Current opinion in toxicology最新文献_第9页

Autoimmune-mediated hemotoxicities 自身免疫介导的血液毒性

IF 4.6

Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2019.12.001

Alessandra Vultaggio , Andrea Matucci , Francesca Nencini , Susanna Bormioli , Enrico Maggi

引用次数: 0

Cardiovascular disease and toxic metals 心血管疾病和有毒金属

IF 4.6

Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2020.01.004

Çiğdem Sevim , Elif Doğan , Selim Comakli

引用次数: 29

Use of genome editing tools in environmental health research 基因组编辑工具在环境健康研究中的应用。

IF 4.6

Current opinion in toxicology Pub Date : 2019-12-01 DOI: 10.1016/j.cotox.2019.02.007

Julia E. Rager , Celeste Carberry , Rebecca C. Fry

引用次数: 6

Genomic tools for environmental epigenetics and implications for public health 环境表观遗传学的基因组工具及其对公共卫生的影响。

IF 4.6

Current opinion in toxicology Pub Date : 2019-12-01 DOI: 10.1016/j.cotox.2019.02.008

Bambarendage P.U. Perera , Laurie K. Svoboda , Dana C. Dolinoy

{"title":"Genomic tools for environmental epigenetics and implications for public health","authors":"Bambarendage P.U. Perera , Laurie K. Svoboda , Dana C. Dolinoy","doi":"10.1016/j.cotox.2019.02.008","DOIUrl":"10.1016/j.cotox.2019.02.008","url":null,"abstract":"<div>Epigenetics refers to the study of mitotically heritable and potentially reversible changes in gene expression unrelated to the DNA sequence itself, influenced by epigenetic marks including chromatin modifications, noncoding RNA (ncRNA), and alterations to DNA itself via methylation and hydroxymethylation. Epigenetics has taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration; however, its integration into the field of environmental health sciences and toxicology (e.g. toxicoepigenetics) is in its infancy. This review highlights the need to evaluate surrogate and target tissues in the field of toxicoepigenetics as the National Institute of Environmental Health Sciences multiphased Toxicant Exposure and Response by Genomic and Epigenomic Regulators of Transcription consortia make headway and the emergence of ncRNA biomarkers. The review also discusses lead (Pb) as a potential toxicoepigenetic exposure, where prenatal and postnatal Pb exposure is associated with reprogramming of DNA methylation, histone modifications, and microRNA expression, representing potential biomarkers or predictors for Pb-induced health outcomes. Finally, new advances in epigenome editing, highlighting the potential of small ncRNA, will be explored for environmental health sciences research.</div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2019.02.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47112353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Integrating gene expression biomarker predictions into networks of adverse outcome pathways 将基因表达生物标志物预测整合到不良结果通路网络中

IF 4.6

Current opinion in toxicology Pub Date : 2019-12-01 DOI: 10.1016/j.cotox.2019.05.006

J. Christopher Corton

{"title":"Integrating gene expression biomarker predictions into networks of adverse outcome pathways","authors":"J. Christopher Corton","doi":"10.1016/j.cotox.2019.05.006","DOIUrl":"10.1016/j.cotox.2019.05.006","url":null,"abstract":"<div>Microarray profiling in the context of toxicity testing in animals has been used for years to identify mechanisms of toxicity, derive points of departure using dose–response modeling, and determine human relevance. High-throughput transcriptomic technologies are increasingly being used to screen environmental chemicals in vitro to identify molecular targets and provide mechanistic context for regulatory testing. This review will discuss the use of gene expression biomarkers to make predictions of activity of molecular targets of chemicals that can be linked to adverse outcomes in a number of cellular and tissue contexts. Gene expression biomarkers are built using global gene expression comparisons from cells or tissues exposed to chemicals with known effects on the factor of interest. Incorporating profiles in which the expression of the factor is altered (e.g. in gene-null mice) facilitates the identification of predictive genes. As an example of their use, biomarkers that predict molecular initiating events and key events in liver cancer adverse outcome pathways have been shown to accurately identify chemical–dose combinations in short-term studies that lead to liver cancer in 2-year bioassays. In the near future, batteries of biomarkers that predict modulation of important targets of environmental chemicals could be used to interpret high-throughput transcriptomic screening data.</div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2019.05.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46526662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Omics-based input and output in the development and use of adverse outcome pathways 在不利结果途径的开发和使用中基于组学的输入和输出

IF 4.6

Current opinion in toxicology Pub Date : 2019-12-01 DOI: 10.1016/j.cotox.2019.02.006

