Brachytherapy最新文献

{"title":"PO15","authors":"Ke Xu","doi":"10.1016/j.brachy.2023.06.116","DOIUrl":"https://doi.org/10.1016/j.brachy.2023.06.116","url":null,"abstract":"Purpose To explore the factors influencing the short-term efficacy of 125I seed implantation in the treatment of perivascular lymph node metastasis of cervical cancer after radiotherapy and chemotherapy. Materials and Methods 30 patients with recurrent cervical cancer and perivascular lymph node metastasis after radiotherapy and chemotherapy, aged 28-76 years old, 16 cases of squamous cell carcinoma, 14 cases of adenocarcinoma, particle activity 0.4-0.7 mCi, peripheral dose 60-128 Gy, who were treated in our hospital from January 2006 to December 2018, were retrospectively analyzed, NRS was used to evaluate the improvement of pain and the occurrence of complications, single factor and multiple factor analysis were used to explore the factors affecting the efficacy, and the ROC curve was analyzed. Results All patients successfully completed the operation. The curative effect was evaluated in 6 months after the operation, including 14 cases of CR+PR and 16 cases of SD+PD. Univariate analysis: the size of lymph nodes and D90 immediately after the operation were the factors affecting the curative effect (P=0.001, 0.025). Multivariate analysis: tumor size was an independent pre-and post-factor affecting the curative effect (P=0.048). The ROC curve analysis showed that the longest diameter of lymph nodes was less than 4.85cm, and the prescription dose was greater than 76Gy, which was the best predictor of curative effect (AUC under the curve=0.853, 0.741; P=0.001, 0.025). The postoperative pain score was significantly reduced, and the difference was statistically significant (Z=-4.271, P<0.001). There was no fever, hemorrhage, bone marrow suppression, liver and kidney insufficiency, radiation skin and mucosa reaction in the follow-up of 6 months after operation Complications such as particle displacement. Conclusion 125I seed is safe and effective in the treatment of perivascular lymph node metastasis of cervical cancer after radiotherapy and chemotherapy. The short-term effect is better when the tumor length is less than 4.85 cm and the prescription dose is greater than 76 Gy. The long-term effect and complications need further study. To explore the factors influencing the short-term efficacy of 125I seed implantation in the treatment of perivascular lymph node metastasis of cervical cancer after radiotherapy and chemotherapy. 30 patients with recurrent cervical cancer and perivascular lymph node metastasis after radiotherapy and chemotherapy, aged 28-76 years old, 16 cases of squamous cell carcinoma, 14 cases of adenocarcinoma, particle activity 0.4-0.7 mCi, peripheral dose 60-128 Gy, who were treated in our hospital from January 2006 to December 2018, were retrospectively analyzed, NRS was used to evaluate the improvement of pain and the occurrence of complications, single factor and multiple factor analysis were used to explore the factors affecting the efficacy, and the ROC curve was analyzed. All patients successfully completed the operation. The","PeriodicalId":93914,"journal":{"name":"Brachytherapy","volume":"2012 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135434367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO123","authors":"Takashi Kawanaka, Chisato Tonoiso, Akiko Kubo, HItoshi Ikushima, Masafumi Harada","doi":"10.1016/j.brachy.2023.06.223","DOIUrl":"https://doi.org/10.1016/j.brachy.2023.06.223","url":null,"abstract":"Purpose In Japan, cylindrical excisions are commonly performed in partial mastectomies for breast-conserving therapy, as opposed to the typical lumpectomies. Hence, when implementing Accelerated Partial Breast Irradiation (APBI) with the use of SAVI, a multi-lumen single catheter for partial breast irradiation with brachytherapy, discrepancies were noted between the shape of the excision cavity and the SAVI. Our institution reexamined the correlation between the form of the excision cavity and the shape of SAVI in instances of APBI that utilized post-operative SAVI insertion. To reconcile the discrepancy between the surgical cavity and the shape of the SAVI, we devised a hybrid APBI incorporating a supplementary catheter into the surrounding region of the SAVI and validated the dose distribution through simulation with a restricted quantity of supplementary catheters. Utilizing the obtained results, we present the outcomes of the hybrid APBI in actual clinical application. The objective of this