Brain communications最新文献

{"title":"Noninvasive classification of physiological and pathological high frequency oscillations in children.","authors":"Lorenzo Fabbri, Eleonora Tamilia, Margherita A G Matarrese, Linh Tran, Saleem I Malik, Dave Shahani, Cynthia G Keator, Steven M Stufflebeam, Phillip L Pearl, M Scott Perry, Christos Papadelis","doi":"10.1093/braincomms/fcaf170","DOIUrl":"10.1093/braincomms/fcaf170","url":null,"abstract":"<p><p>High frequency oscillations have been extensively investigated as interictal biomarkers of epilepsy. Yet, their value is largely debated due to the presence of physiological oscillations, which complicate distinguishing between normal versus abnormal events. So far, this debate has been addressed using intracranial EEG data from patients with drug-resistant epilepsy. Yet, this approach suffers from inability to record control data from healthy subjects and lack of whole brain coverage. Here, we aim to differentiate physiological from pathological high frequency oscillations using non-invasive whole brain electrophysiological recordings from children with drug-resistant epilepsy and typically developing controls. We recorded high-density EEG and magnetoencephalography data from 47 controls (median age: 11 years; 25 females) and 54 children with drug-resistant epilepsy (median age: 14 years, 33 females). We detected high frequency oscillations (in ripple frequency band) semi-automatically and localized their cortical generators through electric or magnetic source imaging. From each ripple, we extracted a set of temporal, morphological, spectral and spatial features. We then compared the features between ripples recorded from the epileptic brain (further distinguished into those from epileptogenic and non-epileptogenic regions) and those recorded from the control group (normal brain). We used these features to cross-validate a Naïve-Bayes algorithm for classifying each ripple recorded from children with epilepsy as coming from an epileptogenic region or not. We observed more high frequency oscillations on EEG than magnetoencephalography recordings (<i>P</i> < 0.001) both in the epilepsy and control groups. Physiological high frequency oscillations (recorded from controls) showed lower power, shorter duration and less variability (in both amplitude and duration) than those recorded from the epilepsy group (<i>P</i> < 0.001). Inter-channel latency of physiological ripples was longer compared to ripples from the epileptogenic regions (<i>P</i> < 0.01), while it was similar to the ripples from non-epileptogenic regions (<i>P</i> > 0.05). Ripples from epileptogenic regions showed larger extent than those from non-epileptogenic regions or from the control group (<i>P</i> < 0.001). The classification model showed an accuracy of 73%, with negative and positive predictive values of 73% and 70% (<i>P</i> < 0.0001), respectively, in classifying high frequency oscillations from the drug-resistant epilepsy group (as either epileptogenic or not). Our study indicates that physiological high frequency oscillations, recorded from the healthy brain, have distinct temporal, morphological, spectral and spatial features compared to those generated by the epileptic brain. The differentiation of pathological from physiological high frequency oscillations through non-invasive full-head techniques may augment the presurgical evaluation process of children with drug-re","PeriodicalId":93915,"journal":{"name":"Brain communications","volume":"7 3","pages":"fcaf170"},"PeriodicalIF":4.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological features of post-stroke pain: a comprehensive analysis for subtypes.","authors":"Yuki Igawa, Michihiro Osumi, Yusaku Takamura, Hidekazu Uchisawa, Shinya Iki, Takeshi Fuchigami, Shinji Uragami, Yuki Nishi, Nobuhiko Mori, Koichi Hosomi, Shu Morioka","doi":"10.1093/braincomms/fcaf128","DOIUrl":"https://doi.org/10.1093/braincomms/fcaf128","url":null,"abstract":"<p><p>Post-stroke pain is heterogeneous and includes both nociceptive and neuropathic pain. These subtypes can be comprehensively assessed using several clinical tools, such as pain-related questionnaires, quantitative somatosensory tests and brain imaging. In the present study, we conducted a comprehensive assessment of patients with central post-stroke pain and non-central post-stroke pain and analysed their clinical features. We also performed a detailed analysis of the relationships between brain lesion areas or structural disconnection of the white matter and somatosensory dysfunctions. In this multicentre cross-sectional study, 70 patients were divided into 24 with central post-stroke pain, 26 with non-central post-stroke pain and 20 with no-pain groups. Multiple logistic regression analysis