{"title":"Predictive power of isolated high home systolic blood pressure for cardiovascular outcomes in individuals with type 2 diabetes mellitus: KAMOGAWA-HBP study.","authors":"Yukako Hosomi, Emi Ushigome, Nobuko Kitagawa, Noriyuki Kitagawa, Toru Tanaka, Goji Hasegawa, Masayoshi Ohnishi, Sei Tsunoda, Hidetaka Ushigome, Naoto Nakamura, Mai Asano, Masahide Hamaguchi, Masahiro Yamazaki, Michiaki Fukui","doi":"10.1177/14791641231221264","DOIUrl":"https://doi.org/10.1177/14791641231221264","url":null,"abstract":"<p><strong>Aims/introduction: </strong>Isolated high home systolic blood pressure (IHHSBP) is a risk for cardiovascular disease (CVD). However, no study has shown an association between IHHSBP and CVD in diabetes. We examined the association between IHHSBP and CVD in type 2 diabetes.</p><p><strong>Materials and methods: </strong>This retrospective cohort study included 1082 individuals with type 2 diabetes, aged 20 to 90 years, without a history of macrovascular complications. Home blood pressure (HBP) was measured three times every morning and evening for 14 days. Cox proportional hazards models were used to examine the relationship between IHHSBP and CVD incidence.</p><p><strong>Results: </strong>With the normal HBP group as the reference, the adjusted hazard ratio (HR) (95% confidence interval [CI]) for CVD was 1.58 (1.02-2.43) in the IHHSBP group. Correcting for antihypertensive medication use did not change HR. Based on sex, the adjusted HR (95% CI) for CVD was 1.25 (0.74-2.13) in males and 2.28 (1.01-5.15) in females.</p><p><strong>Conclusions: </strong>In individuals with type 2 diabetes, those with IHHSBP had a higher HR for cardiovascular disease than those with normal HBP. But, Isolated high home diastolic blood pressure and high HBP were not. The association between IHHSBP and CVD was stronger in females than in males.</p>","PeriodicalId":93978,"journal":{"name":"Diabetes & vascular disease research","volume":"20 6","pages":"14791641231221264"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10710111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138807847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ned Premyodhin, Wenjun Fan, Millie Arora, Matthew J Budoff, Alka M Kanaya, Namratha Kandula, Latha Palaniappan, Jamal S Rana, Masood Younus, Nathan D Wong
{"title":"Association of diabetes with coronary artery calcium in South Asian adults and other race/ethnic groups: The multi-ethnic study of atherosclerosis and the mediators of atherosclerosis in South Asians living in America study.","authors":"Ned Premyodhin, Wenjun Fan, Millie Arora, Matthew J Budoff, Alka M Kanaya, Namratha Kandula, Latha Palaniappan, Jamal S Rana, Masood Younus, Nathan D Wong","doi":"10.1177/14791641231204368","DOIUrl":"10.1177/14791641231204368","url":null,"abstract":"<p><strong>Purpose: </strong>South Asian (SA) persons have increased risks for diabetes mellitus (DM) and atherosclerotic cardiovascular disease (ASCVD). We examined whether the association of DM with subclinical atherosclerosis assessed by coronary artery calcium (CAC) differs in SA versus other ethnic groups.</p><p><strong>Methods: </strong>We studied adults from the Multi-Ethnic Study of Atherosclerosis and the Mediators of Atherosclerosis in South Asians Living in America studies without ASCVD. CAC was examined among those normoglycemic, pre-DM and DM. Logistic regression examined pre-DM and DM with the odds of any CAC > 0 and CAC <u>≥</u> 100.</p><p><strong>Results: </strong>Among 7562 participants, CAC > 0 and CAC <u>≥</u> 100 in those with DM was highest in non-Hispanic White (NHW) (80% and 48%) and SA (72% and 41%) persons. Adjusted Ln (CAC + 1) was highest in NHW (3.68 ± 0.21) and SA (3.60 ± 0.23) (<i>p</i> < .01) DM patients. SA and NHW adults with DM (vs normoglycemic) had highest odds of CAC > 0 (2.13 and 2.27, respectively, <i>p</i> < .01). For CAC <u>≥</u> 100, SA and Chinese adults had the highest odds (2.28 and 2.27, respectively, <i>p</i> < .01). Fasting glucose and glycated hemoglobin were most strongly associated with CAC among SA.</p><p><strong>Conclusions: </strong>Diabetes mellitus most strongly relates to any CAC in SA and NHW adults and CAC <u>≥</u> 100 in SA and Chinese adults, helping to explain the relation of DM with ASCVD in these populations.</p>","PeriodicalId":93978,"journal":{"name":"Diabetes & vascular disease research","volume":"20 5","pages":"14791641231204368"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41166102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Extracellular vesicles in gestational diabetes mellitus: A scoping review.","authors":"Tanvi Bathla, Akram Abolbaghaei, Agafe Bless Reyes, Dylan Burger","doi":"10.1177/14791641221093901","DOIUrl":"10.1177/14791641221093901","url":null,"abstract":"<p><p>Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy worldwide. Despite extensive study, the molecular mechanisms leading to GDM and associated perinatal complications are not well understood. The condition is also associated with an increased risk of future cardiometabolic disease in both mothers and their offspring. Thus, there is a pressing need for the development of effective screening tools and to identify novel molecular mechanisms responsible for the short and long-term risks associated with GDM. In this regard, extracellular vesicles (EVs) offer promise as novel biomarkers of GDM-mediated changes to both mother and fetus. The purpose of this scoping review is to provide an overview of studies examining EVs in the context of GDM. EMBASE and Ovid Medline were searched for articles published from inception to December 2020. We update current knowledge in this area and identify key knowledge gaps with recommendations for future research.</p>","PeriodicalId":93978,"journal":{"name":"Diabetes & vascular disease research","volume":"19 2","pages":"14791641221093901"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e4/57/10.1177_14791641221093901.PMC9021497.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41223853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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