Current opinion in toxicology最新文献_第8页

Mechanisms underlying disruptive effects of pesticides on the thyroid function 农药对甲状腺功能破坏性影响的机制

IF 4.6

Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2019.10.003

Antonio F. Hernández , Susanne H. Bennekou , Andy Hart , Luc Mohimont , Gerrit Wolterink

{"title":"Mechanisms underlying disruptive effects of pesticides on the thyroid function","authors":"Antonio F. Hernández , Susanne H. Bennekou , Andy Hart , Luc Mohimont , Gerrit Wolterink","doi":"10.1016/j.cotox.2019.10.003","DOIUrl":"https://doi.org/10.1016/j.cotox.2019.10.003","url":null,"abstract":"<div>The regulation of thyroid hormones (THs) production and physiological action is complex and can be adversely disrupted by a broad spectrum of chemicals at environmentally relevant concentrations through different and intricate mechanisms. This study reviews the current knowledge on how chemicals, in particular pesticides, can disrupt TH homeostasis. These include a) inhibition of TH biosynthesis in the thyroid follicular cells resulting in perturbation of the hypothalamic–pituitary–thyroid (HPT) axis; b) interference with TH transport proteins in the bloodstream; c) liver enzyme induction leading to increased inactivation and further excretion of TH from the body; d) interference with conversion of TH into the active form in peripheral tissues; e) interference with the transport of TH through cell membranes; and f) binding to intracellular TH receptors and further dysregulation of downstream gene expression sensitive to TH. Most pesticides included in the cumulative assessment group “hypothyroidism” by EFSA affect the HPT axis through upregulation of TH elimination pathways. A better understanding of the molecular mechanism behind the adverse effects, or at least the mode of action of each pesticide, reduces the uncertainty when the combined risk of dietary exposure to pesticides is assessed according to the dose-addition model.</div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2019.10.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138244251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Editorial overview: Translational toxicology: hematotoxicities during drug development 编辑概述:转化毒理学:药物开发过程中的血液毒性

IF 4.6

Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2019.12.004

Birgit Fogal, Marc Pallardy

引用次数: 0

Mechanisms of hepatic cancer by persistent organic pollutants 持久性有机污染物对肝癌的影响机制

IF 4.6

Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2020.02.001

James E. Klaunig, Luma Melo, Karen Tilmant

引用次数: 5

Limitations in the evidential basis supporting health benefits from a decreased exposure to pesticides through organic food consumption 支持通过食用有机食品减少接触农药对健康有益的证据基础存在局限性

IF 4.6

Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2019.11.003

Robin Mesnage , Ioannis N. Tsakiris , Michael N. Antoniou , Aristides Tsatsakis

引用次数: 20

Intestinal microbiome and metal toxicity 肠道微生物群与金属毒性

IF 4.6

Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2019.09.009

Senait Assefa, Gerwald Köhler

引用次数: 26

Editorial overview: The environment and man: A Study in mechanistic toxicology 编辑综述：环境与人：机制毒理学研究

IF 4.6

Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2020.03.007

David R. Wallace, Aleksandra Buha, Jonathan J. Powell, Aristidis Tsatsakis

引用次数: 1

New perspectives on cytokine pathways modulation by pesticide exposure 农药暴露对细胞因子途径调控的新视角

IF 4.6

Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2020.01.002

Chiara Costa , Giusi Briguglio , Rosaria Catanoso , Federica Giambò , Irene Polito , Michele Teodoro , Concettina Fenga

{"title":"New perspectives on cytokine pathways modulation by pesticide exposure","authors":"Chiara Costa , Giusi Briguglio , Rosaria Catanoso , Federica Giambò , Irene Polito , Michele Teodoro , Concettina Fenga","doi":"10.1016/j.cotox.2020.01.002","DOIUrl":"10.1016/j.cotox.2020.01.002","url":null,"abstract":"<div>Immune cells are able to release a variety of inflammation mediators, activating proinflammatory and antiinflammatory processes and regulating intracellular pathways. Consequences of chronic or early-life exposure to pesticides may be extended beyond innate immune dysfunction to the increased risk of late-life chronic inflammatory-based diseases. This study aims to summarize some of the most recent advancements in occupational toxicology, focusing on biological mechanisms linking environmental exposure to pesticides, inflammation, and cytokine modulation, as well as genetic polymorphisms or epigenetic modifications which can represent factors of vulnerability for exposed workers. Choosing appropriate toxicity biomarkers is also one of the main concerns in the field of immunotoxicology; for this purpose, new technologies have been introduced for the monitoring of pesticides blood levels along with molecular alterations. These approaches will allow the assessment of the actual body burden of environmental pollutants associating it with a screening for the early diagnosis of pathologies.</div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2020.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43643948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Estrogen disruptors and neuroimmune signaling in obesity: focus on bisphenol A 雌激素干扰物和肥胖中的神经免疫信号:关注双酚A

