Clinical implant dentistry and related research最新文献

{"title":"Soft Tissue Augmentation at Single Implants With Collagen Matrix or Connective Tissue Graft: 7.5-Year Follow-Up of a RCT.","authors":"Margherita G Liguori, Franz J Strauss, Thomas J W Gasser, Ronald E Jung, Nadja Naenni, Daniel S Thoma","doi":"10.1111/cid.70146","DOIUrl":"10.1111/cid.70146","url":null,"abstract":"<p><strong>Aim: </strong>To compare up to 7.5-year clinical and patient-reported outcomes of implant sites previously augmented using a volume-stable collagen matrix (VCMX) or connective tissue graft (SCTG) in the esthetic zone.</p><p><strong>Methods: </strong>The original randomized controlled trial (RCT) enrolled 20 patients who received soft tissue augmentation with VCMX or SCTG at single implant sites. Clinical assessments and standardized measurements were performed at baseline after crown insertion (BL) and at 6 months, 1, 3, 5, and 7.5 years. The primary outcome was mucosal thickness. Secondary outcomes included marginal bone levels, probing depth, bleeding on probing, plaque index, pink esthetic score (PES), OHIP-14, and buccal profilometric changes. Group comparisons were performed using mixed-effects and generalized estimating equation (GEE) models, which account for within-patient correlations due to repeated measurements and allow inclusion of all available data without requiring imputation for missing observations.</p><p><strong>Results: </strong>Of the 20 originally recruited patients, 12 were available for re-examination at 7.5 years (five in the SCTG group and seven in the VCMX group). Mucosal thickness at crown delivery ranged from 2 to 4 mm across the study population. Adjusted mean differences (VCMX-SCTG) in mucosal thickness were +0.70 mm at BL, -0.02 mm at 6 months, +0.1 mm at 1 year, +0.1 mm at 3 years, +0.1 mm at 5 years and -0.1 mm at 7.5 years. None of these differences reached statistical significance (p > 0.05). For all secondary outcomes, no statistically significant inter-group differences were detected (p > 0.05) except for BOP at 5 years follow-up.</p><p><strong>Conclusion: </strong>Both augmentation approaches achieved stable peri-implant mucosal dimensions, preserved marginal bone levels, and favorable esthetic and patient-reported outcomes over 7.5 years. Volume-stable collagen matrices might be a viable alternative to SCTG for peri-implant soft-tissue augmentation; however, adequately powered RCTs are needed to confirm these long-term observations.</p><p><strong>Trials registration: </strong>DRKS00017484.</p>","PeriodicalId":93944,"journal":{"name":"Clinical implant dentistry and related research","volume":"28 2","pages":"e70146"},"PeriodicalIF":4.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Zirconia and Titanium Implants Placed at Two Supracrestal Levels in Fresh Extraction Socket: Canine Periodontitis Model\".","authors":"","doi":"10.1111/cid.70152","DOIUrl":"10.1111/cid.70152","url":null,"abstract":"","PeriodicalId":93944,"journal":{"name":"Clinical implant dentistry and related research","volume":"28 2","pages":"e70152"},"PeriodicalIF":4.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13484045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"3D-Analysis of Peri-Implant Soft Tissue Gain With Collagen Matrix and Connective Tissue Graft: A Randomized Control Trial\".","authors":"","doi":"10.1111/cid.70153","DOIUrl":"10.1111/cid.70153","url":null,"abstract":"","PeriodicalId":93944,"journal":{"name":"Clinical implant dentistry and related research","volume":"28 2","pages":"e70153"},"PeriodicalIF":4.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13484023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stepwise Modified Transcrestal Sinus Floor Elevation in Sites With 3-5-mm Residual Bone Height: A Retrospective Study.","authors":"Wenjun Duan, Kexin Yang, Katong Lo, Zheyuan Sun, Fang Wang, Feihong Gan, Jiakang Yang, Baixiang Wang","doi":"10.1111/cid.70150","DOIUrl":"10.1111/cid.70150","url":null,"abstract":"<p><strong>Objectives: </strong>This retrospective study compared the clinical and radiographic outcomes of a stepwise modified transcrestal sinus floor elevation (SM-TSFE) with the lateral sinus floor elevation (LSFE) for simultaneous implant placement in sites with 3-5 mm of residual bone height (RBH).</p><p><strong>Materials and methods: </strong>A total of 149 patients with 3-5-mm RBH underwent simultaneous implant placement using either SM-TSFE (n = 69) or LSFE (n = 80). The follow-up period ranged from 6 months to 8 years. Evaluated clinical outcomes included implant survival rates, sinus membrane perforation, and postoperative complications. Radiographic assessments included preoperative RBH, marginal bone loss (MBL), and vertical bone height changes.