{"title":"PO110","authors":"Juan Wang, Guohui Cao","doi":"10.1016/j.brachy.2023.06.211","DOIUrl":null,"url":null,"abstract":"Purpose To investigate the prognostic value of neutrophil-lymphocyte ratio in patients with advanced lung cancer treated with radioactive iodine 125 seeds implantation. Methods From January 2017 to March 2021, 49 patients with advanced lung cancer received iodine 125 seed implantation in our hospital. use χ The influencing factors of clinical efficacy were analyzed. The optimal preoperative NLR limit was obtained by establishing the receiver operating characteristic curve (ROC). The clinicopathological factors were analyzed by logistic univariate analysis and multivariate survival analysis by binary logistics. Results The total effective rate of 49 patients 6 months after treatment was 65.31% (32 / 49). Univariate analysis showed that the maximum tumor diameter (χ2 = 6.69, P = 0.0097), postoperative D90 (χ2= 9.55, P = 0.002), preoperative NLR(χ2= 9.32, P = 0.0023). Multivariate analysis showed that postoperative D90 (P = 0.048) and preoperative NLR (P = 0.018) were independent prognostic factors of local effective rate after lung cancer seed implantation. Conclusions Radioactive iodine 125 seed implantation showed good efficacy in the treatment of patients with advanced lung cancer. Preoperative NLR and postoperative D90 were independent prognostic factors for the effective rate after lung cancer seed implantation, High NLR is a poor prognostic factor for lung cancer seed implantation. To investigate the prognostic value of neutrophil-lymphocyte ratio in patients with advanced lung cancer treated with radioactive iodine 125 seeds implantation. From January 2017 to March 2021, 49 patients with advanced lung cancer received iodine 125 seed implantation in our hospital. use χ The influencing factors of clinical efficacy were analyzed. The optimal preoperative NLR limit was obtained by establishing the receiver operating characteristic curve (ROC). The clinicopathological factors were analyzed by logistic univariate analysis and multivariate survival analysis by binary logistics. The total effective rate of 49 patients 6 months after treatment was 65.31% (32 / 49). Univariate analysis showed that the maximum tumor diameter (χ2 = 6.69, P = 0.0097), postoperative D90 (χ2= 9.55, P = 0.002), preoperative NLR(χ2= 9.32, P = 0.0023). Multivariate analysis showed that postoperative D90 (P = 0.048) and preoperative NLR (P = 0.018) were independent prognostic factors of local effective rate after lung cancer seed implantation. Radioactive iodine 125 seed implantation showed good efficacy in the treatment of patients with advanced lung cancer. Preoperative NLR and postoperative D90 were independent prognostic factors for the effective rate after lung cancer seed implantation, High NLR is a poor prognostic factor for lung cancer seed implantation.","PeriodicalId":93914,"journal":{"name":"Brachytherapy","volume":"23 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"PO110\",\"authors\":\"Juan Wang, Guohui Cao\",\"doi\":\"10.1016/j.brachy.2023.06.211\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Purpose To investigate the prognostic value of neutrophil-lymphocyte ratio in patients with advanced lung cancer treated with radioactive iodine 125 seeds implantation. Methods From January 2017 to March 2021, 49 patients with advanced lung cancer received iodine 125 seed implantation in our hospital. use χ The influencing factors of clinical efficacy were analyzed. The optimal preoperative NLR limit was obtained by establishing the receiver operating characteristic curve (ROC). The clinicopathological factors were analyzed by logistic univariate analysis and multivariate survival analysis by binary logistics. Results The total effective rate of 49 patients 6 months after treatment was 65.31% (32 / 49). Univariate analysis showed that the maximum tumor diameter (χ2 = 6.69, P = 0.0097), postoperative D90 (χ2= 9.55, P = 0.002), preoperative NLR(χ2= 9.32, P = 0.0023). Multivariate analysis showed that postoperative D90 (P = 0.048) and preoperative NLR (P = 0.018) were independent prognostic factors of local effective rate after lung cancer seed implantation. Conclusions Radioactive iodine 125 seed implantation showed good efficacy in the treatment of patients with advanced lung cancer. Preoperative NLR and postoperative D90 were independent prognostic factors for the effective rate after lung cancer seed implantation, High NLR is a poor prognostic factor for lung cancer seed implantation. To investigate the prognostic value of neutrophil-lymphocyte ratio in patients with advanced lung cancer treated with radioactive iodine 125 seeds implantation. From January 2017 to March 2021, 49 patients with advanced