Dermatitis : contact, atopic, occupational, drug最新文献

{"title":"Time-Series Analysis of the Association Between Daily Outpatient Visits for Adult Atopic Dermatitis and Air Pollution in Beijing.","authors":"Huanhuan Qu, Rongrong Xu, Ning Wang, Zhigang Li, Jing Lang, Yaning Li, Jinhe Wang, Yaqin Li, Jianxun Ren, Na Lang","doi":"10.1177/17103568251380252","DOIUrl":"https://doi.org/10.1177/17103568251380252","url":null,"abstract":"<p><p><u><b><i></i></b></u> <u><b><i>Background:</i></b></u> Few studies have examined the potential impact of air pollutants on atopic dermatitis (AD) in adults. <u><b><i>Objective:</i></b></u> This study aims to assess the relationship between atmospheric pollutants and the frequency of daily outpatient visits for AD in adults in Beijing. <u><b><i>Methods:</i></b></u> Data from Xiyuan Hospital were analyzed to assess the relationship between atmospheric pollutants and the frequency of daily outpatient visits for AD in adults in Beijing. <u><b><i>Results:</i></b></u> For individuals aged 41-60 years, a 10 <b>μ</b>g/m³ increase in particulate matter (PM)_2.5, PM₁₀, nitrogen dioxide (NO₂), sulfur dioxide (SO₂), and ozone (O₃) corresponded to a 0.3-2.9 increase, while a 10 mg/m³ increase in carbon monoxide (CO) was associated with a 3.4 increase (odds ratio [OR] = 1.034; 95% confidence interval [CI]: 1.014-1.054). Among individuals aged ≥60 years, a positive association with all pollutants was observed, particularly CO, presenting the strongest link to outpatient visits on day 6 (OR = 1.024; 95% CI: 1.003-1.044). Adult female patients with AD exhibited heightened susceptibility to air pollution, as evidenced by the positive correlations between the concentrations of PM_2.5, PM₁₀, SO₂, CO, NO₂, and O₃ and the frequency of female outpatient visits. <u><b><i>Conclusion:</i></b></u> These findings highlight the positive relationship between air pollution and outpatient visits in adult patients with AD.</p>","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Letter:</i> Sticky Sensitivities: Investigating Allergens Found in Athletic Tape Adhesives.","authors":"Brailyn Weber, Sarah Karels, Kimberly Capers Arrington, Katherine Lee","doi":"10.1177/17103568251386872","DOIUrl":"https://doi.org/10.1177/17103568251386872","url":null,"abstract":"","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Patch to Plate: Evaluation of Systemic Symptoms in Patients With Positive Patch Test Reactions to Sodium Disulfite.","authors":"Sarah Karels, Brailyn Weber, Ella Chrenka, Katherine Lee, Solveig Ophaug","doi":"10.1177/17103568251386010","DOIUrl":"https://doi.org/10.1177/17103568251386010","url":null,"abstract":"<p><p><u><b><i></i></b></u> <u><b><i>Background:</i></b></u> Sodium disulfite is a well-established contact allergen. Whether individuals with this contact allergy also experience systemic symptoms after ingesting sulfites remains unclear. <u><b><i>Objective:</i></b></u> To evaluate whether patients with positive patch test reactions to sodium disulfite report systemic symptoms after consuming high-sulfite-containing foods and beverages compared with patch test-negative controls. <u><b><i>Methods:</i></b></u> In this retrospective cross-sectional study, 41 patients with positive and 41 patients with negative patch tests to sodium disulfite completed a standardized survey assessing symptoms (eg, headache, coughing, gastrointestinal distress) following consumption of high-sulfite foods and beverages. Symptom frequency, severity, and triggers were analyzed and compared between groups. <u><b><i>Results:</i></b></u> Systemic symptoms were significantly more common among patch test-positive individuals (57.9%) compared with controls (26.8%, <i>P</i> = 0.005), particularly with wine (58.1% vs 25.6%, <i>P</i> = 0.006). Stronger patch test reactions correlated with greater symptom frequency and severity. <u><b><i>Conclusions:</i></b></u> Patients with sodium disulfite contact allergy more frequently report systemic symptoms after ingesting high-sulfite foods and beverages. These findings suggest a possible overlap between contact allergy and systemic intolerance, supporting a potential role for dietary counseling in select patch test-positive patients.