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Canadian journal of diabetes最新文献

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NOX5 LINKS OXIDATIVE STRESS AND ENDOPLASMIC RETICULUM STRESS TO ENABLE VASCULAR SMOOTH MUSCLE CELL PHENOTYPIC SWITCHING IN HYPERTENSION Nox5连接氧化应激和内质网应激，使高血压血管平滑肌细胞表型转换
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.336
L. Camargo, S. Mary, S. Lilla, S. Zanivan, R. Hartley, C. Delles, W. Fuller, Y. Wang, F. Rios, A. Montezano, R. Touyz
{"title":"NOX5 LINKS OXIDATIVE STRESS AND ENDOPLASMIC RETICULUM STRESS TO ENABLE VASCULAR SMOOTH MUSCLE CELL PHENOTYPIC SWITCHING IN HYPERTENSION","authors":"L. Camargo, S. Mary, S. Lilla, S. Zanivan, R. Hartley, C. Delles, W. Fuller, Y. Wang, F. Rios, A. Montezano, R. Touyz","doi":"10.1016/j.jcjd.2023.10.336","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.336","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IMPACT OF SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITORS ON QUALITY OF LIFE IN HEART FAILURE ACROSS THE EJECTION FRACTION SPECTRUM: SYSTEMATIC REVIEW AND META-ANALYSIS 钠-葡萄糖共转运蛋白-2抑制剂对射血分数范围内心力衰竭患者生活质量的影响:系统回顾和荟萃分析
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.319
Y. Shah, R. Turgeon
{"title":"IMPACT OF SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITORS ON QUALITY OF LIFE IN HEART FAILURE ACROSS THE EJECTION FRACTION SPECTRUM: SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"Y. Shah, R. Turgeon","doi":"10.1016/j.jcjd.2023.10.319","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.319","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CYSTIC FIBROSIS-RELATED DIABETES DEVELOPS FROM A COMBINATION OF INSULIN SECRETORY DEFECTS AND INSULIN RESISTANCE 囊性纤维化相关性糖尿病是胰岛素分泌缺陷和胰岛素抵抗的结合
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.241
M. Bolduc, K. Potter, M. Olmos, A. Bonhoure, A. Coriati, F. Tremblay, A. Lavoie, M. Carricart, P. Senior, V. Boudreau, R. Rabasa-Lhoret
{"title":"CYSTIC FIBROSIS-RELATED DIABETES DEVELOPS FROM A COMBINATION OF INSULIN SECRETORY DEFECTS AND INSULIN RESISTANCE","authors":"M. Bolduc, K. Potter, M. Olmos, A. Bonhoure, A. Coriati, F. Tremblay, A. Lavoie, M. Carricart, P. Senior, V. Boudreau, R. Rabasa-Lhoret","doi":"10.1016/j.jcjd.2023.10.241","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.241","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
QUANTIFICATION OF NEUROVASCULATURE CHANGES IN A POST-HEMORRHAGIC STROKE ANIMAL-MODEL 出血性脑卒中动物模型神经血管变化的定量分析
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.346
O. Perry, M. Doschak, N. Daneshtalab
{"title":"QUANTIFICATION OF NEUROVASCULATURE CHANGES IN A POST-HEMORRHAGIC STROKE ANIMAL-MODEL","authors":"O. Perry, M. Doschak, N. Daneshtalab","doi":"10.1016/j.jcjd.2023.10.346","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.346","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"323 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE LONG-CHAIN FATTY-ACID RECEPTOR FFA4 STIMULATES INSULIN SECRETION VIA INHIBITION OF SOMATOSTATIN RELEASE FROM DELTA CELL 长链脂肪酸受体ffa4通过抑制生长抑素释放来刺激胰岛素分泌
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.176
L. Reininger, N. Cinque, C. Tremblay, M. Ethier, J. Ghislain, M. Huising, V. Poitout
{"title":"THE LONG-CHAIN FATTY-ACID RECEPTOR FFA4 STIMULATES INSULIN SECRETION VIA INHIBITION OF SOMATOSTATIN RELEASE FROM DELTA CELL","authors":"L. Reininger, N. Cinque, C. Tremblay, M. Ethier, J. Ghislain, M. Huising, V. Poitout","doi":"10.1016/j.jcjd.2023.10.176","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.176","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"389 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STABILITY OF A1C VALUES OVER TIME AMONG ADULTS WITH TYPE 1 DIABETES: A MULTISTATE MODEL FROM A RETROSPECTIVE POPULATION-BASED COHORT STUDY 成年1型糖尿病患者a1c值随时间的稳定性:来自回顾性人群队列研究的多状态模型
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.219
L. Lovblom, K. Everett, G. Booth, G. Tomlinson, A. Weisman
{"title":"STABILITY OF A1C VALUES OVER TIME AMONG ADULTS WITH TYPE 1 DIABETES: A MULTISTATE MODEL FROM A RETROSPECTIVE POPULATION-BASED COHORT STUDY","authors":"L. Lovblom, K. Everett, G. Booth, G. Tomlinson, A. Weisman","doi":"10.1016/j.jcjd.2023.10.219","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.219","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TYPE 2 DIABETES REMISSION WITH AN INTENSIVE MULTIDISCIPLINARY INTERVENTION: THE DIABEPIC 2 PILOT STUDY 2型糖尿病缓解与强化多学科干预:2型糖尿病试点研究