was used to summarize the relationships between each pathological feature (for the central post-stroke pain and non-central post-stroke pain groups) and pain-related factors or the results of quantitative somatosensory tests. Relationships between somatosensory dysfunctions and brain lesion areas were analysed using voxel-based lesion-symptom mapping and voxel-based disconnection-symptom mapping. All pathology feature models indicated that central post-stroke pain was associated with cold hypoesthesia at 8°C (β = 2.98, odds ratio = 19.6, 95% confidence interval = 2.7-141.8), cold hyperalgesia at 8°C (β = 2.61, odds ratio = 13.6, 95% confidence interval = 1.13-163.12) and higher Neuropathic Pain Symptom Inventory scores (for spontaneous and evoked pain items only; β = 0.17, odds ratio = 1.19, 95%, confidence interval = 1.07-1.32), whereas non-central post-stroke pain was associated with joint pain (β = 5.01, odds ratio = 149.854, 95%, confidence interval = 19.93-1126.52) and lower Neuropathic Pain Symptom Inventory scores (β = -0.17, odds ratio = 0.8, 95%, confidence interval = 0.75-0.94). In the voxel-based lesion-symptom mapping, the extracted lesion areas indicated mainly voxels significantly associated with cold hyperalgesia, allodynia at 8°C and 22°C and heat hypoesthesia at 45°C. These extracted areas were mainly in the putamen, insular cortex, hippocampus, Rolandic operculum, retrolenticular part of internal and external capsules and sagittal stratum. In voxel-based disconnection-symptom mapping, the extracted disconnection maps were significantly associated with cold hyperalgesia at 8°C, and heat hypoesthesia at 37°C and 45°C. These structural disconnection patterns were mainly in the cingulum frontal parahippocampal tract, the reticulospinal tract and the superior longitudinal fasciculus with a widespread interhemispheric disconnection of the corpus callosum. These findings serve as important indicators to facilitate decision-making and optimize precision treatments through data dimensionality reduction when diagnosing post-stroke pain using clinical assessments, such as bedside quantitative sensory testing, pain-related factors, pain questionna","PeriodicalId":93915,"journal":{"name":"Brain communications","volume":"7 3","pages":"fcaf128"},"PeriodicalIF":4.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The risk of neurotechnology as an instrument of colonialism.","authors":"Judy Illes, Makarena Dudley, Lucia Machova Urdzikova, Ioana Podina, Monique Pyrrho","doi":"10.1093/braincomms/fcaf139","DOIUrl":"https://doi.org/10.1093/braincomms/fcaf139","url":null,"abstract":"<p><p>Illes et al. focus on strategies and solutions to prevent neurotechnologies from being used to perpetuate colonial power dynamics.</p>","PeriodicalId":93915,"journal":{"name":"Brain communications","volume":"7 3","pages":"fcaf139"},"PeriodicalIF":4.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference range for serum neurofilament light chain: findings from healthy Thai adults.","authors":"Nontapat Sukhonpanich, Tatchaporn Ongphichetmetha, Ekdanai Uawithya, Jiraporn Jitprapaikulsan, Natthapon Rattanathamsakul, Naraporn Prayoonwiwat, Sasitorn Siritho","doi":"10.1093/braincomms/fcaf166","DOIUrl":"https://doi.org/10.1093/braincomms/fcaf166","url":null,"abstract":"<p><p>Serum neurofilament light chain is a notable biomarker for detecting axonal injury and has shown significant potential for clinical applications. Establishing a reference interval and cut-off level is a critical step towards implementing a serum neurofilament light chain in routine clinical practice. In this study, we aimed to establish a reference range of serum neurofilament light chains for the Thai population. Blood samples were collected from healthy Thai adults without a history of neurological diseases and screened at the Siriraj Hospital. The relationship between age, sex and log₁₀-transformed serum neurofilament light chain levels was analysed using linear regression. A crude reference interval was calculated as the 2.5-97.5th percentile values. An age-normative percentile curve for serum neurofilament light chain was derived using the generalized additive model for location, scale and shape. A total of 223 subjects (96 males and 127 females) aged 18-70 years were recruited. Male sex (<i>P</i> = 0.008) and older age (<i>P</i>  <i><</i> 0.001) were significantly associated with higher serum neurofilament light chain levels. A median of the observed serum neurofilament light chain values was 5.8 pg/ml (95% confidence interval 5.4-6.2), ranging from 1.0 to 18.4 pg/ml, with a crude reference interval of 2.3-15.9 pg/ml. The 2.5-97.5th percentile intervals for serum neurofilament light chain by age group were as follows: 20-29 years (<i>n</i> = 