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The role of oxidative stress in toxicities due to drugs of abuse 氧化应激在药物滥用毒性中的作用
IF 4.6
Current opinion in toxicology Pub Date : 2020-04-01 DOI: 10.1016/j.cotox.2020.04.003
Leeann R. Pavlek , Julie Dillard , Lynette K. Rogers
{"title":"The role of oxidative stress in toxicities due to drugs of abuse","authors":"Leeann R. Pavlek ,&nbsp;Julie Dillard ,&nbsp;Lynette K. Rogers","doi":"10.1016/j.cotox.2020.04.003","DOIUrl":"10.1016/j.cotox.2020.04.003","url":null,"abstract":"<div><p><span>Abuse of illicit drugs is a growing problem across the world, with rates of drug use and overdose increasing for most major classes of substances. In addition to the social and public health implications of drug abuse, these drugs have a multitude of toxicities affecting all major organ systems. Depending on the drug, dosage, and </span>route of administration<span><span>, different toxicity profiles are seen. Based on findings from both animal models and human studies, </span>oxidative stress is increasingly recognized as a common underlying etiology for many of the adverse effects seen. In addition to toxicities, oxidative stress also is shown to play a role in addiction and withdrawal. A thorough understanding of the role of oxidative stress in these conditions is key for future research to design therapeutic agents to better prevent and treat toxicities.</span></p></div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2020.04.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46162822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Interactions between oxidative stress and cardiorespiratory fitness: Old and new biomarkers 氧化应激与心肺健康之间的相互作用：新旧生物标志物
IF 4.6
Current opinion in toxicology Pub Date : 2020-04-01 DOI: 10.1016/j.cotox.2020.03.005
Marco Bernardi , Ilaria Peluso
{"title":"Interactions between oxidative stress and cardiorespiratory fitness: Old and new biomarkers","authors":"Marco Bernardi ,&nbsp;Ilaria Peluso","doi":"10.1016/j.cotox.2020.03.005","DOIUrl":"10.1016/j.cotox.2020.03.005","url":null,"abstract":"<div><p><span>Enzymes<span><span><span>, nonenzymatic total antioxidant capacity and reactive oxygen species-induced modifications on </span>lipids, </span>DNA and proteins are usually used to evaluate </span></span>oxidative stress<span> (OS) in humans. Asymmetric dimethylarginine<span> (ADMA) has been suggested as a new OS marker. Antioxidant status may be improved by exogenous antioxidant intake or endurance training, which increases cardiorespiratory fitness (CRF). We reviewed studies on both OS markers and CRF. All markers were affected by age, gender, health, and exercise type. Exercise training with or without antioxidant interventions improved CRF and/or OS old markers, whereas more studies are needed for ADMA. CRF has high clinical significance and its measure should be included in the health assessment and in the redox status evaluated through OS markers.</span></span></p></div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2020.03.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47508681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
An overview of molecular mechanisms in cadmium toxicity 镉毒性的分子机制综述
IF 4.6
Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2019.12.002
Danijela Đukić-Ćosić, Katarina Baralić, Dragana Javorac, Aleksandra Buha Djordjevic, Zorica Bulat
{"title":"An overview of molecular mechanisms in cadmium toxicity","authors":"Danijela Đukić-Ćosić,&nbsp;Katarina Baralić,&nbsp;Dragana Javorac,&nbsp;Aleksandra Buha Djordjevic,&nbsp;Zorica Bulat","doi":"10.1016/j.cotox.2019.12.002","DOIUrl":"10.1016/j.cotox.2019.12.002","url":null,"abstract":"<div><p>Cadmium (Cd), one of the most important environmental pollutants, can cause a number of toxic effects. These effects are the result of more than one mechanisms of toxicity, all interrelated in their complexity. Thus, it is difficult to identify a fine line between these mechanisms of Cd toxicity, making their understanding highly complicated. The most important mechanisms by which Cd manifests its toxic effects include changes in gene expression and inhibition of damaged DNA repair, interference of apoptosis and autophagy, oxidative stress, and interaction with bioelements. In this review, we will give a brief overview of the recent developments and findings on the most relevant general and specific mechanisms and molecular pathways of Cd toxicity.</p></div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2019.12.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42234529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 75
Endocrine-disrupting mechanisms of polychlorinated biphenyls 多氯联苯的内分泌干扰机制
IF 4.6
Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2019.10.006
Aleksandra Buha Djordjevic, Evica Antonijevic, Marijana Curcic, Vesna Milovanovic, Biljana Antonijevic