IF 4.6

Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2019.09.006

Randall L. Davis, Kathleen S. Curtis

引用次数: 3

Methylmercury and developmental neurotoxicity: A global concern 甲基汞与发育性神经毒性:一个全球关注的问题

IF 4.6

Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2020.01.005

Jan Aaseth , David R. Wallace , Kristine Vejrup , Jan Alexander

{"title":"Methylmercury and developmental neurotoxicity: A global concern","authors":"Jan Aaseth , David R. Wallace , Kristine Vejrup , Jan Alexander","doi":"10.1016/j.cotox.2020.01.005","DOIUrl":"10.1016/j.cotox.2020.01.005","url":null,"abstract":"<div>Methylmercury (MeHg) is a globally relevant environmental neurotoxic pollutant. Recent evidence from the Faroe Islands and Seychelles cohort studies suggest that maternal exposure to MeHg via consumption of contaminated fish and seafood results in transplacental exposure of the fetus to MeHg, seriously affecting fetal neurodevelopment. In birth cohorts, with mercury exposure below the existing tolerable weekly intake (1.3 μg/kg b.w., European Food Safety Authority) MeHg exposure associations to adverse neurodevelopmental effects have been observed. However, there are inconsistencies between studies, attributing confounding factors as the primary source of data variability. We summarize current knowledge of MeHg-mediated effects during nervous system development. Major molecular targets are thiols and selenols and, in particular, selenoenzymes, resulting in exacerbated oxidative stress–related damage. Generation of reactive oxygen species (ROS) is an underlying trigger for apoptosis. Low levels of MeHg can induce apoptotic death in cerebellar neurons, and MeHg can induce endoplasmic reticulum stress, disrupt calcium homeostasis, and cause mitochondrial disruption. At a cellular level, the effects of MeHg exposure involve the dysfunction of a myriad of neurodevelopment and neurobehavioral functions.</div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2020.01.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45286293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Gastrointestinal absorption and toxicity of nanoparticles and microparticles: Myth, reality and pitfalls explored through titanium dioxide 纳米颗粒和微粒的胃肠道吸收和毒性:通过二氧化钛探索的神话，现实和陷阱

IF 4.6

Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2020.02.007

Alessandra Barreto da Silva, Michelle Miniter, William Thom, Rachel E. Hewitt, John Wills, Ravin Jugdaohsingh, Jonathan J. Powell

{"title":"Gastrointestinal absorption and toxicity of nanoparticles and microparticles: Myth, reality and pitfalls explored through titanium dioxide","authors":"Alessandra Barreto da Silva, Michelle Miniter, William Thom, Rachel E. Hewitt, John Wills, Ravin Jugdaohsingh, Jonathan J. Powell","doi":"10.1016/j.cotox.2020.02.007","DOIUrl":"10.1016/j.cotox.2020.02.007","url":null,"abstract":"<div>Daily oral exposure to vast numbers (>1013/adult/day) of micron or nanosized persistent particles has become the norm for many populations. Significant airborne particle exposure is deleterious, so what about ingestion? Titanium dioxide in food grade form (fgTiO2), which is an additive to some foods, capsules, tablets, and toothpaste, may provide clues. Certainly, exposed human populations accumulate these particles in specialized intestinal cells at the base of large lymphoid follicles (Peyer's patches) and it is likely that a degree of absorption goes beyond this, that is, lymphatics to blood circulation to tissues. The authors of this study critically review the evidence and pathways. Regarding potential adverse effects, the authors primary message, for today's state-of-the-art, is that in vivo models have not been good enough and at times woeful. The authors provide a ‘caveats list’ to improve approaches and experimentation and illustrate why studies on biomarkers of particle uptake, and lower gut/mesenteric lymph nodes as targets, should be prioritized.</div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2020.02.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38074014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17