investigation was to examine and augment the congruity between the SAVI applicator and the residual excision cavity following partial mastectomy in cases of APBI with SAVI in Japan. Materials and Methods Our evaluation encompasses four instances of APBI with postoperative insertion of SAVI, conducted at our institution between December 2018 and May 2019. The affected breasts included three right and one left, with two cases each affecting regions C and D. Through a postoperative insertion approach, each case was strategically placed from the inframammary fold. The treatment plan was executed using Oncentra brachy (Electa), with a prescribed dose of 34 Gy/10 Fr delivered through IPSA for PTV_EVAL. Our review of the outcomes prompted the implementation of hybrid APBI in three patients from the year 2020. Results The mean volume of the PTV_EVAL was observed to be 75.71 mL in the four cases of Accelerated Partial Breast Irradiation (APBI) with postoperative insertion of the SAVI applicator evaluated in this study. Out of these, three cases demonstrated a deviation of more than 10% in volume between the SAVI applicator and AIR, resulting in suboptimal dose delivery to the target volume (PTV_EVAL), which was evidenced by D90 failing to reach 90% in each case. Upon further analysis, the discrepancy was found to arise from the irregular shape of AIR on the chest wall side or bilaterally on the CT cross-section perpendicular to the SAVI, which had taken on a dog-ear form. To address this issue, a virtual hybrid APBI approach was implemented by adding one or two catheters placed along the SAVI applicator, leading to a substantial improvement in the D90 of PTV_EVAL in all three cases, reaching 90% in each. Based on this result, the hybrid approach was executed by inserting intra-tissue catheters near the prominent AIR, parallel to the SAVI applicator, under ultrasound guidance. The average D90 delivered by the SAVI alone was 74.39%, which improved to 95.90% with the ","PeriodicalId":93914,"journal":{"name":"Brachytherapy","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135434381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO14","authors":"Juan Wang, Yansong Liang, Hongtao Zhang, Jinxin Zhao","doi":"10.1016/j.brachy.2023.06.115","DOIUrl":"https://doi.org/10.1016/j.brachy.2023.06.115","url":null,"abstract":"","PeriodicalId":93914,"journal":{"name":"Brachytherapy","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135434386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO113","authors":"Juan Wang, Zeyang Wang, Yansong Liang, Hongtao Zhang","doi":"10.1016/j.brachy.2023.06.214","DOIUrl":"https://doi.org/10.1016/j.brachy.2023.06.214","url":null,"abstract":"Objective To evaluate the advantages and value of three-dimensional-printing template (3D-PT) guided 125I seed implantation for recurrent and metastatic cancer of head and neck. Methods 99patients(99 targets), received 125I seeds implantation at Heibei General hospital from Apr. 2015 to Feb. 2019 enrolled in this study. Patients were divided into two groups according to whether being guided by 3D-PT: Group A and Control B. A within-group comparison completed including the differences of the seeds number, target volume, and dosimetric parameters (D90, V90, V100 , and V150 ) between pre- and post-operative of the 2 groups, and between-group comparison including scan times, operation time, implantation time of each seed, the quality evaluation, local control rate (LCR), effective rate and complications in 2 and 3 months. Result The difference of scan times, operation time, implantation time of each seed of the two groups was significant (P<0.05). The within-group comparison of the seeds number, target volume, and dosimetric parameters in Group A (P>0.05) and the seeds number, target volume, D90, V90 of Group B(P>0.05) showed no statistically significant differences and V100 of pre- was greater than post-, V150 of post was greater than pre- in Group B (P<0.05) showed statistically significant differences. The postoperative V100 and preoperative V150 of Group A was greater than Group B (P<0.05), and the difference of rest index showed no statistically significant differences. The occurrence of puncture site pain of Group A was less than Group B, curative effect in 3 months of Group A was greater than Group B, and showed statistically significant difference (P<0.05).And the quality evaluation, curative effect and LCR in 2 monthsand3 months LCR, and postoperative hoarseness showed no statistically significant difference(P>0.05). Conclusion Comparing to