Congenital anomalies最新文献_第4页

Endocrine disruptor issues in Japan 日本的内分泌干扰物问题

Congenital anomalies Pub Date : 2002-06-01 DOI: 10.1111/j.1741-4520.2002.tb00859.x

T. Iguchi, M. Sumi, S. Tanabe

引用次数: 36

A selective loss of small‐diameter myelinated optic nerve axons in rats prenatally exposed to ethanol 胎儿暴露于乙醇的大鼠小直径髓鞘视神经轴突选择性丧失

Congenital anomalies Pub Date : 2002-06-01 DOI: 10.1111/j.1741-4520.2002.tb00861.x

K. Sawada, H. Sakata-Haga, S. Komatsu, Kyoko Ohta, Y. Jeong, Y. Fukui

引用次数: 11

Activities and Announcement 活动及公告

Congenital anomalies Pub Date : 2002-06-01 DOI: 10.1111/j.1741-4520.2002.tb00867.x

引用次数: 0

Perinatal development of the rat hip joint with restrained fetal movement 胎动受限大鼠髋关节围生期发育

Congenital anomalies Pub Date : 2002-06-01 DOI: 10.1111/j.1741-4520.2002.tb00863.x

Ryuju Hashimoto, I. Kihara, H. Otani

{"title":"Perinatal development of the rat hip joint with restrained fetal movement","authors":"Ryuju Hashimoto, I. Kihara, H. Otani","doi":"10.1111/j.1741-4520.2002.tb00863.x","DOIUrl":"https://doi.org/10.1111/j.1741-4520.2002.tb00863.x","url":null,"abstract":"ABSTRACT We compared the structures of the femoral head (FH) of neonates between normal and operated legs with restrained fetal movement using an exo utero technique. At embryonic day (E) 16.5, one hind limb was sutured onto the embryonic membrane and the fetuses were allowed to develop exo utero until the term (E22.5). There was no significant difference in the largest diameter of the FH between the non‐operated and operated side FH in the operated neonates and the FH of the non‐operated neonates. By scanning electron microscopy, roughness and collagen fiber bundles, which were detected on the surface of the operated side FH at E18.5, disappeared at E22.5. However, the operated side FH was deformed and the surface cell arrangement was more irregular than that of the controls at E22.5 by light microscopy. These results suggest that the abnormality of cell arrangement caused by the restraint of fetal movement may induce the deformity and irregularity of the FH surface, although this operation may not disturb the basic cellular activities such as cell proliferation as well as the secretion of cartilage matrix and collagen fibers. To further investigate the recovery process in the operated newborns after releasing the restraint, we bred them artificially for a considerable period after birth. The operated side FH surface of the neonate bred for 45 hours was smoother than that at E22.5 and similar to that of the non‐operated side FH. This result suggests that the proper movement of the extremities after birth may recover the deformity caused by restrained fetal joint movement","PeriodicalId":93953,"journal":{"name":"Congenital anomalies","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82099220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

A case of midline cervical cleft 颈中线裂1例

Congenital anomalies Pub Date : 2002-06-01 DOI: 10.1111/j.1741-4520.2002.tb00864.x

M. Tsukuno, Yoko Kite, K. Kurihara

引用次数: 10

Activities and Announcement 活动及公告

Congenital anomalies Pub Date : 2002-03-01 DOI: 10.1111/j.1741-4520.2002.tb00856.x

引用次数: 0

Vascular endothelial growth factor in edematous mouse embryos induced by retinoic acid in utero 维甲酸致小鼠宫内水肿胚胎血管内皮生长因子的研究

Congenital anomalies Pub Date : 2001-06-01 DOI: 10.1111/j.1741-4520.2001.tb00820.x

Y. Yasuda, Y. Fujita, Koichi Ueda, T. Matsuo, M. Onozaki, M. Sakamoto, H. Konishi

{"title":"Vascular endothelial growth factor in edematous mouse embryos induced by retinoic acid in utero","authors":"Y. Yasuda, Y. Fujita, Koichi Ueda, T. Matsuo, M. Onozaki, M. Sakamoto, H. Konishi","doi":"10.1111/j.1741-4520.2001.tb00820.x","DOIUrl":"https://doi.org/10.1111/j.1741-4520.2001.tb00820.x","url":null,"abstract":"ABSTRACT Vascular endothelial growth factor (VEGF) is induced by hypoxic environment and contributes to vascular formation in both developing embryos and adults. Exogenous retinoic acid (RA) induces avascular yolk sacs with anemic stunted embryos of day 9 and 10 of gestation when RA is given to pregnant mice on day 6, 6.5 or 7 of pregnancy (Yasuda et al., 1996). We undertook the present studies to find out whether VEGF is activated and plays any role in those RA‐exposed embryos. Embryos were obtained from dams given 60 mg/kg of RA on day 6 or 7 of pregnancy and sacrificed three days later. Most RA‐exposed embryos showed edematous swelling without prominent vascular nets, but had beating heart tubes on day 9 and day 10 of gestation. Microscopic examination of developing tissue components showed various degrees of degeneration, and distension of the dorsal aorta when the body cavity was dosed. Northern blot analysis revealed expression of VEGF mRNA in the RA‐exposed and control embryos. The highest expression of VEGF mRNA was seen in the embryos of day 10 exposed to RA on day 7, and these embryos had a significantly lower ATP content than did the controls (p < 0.01). Immunoreactive VEGF was detectable in both experimental and control embryos; in the former it was especially visible in the distended neuroepithelium, endothelium and membranes. These VEGF‐immunoreactive regions also expressed another permeability factor, bradykinin. These findings suggest that VEGF upregulated by hypoxic conditions in edematous embryos induced by RA exposure in utero acts as hyperpermeability.","PeriodicalId":93953,"journal":{"name":"Congenital anomalies","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81499648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Induction of cleft palate in aniline hydrochloride‐treated rats: Possible effect of maternal methemoglobinemic hypoxia 盐酸苯胺处理大鼠腭裂的诱导:母体高铁血红蛋白缺氧的可能影响

