Diabetes & vascular disease research最新文献_第5页

The triglyceride-glucose index and mortality in chronic kidney and cardiovascular disease patients: A cohort study. 慢性肾脏和心血管疾病患者的甘油三酯-葡萄糖指数与死亡率：一项队列研究

IF 3

Diabetes & vascular disease research Pub Date : 2025-11-01 Epub Date: 2025-12-07 DOI: 10.1177/14791641251407680

Yuying Hou, Li Tian, Yinsong Luo, Xiaorui Li, Kaiping Gao, Jiaye Liu

{"title":"The triglyceride-glucose index and mortality in chronic kidney and cardiovascular disease patients: A cohort study.","authors":"Yuying Hou, Li Tian, Yinsong Luo, Xiaorui Li, Kaiping Gao, Jiaye Liu","doi":"10.1177/14791641251407680","DOIUrl":"10.1177/14791641251407680","url":null,"abstract":"BackgroundChronic kidney disease (CKD) comorbid with cardiovascular disease (CVD) results in substantial mortality. The predictive value of the triglyceride-glucose (TyG) index for mortality in this population remains unverified. We aimed to evaluate the association of the TyG index with mortality in individuals with CKD and CVD.MethodsUsing National Health and Nutrition Examination Survey (NHANES) data (1999-2018), we analyzed 1104 adults with CKD and CVD. Multivariable Cox proportional hazards models and restricted cubic splines assessed associations between the TyG index and mortality. Threshold effects were evaluated.ResultsOver a median 10.3-years follow-up, 623 all-cause and 311 cardiovascular deaths occurred. A significant U-shaped association existed between the TyG index and both all-cause (p-nonlinear = 0.002) and cardiovascular mortality (p-nonlinear = 0.014). Above a threshold of 8.91, higher TyG index predicted increased all-cause mortality risk (HR 1.34, 95% CI 1.07-1.67; p = 0.01). Below 8.91, the association was non-significant (HR 0.82, 95% CI 0.62-1.28; p = 0.537). This U-shaped relationship was significant in males (p-nonlinear < 0.05) but not females.ConclusionsThe TyG index demonstrates a U-shaped association with all-cause and cardiovascular mortality in patients with comorbid CKD and CVD. Maintaining TyG index within a specific range may reduce mortality risk, highlighting its potential role in risk stratification and targeted management.","PeriodicalId":93978,"journal":{"name":"Diabetes & vascular disease research","volume":"22 6","pages":"14791641251407680"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12682991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145703627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative prognostic value of hemoglobin glycation index and glycation gap for mortality risk in adults: A population-based study. 血红蛋白糖化指数和糖化差距对成人死亡风险的比较预后价值：一项基于人群的研究。

IF 3

Diabetes & vascular disease research Pub Date : 2025-11-01 Epub Date: 2025-12-11 DOI: 10.1177/14791641251407635

Xiaoying Sun, Ping Yu, Chun Zhang

{"title":"Comparative prognostic value of hemoglobin glycation index and glycation gap for mortality risk in adults: A population-based study.","authors":"Xiaoying Sun, Ping Yu, Chun Zhang","doi":"10.1177/14791641251407635","DOIUrl":"10.1177/14791641251407635","url":null,"abstract":"ObjectiveThis study aimed to compare hemoglobin glycation index (HGI) and glycation gap (GG), markers of the discordance between measured and predicted hemoglobin A1c levels, for predicting all-cause and cardiovascular disease (CVD) mortality in a nationally representative population.MethodsData of 3468 adults were retrieved from the 1999-2004 US National Health and Nutrition Examination Survey. Participants were stratified into four groups based on the median of absolute values of HGI and GG. Associations between HGI, GG and mortality risk were evaluated with Cox proportional hazard model and time-dependent receiver-operating characteristic curves.ResultsOver a median follow-up of 101 months, 733 (12.48%) participants died, of which 210 were from CVD causes. Compared to the HGI-/GG-group, the HGI+/GG+ group had an hazard ratio (95% confidence interval) of 1.36 (1.02-1.82) for all-cause mortality and 1.91 (1.00-3.64) for CVD mortality. Restricted cubic spline curves demonstrated a positively linear relationship between absolute values of HGI, GG and mortality risk. Time-dependent receiver-operating characteristic curves revealed comparable predictive accuracy for HGI and GG, with area under the curve ranged between 0.50 and 0.60 across follow-up periods.ConclusionsCombined HGI and GG assessment may provide guidance on risk stratification and identification of high-risk individuals.","PeriodicalId":93978,"journal":{"name":"Diabetes & vascular disease research","volume":"22 6","pages":"14791641251407635"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12698974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Unraveling the causal role of sleep traits in development of diabetic retinopathy: A UK Biobank observational study and Mendelian randomization". “揭示睡眠特征在糖尿病视网膜病变发展中的因果作用：一项英国生物银行观察研究和孟德尔随机化”的勘误表。