CT-guidance, the application of 3D-PT can reduce the operation time and CT scan times, reduce complications and improve curative effect. To evaluate the advantages and value of three-dimensional-printing template (3D-PT) guided 125I seed implantation for recurrent and metastatic cancer of head and neck. 99patients(99 targets), received 125I seeds implantation at Heibei General hospital from Apr. 2015 to Feb. 2019 enrolled in this study. Patients were divided into two groups according to whether being guided by 3D-PT: Group A and Control B. A within-group comparison completed including the differences of the seeds number, target volume, and dosimetric parameters (D90, V90, V100 , and V150 ) between pre- and post-operative of the 2 groups, and between-group comparison including scan times, operation time, implantation time of each seed, the quality evaluation, local control rate (LCR), effective rate and complications in 2 and 3 months. The difference of scan times, operation time, implantation time of each seed of the two groups was significant (P<0.05). The within-group comparison of the seeds number, tar","PeriodicalId":93914,"journal":{"name":"Brachytherapy","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135434404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO102","authors":"Genghao Zhao, Huajian Wu, Wenyue Duan, Jinyu Wu, Liang Yang, Zhe Wang, Ruoyu Wang","doi":"10.1016/j.brachy.2023.06.203","DOIUrl":"https://doi.org/10.1016/j.brachy.2023.06.203","url":null,"abstract":"Purpose This study aimed to assess the clinical efficacy and safety of Stereotactic ablative brachytherapy (SABT) for unresectable or inoperable head and neck cancers. Material and Methods This study retrospectively assessed the clinical data of 40 patients with unresectable or inoperable head and neck cancers treated with SABT from October 2016 to October 2021. The variables assessed were local efficacy, progression-free-survival (PFS) rate, overall survival (OS) rate, and radiological adverse effects. Results The median follow-up was of 34 months (range, 5-59 months), and PFS rate at 6, 12, and 24 months was 90.0%, 74.7%, and 66.3%, respectively. The median survival time was of 16 months [95% confidence interval (CI), 10.2-21.8 months] and the OS rate at 6, 12, and 24 months was 97.5%, 70.0%, and 34.6%, respectively. The results of the univariate analysis revealed that the type of pathology and GTV D90 were related to PFS rate (P<0.05). However, the type of pathology, GTV D90, age, and implantation site were related to OS rate (P<0.05). The results of the multivariate analysis revealed that the GTV D90 was related to PFS rate (P<0.05). The type of pathology and GTV D90 were related to OS rate (P<0.05). The evaluation of postoperative radiological adverse reactions revealed that seven cases (17.5%) developed grade I/II skin reactions, four cases (10.0%) developed grade I/II oral mucosal reactions, and no cases developed grade III or higher adverse reactions. Postoperative seed dislocation occurred in three patients with tongue cancer. Conclusions SABT has produced good local control and mild adverse reactions in the treatment of unresectable or inoperable head and neck cancers. Additionally, it is safe, feasible, minimally invasive, and has fewer adverse effects than other treatment modalities. This study aimed to assess the clinical efficacy and safety of Stereotactic ablative brachytherapy (SABT) for unresectable or inoperable head and neck cancers. This study retrospectively assessed the clinical data of 40 patients with unresectable or inoperable head and neck cancers treated with SABT from October 2016 to October 2021. The variables assessed were local efficacy, progression-free-survival (PFS) rate, overall survival (OS) rate, and radiological adverse effects. The median follow-up was of 34 months (range, 5-59 months), and PFS rate at 6, 12, and 24 months was 90.0%, 74.7%, and 66.3%, respectively. The median survival time was of 16 months [95% confidence interval (CI), 10.2-21.8 months] and the OS rate at 6, 12, and 24 months was 97.5%, 70.0%, and 34.6%, respectively. The results of the univariate analysis revealed that the type of pathology and GTV D90 were related to PFS rate (P<0.05). However, the type of pathology, GTV D90, age, and implantation site were related to OS rate (P<0.05). The results of the multivariate analysis revealed that the GTV D90 was related to PFS rate (P<0.05). The type of pathology and GTV D90 were related to OS