{"title":"Endocrine-disrupting mechanisms of polychlorinated biphenyls","authors":"Aleksandra Buha Djordjevic,&nbsp;Evica Antonijevic,&nbsp;Marijana Curcic,&nbsp;Vesna Milovanovic,&nbsp;Biljana Antonijevic","doi":"10.1016/j.cotox.2019.10.006","DOIUrl":"10.1016/j.cotox.2019.10.006","url":null,"abstract":"<div><p><span>The extent of human exposure to chemicals, their endocrine-disrupting mechanisms of action, and the relationship between exposure and various human diseases raise significant scientific and public health concerns. Polychlorinated biphenyls (PCBs) belong to the group of organic compounds known as persistent organic pollutants, characterized by long-range transport, persistence, bioaccumulation, and high toxicity. They have been identified as endocrine-disrupting chemicals. </span><em>In vivo</em> and <em>in vitro</em> studies have shown that endocrine-disrupting effects of PCBs mainly involve thyroid and reproductive function. In the review presented, these effects were placed in the context of the most recent findings on PCB-induced endocrine-disrupting mechanisms and modes of action.</p></div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2019.10.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45427024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Genotoxicity of engineered nanomaterials found in the human environment 人类环境中发现的工程纳米材料的遗传毒性
IF 4.6
Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2019.12.003
A. Wallace Hayes , Saura C. Sahu
{"title":"Genotoxicity of engineered nanomaterials found in the human environment","authors":"A. Wallace Hayes ,&nbsp;Saura C. Sahu","doi":"10.1016/j.cotox.2019.12.003","DOIUrl":"10.1016/j.cotox.2019.12.003","url":null,"abstract":"<div><p>Engineered nanomaterials<span><span> (ENMs) are unique in our modern industrial world; however, limited information is currently available regarding exposure and hazard information, including the genotoxicity of such materials. Much work remains to be carried out for developing, validating, and harmonizing a tool chest for the genotoxicity of nanomaterials. Gaps remain in our understanding of potential mechanisms of the genotoxicity of nanomaterials. Until more appropriate tests are available for testing of ENMs, the potential impact of ENMs may continue to be underestimated without proper consideration of the genotoxicity potential of such materials. Clearly, resources need to be devoted to better approaches to the </span>hazard identification of nanomaterials to insure safe development and application of nanotechnology and for the protection of human health and the environment.</span></p></div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2019.12.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43171108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Cadmium, arsenic, and lead: elements affecting male reproductive health 镉、砷和铅:影响男性生殖健康的元素
IF 4.6
Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2019.09.005
Blanka Tariba Lovaković
{"title":"Cadmium, arsenic, and lead: elements affecting male reproductive health","authors":"Blanka Tariba Lovaković","doi":"10.1016/j.cotox.2019.09.005","DOIUrl":"10.1016/j.cotox.2019.09.005","url":null,"abstract":"<div><p><span>The decline of male fertility has become a serious public health concern over the last decades, coinciding with an increase in environmental exposure to toxic pollutants. Toxic elements cadmium (Cd), arsenic (As), and lead (Pb) seem to contribute to declining fertility in men through progressive impairment of semen quality. </span>Reproductive toxicity of these elements is mediated by multiple mechanisms. Although experimental animal studies generally support an adverse role of Cd, As, and Pb in human reproduction issues, data on the effects induced by the levels of toxic elements that represent environmental exposure are inconsistent. This review summarizes reports from experimental studies in animals and epidemiological observational findings from environmental exposure to Cd, As, and Pb, with special focus on semen quality parameters as the indicator of male fertility.</p></div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2019.09.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46640221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Risk assessments in nanotoxicology: bioinformatics and computational approaches 纳米毒理学的风险评估:生物信息学和计算方法
IF 4.6
Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2019.08.006
Konstantin Pikula , Alexander Zakharenko , Vladimir Chaika , Konstantin Kirichenko , Aristidis Tsatsakis , Kirill Golokhvast
{"title":"Risk assessments in nanotoxicology: bioinformatics and computational approaches","authors":"Konstantin Pikula ,&nbsp;Alexander Zakharenko ,&nbsp;Vladimir Chaika ,&nbsp;Konstantin Kirichenko ,&nbsp;Aristidis Tsatsakis ,&nbsp;Kirill Golokhvast","doi":"10.1016/j.cotox.2019.08.006","DOIUrl":"10.1016/j.cotox.2019.08.006","url":null,"abstract":"<div><p><span>A massive-scale production of engineered nanoparticles (ENPs) becomes one of the most important environmental issues. The mechanisms of ENPs' (eco)toxic action are not fully understood, and the estimation of those mechanisms is a complicated task because even slight changes in particle characteristics could dramatically change their toxicity. As a result of continuous manufacturing of ENPs with specific functionality and different physicochemical properties, conventional methods of </span><em>in vivo</em> and <em>in vitro</em><span> testing would not be able to fill the existing knowledge gap in nanotoxicology. The objectives of this review are to overlook the current achievements based on the new approaches of ENPs' risk assessment, such as bioinformatics approaches and machine learning tools. These methods confirmed their ability to reliable prediction and evaluation of ENPs' behavior and their toxic endpoints. Databases and projects based on these methods and approaches would be highly useful in addressing the problem of ENPs’ regulation.</span></p></div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2019.08.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43842136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Threshold in the toxicology of metals: Challenges and pitfalls of the concept 金属毒理学中的阈值：概念的挑战和陷阱