</p><p><strong>Results: </strong>Cumulative implant survival rates were comparable between SM-TSFE (91.30%) and LSFE (93.75%) groups (p = 0.537). However, the SM-TSFE group demonstrated a significantly lower sinus membrane perforation rate (7.24%) compared to the LSFE group (18.75%; p = 0.047). Multivariate analysis identified maxillary sinus septa as the strongest risk factor for perforation (p = 0.002). Regarding implant failure, TiUnite surface (p = 0.035) and membrane perforation (p = 0.039) were significant risk factors, while higher marginal bone height (MBH) was identified as a protective factor (p = 0.003). Both groups exhibited comparable MBL at 2 years post-loading (p > 0.05).</p><p><strong>Conclusion: </strong>In sites with 3-5 mm of RBH, SM-TSFE provides implant survival rates comparable to LSFE over the observation period but offers a significant safety advantage due to a substantially lower rate of sinus membrane perforation.</p>","PeriodicalId":93944,"journal":{"name":"Clinical implant dentistry and related research","volume":"28 2","pages":"e70150"},"PeriodicalIF":4.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thread Depth Effects on Stability and Positional Accuracy in Guided Immediate Implants: A Randomized Controlled Trial.","authors":"Na-Yoon Kwon, Ji-Young Jung, Kyung-A Ko, Seung-Hyun Park, Franz Josef Strauss, Jung-Seok Lee","doi":"10.1111/cid.70145","DOIUrl":"10.1111/cid.70145","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the influence of implant thread depth on implant stability and positional accuracy in fully guided immediate implant placement.</p><p><strong>Materials and methods: </strong>Fifty-four patients received a reference tapered (BLT), a standard-thread (MST), or a deep-thread implant (MDT). Fifty-four implants were placed using fully guided surgery and evaluated over 1-year follow-up. Primary outcomes were implant stability (insertion torque, ISQ, ISV). Secondary outcomes included positional accuracy and marginal bone level (MBL) at 12 months.</p><p><strong>Results: </strong>Primary and longitudinal stability were comparable across groups. Insertion torque was highest for MDT implants, followed by MST and BLT implants (BLT: 35.28 ± 11.18; MST: 40.00 ± 11.88; MDT: 43.89 ± 10.92 Ncm; p = 0.062). A higher proportion of MDT implants achieved insertion torque ≥ 40 Ncm (MDT: 14/18; MST: 12/18; BLT: 8/18). Angular deviation differed among implant groups (MDT: 5.57° ± 3.71°; BLT: 4.73° ± 2.46°; MST: 3.58° ± 1.81°; p = 0.062). In subgroup analysis comparing implants differing only in thread depth (MST vs. MDT), angular deviation was significantly greater for MDT (p = 0.029), particularly in molar sites. At 12 months, MBL did not differ significantly among groups.</p><p><strong>Conclusions: </strong>In fully guided immediate implant placement, deeper-thread implants showed higher insertion torque values but were associated with greater angular deviation, while longitudinal stability and marginal bone levels remained comparable. Deeper-thread designs may be beneficial when enhanced primary stability is required, provided careful angulation control is ensured.</p><p><strong>Trial registration: </strong>cris.nih.go.kr Identifier: KCT0009402; This clinical trial was not registered prior to participant recruitment and randomization.</p>","PeriodicalId":93944,"journal":{"name":"Clinical implant dentistry and related research","volume":"28 2","pages":"e70145"},"PeriodicalIF":4.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Estimated Role of Yes-Associated Protein in the Etiology of Peri-Implantitis: A Case-Control Study.","authors":"Samar Mohamed Emam, Mohamed Moataz Khamis, Medhat Haroun, Nermine Moussa","doi":"10.1111/cid.70148","DOIUrl":"10.1111/cid.70148","url":null,"abstract":"<p><strong>Objective: </strong>To investigate for the first time the difference in Yes-associated protein (YAP) gene expression and protein levels in the peri-implant crevicular fluid of healthy osseointegrated titanium implants and those showing early signs of peri-implantitis before loading; and to investigate the immunomodulatory effect of titanium on YAP expression by comparing YAP protein levels around healthy implants with those in the gingival crevicular fluid of healthy teeth.</p><p><strong>Materials and methods: </strong>Sixty-six systemically healthy individuals were recruited. Fold change in YAP gene expression was evaluated by q-PCR, and YAP protein level was measured by ELISA in clinical conditions of peri-implant health (n = 22) and peri-implantitis (n = 22) before insertion of implant-supported prosthesis to avoid the effect of loading on mechanosensitive YAP. The level of YAP protein was measured in healthy periodontal tissues (n = 22) in the absence of traumatic occlusion and compared with healthy peri-implant environment.</p><p><strong>Results: </strong>Statistical analysis revealed that YAP gene expression relatively increased by 35% in the presence of peri-implantitis with a non-significant p-value of 0.938. YAP protein levels pairwise comparison between the studied groups was statistically significant with p-value < 0.005. The least value of YAP was in healthy periodontium, followed by healthy peri-implant tissue and finally a remarkable increase in the presence of peri-implantitis. Gender was a significant predictor of YAP, with higher levels in females in the presence of implants.