r","PeriodicalId":93914,"journal":{"name":"Brachytherapy","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135434419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO110","authors":"Juan Wang, Guohui Cao","doi":"10.1016/j.brachy.2023.06.211","DOIUrl":"https://doi.org/10.1016/j.brachy.2023.06.211","url":null,"abstract":"Purpose To investigate the prognostic value of neutrophil-lymphocyte ratio in patients with advanced lung cancer treated with radioactive iodine 125 seeds implantation. Methods From January 2017 to March 2021, 49 patients with advanced lung cancer received iodine 125 seed implantation in our hospital. use χ The influencing factors of clinical efficacy were analyzed. The optimal preoperative NLR limit was obtained by establishing the receiver operating characteristic curve (ROC). The clinicopathological factors were analyzed by logistic univariate analysis and multivariate survival analysis by binary logistics. Results The total effective rate of 49 patients 6 months after treatment was 65.31% (32 / 49). Univariate analysis showed that the maximum tumor diameter (χ2 = 6.69, P = 0.0097), postoperative D90 (χ2= 9.55, P = 0.002), preoperative NLR(χ2= 9.32, P = 0.0023). Multivariate analysis showed that postoperative D90 (P = 0.048) and preoperative NLR (P = 0.018) were independent prognostic factors of local effective rate after lung cancer seed implantation. Conclusions Radioactive iodine 125 seed implantation showed good efficacy in the treatment of patients with advanced lung cancer. Preoperative NLR and postoperative D90 were independent prognostic factors for the effective rate after lung cancer seed implantation, High NLR is a poor prognostic factor for lung cancer seed implantation. To investigate the prognostic value of neutrophil-lymphocyte ratio in patients with advanced lung cancer treated with radioactive iodine 125 seeds implantation. From January 2017 to March 2021, 49 patients with advanced lung cancer received iodine 125 seed implantation in our hospital. use χ The influencing factors of clinical efficacy were analyzed. The optimal preoperative NLR limit was obtained by establishing the receiver operating characteristic curve (ROC). The clinicopathological factors were analyzed by logistic univariate analysis and multivariate survival analysis by binary logistics. The total effective rate of 49 patients 6 months after treatment was 65.31% (32 / 49). Univariate analysis showed that the maximum tumor diameter (χ2 = 6.69, P = 0.0097), postoperative D90 (χ2= 9.55, P = 0.002), preoperative NLR(χ2= 9.32, P = 0.0023). Multivariate analysis showed that postoperative D90 (P = 0.048) and preoperative NLR (P = 0.018) were independent prognostic factors of local effective rate after lung cancer seed implantation. Radioactive iodine 125 seed implantation showed good efficacy in the treatment of patients with advanced lung cancer. Preoperative NLR and postoperative D90 were independent prognostic factors for the effective rate after lung cancer seed implantation, High NLR is a poor prognostic factor for lung cancer seed implantation.","PeriodicalId":93914,"journal":{"name":"Brachytherapy","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135434431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO65","authors":"Eulanca Yuka Liu, Eric Lin, Puja Venkat, Alan Lee, Jay Shiao, Andrew Wong, Austin Yu, Mary Ann Hagio, Sang-June Park, D. Jeffrey Demanes, Albert J. Chang","doi":"10.1016/j.brachy.2023.06.166","DOIUrl":"https://doi.org/10.1016/j.brachy.2023.06.166","url":null,"abstract":"Purpose This retrospective study compares high dose rate brachytherapy (HDR BT) monotherapy against HDR BT and external beam radiation therapy (EBRT), with and without androgen deprivation therapy (ADT), to determine non-inferiority of HDR BT alone in the treatment of unfavorable intermediate risk (UIR) prostate cancer. Materials/Methods Data were obtained from two registries from 1991-present. 