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.224
V. Dionne, J. Iglesies-Grau, E. Latour, F. Besnier, D. Maxime, C. Gagnon, M. Gayda, M. Juneau, A. Nigam, P. L'Allier, F. Simard, L. Bherer, V. Pelletier
{"title":"TYPE 2 DIABETES REMISSION WITH AN INTENSIVE MULTIDISCIPLINARY INTERVENTION: THE DIABEPIC 2 PILOT STUDY","authors":"V. Dionne, J. Iglesies-Grau, E. Latour, F. Besnier, D. Maxime, C. Gagnon, M. Gayda, M. Juneau, A. Nigam, P. L'Allier, F. Simard, L. Bherer, V. Pelletier","doi":"10.1016/j.jcjd.2023.10.224","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.224","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IMPACT OF MFN2 DELETION ON INSULIN SECRETION AND TRANSIENT MITOCHONDRIAL PERMEABILITY TRANSITION PORE OPENING IN HUMAN ENDOCBH3 BETA CELLS mfn2缺失对人endocbh3 β细胞胰岛素分泌和瞬时线粒体通透性过渡孔打开的影响
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.169
R. Melhem, L. Delgadillo Silva, G. Rutter
{"title":"IMPACT OF MFN2 DELETION ON INSULIN SECRETION AND TRANSIENT MITOCHONDRIAL PERMEABILITY TRANSITION PORE OPENING IN HUMAN ENDOCBH3 BETA CELLS","authors":"R. Melhem, L. Delgadillo Silva, G. Rutter","doi":"10.1016/j.jcjd.2023.10.169","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.169","url":null,"abstract":"Mitofusins are membrane-bound GTPases responsible for the fusion of mitochondria in mammalian cells and, thus, the maintenance of an interconnected mitochondrial network. Correspondingly, mutations in human MFN2 are associated with lipodystrophies and increased diabetes risk. Our group has recently reported that deleting the mouse homologues Mfn1 and Mfn2 selectively in the beta cell results in mitochondrial fragmentation, severely impaired insulin secretion, and hyperglycemia (Georgiadou et al, Diabetes, 2022). The latter is partly reversed by treatment with glucagon-like peptide-1 receptor (GLP1R) agonists, such as exednin-4 (Ex4). Whether these findings also apply to human beta cells has been unclear up to now.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"145 7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COMPARISON OF THE EFFECTS OF SEMAGLUTIDE ON LIVER HISTOLOGY IN PATIENTS WITH NON-ALCOHOLICS STEATOHEPATITIS CIRRHOSIS BETWEEN MACHINE LEARNING MODEL ASSESSMENT AND PATHOLOGIST EVALUATION 西马鲁肽对非酒精性脂肪性肝炎肝硬化患者肝脏组织学影响的机器学习模型评估与病理评估比较
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.286
D. Grbic, R. Loomba, V. Cejvanovic, J. Iyer, M. Kjaer, N. Krarup, A. Sejling, J. Pericas
{"title":"COMPARISON OF THE EFFECTS OF SEMAGLUTIDE ON LIVER HISTOLOGY IN PATIENTS WITH NON-ALCOHOLICS STEATOHEPATITIS CIRRHOSIS BETWEEN MACHINE LEARNING MODEL ASSESSMENT AND PATHOLOGIST EVALUATION","authors":"D. Grbic, R. Loomba, V. Cejvanovic, J. Iyer, M. Kjaer, N. Krarup, A. Sejling, J. Pericas","doi":"10.1016/j.jcjd.2023.10.286","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.286","url":null,"abstract":"In trials of non-alcoholic steatohepatitis (NASH), liver biopsies are evaluated by pathologists; however, machine learning (ML) has shown promise in assessing biopsies. PathAI has developed ML models to provide such assessments. This post-hoc analysis included data from a randomized, double-blind, placebo-controlled phase 2 trial (NCT03987451) of patients with compensated NASH cirrhosis to study the effects of semaglutide on individual histological components of NASH assessed by the ML models.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"335 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ROLE OF LOW-DOSE ASPIRIN FOR THE PRIMARY PREVENTION OF ISCHEMIC VASCULAR EVENTS: AN UPDATED SYSTEMATIC REVIEW AND META-ANALYSIS 低剂量阿司匹林对缺血性血管事件一级预防的作用:一项最新的系统综述和荟萃分析
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.351
C. Moazzami, C. Laferrière, B. Potter, M. Lordkipanidze, G. Marquis-Gravel, A. Fama, K. Bainey, E. Belley-Cote
{"title":"ROLE OF LOW-DOSE ASPIRIN FOR THE PRIMARY PREVENTION OF ISCHEMIC VASCULAR EVENTS: AN UPDATED SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"C. Moazzami, C. Laferrière, B. Potter, M. Lordkipanidze, G. Marquis-Gravel, A. Fama, K. Bainey, E. Belley-Cote","doi":"10.1016/j.jcjd.2023.10.351","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.351","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"332 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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