57): 1.7-8.7 pg/ml; 30-39 years (<i>n</i> = 58): 2.5-10.6 pg/ml; 40-49 years (<i>n</i> = 59): 3.5-14.3 pg/ml; 50-59 years (<i>n</i> = 37): 4.7-15.8 pg/ml and 60-69 years (<i>n</i> = 12): 4.2-18.2 pg/ml. The age-normative serum neurofilament light chain curve predicted the 97.5th percentile of 8.2, 9.9, 11.7, 14.6 and 19.9 pg/ml for ages 20, 30, 40, 50 and 60, respectively. This study is the first to establish reference values for serum neurofilament light chains in Thailand. The age-normative upper reference curve is closely aligned with observed values and those previously reported in other studies, providing a robust framework for clinical implementation. However, further validation in larger cohorts and among individuals with neurological diseases is warranted.</p>","PeriodicalId":93915,"journal":{"name":"Brain communications","volume":"7 3","pages":"fcaf166"},"PeriodicalIF":4.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Analysis of DNA from brain tissue on stereo-EEG electrodes reveals mosaic epilepsy-related variants.","authors":"","doi":"10.1093/braincomms/fcaf160","DOIUrl":"https://doi.org/10.1093/braincomms/fcaf160","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/braincomms/fcaf113.].</p>","PeriodicalId":93915,"journal":{"name":"Brain communications","volume":"7 2","pages":"fcaf160"},"PeriodicalIF":4.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain biopsy and metagenomic sequencing enhance aetiological diagnosis of encephalitis.","authors":"Yusuke Sakiyama, Jun-Hui Yuan, Akiko Yoshimura, Mika Takeuchi, Yoshimitsu Maki, Takuma Mori, Jun Takei, Masahiro Ando, Yu Hiramatsu, Satoshi Nozuma, Yujiro Higuchi, Hajime Yonezawa, Mari Kirishima, Masayuki Suzuki, Takahiro Kano, Monami Tarisawa, Shunta Hashiguchi, Misako Kunii, Shoki Sato, Ikuko Takahashi-Iwata, Akihiro Hashiguchi, Eiji Matsuura, Shuji Izumo, Akihide Tanimoto, Hiroshi Takashima","doi":"10.1093/braincomms/fcaf165","DOIUrl":"https://doi.org/10.1093/braincomms/fcaf165","url":null,"abstract":"<p><p>Identifying the aetiology of CNS diseases, regardless of their infectious or non-infectious nature, is often intricate. Next-generation sequencing (NGS) has emerged as a powerful tool for sensitive and unbiased screening of tissue or body fluid specimens. This study aimed to investigate the underlying aetiology of patients with suspected infectious CNS diseases. Between April 2013 and October 2021, we collected brain tissue samples from 33 patients diagnosed with encephalitis or encephalitis-like CNS diseases, obtained via biopsy or autopsy, and underwent metagenomic NGS (mNGS) in conjunction with pathological evaluations. Moreover, we employed PCR-based assays and pathogen-specific immunostaining to corroborate the presence of pathogens within the tissue samples. Among the 33 patients, mNGS elucidated pathogen-specific genomic sequences in 7 cases (21.2%), including halobacteria (archaea), <i>Balamuthia mandrillaris</i>, Epstein-Barr virus, <i>Toxoplasma gondii</i> and herpes simplex virus. Additionally, brain tissue mNGS ruled out known pathogens, identifying 14 cases (42.4%) of non-infectious CNS diseases, which included neoplastic, autoimmune/inflammatory and amyloid angiopathy conditions. The adjustment of therapeutic strategies based on these findings led to improvements in clinical symptoms, imaging outcomes and patient prognosis. Brain biopsy serves as both a direct pathological research target and a valuable source of samples for unbiased high-throughput sequencing. Our study illustrates the reliability of mNGS on brain tissue, which significantly improves the diagnostic rate for suspected encephalitis or encephalitis-like diseases of unknown aetiology. These findings underscore the importance of mNGS in guiding more precise and effective therapeutic interventions for patients in clinical practice.</p>","PeriodicalId":93915,"journal":{"name":"Brain communications","volume":"7 3","pages":"fcaf165"},"PeriodicalIF":4.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular risk factor associations with subjective cognitive decline and mild behavioural impairment.","authors":"Dylan X Guan, Aditya Aundhakar, Sarah Tomaszewski Farias, Clive Ballard, Byron Creese, Anne Corbett, Ellie Pickering, Pamela Roach, Eric E Smith, Zahinoor Ismail","doi":"10.1093/braincomms/fcaf163","DOIUrl":"10.1093/braincomms/fcaf163","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Subjective cognitive decline and mild behavioural impairment identify older persons more likely to have early Alzheimer's disease. Vascular co-pathologies may also contribute to new onset and persistent cognitive and behavioural symptoms later in life. We investigated vascular risk factor associations with subjective cognitive decline and mild behavioural