Mathieu Vinken

引用次数: 20

CRISPR genomic screening informs gene–environment interactions CRISPR基因组筛选为基因与环境的相互作用提供信息

IF 4.6

Current opinion in toxicology Pub Date : 2019-12-01 DOI: 10.1016/j.cotox.2019.02.009

Amin Sobh, Chris Vulpe

引用次数: 5

Next-generation sequencing data for use in risk assessment 用于风险评估的下一代测序数据。

IF 4.6

Current opinion in toxicology Pub Date : 2019-12-01 DOI: 10.1016/j.cotox.2019.02.010

Bruce Alexander Merrick

{"title":"Next-generation sequencing data for use in risk assessment","authors":"Bruce Alexander Merrick","doi":"10.1016/j.cotox.2019.02.010","DOIUrl":"10.1016/j.cotox.2019.02.010","url":null,"abstract":"<div>Next-generation sequencing (NGS) represents several powerful platforms that have revolutionized RNA and DNA analysis. The parallel sequencing of millions of DNA molecules can provide mechanistic insights into toxicology and provide new avenues for biomarker discovery with growing relevance for risk assessment. The evolution of NGS technologies has improved over the last decade with increased sensitivity and accuracy to foster new biomarker assays from tissue, blood, and other biofluids. NGS technologies can identify transcriptional changes and genomic targets with base pair precision in response to chemical exposure. Furthermore, there are several exciting movements within the toxicology community that incorporate NGS platforms into new strategies for more rapid toxicological characterizations. These include the Tox21 in vitro high-throughput transcriptomic screening program, development of organotypic spheroids, alternative animal models, mining archival tissues, liquid biopsy, and epigenomics. This review will describe NGS-based technologies, demonstrate how they can be used as tools for target discovery in tissue and blood, and suggest how they might be applied for risk assessment.</div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2019.02.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37377631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Editorial overview: ‘Toxico-omic’ distillation for regulatory application in human health 编辑概述:用于人类健康监管应用的“毒物组学”蒸馏

IF 4.6

Current opinion in toxicology Pub Date : 2019-12-01 DOI: 10.1016/j.cotox.2019.09.007

Brian N. Chorley, Susan D. Hester

引用次数: 0

Toxicogenomic applications in risk assessment at Health Canada 加拿大卫生部的毒物基因组学在风险评估中的应用

IF 4.6

Current opinion in toxicology Pub Date : 2019-12-01 DOI: 10.1016/j.cotox.2019.02.005

Carole L. Yauk , Carmen Cheung , Tara S. Barton-Maclaren , Sherri Boucher , Julie Bourdon-Lacombe , Vinita Chauhan , Matthew Gagné , Zoe Gillespie , Sabina Halappanavar , Michael Honeyman , Steven R. Jones , Elaine Jones-McLean , Sarah Labib , Jane MacAulay , Jocelyn Moore , Martin Paquette , Nicholas Petronella , Souleh Semalulu , Andrew Slot , Alisa Vespa , Cindy L.A. Woodland

{"title":"Toxicogenomic applications in risk assessment at Health Canada","authors":"Carole L. Yauk , Carmen Cheung , Tara S. Barton-Maclaren , Sherri Boucher , Julie Bourdon-Lacombe , Vinita Chauhan , Matthew Gagné , Zoe Gillespie , Sabina Halappanavar , Michael Honeyman , Steven R. Jones , Elaine Jones-McLean , Sarah Labib , Jane MacAulay , Jocelyn Moore , Martin Paquette , Nicholas Petronella , Souleh Semalulu , Andrew Slot , Alisa Vespa , Cindy L.A. Woodland","doi":"10.1016/j.cotox.2019.02.005","DOIUrl":"https://doi.org/10.1016/j.cotox.2019.02.005","url":null,"abstract":"<div>Based on increasing use of mechanistic information in risk assessment, Health Canada's (HC) Task Force on Scientific Risk Assessment established a working group to review and report on the application of toxicogenomics across HC's risk assessment bureaus. The aim was to review current applications and needs for toxicogenomics at HC, to document existing challenges and to promote consistent/coherent risk assessments that consider toxicogenomics. Overall, HC foresees a role for toxicogenomics in risk assessment. To date, select bureaus have incorporated toxicogenomic data, primarily in weight of evidence approaches, to support mode of action analysis. Future efforts to foster networks for increasing expertise/capacity around toxicogenomic data interpretation were viewed as valuable endeavours, and continued support of research to advance applications was recommended.</div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2019.02.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138400342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5