</p>","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Causal Relationship Between Atopic Dermatitis and Malignancies: A Comprehensive Observational and Genetic Study.","authors":"Yang He, Abai Xu, Xiangbin Mi, Nina Tang","doi":"10.1177/17103568251384311","DOIUrl":"https://doi.org/10.1177/17103568251384311","url":null,"abstract":"<p><p><u><b><i></i></b></u> <u><b><i>Background:</i></b></u> Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by immune dysregulation. The global rise in the incidence of both AD and cancer suggests a potential link through shared immune-inflammatory pathways. <u><b><i>Objective:</i></b></u> This study aimed to investigate the causal relationship between AD and multiple cancer types and to explore potential underlying biological mechanisms. <u><b><i>Methods:</i></b></u> A two-sample Mendelian randomization (MR) analysis was conducted using data from a genome-wide association study of 6,224 AD patients. Seventeen cancer types were assessed. Additionally, expression quantitative trait loci analysis, pathway enrichment, and survival analyses were performed. <u><b><i>Results</i>:</b></u> MR analysis identified a significant causal relationship between AD and the risk of esophageal cancer (odds ratio [OR] = 0.88, <i>P</i> = 0.0247) as well as colorectal cancer (OR = 0.94, <i>P</i> = 0.0154). Subsequent research revealed differential expression between tumor and normal tissues, with pathway enrichment highlighting immune processes. No survival association was found in esophageal cancer, but <i>MFN2</i> and <i>SIPA1</i> expression levels could affect outcomes in colorectal cancer. <u><b><i>Conclusion:</i></b></u> This study provides evidence for a protective causal relationship between AD and the risks of esophageal and colorectal cancers. Immune and inflammatory pathways may mediate this link.</p>","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Predictors of Low-Dose Abrocitinib in Chinese Adults with Moderate-to-Severe Atopic Dermatitis: A Prospective Study.","authors":"Yuqi Zhang, Wei Liu, Xuejun Chen, Xiyuan Zhou","doi":"10.1177/17103568251383494","DOIUrl":"https://doi.org/10.1177/17103568251383494","url":null,"abstract":"<p><p><u><b><i></i></b></u> <u><b><i>Background:</i></b></u> Real-world data on abrocitinib 100 mg for moderate-to-severe atopic dermatitis (AD) in Asians remain limited. This study evaluates effectiveness, regional responses, safety, and predictors of low-dose abrocitinib in Chinese adults. <u><b><i>Methods:</i></b></u> A single-center prospective study (n = 40) in adults with moderate-to-severe atopic dermatitis received abrocitinib 100 mg once daily. Assessments occurred at baseline, Weeks 2, 4, 12, and 24. Primary endpoints: Week 12 Eczema Area and Severity Index 75% improvement (EASI-75) and safety. Secondary: region-specific Eczema Area and Severity Index improvement, patient-reported outcomes, and predictive factor analysis. Univariate logistic regression was used to identify predictors of response; multivariable analyses were exploratory due to limited sample size. <u><b><i>Results:</i></b></u> At Week 12, 60.0% achieved EASI-75, 42.5% EASI-90, and 42.5% Investigator Global Assessment response. Significant improvements occurred in EASI (-90.8%), pruritus, and quality-of-life. By Week 24 (subgroup), EASI-75 and EASI-90 rates rose to 90.9% and 68.2%, respectively. Regional EASI reduction exceeded 90% in head/neck, trunk, and upper limbs. Baseline immunoglobulin E (IgE) ≥100 IU/mL predicted a lower Week 2 response (OR = 0.20; <i>P</i> = 0.030), while age ≥45 years showed a non-significant trend toward better Week 4 response. Safety analysis included all 40 patients through Week 12 and 22 