impairment. Cross-sectional data for 1285 (81.0% female) participants without mild cognitive impairment or dementia enrolled in the Canadian Platform for Research Online to Investigate Health, Quality of Life, Cognition, Behaviour, Function, and Caregiving in Aging were analyzed. Vascular risk factors included body mass index class, self-reported clinician diagnoses of hypertension, high cholesterol, diabetes, self-reported smoking, and the cumulative number of vascular risk factors. Outcomes were the Everyday Cognition scale and Mild Behavioural Impairment Checklist. Logistic and negative binomial regressions were used to model odds and severity of subjective cognitive decline and mild behavioural impairment as a function of individual or cumulative vascular risk factors. Having three or more vascular risk factors (odds ratio = 1.23, 95% confidence interval [1.04-1.47]), actively smoking (odds ratio = 1.54, 95% confidence interval [1.29-1.82]), being overweight (odds ratio = 1.46, 95% confidence interval [1.22-1.74]), and having diabetes (odds ratio = 1.29, 95% confidence interval [1.09-1.53]) were associated with higher odds of subjective cognitive decline. Having any number of vascular risk factors was dose-dependently associated with higher odds of mild behavioural impairment, as were all five vascular risk factors individually; active smokers (odds ratio = 2.67, 95% confidence interval [2.25-3.18]) and obese persons (odds ratio = 2.29, 95% confidence interval [1.91-2.75]) had over twice the odds of mild behavioural impairment. Vascular risk factors associations with subjective cognitive decline were stronger in participants with mild behavioural impairment. All vascular risk factors were linked to higher Everyday Cognition and Mild Behavioural Impairment Checklist total scores, indicating greater subjective cognitive decline and mild behavioural impairment symptom severity. Overweight body mass index, hypertension, and high cholesterol associations with subjective cognitive decline and mild behavioural impairment were stronger in middle-aged adults than older adults, but diabetes and active smoking had greater effects in older adults. Vascular risk factors are strongly related to experiences of cognitive and behavioural changes in later life, even in the absence of objective cognitive impairment. Furthermore, vascular associations with subjective cognitive decline symptoms may be more pronounced in persons with concomitant behavioural decline. Vascular pathologies may contribute to both cognitive and behavioural markers traditionally linked to Alzheimer's disease in older persons, pri","PeriodicalId":93915,"journal":{"name":"Brain communications","volume":"7 3","pages":"fcaf163"},"PeriodicalIF":4.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding migraine disorders: parathyroid hormone-related peptide receptors as key genetic drivers.","authors":"Andreia Dias, Marta Ferreira, Mariana Santos, Alda Sousa, Carla Oliveira, Miguel Alves-Ferreira, Carolina Lemos","doi":"10.1093/braincomms/fcaf142","DOIUrl":"https://doi.org/10.1093/braincomms/fcaf142","url":null,"abstract":"<p><p>Migraine is a complex neurological disorder, and the most common migraine categories are migraine with aura and without aura. The higher prevalence of migraine in related individuals compared to the general population indicates a potential genetic predisposition; however, gene expression, which is influenced by both genetic and environmental factors, can also be a major factor in the migraine susceptibility. Given the high number of Portuguese migraine patients whose diagnosis and treatment have not yet been well established, we decided to carry out a whole transcriptome analysis within a migraine Portuguese cohort. This study aims to identify potential biomarkers that could contribute to improved migraine therapy. We performed total RNA sequencing on whole blood samples from 15 migraine patients and 12 age-matched controls. Differential expression analysis and gene set enrichment analysis were performed in different migraine subgroups. Finally, we performed the protein-protein interaction networks of differentially expressed genes. Gene set enrichment analysis comparing migraine patients with controls highlighted upregulated pathways linked to metabolism, and downregulated immuno-inflammatory pathways. Moreover, the groups of female migraine patients and female migraine without aura patients emphasized significant upregulated pathways, including G protein-coupled receptors signalling pathways, when compared with female controls. Interestingly, we found two important differentially expressed genes related to parathyroid hormone: <i>PTH1R</i> and <i>PTH2</i>. <i>PTH1R</i> was upregulated in female migraine without aura versus female controls, while <i>PTH2</i> was both upregulated between female migraine patients and female controls, as well as between female migraine without aura and controls. Here, we show, for the first time, the involvement of parathyroid hormone receptors and their associated gene expression patterns in female migraine patients. These molecules stand out as sturdy and promising biomarkers for innovative therapeutic in female migraine patients.