IF 3

Diabetes & vascular disease research Pub Date : 2025-11-01 Epub Date: 2025-12-11 DOI: 10.1177/14791641251405416

引用次数: 0

Unusual painless upper limb ischemia in a patient with diabetes. A case study. 糖尿病患者异常无痛上肢缺血1例。案例研究。

IF 3

Diabetes & vascular disease research Pub Date : 2025-11-01 Epub Date: 2025-11-17 DOI: 10.1177/14791641251380498

Jakub Pyrkosz, Gabriela Augustynowicz, Michał Kisiel, Maciej Rabczyński, Paweł Pochciał, Katarzyna Madziarska

引用次数: 0

Risk factors of early-onset type 2 diabetes: A systematic review and meta-analysis. 早发性2型糖尿病的危险因素：一项系统回顾和荟萃分析

IF 3

Diabetes & vascular disease research Pub Date : 2025-11-01 Epub Date: 2025-12-19 DOI: 10.1177/14791641251400358

Shengying Hu, Yizhu Zhang, Angela C Y Poon, Yan Ji, Botian Hou, Chenye Zhang, Hongyu Sun, Yumei Sun

{"title":"Risk factors of early-onset type 2 diabetes: A systematic review and meta-analysis.","authors":"Shengying Hu, Yizhu Zhang, Angela C Y Poon, Yan Ji, Botian Hou, Chenye Zhang, Hongyu Sun, Yumei Sun","doi":"10.1177/14791641251400358","DOIUrl":"10.1177/14791641251400358","url":null,"abstract":"BackgroundEarly-onset type 2 diabetes (T2DM), diagnosed before age 40, progresses rapidly and has a higher risk of complications compared to late-onset T2DM. Its global prevalence is rising, but the underlying risk factors are insufficiently understood.ObjectiveThis systematic review and meta-analysis aimed to evaluate risk factors associated with early-onset T2DM to support clinical decision-making and inform preventive strategies.Methods37 studies (cohort, case-control, cross-sectional) were identified from PubMed, Web of Science, and Embase up to October 31, 2024. Data were analyzed using STATA 17.0, and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Subgroup analyses were performed by region, study type, and sample size.ResultsCompared with normoglycemic individuals, early-onset T2DM was strongly associated with family history of diabetes (OR = 4.54, 95%CI: 2.31-8.90), high BMI (OR = 2.87, 95%CI: 2.22-3.80), maternal gestational diabetes (OR = 3.01, 95%CI: 2.44-3.72), and elevated fasting glucose (OR = 8.73, 95%CI: 4.91-16.92). Subgroup and sensitivity analyses confirmed the robustness of these findings despite persistent heterogeneity. In comparisons with late-onset T2DM, family history (OR = 2.90), male sex (OR = 1.57), and BMI (OR = 1.12 per unit) remained significant risk factors.ConclusionEarly-onset T2DM is shaped by familial, metabolic, and lifestyle determinants. Incorporating these factors into early screening and intervention programs, particularly lifestyle modification in young high-risk populations, is essential to reduce disease burden and delay progression.","PeriodicalId":93978,"journal":{"name":"Diabetes & vascular disease research","volume":"22 6","pages":"14791641251400358"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12717410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined effect of body mass index and atherogenic index of plasma on risk of stroke among individuals with abnormal glucose metabolism: Evidence from the China health and retirement longitudinal study. 体重指数和血浆动脉粥样硬化指数对糖代谢异常人群脑卒中风险的联合影响：来自中国健康与退休纵向研究的证据

IF 3

Diabetes & vascular disease research Pub Date : 2025-09-01 Epub Date: 2025-09-15 DOI: 10.1177/14791641251380212

Yushan Liao, Liheng Chen, Jinshen Huang, Haiqiong Liu, Zehua Li, Jing Yan, Yanbin Cai, Yu Sun, Wen Jin, Jingbin Guo

