Experimental and therapeutic medicine最新文献

{"title":"Prior curative-intent treatment strategy affects progression outcomes of first-line immunotherapy in metastatic non-small cell lung cancer: A retrospective cohort study.","authors":"Ruhper Cekin, Didar Senocak, Serdar Arici, Alpaslan Ozgun","doi":"10.3892/etm.2026.13127","DOIUrl":"10.3892/etm.2026.13127","url":null,"abstract":"<p><p>Non-small cell lung cancer (NSCLC) represents the most prevalent histological subtype of lung malignancies, accounting for the vast majority of new diagnoses and remaining a leading cause of oncology-related mortality worldwide. Despite recent therapeutic advancements, the disease maintains a formidable clinical burden, with global incidence rates continuing to rise. Consequently, optimizing treatment sequencing and identifying predictive factors for therapy response remain critical priorities in improving long-term patient outcomes. The present study aimed to evaluate the impact of prior curative-intent treatment strategy on disease progression outcomes during first-line immunotherapy in patients with metastatic NSCLC. The present retrospective, single-center cohort study included 62 patients with advanced NSCLC who developed metastatic disease after receiving curative-intent treatment. Before metastasis, patients had been administered with either adjuvant chemotherapy or definitive chemoradiotherapy. All patients subsequently received first-line immunotherapy after developing metastatic disease. The primary endpoint was disease progression status (presence or absence) during a 24-month follow-up period. Progression-free survival (PFS) was evaluated among patients with disease progression. Results showed that during the 24-month follow-up, disease progression occurred in 33 patients (53.2%). Although not statistically significant, progression was observed more frequently in patients previously treated with adjuvant chemotherapy compared with those who had received definitive chemoradiotherapy (68.0 vs. 43.2%; P=0.055). Among the patients who developed progression, the median PFS was 7.98 months for those in the adjuvant chemotherapy group and 9.82 months for those in the definitive chemoradiotherapy group, with no statistically significant difference observed between the groups. First-line immunotherapy-related adverse events occurred at comparable rates in both groups, with the most frequent toxicities being thyroid dysfunction, pulmonary toxicity and neuropathy. In summary, compared with prior adjuvant chemotherapy, prior definitive chemoradiotherapy demonstrated a potential trend toward a lower risk of disease progression during first-line immunotherapy for metastatic NSCLC, without an associated increase in treatment-related toxicity, such as immune-related adverse events. These findings suggested that previous curative-intent treatment strategies may influence progression outcomes during subsequent immunotherapy.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 5","pages":"132"},"PeriodicalIF":2.3,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147611097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the dynamics of the splenium: A comprehensive analysis of flair hyperintensity variations.","authors":"Ezel Yaltirik Bilgin, Özkan Ünal, Yasin Özdemir, Onur Şimşek","doi":"10.3892/etm.2026.13128","DOIUrl":"10.3892/etm.2026.13128","url":null,"abstract":"<p><p>The splenium of the corpus callosum plays a pivotal role in interhemispheric communication and undergoes various changes with ageing. The present study aimed to elucidate the age-related variations in splenial fluid-attenuated inversion recovery (FLAIR) hyperintensity, providing insights into the normal ageing process of the brain and enhancing the clinical interpretation of magnetic resonance (MR) imaging. In the present retrospective cohort study, cerebral MR imaging of 1,176 patients was analysed following application of strict inclusion and exclusion criteria to isolate age and sex-related changes and other factors that can affect splenium hyperintensity. The present study focused on measuring the thickness (anteroposterior) of splenial FLAIR hyperintensity, with interobserver agreement assessed to ensure measurement reliability. Statistical analyses, including the Mann-Whitney U test for sex comparisons and the Kruskal-Wallis test for age group comparisons, were employed to investigate the effects of age, sex, radiation therapy and Fazekas score on splenial FLAIR hyperintensity. The present study demonstrated a significant increase in the presence of splenial FLAIR hyperintensity and thickness (P<0.001; P=0.006) with advancing age, particularly in individuals >57 years of age. No significant differences were observed between male and female participants, suggesting that these age-related changes were consistent across sex. Splenium hyperintensity thickness was significantly higher in the group that received radiation therapy and in the patient group with a Fazekas score of 3 (0.048, 0.018). Interobserver agreement was evaluated using the intraclass correlation coefficient (ICC) to assess measurement consistency (ICC=0.977; P<0.001). The present study provides crucial insights into the age-related dynamics of the splenium.