Nicholas T Le, Lauren W Hastings, Conan H Lee, Olivia Keller, Chidubem A V Okeke, Christian B De Guzman, Sydney D Sullivan, Peggy A Wu
{"title":"<i>Letter:</i> Demographics of Positive Patch Test Reactions to Propylene Glycol.","authors":"Nicholas T Le, Lauren W Hastings, Conan H Lee, Olivia Keller, Chidubem A V Okeke, Christian B De Guzman, Sydney D Sullivan, Peggy A Wu","doi":"10.1177/17103568261442846","DOIUrl":"https://doi.org/10.1177/17103568261442846","url":null,"abstract":"","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":"17103568261442846"},"PeriodicalIF":3.2,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>Letter:</i> Description of Two Cases of Spider Bites Attributed to <i>Loxosceles rufescens</i> (Araneae, Sicariidae) in Albania.","authors":"Blerina Vrenozi, Michel Dugon","doi":"10.1177/17103568261444624","DOIUrl":"https://doi.org/10.1177/17103568261444624","url":null,"abstract":"","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":"17103568261444624"},"PeriodicalIF":3.2,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jo Anne Lim, Adawiyah Jamil, Mohan Amurugam, Yee Cheng Kueh
{"title":"Memory Deficits in Adults with Atopic Dermatitis: The Overlooked Impact of Sleep Disturbance.","authors":"Jo Anne Lim, Adawiyah Jamil, Mohan Amurugam, Yee Cheng Kueh","doi":"10.1177/17103568261443029","DOIUrl":"https://doi.org/10.1177/17103568261443029","url":null,"abstract":"<p><strong>Background: </strong>Sleep disturbance is highly prevalent in atopic dermatitis (AD), yet its contribution to memory deficits remains underexplored.</p><p><strong>Aims: </strong>To characterize sleep disturbance and memory dysfunction in adults with AD, examine their relationship with disease severity, and identify predictors of impaired memory.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among adult patients with AD . Sleep and memory were assessed using the Pittsburgh Sleep Quality Index (PSQI) and Everyday Memory Questionnaire-Revised (EMQ-R). Associations were analyzed using multivariate models.</p><p><strong>Results: </strong>Seventy-eight patients participated. Poor sleep quality was reported in 77%, and 64% exhibited memory dysfunction. Sleep latency increased with disease severity (mild: 32 ± 13 minutes; moderate: 49 ± 34 minutes; severe: 63 ± 33 minutes; <i>P</i> <0.001), while sleep duration decreased (mild: 6.7 ± 1.2 hours; moderate: 5.5 ± 1.8 hours; severe: 4.5 ± 1.9 hours; <i>P</i> <0.001). EMQ-R global scores were highest in severe AD (35 ± 11 vs. moderate: 19 ± 11; mild: 7.9 ± 7.9; <i>P</i> <0.001). Higher PSQI scores were strongly associated with greater memory dysfunction (β = 1.7), poorer retrieval (β = 1.1), and impaired attention tracking (β = 0.7), all <i>P</i> <0.001. Poor sleep quality (adjusted odds ratio [AOR] = 4.4) and daytime dysfunction (AOR = 3.1) independently predicted memory impairment.</p><p><strong>Conclusion: </strong>Sleep and memory disturbances were associated with increasing atopic dermatitis severity in adults, supporting the relevance of routine sleep evaluation when addressing memory performance.</p>","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":"17103568261443029"},"PeriodicalIF":3.2,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147730970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>Letter:</i> Response to Cost-per-Responder Analysis of Tralokinumab Versus Dupilumab for Moderate-to-Severe Atopic Dermatitis Across Universal Health Care Systems.","authors":"Yousra Kamel El Bahy, Pierre Johansen","doi":"10.1177/17103568261441048","DOIUrl":"https://doi.org/10.1177/17103568261441048","url":null,"abstract":"","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":"17103568261441048"},"PeriodicalIF":3.2,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>Letter:</i> Cost-per-Responder Analysis of Tralokinumab Versus Dupilumab for Moderate-to-Severe Atopic Dermatitis Across Universal Health Care Systems.","authors":"Aamir N Hussain","doi":"10.1177/17103568261441052","DOIUrl":"https://doi.org/10.1177/17103568261441052","url":null,"abstract":"","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":"17103568261441052"},"PeriodicalIF":3.2,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sanjana Likki, Troy Austin Black, Rajani Katta, Megan N Rogge
{"title":"Improving Patch Test Interpretation in Skin of Color: Development and Evaluation of an Asynchronous Educational Module.","authors":"Sanjana Likki, Troy Austin Black, Rajani Katta, Megan N Rogge","doi":"10.1177/17103568261435300","DOIUrl":"https://doi.org/10.1177/17103568261435300","url":null,"abstract":"<p><strong>Background: </strong>Patch testing is the gold standard for diagnosing allergic contact dermatitis, yet interpretation in patients with skin of color (SOC) can be challenging, as positive reactions may appear differently. Limited SOC-specific training may further contribute to diagnostic gaps.</p><p><strong>Objective: </strong>To develop and evaluate an asynchronous, web-based module to improve health care provider recognition and interpretation of patch test reactions in SOC.