{"title":"Combined effect of body mass index and atherogenic index of plasma on risk of stroke among individuals with abnormal glucose metabolism: Evidence from the China health and retirement longitudinal study.","authors":"Yushan Liao, Liheng Chen, Jinshen Huang, Haiqiong Liu, Zehua Li, Jing Yan, Yanbin Cai, Yu Sun, Wen Jin, Jingbin Guo","doi":"10.1177/14791641251380212","DOIUrl":"10.1177/14791641251380212","url":null,"abstract":"ObjectiveWe aimed to explored the association between atherogenic index of plasma (AIP), body mass index (BMI) and stroke risk among people with abnormal glucose metabolism.MethodsThis study included participants with abnormal glucose metabolism from the China Health and Retirement Longitudinal Study (CHARLS). AIP was computed using the formula log (Triglyceride/High-density lipoprotein cholesterol). Participants were categorized into high and low levels based on median values for both AIP and BMI. Logistic regression models were employed to investigate the associations between AIP, BMI, and stroke.ResultsIn the longitudinal analysis, 195 out of 3,682 individuals (5.3%) experienced stroke. Joint effects of AIP and BMI on stroke risk indicated that odds ratios for stroke were 1.41 (0.86-2.31) for high AIP & low BMI group, 1.81 (1.14-2.89) for low AIP & high BMI group, and 2.15 (1.42-3.27) for high AIP & high BMI group when compared to low AIP & low BMI group. A significant interaction was observed between AIP and BMI regarding stroke risk. However, this association appeared diminished within cross-sectional evaluations.ConclusionElevated levels of both AIP and BMI are significantly correlated with an increased risk of stroke among individuals exhibiting abnormal glucose metabolism during longitudinal analysis.","PeriodicalId":93978,"journal":{"name":"Diabetes & vascular disease research","volume":"22 5","pages":"14791641251380212"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12437249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visceral adipose tissue accumulation and risk of organ complications among individuals with type 2 diabetes mellitus: A two-sample Mendelian randomization study. 内脏脂肪组织积累和2型糖尿病患者器官并发症的风险：一项双样本孟德尔随机研究

IF 3

Diabetes & vascular disease research Pub Date : 2025-09-01 Epub Date: 2025-10-23 DOI: 10.1177/14791641251388653

Xingji Lian, Xiaomin Zeng, Bing Zhang, Yan Huang, Xiaohui Peng, Yanhui Wang, Chongzhe Yang, Yuyu Huang

{"title":"Visceral adipose tissue accumulation and risk of organ complications among individuals with type 2 diabetes mellitus: A two-sample Mendelian randomization study.","authors":"Xingji Lian, Xiaomin Zeng, Bing Zhang, Yan Huang, Xiaohui Peng, Yanhui Wang, Chongzhe Yang, Yuyu Huang","doi":"10.1177/14791641251388653","DOIUrl":"10.1177/14791641251388653","url":null,"abstract":"Visceral adiposity is a pivotal pathogenic driver of type 2 diabetes mellitus (T2DM) and its vascular complications. We performed two-sample Mendelian randomization (MR) analyses to examine the causal relationships between visceral adipose tissue (VAT) accumulation and diabetes complications. Single nucleotide polymorphisms (SNPs) specific to VAT accumulation were identified through large-scale genome-wide association studies (GWAS) at genome-wide significance (P < 5 × 10-8), using the inverse variance weighted (IVW) approach for primary analyses. The MR-IVW random-effects model revealed significant associations between genetically predicted VAT accumulation and increased risks for T2DM complications: multi-organ (OR = 2.58, 95% CI, 2.21-3.03), neurological (OR = 3.58, 95% CI, 2.34-5.47), retinopathy (OR = 2.90, 95% CI, 2.21-3.81), nephropathy (OR = 3.14, 95% CI, 2.23-4.45), and peripheral vascular (OR = 3.32, 95% CI, 2.31-4.76). Consistency across complementary MR methods supported the causal inference. This study provides genetic evidence that VAT accumulation is causally associated with increased risk of multiple T2DM complications, including neurological, ocular, kidney, and peripheral vascular outcomes. Future research should prioritize mechanistic studies to elucidate VAT-driven inflammatory and lipotoxic pathways in diabetic complications.","PeriodicalId":93978,"journal":{"name":"Diabetes & vascular disease research","volume":"22 5","pages":"14791641251388653"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12569360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145356972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

US eligibility and preventable cardiovascular disease events from semaglutide in type 2 diabetes. 西马鲁肽治疗2型糖尿病的美国资格和可预防的心血管疾病事件

IF 3

Diabetes & vascular disease research Pub Date : 2025-09-01 Epub Date: 2025-09-04 DOI: 10.1177/14791641251376551