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 5","pages":"133"},"PeriodicalIF":2.3,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct venous-to-arterial communication as a novel mechanism for ectopic embolism following esophageal variceal embolization: A case report.","authors":"Youchun Lei, You Ke, Tianwen Yang, Zhengguo Xu","doi":"10.3892/etm.2026.13125","DOIUrl":"10.3892/etm.2026.13125","url":null,"abstract":"<p><p>Ectopic embolism is an infrequent but potentially life-threatening complication following esophageal variceal embolization. Although it has been hypothesized to result from right-to-left shunting via pulmonary arteriovenous malformations or patent foramen ovale, definitive anatomical routes often remain undetected. The present case study reports a 57-year-old male patient with decompensated cirrhosis who developed acute bilateral visual loss and lower limb weakness within 24 h after undergoing transjugular intrahepatic portosystemic shunt placement combined with endovascular embolization of esophageal varices. Brain imaging confirmed multiple acute cerebral infarctions; notably, angiographic review revealed an abnormal direct venous connection between the esophageal variceal plexus and the left heart/ascending aorta, bypassing the pulmonary circuit. No cardiac or pulmonary shunts were identified. This direct communication likely permitted embolic material to enter the systemic circulation, causing cerebral artery occlusion. In conclusion, to the best of our knowledge, the present case provides the first angiographic evidence of a direct vascular route from esophageal varices to the systemic arterial system. The present finding underscores the importance of comprehensive imaging before embolization and suggests that solid embolic agents such as coils may be preferable in select patients to prevent ectopic embolism.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 5","pages":"130"},"PeriodicalIF":2.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of older age on prognosis in hypersensitivity pneumonitis: A systematic review and meta-analysis.","authors":"Konstantinos Dodos, Tsampika-Vasileia Kalamara, Vasiliki Therapioti-Mavroudi, Nikolaos Trakas, Eleni Sklapani, Demetrios A Spandidos, Alexandru Corlateanu, Vasiliki Epameinondas Georgakopoulou","doi":"10.3892/etm.2026.13123","DOIUrl":"10.3892/etm.2026.13123","url":null,"abstract":"<p><p>Hypersensitivity pneumonitis (HP) is a heterogeneous immune-mediated interstitial lung disease with markedly variable clinical outcomes. Increasing age has been repeatedly suggested as a determinant of worse prognosis; however, to the best of our knowledge, its independent prognostic impact has not been systematically quantified. A systematic review and meta-analysis were conducted in the present study in accordance with PRISMA guidelines and registered in PROSPERO (CRD420251004649). Medline, Google Scholar and Cochrane databases were searched from 1980 to 2025 for studies evaluating the association between older age and adverse outcomes in HP. Eligible studies included adult HP populations with comparative age data and reported prognostic outcomes, including mortality, rapid forced vital capacity decline, respiratory failure and need for long-term oxygen therapy. A random-effects model was applied, and heterogeneity was assessed using the I² statistic. A total of six observational studies comprising 1,518 patients with HP were included. Across studies, older age consistently associated with poorer outcomes, including increased mortality, higher likelihood of fibrotic disease and greater risk of respiratory failure. In studies reporting age as a continuous variable, pooled analysis demonstrated that each additional year of age was associated with a 5.4% increase in the hazard of death (pooled hazard ratio=1.054; 95% CI 1.030-1.079), with moderate heterogeneity (I²=36.4%); sensitivity analyses confirmed the robustness of the findings. Advanced age is a significant adverse prognostic factor in HP, independently associated with increased mortality and disease progression. These findings support the incorporation of age into prognostic models and risk stratification strategies and highlight the need for age-adapted diagnostic vigilance and individualized management approaches in older patients with HP.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 5","pages":"128"},"PeriodicalIF":2.