Experimental and therapeutic medicine最新文献

{"title":"[Retracted] Cardioprotective effect of epigallocatechin‑3‑gallate against myocardial infarction in hypercholesterolemic rats","authors":"Wei Zhong, Xiao-Dong Huan, Qian Cao, Jun Yang","doi":"10.3892/etm.2024.12396","DOIUrl":"https://doi.org/10.3892/etm.2024.12396","url":null,"abstract":"","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"48 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139606869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Britannin inhibits cell proliferation, migration and glycolysis by downregulating KLF5 in lung cancer","authors":"Ying Wang, Botao Yu, Mengyuan Qu, Fengjuan Liu, Xiao Wu","doi":"10.3892/etm.2024.12397","DOIUrl":"https://doi.org/10.3892/etm.2024.12397","url":null,"abstract":"","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"9 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139608511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CX‑5461 potentiates imatinib‑induced apoptosis in K562 cells by stimulating KIF1B expression","authors":"Chaochao Dai, Xiaopei Cui, Jie Wang, Bo Dong, Haiqing Gao, Mei Cheng, Fan Jiang","doi":"10.3892/etm.2024.12395","DOIUrl":"https://doi.org/10.3892/etm.2024.12395","url":null,"abstract":"","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"101 34","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139615888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Corrected] miR‑590‑5p may regulate colorectal cancer cell viability and migration by targeting PDCD4","authors":"Ting Guo, Jun Wang, Guochang Cheng, He Huang","doi":"10.3892/etm.2024.12392","DOIUrl":"https://doi.org/10.3892/etm.2024.12392","url":null,"abstract":"","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":" 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139616516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piperacillin‑tazobactam‑induced myocardial injury with heart failure: A case report","authors":"Yi Liu, Chuan An, Xin Ai, Xinyu Zhang, Lin Shi, Quanlin Zhao","doi":"10.3892/etm.2024.12393","DOIUrl":"https://doi.org/10.3892/etm.2024.12393","url":null,"abstract":"","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"5 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139616720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel animal model of abdominal aortic aneurysm by mechanical injury","authors":"Soo-Hong Kim, J. Park, Dong Kim, Jin-Ho Mun, Jae Chung, Sang Lee","doi":"10.3892/etm.2024.12391","DOIUrl":"https://doi.org/10.3892/etm.2024.12391","url":null,"abstract":"","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":" 32","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139619858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNAs in chronic pediatric diseases (Review)","authors":"Mingyao Zhang, Yanhua Han","doi":"10.3892/etm.2024.12388","DOIUrl":"https://doi.org/10.3892/etm.2024.12388","url":null,"abstract":"","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139623201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HMGB1 enhances the migratory and invasive abilities of A2780/DDP cells by facilitating epithelial to mesenchymal transition via GSK‑3β","authors":"Jinhua Wang, Qiaomei Zheng, Yanjing Zhao, S. Chen, Lihong Chen","doi":"10.3892/etm.2024.12390","DOIUrl":"https://doi.org/10.3892/etm.2024.12390","url":null,"abstract":"","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139622448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of metabolic dysfunction‑associated fatty liver disease on the risk of hepatocellular carcinoma in patients with chronic hepatitis B: A systematic review and meta‑analysis","authors":"Sixing Shen, L. Pan","doi":"10.3892/etm.2024.12387","DOIUrl":"https://doi.org/10.3892/etm.2024.12387","url":null,"abstract":"","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":" 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139623538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of differentially expressed genes associated with ferroptosis in Crohn's disease.","authors":"Wenquan Zhang, Zhaoshui Li, Hongbo Li, Dianliang Zhang","doi":"10.3892/etm.2024.12378","DOIUrl":"10.3892/etm.2024.12378","url":null,"abstract":"<p><p>Ferroptosis-related genes may play a critical regulatory role in the pathogenesis of Crohn's disease (CD). The purpose of the present study was to identify genes expressed in CD that are associated with ferroptosis, and to provide guidance in the diagnosis and therapy of CD. CD mRNA expression data were initially gathered from the Gene Expression Omnibus (GEO) database. GSE75214 and GSE102133 datasets were selected as the major targets and were analyzed for differentially expressed genes (DEGs). Subsequently, R software was used to analyze the common genes among the DEGs between CD and ferroptosis-related genes. Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genome pathway analysis were conducted to identify related pathways and functions. Protein-protein interaction (PPI) analysis was performed to identify target genes. The DSigDB website was used to predict potential target drugs for hub genes. Reverse transcription-quantitative (RT-q) PCR was employed to detect the expression of these ferroptosis-related genes in clinical samples obtained from healthy controls and patients with CD. According to the two GEO datasets, 13 ferroptosis DEGs (11 upregulated genes and two downregulated genes) were identified in CD with thresholds of P<0.05 and |log2 fold change|>1, and were selected for further analysis. PPI analysis indicated the mutual effects among these genes and filtered out five hub genes. The top 10 potential targeted drugs were selected. The qPCR results showed that the expression levels of three genes, namely, IL-6, prostaglandin-endoperoxide synthase 2 (PTGS2) and dual oxidase 2 (DUOX2), were different between CD samples and healthy samples. This result was consistent with the results obtained from the bioinformatics analysis. In conclusion, bioinformatics analysis identified a total of 13 ferroptosis-associated genes in CD. Further verification by qPCR showed that IL-6, PTGS2 and DUOX2 may affect the process of CD by regulating ferroptosis. These findings might provide new biomarkers, diagnostic and therapeutic markers for CD.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"27 2","pages":"89"},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139565181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}