873-879"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical Comparison Between Fixation Techniques for First-Metatarsophalangeal Joint Arthrodesis.","authors":"Chase M Romere, Jason P Sidrak, Justin F M Hollenbeck, Kevin A Schafer, Craig T Haytmanek, Jonathon D Backus","doi":"10.1177/10711007251341886","DOIUrl":"10.1177/10711007251341886","url":null,"abstract":"<p><strong>Background: </strong>Metatarsophalangeal (MTP) arthrodesis is the gold standard for treatment of end-stage degeneration or severe hallux valgus deformities. Traditional fixation uses stainless steel or titanium plates, often with a crossing screw. Nitinol, a superelastic nickel-titanium alloy, offers dynamic compression. Nevertheless, it is unknown how nitinol implantation in the context of first-MTP arthrodesis performs biomechanically. We hypothesized that nitinol constructs would demonstrate biomechanical performance comparable or superior to a traditional plate-and-screw construct.</p><p><strong>Methods: </strong>Twelve pairs of cadaveric metatarsophalangeal joints were organized into 3 groups according to a balanced incomplete block design: (1) a traditional titanium plate and cross-screw (PS) construct, (2) a nitinol staple and cross screw (NSS) construct, and (3) a proprietary nitinol hybrid screw (NHS) construct. The PS construct consisted of a plate with a compression cross screw; the NSS construct consisted of a nitinol staple with a compression cross screw; and the NHS construct consisted of a hybrid nitinol staple with a compression cross screw. Each specimen was cyclically loaded over 100 cycles at 1 Hz from 20 to 90 N followed by failure testing. A high-definition camera recorded gapping. Failure load, deflection, and stiffness were recorded.</p><p><strong>Results: </strong>Compared with the PS construct, both nitinol constructs (NSS and NHS) demonstrated significantly higher failure loads (NSS: 196 ± 101 N, <i>P</i> = .011; NHS: 161 ± 45 N, <i>P</i> = .045), greater stiffness (NSS: 33 ± 15 N/mm, <i>P</i> = .012; NHS: 29 ± 12 N/mm, <i>P</i> = .042), reduced deflection after cyclic loading (NSS: 6 ± 3 mm, <i>P</i> = .047; NHS: 7 ± 3 mm, <i>P</i> = .048), and decreased gapping at failure (NSS: 1 ± 1 mm, <i>P</i> = .003; NHS: 2 ± 1 mm, <i>P</i> = .008). No significant differences were observed between NSS and NHS.</p><p><strong>Conclusion: </strong>Nitinol constructs for MTP arthrodesis demonstrated superior mechanical performance compared with a traditional plate-and-screw construct, with higher failure load and stiffness.</p><p><strong>Clinical relevance: </strong>These results support the growing use of nitinol for joint fusion, highlighting its potential to improve load to failure and reduce displacement under cyclic loading.</p>","PeriodicalId":94011,"journal":{"name":"Foot & ankle international","volume":" ","pages":"895-902"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectory of Recovery Following Total Ankle Arthroplasty Using Patient-Reported Outcomes Measurement Information System (PROMIS).","authors":"Andres Piscoya, Callie Liu, Stephanie Chen, Zachary Rockov, Brett Ewing, Max Michalski, David Thordarson, Timothy Charlton","doi":"10.1177/10711007251343526","DOIUrl":"10.1177/10711007251343526","url":null,"abstract":"<p><strong>Background: </strong>Total ankle arthroplasty (TAA) is a common method of treatment for end-stage ankle arthritis (ESAA). The utilization of Patient-Reported Outcomes Measurement Information System (PROMIS) allows for standardized assessment of patient-driven outcomes, but few studies have been published on outcomes of TAA using PROMIS. The purpose of this study was to describe the recovery trajectory of patients undergoing TAA for ESAA for up to 1 year after surgery using PROMIS scores for physical function (PF), pain interference (PI), and depression (DP).</p><p><strong>Methods: </strong>A retrospective review of patients undergoing TAA for ESAA over a 5-year period (January 2018-October 2023) was performed. Preoperative and postoperative PROMIS scores were collected and compared at multiple time points leading up to 1 year after surgery. Demographic variables were compared. All patients included in this study underwent primary TAA. Patients were excluded from this study if they had contralateral TAA within 1 year of the previous TAA, and/or they did not have 1 preoperative or at least 2 postoperative PROMIS scores.</p><p><strong>Results: </strong>In total, 109 patients met inclusion criteria with a mean age of 65.3 (SD 9.2) years. No patients undergoing TAA had Medicaid and 50% had Medicare. The mean PROMIS PF scores at 1, 3, 6 months and 1 year were 28.2, 38.5, 41.8, and 43.1, respectively. The mean PROMIS PI scores at 1, 3, 6 months and 1 year were 57.1, 59.2, 56.2, and 55.8, respectively. Most of the improvement for both PF and PI scores from preoperative occurred within the first 6 months of recovery, with average improvements of 5.0 points for PF and -8.4 points for PI. Patients had statistically and clinically significant improvements in PROMIS scores at multiple postoperative time points. Patients had statistically significant improvement in PROMIS scores through various time points in their recovery.