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and therapeutic challenges of isolated spinal vasculitis: A case report.","authors":"Yajun Yao, Ge-Hong Dong, De-Cai Tian","doi":"10.3892/etm.2026.13124","DOIUrl":"10.3892/etm.2026.13124","url":null,"abstract":"<p><p>The present case report describes a 31-year-old male patient with isolated spinal vasculitis. The patient initially presented with right-hand numbness and weakness, which later extended to both lower limbs, causing gait instability. MRI scans performed after the symptoms had extended to both lower limbs revealed a cervical lesion with T1 hypointensity, T2 hyperintensity and heterogeneous enhancement, initially suspected to be a tumor. Histopathological analysis of the spinal cord biopsy specimen revealed lymphocytic infiltration surrounding the small vessels of spinal cord, supporting a diagnosis of primary isolated spinal vasculitis. The patient was treated with high-dose intravenous methylprednisolone for 9 days (500 mg for 3 days, 250 mg for 3 days and 120 mg for 3 days), resulting in pronounced clinical improvement on follow-up neurological examination and no recurrence at the 2-year follow-up without additional immunosuppressive therapy. The present case underscores the diagnostic challenge of distinguishing vasculitis from spinal tumors and highlights the uncertainty regarding long-term recurrence prevention strategies.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 5","pages":"129"},"PeriodicalIF":2.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory effects of oridonin on an <i>in vitro</i> model using LPS-treated human intestinal Caco-2 cells.","authors":"Maonan Wang, Bo Xu, Linyue Li, Yu Wang, Mingcheng Li","doi":"10.3892/etm.2026.13121","DOIUrl":"10.3892/etm.2026.13121","url":null,"abstract":"<p><p>Oridonin (Ori) attenuates dextran sulfate sodium-induced ulcerative colitis (UC) in mice, and its underlying mechanism involves the sirtuin 1 (SIRT1)/NF-κB/p53 pathway. In the present study, lipopolysaccharide (LPS)-stimulated Caco-2 cells were used as an <i>in vitro</i> model to mimic human intestinal epithelial inflammation, to ascertain the anti-inflammatory effects of Ori on a cell model of UC. The concentrations of TNF-α and IL-1β were quantified using ELISA, the expression levels of SIRT1, NF-κB and p53 were assessed through western blot analysis, and cell viability was determined using the Cell Counting Kit-8. The results showed that cell viability was affected by treatment with Ori at different doses. Ori significantly inhibited the optical density values in a dose-dependent manner at the doses of 5.0-80.0 µM whereas it did not affect viability at the doses of 0.625-2.50 µM, compared with in the control group. These findings suggested that the inhibitory effect of Ori on intestinal epithelial cells did not result from cytotoxic action at the doses of 0.625-2.50 µM. Furthermore, Ori suppressed the inflammatory response in intestinal epithelial cells by significantly reducing LPS-induced secretion of the pro-inflammatory cytokines TNF-α and IL-1β with a ~2-fold reduction. Additionally, Ori significantly increased the protein expression levels of SIRT1, and decreased the protein expression levels of NF-κB and p53. In conclusion, the present results indicated that the inhibition of NF-κB-mediated inflammation may be a key mechanism by which Ori exerts its therapeutic effects on UC.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 5","pages":"127"},"PeriodicalIF":2.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management after two consecutive suction losses during small-incision lenticule extraction: A case report.","authors":"Luanying Wei, Tiantian Qi, Nan Li, Qiang Shi, Shengjian Mi, Cheng Pei","doi":"10.3892/etm.2026.13122","DOIUrl":"10.3892/etm.2026.13122","url":null,"abstract":"<p><p>Suction loss is a small-incision lenticule extraction (SMILE) surgery complication which may compromise postoperative visual quality. Most instances of intraoperative suction loss can be promptly remedied; however, the reports of two consecutive suction losses leading to an incomplete procedure are limited. In the present case report a 24-year-old man underwent SMILE at the General Hospital of Ningxia Medical University (Yinchuan, China); the surgery was successfully completed in the right eye, nevertheless, the left eye experienced two consecutive suction losses, resulting in incomplete treatment. At ~1.5 months post operation, the patient presented to The First Affiliated Hospital of Xi'an Jiaotong University (Xi'an, China) where the treating physicians were unaware of the exact details of the first procedure. At that time, the uncorrected distance visual acuity in the left eye was 20/400, and the corrected distance visual acuity was 20/16. Subsequently, the patient received femtosecond laser-assisted <i>in situ</i> keratomileusis surgery for the left eye. At the 1-month postoperative visit, the uncorrected distance visual acuity had improved to 20/13. The present case demonstrates that suction loss carries a certain probability (0.17-5.06%) during SMILE, with two consecutive intraoperative suction losses being even more uncommon; however, with remedial measures, favorable postoperative visual outcomes can be secured.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 5","pages":"126"},"PeriodicalIF":2.