</p><p><strong>Methods: </strong>Clinical photographs across Fitzpatrick skin types I-VI were used to create a handout and PowerPoint covering reaction grading, features more common in SOC, interpretation strategies, and population-specific allergens. Forty health care providers completed pre- and post-intervention surveys on confidence, knowledge, and perceptions of the materials.</p><p><strong>Results: </strong>Overall confidence in patch test interpretation increased significantly, including confidence specific to patients with SOC. Recognition of SOC-specific erythema characteristics and positive reaction patterns improved by more than 20 percentage points, and knowledge of population-specific allergens improved substantially. Participants rated the materials as highly helpful.</p><p><strong>Conclusions: </strong>This asynchronous, SOC-focused educational intervention improved health care provider confidence and accuracy in interpreting patch tests, supporting the value of targeted training to reduce diagnostic disparities and enhance care.</p>","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":"17103568261435300"},"PeriodicalIF":3.2,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of Sun-Reactive Phototype, But Not Pigmentary Phenotype, With the Risk of Atopic Dermatitis: A Population-Based Analysis.","authors":"Yakun Hu, Meihong Da, Fei Wang","doi":"10.1177/17103568261435766","DOIUrl":"https://doi.org/10.1177/17103568261435766","url":null,"abstract":"<p><strong>Background: </strong>The role of ultraviolet radiation in atopic dermatitis (AD) is paradoxical, and the relationships between distinct skin phenotypes and AD risk are poorly understood. It is unclear whether skin functional sun reactivity or baseline skin pigmentation is associated with AD susceptibility.</p><p><strong>Objective: </strong>To disentangle the independent associations of sun-reactive phototype and pigmentary phenotype with the prevalence of AD in a representative US population.</p><p><strong>Methods: </strong>This cross-sectional study analyzed data from 2656 participants in the National Health and Nutrition Examination Survey. We used multivariate logistic regression to calculate odds ratios for AD, adjusting for a comprehensive set of covariates. A multiple imputation sensitivity analysis was performed.</p><p><strong>Results: </strong>After full adjustment, less sun-sensitive phototypes were associated with significantly lower odds of AD compared with the most sensitive phototypes. In contrast, the association between pigmentary phenotype and AD was fully attenuated after adjusting for race. Multiple imputation analysis confirmed the robustness of these findings.</p><p><strong>Conclusion: </strong>An individual's functional sun-reactive phototype, but not their constitutional pigmentary phenotype, is independently associated with the risk of AD.</p>","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":"17103568261435766"},"PeriodicalIF":3.2,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gopalakrishnan Venkatesan, Elena Bigliardi, Malina Yamashita Peterson, Irmina Wallander, Landen Sanderson, Mei Bigliardi, Thomas L Dawson, Giorgia Pastorin, Paul Bigliardi
{"title":"Prospective Cohort Study: Hexyl-2,5-Diaminobenzoate Is a Hypoallergenic Alternative for Patients With Allergic Contact Dermatitis to Para-Phenylenediamine.","authors":"Gopalakrishnan Venkatesan, Elena Bigliardi, Malina Yamashita Peterson, Irmina Wallander, Landen Sanderson, Mei Bigliardi, Thomas L Dawson, Giorgia Pastorin, Paul Bigliardi","doi":"10.1177/17103568261433764","DOIUrl":"https://doi.org/10.1177/17103568261433764","url":null,"abstract":"<p><strong>Background: </strong>Hair dyes, such as p-phenylenediamine (PPD), are a frequent cause of potentially severe allergic contact dermatitis. Our group previously described the synthesis, safety profile, and hair dye properties of novel hair dye alternatives: hexyl-2,5-diaminobenzoate (PPD6) and hexyl 2-amino-5-((4-aminophenyl)amino)benzoate (PPD7).</p><p><strong>Objective: </strong>Our objective was to test the allergenicity of PPD6 and PPD7 with patch tests in individuals with proven contact allergy to PPD.</p><p><strong>Methods: </strong>This prospective cohort study at the University of Minnesota conducted patch testing to PPD6 and PPD7 on 8 subjects. Both in vitro and in chemico tests with PPD6 and PPD7 (DPRA and skin penetration) were done on patients with current or previously relevant positive patch test reactions to PPD or PTD. PPD6 and 7 derivatives were supplied in powder form and diluted to 1% and 2% for testing, with reading and photodocumentation on days 2 and 4.</p><p><strong>Results: </strong>None of the subjects (0/8) reacted to PPD6, while most (5/8) of the subjects reacted to PPD7 and/or to the commercially available PTD (2/8) and ME-PPD (5/8).</p><p><strong>Limitations: </strong>Further studies with larger cohorts are needed using the PPD6 as hair dye in PPD-allergic individuals.</p><p><strong>Conclusion: </strong>PPD6 may be a hypoallergenic alternative for permanent dark hair dye in patients with contact allergy to PPD.</p>","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":"17103568261433764"},"PeriodicalIF":3.2,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}