</p><p><strong>Conclusion: </strong>This study demonstrates that patients who underwent primary TAA have improvements in PROMIS scores at several different time points up to 1 year after surgery. Patients can expect an improvement in pain and function from baseline within 3 months from surgery. Most improvements occur within the first 6 months. More than half of the patients will achieve a PF and PI score within 1 SD of the national average by 6 months, but it can take up to a year for most patients to reach this. Understanding the trajectory of patient recovery at different time points after primary TAA can help set patient expectations and guide intervention.</p>","PeriodicalId":94011,"journal":{"name":"Foot & ankle international","volume":" ","pages":"816-826"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative Radiation Exposure with Percutaneous vs Hybrid Hallux Valgus Correction: A Comparative Study.","authors":"Lorena Bejarano-Pineda, Lercan Aslan, Julien Beldame, Blandine Demeulenaere, Jean-Claude Moati, Rémy Touzard, Joel Vernois, Olivier Laffenêtre","doi":"10.1177/10711007251341894","DOIUrl":"10.1177/10711007251341894","url":null,"abstract":"<p><strong>Background: </strong>Minimally invasive surgery (MIS) for hallux valgus (HV) deformity have gained popularity over traditional open techniques in recent years. However, MIS techniques pose concerns about increased fluoroscopy use and potential radiation exposure. This study seeks to compare the radiation exposure between percutaneous HV correction and a hybrid technique using a mini C-arm.</p><p><strong>Methods: </strong>In this prospective study, 68 patients underwent HV correction surgery between February 2022 and July 2023. Group 1 consisted of 37 patients who underwent percutaneous chevron and Akin osteotomy whereas group 2 consisted of 31 patients who underwent mini-open metatarsal distal chevron osteotomy + Akin percutaneous osteotomy (hybrid) technique. The patients were nonrandomized and allocated to each group according to their surgeons' preference. Radiation exposure was measured using dose-area product (DAP), exposure duration, and passive dosimeters for the surgeon's extremity, lens, and chest, as well as active dosimeters for the surgical team and patients.</p><p><strong>Results: </strong>Group 1 exhibited higher mean DAP (3.02 ± 1.91 cGy/cm²) compared with group 2 (1.56 ± 1.57 cGy/cm², <i>P</i> = .001). Mean radiation exposure duration was also higher in group 1 (56.74 ± 18.40 seconds) than in group 2 (23.54 ± 18.70 seconds, <i>P</i> < .001). Despite higher radiation exposure per case, cumulative doses remained below occupational safety thresholds set by the International Commission on Radiological Protection (ICRP) which are 5 cGy for whole body and lens of the eye, and 50 cGy for hand exposure.</p><p><strong>Conclusion: </strong>Although percutaneous HV correction is associated with greater intraoperative fluoroscopy use, cumulative radiation exposure to patients and surgical teams remains well within ICRP-recommended safety limits when mini C-arm fluoroscopy is used. These findings support the continued use of percutaneous techniques in appropriately selected patients and settings.</p>","PeriodicalId":94011,"journal":{"name":"Foot & ankle international","volume":" ","pages":"880-886"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review on Tibial Cortex Transverse Transport in the Treatment of Ischemic Ulcers of the Lower Limb.","authors":"Abby Luxon, Anxhela Syziu, William D Harrison, Amirul Islam, Lyndon Mason","doi":"10.1177/10711007251341312","DOIUrl":"10.1177/10711007251341312","url":null,"abstract":"<p><strong>Background: </strong>Ischemic foot ulcers are a debilitating but common finding from many different conditions and can result in severe and life-threatening complications such as amputation and death. In recent years, tibial cortex transverse transport (TTT) has been used to treat ischemic ulcers with the aim to improve revascularization and wound healing. Our aim with this systematic review is to analyze the current literature to study the effects this surgery has on the treatment of ischemic ulcers of the lower limb.