Congenital anomalies Pub Date : 2001-06-01 DOI: 10.1111/j.1741-4520.2001.tb00822.x

Kiyoshi Matsumoto, N. Seki, K. Fukuta, Y. Ooshima

{"title":"Induction of cleft palate in aniline hydrochloride‐treated rats: Possible effect of maternal methemoglobinemic hypoxia","authors":"Kiyoshi Matsumoto, N. Seki, K. Fukuta, Y. Ooshima","doi":"10.1111/j.1741-4520.2001.tb00822.x","DOIUrl":"https://doi.org/10.1111/j.1741-4520.2001.tb00822.x","url":null,"abstract":"ABSTRACT Aniline hydrochloride (AH), a methemoglobin formation‐stimulating substance, at a dosage level of 520 mg/kg which does not induce apparent fetal death, was injected subcutaneously into pregnant rats once on day 14, 15 or 16 of gestation in order to assess the stage specificity of cleft palate induction. Also, doses of 260, 390, 520 and 650 mg/kg were administered to pregnant rats on day 15 of gestation, and the dose‐response relationships with respect to fetal cleft palate and maternal methemo‐globinemia induction were studied. In the stage‐specificity study, paleness, decreased body weight gain and elevated methemoglobin concentration were noted in the dams treated with AH. Upon fetal examinations, although reduced body weight was noted in all AH‐treated groups, cleft palate was observed only in fetuses from those dams treated on day 15 of gestation. In the dose‐dependency study, AH induced maternal methemoglobinemia, decreased fetal body weight and increased the incidence of cleft palate dose dependently when administered at dosage levels of 260, 390, 520 and 650 mg/kg on day 15 of gestation. Additionally, administration of methylene blue, a methemoglobinemia‐preventing substance, to the AH‐treated dams ameliorated maternal methemoglobinemia and reduced the incidence of fetal cleft palate. In summation, it is considered that AH stage‐specifically induces cleft palate in rats and that cleft palate is caused not by a direct teratogenic effect of AH but by maternal hypoxia due to methemoglobinemia.","PeriodicalId":93953,"journal":{"name":"Congenital anomalies","volume":"131 1 Suppl 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81142997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Activities and Announcement 活动及公告

Congenital anomalies Pub Date : 2001-06-01 DOI: 10.1111/j.1741-4520.2001.tb00826.x

引用次数: 0

Cardiovascular malformations associated with maternal hypoxia due to methemoglobinemia in aniline hydrochloride‐treated rats 盐酸苯胺处理大鼠高铁血红蛋白血症与母体缺氧相关的心血管畸形

Congenital anomalies Pub Date : 2001-06-01 DOI: 10.1111/j.1741-4520.2001.tb00823.x

Kiyoshi Matsumoto, S. Matsumoto, K. Fukuta, Y. Ooshima

{"title":"Cardiovascular malformations associated with maternal hypoxia due to methemoglobinemia in aniline hydrochloride‐treated rats","authors":"Kiyoshi Matsumoto, S. Matsumoto, K. Fukuta, Y. Ooshima","doi":"10.1111/j.1741-4520.2001.tb00823.x","DOIUrl":"https://doi.org/10.1111/j.1741-4520.2001.tb00823.x","url":null,"abstract":"ABSTRACT Aniline hydrochloride (AH), a methemoglobin‐formation stimulating substance, at a dosage level that does not induce apparent fetal death was injected subcutaneously into pregnant rats once a day on days 6–8, 9–11, 12–14 or 15–17 of gestation in order to assess its ability to stage‐specifically produce cardiovascular malformations. In addition, AH at dosage levels of 195, 260, 325 and 395 rag/kg was injected into pregnant rats subcutaneously once a day on days 12–14 of gestation, and the dose‐dependent induction of ventricular septal defect (VSD) in relation to maternal methemoglobinemia was studied. In the stage‐specificity study, paleness, decreased body weight gain and elevated methemoglobin concentration were noted in the dams. Upon fetal examination, reduced body weight was noted in all AH‐treated groups. AH induced cardiovascular malformations, mainly VSD, which was most frequently observed in the day 12–14 group and also observed in the day 15–17 group. Abnormal branching of subclavian, pulmonary and vertebral arteries were most frequently observed in the day 9–11 group. In the dose‐dependency study, AH induced maternal methemoglobinemia, decreased fetal body weight and increased the incidence of VSD dose dependency. Additionally, administration of methylene blue, a methemoglobinemia‐preventing substance, to the AH‐treated dams ameliorated maternal methemoglobinemia and reduced the incidence of fetal VSD. From these results, it is considered that AH stage‐specifically induces cardiovascular defects, mainly VSD, in rats and that VSD is induced not by a direct teratogenic effect of AH but by maternal hypoxia due to methemoglobinemia.","PeriodicalId":93953,"journal":{"name":"Congenital anomalies","volume":"109 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79746864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3