IF 4.6
Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2019.10.004
Jean-Marc Moulis , Zorica Bulat , Aleksandra Buha Djordjevic
{"title":"Threshold in the toxicology of metals: Challenges and pitfalls of the concept","authors":"Jean-Marc Moulis ,&nbsp;Zorica Bulat ,&nbsp;Aleksandra Buha Djordjevic","doi":"10.1016/j.cotox.2019.10.004","DOIUrl":"10.1016/j.cotox.2019.10.004","url":null,"abstract":"<div><p>Metals qualitatively dominate the chemical elements found on Earth, but life has found a use for only a minority of them. Most metals are mobilized as cations, and thereby interact and are processed by living species. Animals are exposed to environmental metals at chronic low concentrations through food, air particles, and other ways, under conditions that are too rarely reproduced in laboratory settings. Actual metal detoxification systems in animals are not many and of limited efficiency which casts doubt on the existence of any safe concentration — a threshold for nonessential metals. Hence the mechanisms of action of toxic metals at very low doses still have to be adequately addressed to provide means for knowledge-based risk assessment that is increasingly requested by diverse communities.</p></div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2019.10.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46524879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Small and dangerous? Potential toxicity mechanisms of common exposure particles and nanoparticles 又小又危险?常见接触颗粒和纳米颗粒的潜在毒性机制
IF 4.6
Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2020.01.006
Rachel E. Hewitt , Helen F. Chappell , Jonathan J. Powell
{"title":"Small and dangerous? Potential toxicity mechanisms of common exposure particles and nanoparticles","authors":"Rachel E. Hewitt ,&nbsp;Helen F. Chappell ,&nbsp;Jonathan J. Powell","doi":"10.1016/j.cotox.2020.01.006","DOIUrl":"10.1016/j.cotox.2020.01.006","url":null,"abstract":"<div><p>We are continuously exposed to large numbers of nonbiological, persistent particulates through dermal, oral and inhalation routes. At sizes perfect for cell interactions<span><span><span><span>, such modern particle exposures are derived from human engineering either purposefully (e.g. additives/excipients) or inadvertently (e.g. pollution). Whether oral or dermal exposure to common particles has significant adverse effects is not yet known. However, relationships between increased morbidity or mortality and </span>airborne particle exposure are well established. Large </span>nanoparticles<span> and microparticles adsorb environmental molecules, including antigens and allergens, and deliver them to cells potentially with an adjuvant effect. Smaller nanoparticles may have enhanced redox activity because of increased surface areas or band gap effects. Under some circumstances, ultrasmall nanoparticles can ligate cellular receptors or interact with other cell machinery and drive distinct </span></span>cell signalling<span>. These, as well as the potential for inflammasome activation, are discussed as feasible pathways to understanding or debunking particle toxicity.</span></span></p></div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2020.01.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38074013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Heavy metal and pesticide exposure: A mixture of potential toxicity and carcinogenicity 重金属和农药暴露：潜在毒性和致癌性的混合物
IF 4.6
Current opinion in toxicology Pub Date : 2020-02-01 DOI: 10.1016/j.cotox.2020.01.001
David R. Wallace , Aleksandra Buha Djordjevic
{"title":"Heavy metal and pesticide exposure: A mixture of potential toxicity and carcinogenicity","authors":"David R. Wallace ,&nbsp;Aleksandra Buha Djordjevic","doi":"10.1016/j.cotox.2020.01.001","DOIUrl":"10.1016/j.cotox.2020.01.001","url":null,"abstract":"<div><p>There is a growing body of evidence that various pesticides and heavy metals are carcinogenic. If not directly, there is also evidence that shows that these compounds can participate in carcinogenesis in a passive or permissive role, facilitating other compounds from inducing tumor formation. Little evidence is available to aid in understanding the toxicity of metal-pesticide mixtures. In many instances, exposure to subclinical, or subtoxic, levels would be asymptomatic under a single-chemical exposure. But, we do not know how these compounds would act together. A synergistic or potentiating response could be highly possible. By chemically interacting with the environment, as well as each other, metal pesticide mixtures may yield unpredictable toxicity. Because we are not exposed to a single xenobiotic at a time, the importance of studying the toxicity of mixtures has never been more critical.</p></div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2020.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46274373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 64
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