Congenital anomalies最新文献_第4页

Necessity to establish new risk assessment and risk communication for human fetal exposure to multiple endocrine disruptors in Japan 日本建立人类胎儿暴露于多种内分泌干扰物的新风险评估和风险沟通的必要性

Congenital anomalies Pub Date : 2002-06-01 DOI: 10.1111/j.1741-4520.2002.tb00857.x

E. Todaka, C. Mori

{"title":"Necessity to establish new risk assessment and risk communication for human fetal exposure to multiple endocrine disruptors in Japan","authors":"E. Todaka, C. Mori","doi":"10.1111/j.1741-4520.2002.tb00857.x","DOIUrl":"https://doi.org/10.1111/j.1741-4520.2002.tb00857.x","url":null,"abstract":"ABSTRACT Our recent study clearly shows that fetuses are exposed to multiple chemicals including endocrine disruptors in Japan. Although the embryo and fetus stages are the most sensitive period to chemicals in humans' life cycle, the health effects of the chemicals such as endocrine disruptors to them are largely unknown. The conventional risk assessment method cannot assess the risk to fetuses precisely. Now we need a new risk assessment, in which the target is fetuses and not the adults, in addition to the conventional risk assessment At the same time, we also need a new strategy to practically eliminate the risk for the future generations. To make the strategy effective, we suggest a new approach to reduce the risk and avoid the possible adverse health effects, using primary, secondary and tertiary preventions as they are used in public health. We also suggest a new concept of “pre‐primary prevention” to reduce the risk for fetuses. Furthermore, to make this method even more practical, we suggest a new risk communication method. In this paper, we present a framework of risk avoidance of multiple chemical exposure to fetuses.","PeriodicalId":93953,"journal":{"name":"Congenital anomalies","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75471451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Endocrine disruptor issues in Japan 日本的内分泌干扰物问题

Congenital anomalies Pub Date : 2002-06-01 DOI: 10.1111/j.1741-4520.2002.tb00859.x

T. Iguchi, M. Sumi, S. Tanabe

引用次数: 36

A selective loss of small‐diameter myelinated optic nerve axons in rats prenatally exposed to ethanol 胎儿暴露于乙醇的大鼠小直径髓鞘视神经轴突选择性丧失

Congenital anomalies Pub Date : 2002-06-01 DOI: 10.1111/j.1741-4520.2002.tb00861.x

K. Sawada, H. Sakata-Haga, S. Komatsu, Kyoko Ohta, Y. Jeong, Y. Fukui

引用次数: 11

Activities and Announcement 活动及公告

Congenital anomalies Pub Date : 2002-06-01 DOI: 10.1111/j.1741-4520.2002.tb00867.x

引用次数: 0

Perinatal development of the rat hip joint with restrained fetal movement 胎动受限大鼠髋关节围生期发育

Congenital anomalies Pub Date : 2002-06-01 DOI: 10.1111/j.1741-4520.2002.tb00863.x

Ryuju Hashimoto, I. Kihara, H. Otani

{"title":"Perinatal development of the rat hip joint with restrained fetal movement","authors":"Ryuju Hashimoto, I. Kihara, H. Otani","doi":"10.1111/j.1741-4520.2002.tb00863.x","DOIUrl":"https://doi.org/10.1111/j.1741-4520.2002.tb00863.x","url":null,"abstract":"ABSTRACT We compared the structures of the femoral head (FH) of neonates between normal and operated legs with restrained fetal movement using an exo utero technique. At embryonic day (E) 16.5, one hind limb was sutured onto the embryonic membrane and the fetuses were allowed to develop exo utero until the term (E22.5). There was no significant difference in the largest diameter of the FH between the non‐operated and operated side FH in the operated neonates and the FH of the non‐operated neonates. By scanning electron microscopy, roughness and collagen fiber bundles, which were detected on the surface of the operated side FH at E18.5, disappeared at E22.5. However, the operated side FH was deformed and the surface cell arrangement was more irregular than that of the controls at E22.5 by light microscopy. These results suggest that the abnormality of cell arrangement caused by the restraint of fetal movement may induce the deformity and irregularity of the FH surface, although this operation may not disturb the basic cellular activities such as cell proliferation as well as the secretion of cartilage matrix and collagen fibers. To further investigate the recovery process in the operated newborns after releasing the restraint, we bred them artificially for a considerable period after birth. The operated side FH surface of the neonate bred for 45 hours was smoother than that at E22.5 and similar to that of the non‐operated side FH. This result suggests that the proper movement of the extremities after birth may recover the deformity caused by restrained fetal joint movement","PeriodicalId":93953,"journal":{"name":"Congenital anomalies","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82099220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

A case of midline cervical cleft 颈中线裂1例

Congenital anomalies Pub Date : 2002-06-01 DOI: 10.1111/j.1741-4520.2002.tb00864.x

M. Tsukuno, Yoko Kite, K. Kurihara

引用次数: 10

Activities and Announcement 活动及公告

Congenital anomalies Pub Date : 2002-03-01 DOI: 10.1111/j.1741-4520.2002.tb00856.x