</p><p><strong>Methods: </strong>A search was conducted using the 3 databases Web of Science, PubMed, and Scopus to collate all articles associated with the use of TTT in the treatment of lower limb ischemic ulcers. Duplicate articles were removed, and the remaining articles were filtered and screened using set inclusion criteria such as patients with a diagnosed foot ulcer of ischemic origin, patients treated with TTT alone or combined with other techniques on the affected leg, unilateral or bilateral ischemic ulcers, studies that had evidence of treatment outcomes related to ulcer such as visual analog scale (VAS), ankle-brachial index (ABI) measurements, ulcer healing rate and time, recurrence rate, and complications. The exclusion criteria consisted of duplicated studies, overlapping data in studies, TTT used to treat nonulcerous conditions, other systematic reviews, articles with publication language other than English, no access to full text of article, and case reports.</p><p><strong>Results: </strong>A total of 13 articles were included in the final selection, involving 924 patients, with 724 treated with TTT, in which 701 were diabetic patients. The results extracted demonstrated improvements in healing rates and times, vascular endothelial growth factor, ABI scores, VAS scores, and limb salvage. With regard to the complications and risks, pin-site infections and tibial fractures were infrequent and treated quickly.</p><p><strong>Conclusion: </strong>Overall, the use of TTT has been associated with unusual success in improving revascularization and healing times in treating ischemic ulcers of the lower limb resulting in better outcomes for the patient and may provide a potential alternative treatment to the more conventional, widespread treatments currently used in clinical practice. Tibial fractures and pin-site infections are relatively rare complications that have been reported with use of this treatment.</p>","PeriodicalId":94011,"journal":{"name":"Foot & ankle international","volume":" ","pages":"914-924"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porcine Pilon Fractures Result in Significant Chondrocyte Cell Death on Both Sides of the Tibiotalar Joint.","authors":"Graham J DeKeyser, Tyler J Thorne, Aaron Olsen, Justin M Haller","doi":"10.1177/10711007251341310","DOIUrl":"10.1177/10711007251341310","url":null,"abstract":"<p><strong>Background: </strong>The development of posttraumatic osteoarthritis after intra-articular fracture (IAF) of the tibial plafond is multifactorial and complex. The purpose of this study was to evaluate chondrocyte cell death at various areas of the ankle plafond in a high-energy and low-energy porcine pilon fracture model.</p><p><strong>Methods: </strong>Fifteen pilon ankle fractures were created in porcine hindlimbs using a validated large-animal IAF model. Three groups were tested: control pigs (CP), low-energy fracture pigs (LEP), and high-energy fracture pigs (HEP). Chondral samples were taken from the plafond adjacent to fracture (Tib-F), plafond at 5 mm away from the fracture (Tib-C), talus near the fracture (Tal-F), and talus 5 mm away from the fracture (Tal-C). At 48 hours, the samples were stained for live and dead cell labeling and confocal microscopy-evaluated cell death.</p><p><strong>Results: </strong>Cell death was significantly greater for the HEP when compared to the LEP. HEP Tib-F fractional cell death was 41.92% (SD 3.5) compared with LEP Tib-F 28.8% (SD 4.32) (<i>P</i> < .0001) and HEP Tal-F fractional cell death was 40.41% (SD 4.1) compared with LEP Tal-F cell death of 25.91% (SD 4.28) (<i>P</i> = .0018). Similarly, the fractional cell death of chondral samples near the fracture was significantly greater than the cell death 5 mm away from the fracture in both the LEP and HEP (all <i>P</i> < .0001). Finally, despite no visible fractures of the talar dome, the chondrocyte cell death was not significantly different between the tibia and the talus (HEP Tib-F 41.92% vs HEP Tal-F 40.41%, <i>P</i> = .29; LEP Tib-F 28.80% vs LEP Tal-F 25.91%, <i>P</i> = .16).</p><p><strong>Conclusion: </strong>Chondrocyte cell death was greatest at the fracture margin and in high-energy fractures. Interestingly, across both high- and low-energy IAF models, the chondrocyte cell injury rate was similar for both the talar dome and tibial plafond. Future research should focus on mitigating chondrocyte demise after injury.</p><p><strong>Clinical relevance: </strong>The rate of posttraumatic osteoarthritis after tibial plafond injuries in humans is exceedingly high despite advances in operative treatment. This study uses a clinically relevant, large-animal pilon fracture model to evaluate rates of chondrocyte cell death after 48 hours. This study confirms that cartilage cell death is associated with proximity to the fracture lines, higher-energy injury, and that pilon injuries impact cartilage on both the tibia and talus.</p>","PeriodicalId":94011,"journal":{"name":"Foot & ankle international","volume":" ","pages":"827-835"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}