patients through Week 24, with 13 treatment-emergent adverse events reported, predominantly mild to moderate respiratory and gastrointestinal events. No major adverse cardiovascular events were observed during follow-up. <u><b><i>Conclusion:</i></b></u> Low-dose abrocitinib 100 mg once daily is effective and well tolerated, providing rapid and regionally consistent disease control in Chinese adults with moderate-to-severe AD. Baseline IgE may predict early response, supporting personalized management. These findings support low-dose abrocitinib as a viable therapy and highlight its potential role in personalized atopic dermatitis management.</p>","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Allergens in Feminine Hygiene Products.","authors":"Rayad B Shams, Katherine I Jicha, Jackson G Cacioppo, Michael J Duplisea, Aida Lugo-Somolinos","doi":"10.1177/17103568251379483","DOIUrl":"https://doi.org/10.1177/17103568251379483","url":null,"abstract":"<p><p><u><b><i></i></b></u> <u><b><i>Objectives:</i></b></u> Genital allergic contact dermatitis (ACD) can profoundly affect quality of life. The role of different chemical compounds used in maxi pads and pantiliners as potential allergens remains underexplored. This study aims to investigate potential allergens present in these products. <u><b><i>Methods:</i></b></u> A search for pantiliners and maxi pads was conducted on websites of common drug stores, and compounds were identified through online listings, packaging, or manufacturer contact. Compounds were grouped based on chemical composition, structural similarities, or association with compound families using Chemical Abstracts Service (CAS) numbers and synonyms from De Groot's Patch Testing, 4th edition. <u><b><i>Results:</i></b></u> From August 2021 to December 2022, 59 pantiliners and 111 maxi pads were analyzed, identifying 139 unique compounds. On average, pantiliners contained 8.4 compounds, and maxi pads 11. Common compound groups included wood pulp and cellulose materials (100%), polyolefins (100%), adhesives (88.2%), metallic pigments (80.6%), polyethylene glycol (PEG) (72.3%), and unspecified pigments (61.7%). Organic pigments and azo dyes, surfactants, fatty acid diester sulfates, higher alkanes, and synthetic fibers were found in over 25% of products. Antioxidants, solvents, fatty alcohol PEG ether compounds, fragrances, polysiloxanes, salts, and botanical extracts were also common ingredients occurring in over 10% of products. Only 11 products contained no known allergens. <u><b><i>Conclusions:</i></b></u> Pantiliners and maxi pads often contain compounds previously linked to genital ACD. Only California, New York, and Nevada require full ingredient disclosure, suggesting many products lack comprehensive ingredient labeling.</p>","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contact Allergy to Clotrimazole in a Patient With Stasis Dermatitis.","authors":"Brailyn Weber, Sara Hylwa","doi":"10.1177/17103568251383923","DOIUrl":"https://doi.org/10.1177/17103568251383923","url":null,"abstract":"","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergenicity and Unregulated Marketing Claims in Tinted Sunscreens.","authors":"Lauren Gawey, Aditya Joshi, Muhammad Rahman, Alexandra Gottsegen, Shayla Nguyen, Raveena Ghanshani, Khiem A Tran, Jennifer L Hsiao, Lisa Maier, Vivian Y Shi","doi":"10.1177/17103568251382236","DOIUrl":"https://doi.org/10.1177/17103568251382236","url":null,"abstract":"<p><p><u><b><i></i></b></u> <u><b><i>Background:</i></b></u> Tinted sunscreens are gaining popularity among skin of color populations due to their protection against visible light-induced hyperpigmentation and elimination of the white cast. Despite growing use, little is known about their allergenicity or the reliability of safety-oriented marketing claims. <u><b><i>Objective:</i></b></u> To assess the relationship between allergen content, active ingredients, marketing claims, and price in top-rated, best-selling