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory effects of spermidine on lipopolysaccharide-induced inflammation in RAW 264.7 cells.","authors":"Hao Yuan, Fang Peng, Yi-Feng Zhou, Si-Xian Wu, Zhen-Yi Long, Ya-Meng Peng, Yi-Zhao Zhou","doi":"10.3892/etm.2026.13119","DOIUrl":"10.3892/etm.2026.13119","url":null,"abstract":"<p><p>Spermidine (SPD) is a naturally occurring polyamine with anti-inflammatory and antioxidant properties. Given the pivotal role of macrophages in inflammatory pathogenesis (such as rheumatoid arthritis and autoimmune encephalomyelitis), the present study hypothesized that SPD exerts its anti-inflammatory effects by suppressing macrophage polarization. Briefly, RAW 264.7 cells were activated using lipopolysaccharide (LPS) and were treated with a vehicle control (complete DMEM) or varying SPD concentrations. The ratio of M1 and M2 macrophages in each group was determined using flow cytometry. Inflammatory gene expression and cytokine levels were determined using reverse transcription quantitative PCR and ELISA. The levels of NF-κB pathway-associated proteins were measured through western blotting. The findings revealed that the proportion of M1 cells gradually decreased with increasing SPD concentrations. In LPS-stimulated RAW 264.7 cells, SPD markedly decreased the expression of M1 marker genes and notably increased that of M2 marker genes. Furthermore, SPD decreased IL-6 levels and increased IL-10 levels. In addition, the levels of phosphorylated (p)-p65 and p-IκBα, which are NF-κB pathway-associated proteins, were markedly decreased after 24 h of SPD treatment. Overall, SPD treatment inhibited LPS-induced M1 polarization, reduced pro-inflammatory gene/cytokine expression and enhanced anti-inflammatory markers, potentially through NF-κB pathway modulation.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 5","pages":"124"},"PeriodicalIF":2.3,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematemesis resulting from mesenteric venous thrombosis: A case report.","authors":"Chunyu Shi, Zhongmin Li, Lu Pan, Bin Song","doi":"10.3892/etm.2026.13120","DOIUrl":"10.3892/etm.2026.13120","url":null,"abstract":"<p><p>Mesenteric venous thrombosis (MVT) is a rare yet highly lethal condition, characterized by atypical clinical manifestations that often lead to delayed diagnosis and treatment. The present report describes the case of a 29-year-old man with a history of deep vein thrombosis who presented with intermittent upper abdominal pain and hematemesis. An initial abdominal CT scan suggested intestinal obstruction, and further conservative treatment provided temporary relief before the condition worsened with severe hematemesis and hypotension. Emergency surgery revealed MVT complicated by small bowel necrosis, which was managed with necrotic bowel resection, end-to-end anastomosis and postoperative anticoagulation. The patient recovered successfully. Overall, the present report highlights how an early diagnosis, use of contrast-enhanced abdominal CT scans and timely intervention (primarily anticoagulation, with surgery for bowel necrosis/peritonitis) are key in MVT management.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 5","pages":"125"},"PeriodicalIF":2.3,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of spironolactone on cytotoxic damage in osteoblasts.","authors":"So Young Park, Kwang Sik Suh, Hyun-Sook Kim, Soo Jin Yun, Hyunji Sang, Sang Ouk Chin","doi":"10.3892/etm.2026.13117","DOIUrl":"10.3892/etm.2026.13117","url":null,"abstract":"<p><p>Chronic hyperglycemia in diabetes elevates oxidative stress, damaging pancreatic β-cells and worsening complications. Oxidative stress also disrupts osteoblast function, suppresses their maturation and triggers apoptosis, thereby contributing to bone fragility. Spironolactone, an aldosterone receptor antagonist prescribed for the treatment of hypertension and heart failure, has potential protective effects on skeletal health. The present study examined whether spironolactone could protect osteoblasts from damage and restore their differentiation under oxidative conditions caused by 2-deoxy-D-ribose (dRib). MC3T3-E1 pre-osteoblastic cells were incubated with spironolactone (0-100 µM) and 15 mM dRib. Cell toxicity (through lactate dehydrogenase release), markers of differentiation (collagen content, alkaline phosphatase activity and mineral deposition), inflammatory cytokine levels (TNF-α and IL-6), reactive oxygen species (ROS), mitochondrial superoxide levels, endoplasmic reticulum (ER) stress markers (activating transcription factor 6 and inositol-requiring enzyme 1), mitochondrial integrity (mitochondrial membrane potential and ATP levels), glyoxalase I activity and reduced glutathione (GSH) levels were analyzed by ELISA. Pretreatment with spironolactone reduced dRib-induced toxicity and improved differentiation markers in MC3T3-E1 cells. It also lowered the elevated cytokine levels, ROS production, mitochondrial oxidative burden and ER stress responses caused by dRib. Furthermore, spironolactone preserved mitochondrial performance and enhanced antioxidant defenses by increasing GSH levels and glyoxalase I activity, thereby promoting the detoxification of harmful byproducts. These findings suggested that spironolactone may protect osteoblasts by mitigating oxidative and inflammatory stress, stabilizing mitochondrial function and enhancing differentiation. Overall, this highlights the possible benefits of spironolactone in the management of diabetes-related bone fragility.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"31 5","pages":"122"},"PeriodicalIF":2.3,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}