引用次数: 0

Vascular endothelial growth factor in edematous mouse embryos induced by retinoic acid in utero 维甲酸致小鼠宫内水肿胚胎血管内皮生长因子的研究

Congenital anomalies Pub Date : 2001-06-01 DOI: 10.1111/j.1741-4520.2001.tb00820.x

Y. Yasuda, Y. Fujita, Koichi Ueda, T. Matsuo, M. Onozaki, M. Sakamoto, H. Konishi

{"title":"Vascular endothelial growth factor in edematous mouse embryos induced by retinoic acid in utero","authors":"Y. Yasuda, Y. Fujita, Koichi Ueda, T. Matsuo, M. Onozaki, M. Sakamoto, H. Konishi","doi":"10.1111/j.1741-4520.2001.tb00820.x","DOIUrl":"https://doi.org/10.1111/j.1741-4520.2001.tb00820.x","url":null,"abstract":"ABSTRACT Vascular endothelial growth factor (VEGF) is induced by hypoxic environment and contributes to vascular formation in both developing embryos and adults. Exogenous retinoic acid (RA) induces avascular yolk sacs with anemic stunted embryos of day 9 and 10 of gestation when RA is given to pregnant mice on day 6, 6.5 or 7 of pregnancy (Yasuda et al., 1996). We undertook the present studies to find out whether VEGF is activated and plays any role in those RA‐exposed embryos. Embryos were obtained from dams given 60 mg/kg of RA on day 6 or 7 of pregnancy and sacrificed three days later. Most RA‐exposed embryos showed edematous swelling without prominent vascular nets, but had beating heart tubes on day 9 and day 10 of gestation. Microscopic examination of developing tissue components showed various degrees of degeneration, and distension of the dorsal aorta when the body cavity was dosed. Northern blot analysis revealed expression of VEGF mRNA in the RA‐exposed and control embryos. The highest expression of VEGF mRNA was seen in the embryos of day 10 exposed to RA on day 7, and these embryos had a significantly lower ATP content than did the controls (p < 0.01). Immunoreactive VEGF was detectable in both experimental and control embryos; in the former it was especially visible in the distended neuroepithelium, endothelium and membranes. These VEGF‐immunoreactive regions also expressed another permeability factor, bradykinin. These findings suggest that VEGF upregulated by hypoxic conditions in edematous embryos induced by RA exposure in utero acts as hyperpermeability.","PeriodicalId":93953,"journal":{"name":"Congenital anomalies","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81499648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Induction of cleft palate in aniline hydrochloride‐treated rats: Possible effect of maternal methemoglobinemic hypoxia 盐酸苯胺处理大鼠腭裂的诱导:母体高铁血红蛋白缺氧的可能影响

Congenital anomalies Pub Date : 2001-06-01 DOI: 10.1111/j.1741-4520.2001.tb00822.x

Kiyoshi Matsumoto, N. Seki, K. Fukuta, Y. Ooshima

{"title":"Induction of cleft palate in aniline hydrochloride‐treated rats: Possible effect of maternal methemoglobinemic hypoxia","authors":"Kiyoshi Matsumoto, N. Seki, K. Fukuta, Y. Ooshima","doi":"10.1111/j.1741-4520.2001.tb00822.x","DOIUrl":"https://doi.org/10.1111/j.1741-4520.2001.tb00822.x","url":null,"abstract":"ABSTRACT Aniline hydrochloride (AH), a methemoglobin formation‐stimulating substance, at a dosage level of 520 mg/kg which does not induce apparent fetal death, was injected subcutaneously into pregnant rats once on day 14, 15 or 16 of gestation in order to assess the stage specificity of cleft palate induction. Also, doses of 260, 390, 520 and 650 mg/kg were administered to pregnant rats on day 15 of gestation, and the dose‐response relationships with respect to fetal cleft palate and maternal methemo‐globinemia induction were studied. In the stage‐specificity study, paleness, decreased body weight gain and elevated methemoglobin concentration were noted in the dams treated with AH. Upon fetal examinations, although reduced body weight was noted in all AH‐treated groups, cleft palate was observed only in fetuses from those dams treated on day 15 of gestation. In the dose‐dependency study, AH induced maternal methemoglobinemia, decreased fetal body weight and increased the incidence of cleft palate dose dependently when administered at dosage levels of 260, 390, 520 and 650 mg/kg on day 15 of gestation. Additionally, administration of methylene blue, a methemoglobinemia‐preventing substance, to the AH‐treated dams ameliorated maternal methemoglobinemia and reduced the incidence of fetal cleft palate. In summation, it is considered that AH stage‐specifically induces cleft palate in rats and that cleft palate is caused not by a direct teratogenic effect of AH but by maternal hypoxia due to methemoglobinemia.","PeriodicalId":93953,"journal":{"name":"Congenital anomalies","volume":"131 1 Suppl 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81142997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Activities and Announcement 活动及公告

Congenital anomalies Pub Date : 2001-06-01 DOI: 10.1111/j.1741-4520.2001.tb00826.x

引用次数: 0