</p><p><strong>Conclusion: </strong>YAP is a recent biomarker that can predict the presence of inflammation in the peri-implant environment. YAP protein levels are the highest in the presence of titanium implants and early clinical and radiographic signs of peri-implantitis. Studying the YAP-related osteoimmunology of the peri-implant environment offers new insights into a better understanding of the osseointegration process and titanium-induced peri-implantitis.</p>","PeriodicalId":93944,"journal":{"name":"Clinical implant dentistry and related research","volume":"28 2","pages":"e70148"},"PeriodicalIF":4.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular Vesicles as Orchestrators of Osteoimmunomodulation in Peri-Implantitis: Implications for Bone Regeneration.","authors":"Marco Bonilla, María Carretero-Fernández, Juan Sainz, Francisco Mesa","doi":"10.1111/cid.70151","DOIUrl":"10.1111/cid.70151","url":null,"abstract":"<p><strong>Introduction: </strong>Peri-implantitis, characterized by inflammatory bone loss, is a leading cause of dental implant failure. Current regenerative strategies face limitations due to the persistent inflammatory microenvironment. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as promising acellular therapeutics with dual osteogenic and immunomodulatory capacities, offering a novel approach to address the complexity of peri-implant bone defects.</p><p><strong>Methods: </strong>This narrative review synthesizes preclinical evidence on MSC-EVs for peri-implant bone regeneration. It examines methods for EV isolation from various sources. Furthermore, it analyzes advanced engineered delivery systems, such as peptide-functionalized implant surfaces and bioactive scaffolds, designed to enhance local retention and therapeutic efficacy.</p><p><strong>Results: </strong>MSC-EVs orchestrate bone regeneration through multifaceted mechanisms. They directly stimulate osteogenesis by transferring pro-osteogenic miRNAs and proteins, activating key pathways like PI3K/AKT and Wnt/β-catenin. Crucially, they modulate the osteoimmune environment by reprogramming macrophages toward a reparative M2 phenotype, suppressing pro-inflammatory Th1/Th17 responses, and expanding regulatory T cells (Tregs). Concurrently, MSC-EVs inhibit bone resorption by favorably modulating the RANKL/OPG balance and directly interfering with osteoclast differentiation. They also promote neovascularization, a critical factor for healing in ischemic zones. Preclinical models demonstrate that localized delivery via engineered systems significantly enhances osseointegration, bone-implant contact, and regeneration of functional bone-vessel units.</p><p><strong>Conclusion: </strong>MSC-EVs represent a promising and multifaceted therapeutic strategy for bone regeneration in peri-implantitis, simultaneously targeting inflammation, bone resorption, and osteogenesis. While robust preclinical evidence supports their role in halting bone loss and promoting structured regeneration, successful clinical translation requires further standardization, optimization of delivery, and validation in human trials.</p>","PeriodicalId":93944,"journal":{"name":"Clinical implant dentistry and related research","volume":"28 2","pages":"e70151"},"PeriodicalIF":4.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extent of Implantoplasty in the Combined Surgical Therapy of Peri-Implantitis: A Quasi-Randomized Clinical Trial.","authors":"Alberto Monje, Ramon Pons, Conrado Aparicio, Dennis Tarnow, Paul S Rosen, José Nart","doi":"10.1111/cid.70144","DOIUrl":"10.1111/cid.70144","url":null,"abstract":"<p><strong>Objective: </strong>The present study aimed to compare the clinical and radiographic performance of full-length implantoplasty (FLIP) versus partial-length implantoplasty (PLIP) for the supracrestal component as part of combined surgical therapy for peri-implantitis with a ≥ 3 mm depth at the intrabony component.</p><p><strong>Materials and methods: </strong>A single-center, prospective, randomized, controlled, two-arm comparative study was conducted to evaluate the extent of implantoplasty-limited to the supracrestal component (PLIP) or extending to both supracrestal and intrabony components (FLIP)-in the combined surgical management of peri-implantitis. Clinical and radiographic outcomes were assessed 1 year after surgery. Disease resolution was defined using a composite of clinical and radiographic criteria, although sample size was calculated for pocket depth reduction. Generalized estimating equations were applied to calculate unadjusted and adjusted odds ratios.