PO113

Objective To evaluate the advantages and value of three-dimensional-printing template (3D-PT) guided 125I seed implantation for recurrent and metastatic cancer of head and neck. Methods 99patients(99 targets), received 125I seeds implantation at Heibei General hospital from Apr. 2015 to Feb. 2019 enrolled in this study. Patients were divided into two groups according to whether being guided by 3D-PT: Group A and Control B. A within-group comparison completed including the differences of the seeds number, target volume, and dosimetric parameters (D90, V90, V100 , and V150 ) between pre- and post-operative of the 2 groups, and between-group comparison including scan times, operation time, implantation time of each seed, the quality evaluation, local control rate (LCR), effective rate and complications in 2 and 3 months. Result The difference of scan times, operation time, implantation time of each seed of the two groups was significant (P<0.05). The within-group comparison of the seeds number, target volume, and dosimetric parameters in Group A (P>0.05) and the seeds number, target volume, D90, V90 of Group B(P>0.05) showed no statistically significant differences and V100 of pre- was greater than post-, V150 of post was greater than pre- in Group B (P<0.05) showed statistically significant differences. The postoperative V100 and preoperative V150 of Group A was greater than Group B (P<0.05), and the difference of rest index showed no statistically significant differences. The occurrence of puncture site pain of Group A was less than Group B, curative effect in 3 months of Group A was greater than Group B, and showed statistically significant difference (P<0.05).And the quality evaluation, curative effect and LCR in 2 monthsand3 months LCR, and postoperative hoarseness showed no statistically significant difference(P>0.05). Conclusion Comparing to CT-guidance, the application of 3D-PT can reduce the operation time and CT scan times, reduce complications and improve curative effect. To evaluate the advantages and value of three-dimensional-printing template (3D-PT) guided 125I seed implantation for recurrent and metastatic cancer of head and neck. 99patients(99 targets), received 125I seeds implantation at Heibei General hospital from Apr. 2015 to Feb. 2019 enrolled in this study. Patients were divided into two groups according to whether being guided by 3D-PT: Group A and Control B. A within-group comparison completed including the differences of the seeds number, target volume, and dosimetric parameters (D90, V90, V100 , and V150 ) between pre- and post-operative of the 2 groups, and between-group comparison including scan times, operation time, implantation time of each seed, the quality evaluation, local control rate (LCR), effective rate and complications in 2 and 3 months. The difference of scan times, operation time, implantation time of each seed of the two groups was significant (P<0.05). The within-group comparison of the seeds number, target volume, and dosimetric parameters in Group A (P>0.05) and the seeds number, target volume, D90, V90 of Group B(P>0.05) showed no statistically significant differences and V100 of pre- was greater than post-, V150 of post was greater than pre- in Group B (P<0.05) showed statistically significant differences. The postoperative V100 and preoperative V150 of Group A was greater than Group B (P<0.05), and the difference of rest index showed no statistically significant differences. The occurrence of puncture site pain of Group A was less than Group B, curative effect in 3 months of Group A was greater than Group B, and showed statistically significant difference (P<0.05).And the quality evaluation, curative effect and LCR in 2 monthsand3 months LCR, and postoperative hoarseness showed no statistically significant difference(P>0.05). Comparing to CT-guidance, the application of 3D-PT can reduce the operation time and CT scan times, reduce complications and improve curative effect.