tinted sunscreens. <u><b><i>Methods:</i></b></u> We conducted an analysis of 49 tinted sunscreens from 3 major online retailers. Products were evaluated for allergens listed in the 2020 American Contact Dermatitis Society Core Allergen Series, presence of marketing claims, UV filters, and price per ounce. <u><b><i>Results:</i></b></u> Ninety-eight percent of products contained at least 1 allergen (mean 3.1). The average price per ounce was $18.95. Products with multiple shade options were more expensive ($22.92 vs $16.65/oz; <i>P</i> = 0.04), while \"nano-particle free\" products were less expensive ($14.26 vs $20.83/oz; <i>P</i> = 0.04). Marketing claims were abundant (mean 11.7). \"Fragrance free,\" \"cruelty free,\" \"reef friendly,\" and \"nano-particle free\" claims were associated with fewer allergens (<i>P</i> < 0.05). Octisalate and octinoxate correlated with more allergens; zinc oxide with fewer (<i>P</i> < 0.05). <u><b><i>Conclusions:</i></b></u> Tinted sunscreens frequently contain allergens despite safety-related marketing claims. Clinicians should guide product selection based on allergenic potential, active ingredients, and cost.</p>","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bullous Fixed Drug Eruption to Metformin Following a DRESS Syndrome to Allopurinol: What's the Link?","authors":"Lina Bessaad, Sana Mokni, Oumayma Mani, Sarra Saad, Nadia Ghariani Fetoui, Jacem Rouatbi, Safwene Frini, Hajer Bouraoui, Neila Fathallah, Nejet Ghariani, Mohamed Denguezli","doi":"10.1177/17103568251383831","DOIUrl":"https://doi.org/10.1177/17103568251383831","url":null,"abstract":"","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Allergy-Based Approach to Orofacial Granulomatosis: A Narrative Review.","authors":"Vikram N Sahni, Rebecca Yim, Aamir Amanullah, Dev Sahni, Douglas Powell, Rosemary deShazo, Jamie L W Rhoads, Jennie T Clarke, Christopher B Hansen, John J Zone, Christopher M Hull, Zachary H Hopkins","doi":"10.1177/17103568251378523","DOIUrl":"https://doi.org/10.1177/17103568251378523","url":null,"abstract":"<p><p><u><b><i></i></b></u> The relationship between orofacial granulomatous (OFG) conditions and allergy is evolving. Contact allergies are commonly reported, but the impact of allergy avoidance is unclear, and a current review evaluating this literature has not been performed. We identified 46 studies evaluating the impact of allergen avoidance in OFG (33 case reports, 5 case series, 5 single-arm interventional clinical trials, 1 non-randomized uncontrolled trial, and 2 prospective cohort studies). Patch testing was performed in 158 patients, and the most commonly reported allergens were gold (n = 2), mercury (n = 6), cinnamal/cinnamon (n = 27), sorbic acid (n = 7), grass/silver birch/plant-containing products (n = 22), fragrance (n = 5), nickel (n = 7), and benzoic acid (n = 21). When allergen avoidance was trialed, 123/171 (71%) of patients reported some degree of improvement. A validated scoring/grading system for Granulomatous Cheilitis, Melkerrson-Rosenthal syndrome, and OFG has not been developed, so we were unable to formally assess improvement, instead relying on physician- and patient-reported outcomes in addition to oral disease severity score reporting in several studies. Current literature supports both patch testing and a trial of allergen avoidance/elimination diet to improve OFG in those with a positive result. Few controlled studies have been performed to assess this relationship, and more are needed to evaluate the impact of allergen avoidance. If a patient with difficult-to-treat OFG has a positive patch test and exposure to allergens in their diet, we would recommend a trial of allergen avoidance/elimination diet to facilitate a multimodal approach to improving control of this difficult condition.</p>","PeriodicalId":93974,"journal":{"name":"Dermatitis : contact, atopic, occupational, drug","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}