Hridhay Karthikeyan, Wenjun Fan, Nathan D Wong

{"title":"US eligibility and preventable cardiovascular disease events from semaglutide in type 2 diabetes.","authors":"Hridhay Karthikeyan, Wenjun Fan, Nathan D Wong","doi":"10.1177/14791641251376551","DOIUrl":"10.1177/14791641251376551","url":null,"abstract":"BackgroundThe SUSTAIN-6 trial showed the cardiovascular disease (CVD) benefits of semaglutide among patients with type 2 diabetes mellitus (T2DM). We estimated the US population eligibility and preventable CVD events from semaglutide.MethodsUS adults with T2DM were selected from the National Health and Nutrition Examination Survey 2011-2020 based on SUSTAIN-6 eligibility criteria. We estimated composite and secondary CVD events from SUSTAIN-6 treated and placebo published event rates multiplied by the weighted US eligible population, the difference being the number of preventable events which was then divided by 2.1 years to provide annualized estimates.ResultsAmong 4755 (projected to 33.6 million [M]) adults with T2DM, 1132 (6.9 million) fit SUSTAIN-6 criteria. Compared to SUSTAIN-6, our sample more likely had female and black patients, shorter diabetes duration, and was less likely with prior CVD. We estimated 75,681 primary outcome CVD events, 128,329 expanded composite CVD events, 72,390 combined nonfatal MI, nonfatal stroke, and all-cause deaths, 36,195 non-fatal stroke events, 85,552 revascularizations, and 75,681 cases of nephropathy could be prevented annually if eligible T2DM subjects were on semaglutide.ConclusionSemaglutide may prevent over 75,000 CVD events annually if provided to eligible T2DM US adults. Efforts to improve use of these therapies are needed.","PeriodicalId":93978,"journal":{"name":"Diabetes & vascular disease research","volume":"22 5","pages":"14791641251376551"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to editor: Comments on "Early diagnosis value of lncRNA SNHG14 combined with miR-493-5p in gestational diabetes mellitus and its correlation with pregnancy outcome". 致编辑：关于“lncRNA SNHG14联合miR-493-5p在妊娠期糖尿病中的早期诊断价值及其与妊娠结局的相关性”的评论。

IF 3

Diabetes & vascular disease research Pub Date : 2025-07-01 Epub Date: 2025-09-08 DOI: 10.1177/14791641251378415

Fareeha Amjad, Mehak Mehmood, Asma Azam

引用次数: 0

Early diagnosis value of lncRNA SNHG14 combined with miR-493-5p in gestational diabetes mellitus and its correlation with pregnancy outcome. lncRNA SNHG14联合miR-493-5p对妊娠期糖尿病的早期诊断价值及其与妊娠结局的相关性

IF 3

Diabetes & vascular disease research Pub Date : 2025-05-01 Epub Date: 2025-06-06 DOI: 10.1177/14791641251335918

Zongli Ma, Zhijuan Qin, Ying Ji, Meilin Zou, Meiqin Li

{"title":"Early diagnosis value of lncRNA SNHG14 combined with miR-493-5p in gestational diabetes mellitus and its correlation with pregnancy outcome.","authors":"Zongli Ma, Zhijuan Qin, Ying Ji, Meilin Zou, Meiqin Li","doi":"10.1177/14791641251335918","DOIUrl":"10.1177/14791641251335918","url":null,"abstract":"BackgroundTo evaluate the diagnostic value of lncRNA SNHG14 and miR-493-5p in gestational diabetes mellitus (GDM).MethodsThis study consisted of 128 GDM patients and 125 healthy controls. Dual luciferase reporter assay detected binding of lncRNA SNHG14 and miR-493-5p. ROC was applied to evaluate the diagnostic value of lncRNA SNHG14 and miR-493-5p for GDM. Independent factors affecting GDM were evaluated using logistic regression analysis. The role of lncRNA SNHG14, miR-493-5p in pregnancy outcome in GDM patients was assessed by chi-square tests.ResultsLncRNA SNHG14 has a target-binding relationship with miR-493-5p. LncRNA SNHG14 was significantly higher in GDM patients, while miR-493-5p was significantly lower; both were independent risk factors for GDM development. Blood glucose indices (fasting, 1 h and 2 h postprandial) were positively correlated with lncRNA SNHG14 and negatively correlated with miR-493-5p in GDM patients. LncRNA SNHG14 in combination with miR-493-5p increased the diagnostic efficiency for GDM. LncRNA SNHG14 was significantly associated with neonatal weight and neonatal jaundice. MiR-493-5p was significantly associated with neonatal jaundice.ConclusionLncRNA SNHG14 in combination with miR-493-5p may be an early diagnostic marker of GDM. LncRNA SNHG14 and miR-493-5p are associated with adverse pregnancy outcomes (macrosomia, neonatal jaundice) in patients with GDM.","PeriodicalId":93978,"journal":{"name":"Diabetes & vascular disease research","volume":"22 3","pages":"14791641251335918"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0