</p>","PeriodicalId":93915,"journal":{"name":"Brain communications","volume":"7 2","pages":"fcaf142"},"PeriodicalIF":4.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombolysis for acute ischaemic stroke: development and update.","authors":"Jiashuo Lin, Wenbo Zuo, Huijuan Jin, Quanwei He, Shengcai Chen, Bo Hu, Yan Wan","doi":"10.1093/braincomms/fcaf164","DOIUrl":"https://doi.org/10.1093/braincomms/fcaf164","url":null,"abstract":"<p><p>Thrombolytic therapy is a cornerstone in managing acute ischaemic stroke, marking significant advancements in treatment. Various generations of thrombolytics play crucial roles in different strategies, including intravenous thrombolysis, bridging therapy and thrombolysis beyond the conventional time window. The continuous development of thrombolytics has brought notable improvements. Compared to first-generation urokinase, second-generation alteplase and third-generation tenecteplase offer significant pharmacological advantages, such as enhanced fibrin specificity and longer half-lives. Tenecteplase demonstrates non-inferiority to alteplase regarding efficacy and safety, with the added benefit of a more convenient administration method. Ongoing trials continue to reveal additional evidence. Furthermore, other thrombolytic agents, including reteplase and non-immunogenic recombinant staphylokinase, are gaining increasing interest in the medical community. This review examines the structural characteristics, pharmacological properties, efficacy and safety profiles of these thrombolytic drugs. It also provides a detailed analysis of the performance of thrombolytic therapy in different acute ischaemic stroke patient subgroups, aiming to trace the evolution of these treatments and compare their effectiveness in acute ischaemic stroke. The goal is to offer a scientific basis for clinical practices and future development of thrombolytic therapies.</p>","PeriodicalId":93915,"journal":{"name":"Brain communications","volume":"7 3","pages":"fcaf164"},"PeriodicalIF":4.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical routes to preregistration: a guide to enhanced transparency and rigour in neuropsychological research.","authors":"Richard J Binney, Laura J Smith, Stephanie Rossit, Nele Demeyere, Gemma Learmonth, Elena Olgiati, Ajay D Halai, Elisabeth Rounis, Jonathan Evans, Nicola M J Edelstyn, Robert D McIntosh","doi":"10.1093/braincomms/fcaf162","DOIUrl":"https://doi.org/10.1093/braincomms/fcaf162","url":null,"abstract":"<p><p>Preregistration is the act of formally documenting a research plan before collecting (or at least before analysing) the data. It allows those reading a final research report to know which aspects of a study were decided before sight of the data, and which were added later. This enables informed evaluation of the severity with which scientific claims have been tested. We, as the British Neuropsychological Society Open Research Group, conducted a survey to explore awareness and adoption of open research practices within our field. Neuropsychology involves the study of relatively rare or hard-to-access participants, creating practical challenges that, according to our survey, are perceived as barriers to preregistration. We survey the available routes to preregistration, and suggest that the barriers are all surmountable in one way or another. However, there is a tension, in that higher levels of bias control require greater restriction over the flexibility of preregistered studies, but such flexibility is often essential for neuropsychological research. Researchers must therefore consider which route provides the right balance of rigour and pragmatic flexibility to render a preregistered project viable for them. By mapping out the issues and potential solutions, and by signposting relevant resources and publication routes, we hope to facilitate well-reasoned decision-making and empower neuropsychologists to enhance the transparency and rigour of their research. Although we focus neuropsychology, our guidance is applicable to any field that studies hard-to-access human samples, or involves arduous or expensive means of data collection.</p>","PeriodicalId":93915,"journal":{"name":"Brain communications","volume":"7 3","pages":"fcaf162"},"PeriodicalIF":4.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}