</p><p><strong>Results: </strong>A total of 33 patients (N_implants = 40) completed the study. All evaluated clinical parameters in both groups showed statistically significant changes over the study period. A significant intergroup difference was observed for modified sulcus bleeding index (mSBI), favoring FLIP (p = 0.003). Marginal recession (MR) was significantly greater in the FLIP group compared with the PLIP group (p = 0.006) and was more pronounced in the posterior mandible (p = 0.002). No other clinical parameters differed significantly between groups. Regarding marginal bone level (MBL) gain, FLIP demonstrated a statistically significant advantage over PLIP in the adjusted model (p = 0.009). For the remaining radiographic variables, significant changes were observed at the 1-year follow-up assessment, but no significant intergroup differences were detected. Overall disease resolution was achieved in 77.5% of cases. The adjusted model showed no statistically significant difference between the tested groups (OR = 14; p = 0.13). Smoking was consistently associated with less favorable clinical and radiographic outcomes. No major postoperative complications were reported.</p><p><strong>Conclusion: </strong>Combined surgical therapy for peri-implantitis, including implantoplasty and regeneration of the intrabony component, is effective in arresting disease progression and restoring peri-implant health. Extending implantoplasty to the contained intrabony compartment appears to provide additional clinical and radiographic benefits. However, this advantage comes at the expense of increased mucosal recession, highlighting the need for careful case selection and patient counseling.</p>","PeriodicalId":93944,"journal":{"name":"Clinical implant dentistry and related research","volume":"28 2","pages":"e70144"},"PeriodicalIF":4.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Radiographic Outcomes of Transcrestal Sinus Floor Elevation With RBH of 3-5 mm: A Retrospective Study.","authors":"Qianhui Li, Mengyuan Zhang, Jiafei Sun, Yingjie Mao, Fuming He, Qianming Chen, Ping Sun","doi":"10.1111/cid.70143","DOIUrl":"10.1111/cid.70143","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the clinical and radiographic outcomes of transcrestal sinus floor elevation (TSFE) with simultaneous implant placement in sites with residual bone height (RBH) of 3-5 mm.</p><p><strong>Materials and methods: </strong>This retrospective cohort study included patients who underwent TSFE with simultaneous implant placement between December 2017 and September 2023. According to the intraoperative bone grafting status, patients were divided into two groups: the non-grafting group and the grafting group (Bio-Oss Collagen). Patient medical histories were collected, and radiographic parameters were measured at the following timepoints: preoperative (T0), immediate postoperative (T1), healing phase (T2, 4-6 months postoperatively), and follow-up period (T3, 1-6 years postoperatively). Implant survival rate, complication-free survival rate, incidence of sinus membrane perforation (SMP), endo-sinus bone gain volume (ESBGV), endo-sinus bone gain height (ESBGH), marginal bone loss (MBL), apical bone height (ABH), and mean cost of treatment were evaluated. A linear mixed model (LMM) regression was employed to identify key determinants influencing endo-sinus bone augmentation following TSFE.</p><p><strong>Results: </strong>Sixty-six dental implants placed in 57 patients were included (non-grafting group: 26 implants in 21 patients; grafting group: 40 implants in 36 patients). After the 1- to 6-year follow-up, the survival rate of implants was 100% in two groups (p > 0.05) and complication-free survival rate was 84.85% at implant level (non-grafting group: 80.77%, grafting group: 87.50%; p > 0.05) and 82.46% at patient level (non-grafting group: 76.19%, grafting group: 86.11%; p > 0.05). The incidence of SMP was 11.54% and 10.00% in non-grafting and grafting groups, respectively (p > 0.05). ESBGV, ESBGH, and ABH were significantly greater in the grafting group compared to the non-grafting group (p < 0.05). No significant differences in MBL were found (p > 0.05). The total treatment cost was significantly lower in the non-grafting group than in the grafting group (p < 0.05), whereas no significant difference was found in retreatment costs between the groups (p > 0.05). The LMM regression results showed that the core determinant of ESBGV was postoperative maxillary sinus augmentation volume (p < 0.05).</p><p><strong>Conclusion: </strong>Within the limitations of this study, TSFE with simultaneous implant placement demonstrated medium- to long-term stable clinical and radiographic outcomes in the posterior atrophic maxilla ridges with RBH ranging from 3 to 5 mm regardless of bone grafting. While the grafting strategy significantly enhanced endo-sinus bone augmentation, the non-grafted approach was associated with significantly lower overall treatment costs.</p>","PeriodicalId":93944,"journal":{"name":"Clinical implant dentistry and related research","volume":"28 2","pages":"e70143"},"PeriodicalIF":4.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}