633 patients with UIR prostate cancer treated with HDR BT were included. Patients who received only HDR BT received 42-45Gy/6 fractions (fx) or 27 Gy/2 fx. For HDR BT+EBRT, the HDR dose was 20-24 Gy/2 fx, 24 Gy/4 fx, or 15 Gy/1 fx. EBRT patients received 45 Gy/25 fx to the prostate +/- pelvic nodal radiation. GU/GI toxicities were graded according to the Common Terminology Criteria for Adverse Events (CTCAE) v5.0. Treatment group differences were assessed via two-sample T test or ANOVA, and associations between categorical variable and treatment group were assessed via chi-squared or Fisher's exact test. Time-to-event analyses were carried out to evaluate relationship between treatments and primary outcome variables. Five primary endpoints were used to assess freedom from biochemical recurrence (FFBC), freedom from distant metastasis (FFDM), freedom from local failure (FFLF), cancer specific survival (CSS), and overall survival (OS). Univariate analysis was conducted using the Kaplan-Meier method and log-rank test to the primary event. For multivariate analysis, Cox proportional hazard (Cox PH) regression and Fine & Gray competing risk regression were carried out to adjust for potential confounders. For toxicity analysis, the association between the incidence of post-treatment severe GU/GI toxicity reaction, denoted grade 3 or higher, and the treatment group was evaluated via chi-squared or Fisher's exact test. Results Statistical comparisons for HDR, HDR+EBRT-ADT, and HDR+EBRT+ADT are summarized in Table 1. From the Kaplan-Meier curves and log-rank tests, no differences between the three cohorts were identified in all five survival outcomes (FFBC, FFDM, FFLF, OS, CSS), with 5-year survival for HDR, HDR+EBRT-ADT, and HDR+EBRT+ADT FFBC 99%, 95%, and 94% respectively. Multivariate analysis with Cox PH regression showed no differences in FFBC, FFDM, OS, and CSS with addition of EBT alone, or addition of EBT with ADT. Fine and Gray competing regression showed no difference in outcome for HDR, HDR+EBRT-ADT, and HDR+EBRT+ADT with respect to FFBC, FFDM, and CSS. Performing the likelihood ratio test to both the Cox PH and Fine & Gray competing regression models resulted in no differences in all survival outcomes with stable fits between treatment and non-treatment groups. In comparing CTCAE toxicities between the HDR, HDR+EBRT-ADT, and HDR+EBRT+ADT cohorts, no statistically significant differences were identified in GI and GU toxicities when comparing post-treatment and baseline toxicities. No Grade 2 or 3 GI toxicities were identified in any of the groups, while ","PeriodicalId":93914,"journal":{"name":"Brachytherapy","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135434447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO112","authors":"Juan Wang, Xiaolu Pei","doi":"10.1016/j.brachy.2023.06.213","DOIUrl":"https://doi.org/10.1016/j.brachy.2023.06.213","url":null,"abstract":"Purpose A meta-analysis aimed to systematically evaluate the safety and efficiency of iodine-125 (125I) irradiation stent placement for patients with malignant biliary obstruction (MBO) Methods Embase, Medline, PubMed, Cochrane library, and OVID were systematically searched from the earliest to November 2021. The primary endpoints were stent patency and overall survival. The secondary endpoints were total bilirubin (TB) and alanine aminotransferase (ALT) level and complications. Two independent researchers strictly screened the documents, extracted the valuable data, and evaluated the quality of documents. Meta-analysis was performed using Stata 12.0 and RevMan 5.4 software. Results 950 patients were included in nine studies, 415 of them received 125I seed implantation and 535 were in the mental stents group. Meta analysis showed that the stent patency rate in the experimental group improved in 3 months (OR=5.19, 95%CI=2.74-9.8,P<0.01), and that in MBO patients also significantly increased in 6 months (OR=4.46, 95%CI=2.87-6.93, P<0.01). Meanwhile, the postoperative 6-month survival rate was significantly improved (OR=1.63, 95%CI=1.13-2.35, P=0.009).It also reduced patient's mortality risk (HR=0.67, 95%CI=0.5-0.86, P=0.002). Subgroup analysis found that different doses may lead to different patency rates. However, the postoperative 12-month survival rate was not improved. (OR=1.42, 95%CI=0.27-2.6, P=0.25). There was no significant difference in the occurrence of adverse events between the two groups (OR=1.24, 95%CI=0.69-2.21. P=0.47). Conclusions For patients with unresectable malignant biliary obstruction (MBO), placement of an irradiation stent has been demonstrated to offer longer patency and survival compared with the control group. Our aim was to further assess the efficacy of irradiation stents. A meta-analysis aimed to systematically evaluate the safety and efficiency of iodine-125 (125I) irradiation stent placement for patients with malignant biliary obstruction (MBO) Embase, Medline, PubMed, Cochrane library, and OVID were systematically searched from the earliest to November 2021. The primary endpoints were stent patency and overall survival. The secondary endpoints were total bilirubin (TB) and alanine aminotransferase (ALT) level and complications. Two independent researchers strictly screened the documents, extracted the valuable data, and evaluated the quality of documents. Meta-analysis was performed using Stata 12.0 and RevMan 5.4 software. 950 patients were included in nine studies, 415 of them received 125I seed implantation and 535 were in the mental stents group. Meta analysis showed that the stent patency rate in the experimental group improved in 3 months (OR=5.19, 95%CI=2.74-9.8,P<0.01), and that in MBO patients also significantly increased in 6 months (OR=4.46, 95%CI=2.87-6.93, P<0.01). Meanwhile, the postoperative 6-month survival rate was significantly improved (OR=1.63, 95%CI=1.13-2.35, P=0.009).It also reduced patient's","PeriodicalId":93914,"journal":{"name":"Brachytherapy","volume":"135 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135434506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO94","authors":"Derek Liu, Nawaid Usmani, Nick Chng, Ron Sloboda","doi":"10.1016/j.brachy.2023.06.195","DOIUrl":"https://doi.org/10.1016/j.brachy.2023.06.195","url":null,"abstract":"Purpose Prostatic edema following transperineal interstitial permanent prostate brachytherapy implantation is commonly evaluated based on either prostate or implant volume. The current study compares the edema time course between the MR-delineated prostate contour and the CT-localized stranded seeds, enabling pairwise comparison in the presence of individual patient variation. In addition, unique identification of seeds enables the characterization of stranded implant dynamics. Materials and Methods Twenty patients were implanted with stranded Iodine-125 seeds (0.5 U strength) to the prostate at a prescribed dose of 145 Gy, following standard procedure. Pelvic scans were performed using computer tomography (CT) and magnetic resonance imaging (MRI) (T2-weighted fast spin-echo and balanced steady-state free precession (bSSFP)) on the day of implantation (D0), D3, D10, and D30 (30 days post-implant). A Prostate Coordinate System, based on the MR-delineated prostate contour, served as a common coordinate system across all time points. MR(bSSFP)-CT rigid registration was performed based on the mutual information metric. A strand reconstruction software uniquely matched individual seeds to the strand configuration in the preplan. The relative edema, normalized to D30, was calculated for MR-based contours and CT-based seed positions. Correlated movement of seeds within a strand were quantified: strand movement was calculated from the shift in the strand center-of-mass; strand length was determined as the total length of the line segments connecting sequential seeds in a strand. Simulation of the stranded seed model was performed. Initial D0 seed positions were moved based on the observed strand characteristic movement and compared against actual D30 seed positions. Results Prostatic edema resulted in swelling of the prostate, which peaks at D0 and mostly resolves by D30. The contour- and seed- based relative edema were similar and correlated (p < 0.01) in the lateral and ant-pos directions. The edema magnitudes differed noticeably in the sup-inf direction with no statistically significant correlation (p = 0.11). The average strand movement was 0.09, 0.12, and 0.26 cm in the Lateral, Ant-Pos, and Sup-Inf directions respective, resulting in a more compact seed distribution. The movement was largest between D0 and D3 and smallest between D10 and D30. Conversely, the strand length was relatively constant during the initial time points, followed by a length contraction of 5% between D10 and D30. Thus, the stranding material initially limits independent seed movement (i.e. strands moved as a whole) and subsequently loses integrity over time, allowing for strand contraction. Simulation of the stranded seed model reproduced the observed relative edema, particularly in the Sup-Inf strand direction. The average residual distance between simulated and actual D30 seed positions was 0.27 cm. For comparison, the actual seed movement was 0.38 cm and the residual from ","PeriodicalId":93914,"journal":{"name":"Brachytherapy","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135434510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO120","authors":"Sang June Park, Serhii Brovchuk, Zoia Shepil, Oleg Vaskevych, Puja Venkat","doi":"10.1016/j.brachy.2023.06.221","DOIUrl":"https://doi.org/10.1016/j.brachy.2023.06.221","url":null,"abstract":"","PeriodicalId":93914,"journal":{"name":"Brachytherapy","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135434530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}