lung cancer received iodine 125 seed implantation in our hospital. use χ The influencing factors of clinical efficacy were analyzed. The optimal preoperative NLR limit was obtained by establishing the receiver operating characteristic curve (ROC). The clinicopathological factors were analyzed by logistic univariate analysis and multivariate survival analysis by binary logistics. The total effective rate of 49 patients 6 months after treatment was 65.31% (32 / 49). Univariate analysis showed that the maximum tumor diameter (χ2 = 6.69, P = 0.0097), postoperative D90 (χ2= 9.55, P = 0.002), preoperative NLR(χ2= 9.32, P = 0.0023). Multivariate analysis showed that postoperative D90 (P = 0.048) and preoperative NLR (P = 0.018) were independent prognostic factors of local effective rate after lung cancer seed implantation. Radioactive iodine 125 seed implantation showed good efficacy in the treatment of patients with advanced lung cancer. Preoperative NLR and postoperative D90 were independent prognostic factors for the effective rate after lung cancer seed implantation, High NLR is a poor prognostic factor for lung cancer seed implantation.\",\"PeriodicalId\":93914,\"journal\":{\"name\":\"Brachytherapy\",\"volume\":\"23 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brachytherapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.brachy.2023.06.211\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brachytherapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.brachy.2023.06.211","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的探讨中性粒细胞/淋巴细胞比值在放射性碘125粒子植入治疗晚期肺癌患者中的预后价值。方法2017年1月至2021年3月，我院49例晚期肺癌患者行碘125粒子植入术。对影响临床疗效的因素进行χ分析。通过建立受试者工作特征曲线(ROC)获得最佳术前NLR限。临床病理因素采用logistic单因素分析，多因素生存分析采用二元logistic分析。结果49例患者治疗6个月后总有效率为65.31%(32 / 49)。单因素分析显示:肿瘤最大直径(χ2= 6.69, P = 0.0097)、术后D90 (χ2= 9.55, P = 0.002)、术前NLR(χ2= 9.32, P = 0.0023)。多因素分析显示，术后D90 (P = 0.048)和术前NLR (P = 0.018)是影响肺癌粒子植入术局部有效率的独立预后因素。结论放射性碘125粒子植入术治疗晚期肺癌疗效显著。术前NLR和术后D90是影响肺癌粒子植入有效率的独立预后因素，高NLR是肺癌粒子植入的不良预后因素。探讨中性粒细胞/淋巴细胞比值在放射性碘125粒子植入治疗晚期肺癌患者中的预后价值。2017年1月至2021年3月，我院49例晚期肺癌患者行碘125粒子植入术。对影响临床疗效的因素进行χ分析。通过建立受试者工作特征曲线(ROC)获得最佳术前NLR限。临床病理因素采用logistic单因素分析，多因素生存分析采用二元logistic分析。49例患者治疗6个月后总有效率为65.31%(32 / 49)。单因素分析显示:肿瘤最大直径(χ2= 6.69, P = 0.0097)、术后D90 (χ2= 9.55, P = 0.002)、术前NLR(χ2= 9.32, P = 0.0023)。多因素分析显示，术后D90 (P = 0.048)和术前NLR (P = 0.018)是影响肺癌粒子植入术局部有效率的独立预后因素。放射性碘125粒子植入术治疗晚期肺癌疗效显著。术前NLR和术后D90是影响肺癌粒子植入有效率的独立预后因素，高NLR是肺癌粒子植入的不良预后因素。
Purpose To investigate the prognostic value of neutrophil-lymphocyte ratio in patients with advanced lung cancer treated with radioactive iodine 125 seeds implantation. Methods From January 2017 to March 2021, 49 patients with advanced lung cancer received iodine 125 seed implantation in our hospital. use χ The influencing factors of clinical efficacy were analyzed. The optimal preoperative NLR limit was obtained by establishing the receiver operating characteristic curve (ROC). The clinicopathological factors were analyzed by logistic univariate analysis and multivariate survival analysis by binary logistics. Results The total effective rate of 49 patients 6 months after treatment was 65.31% (32 / 49). Univariate analysis showed that the maximum tumor diameter (χ2 = 6.69, P = 0.0097), postoperative D90 (χ2= 9.55, P = 0.002), preoperative NLR(χ2= 9.32, P = 0.0023). Multivariate analysis showed that postoperative D90 (P = 0.048) and preoperative NLR (P = 0.018) were independent prognostic factors of local effective rate after lung cancer seed implantation. Conclusions Radioactive iodine 125 seed implantation showed good efficacy in the treatment of patients with advanced lung cancer. Preoperative NLR and postoperative D90 were independent prognostic factors for the effective rate after lung cancer seed implantation, High NLR is a poor prognostic factor for lung cancer seed implantation. To investigate the prognostic value of neutrophil-lymphocyte ratio in patients with advanced lung cancer treated with radioactive iodine 125 seeds implantation. From January 2017 to March 2021, 49 patients with advanced lung cancer received iodine 125 seed implantation in our hospital. use χ The influencing factors of clinical efficacy were analyzed. The optimal preoperative NLR limit was obtained by establishing the receiver operating characteristic curve (ROC). The clinicopathological factors were analyzed by logistic univariate analysis and multivariate survival analysis by binary logistics. The total effective rate of 49 patients 6 months after treatment was 65.31% (32 / 49). Univariate analysis showed that the maximum tumor diameter (χ2 = 6.69, P = 0.0097), postoperative D90 (χ2= 9.55, P = 0.002), preoperative NLR(χ2= 9.32, P = 0.0023). Multivariate analysis showed that postoperative D90 (P = 0.048) and preoperative NLR (P = 0.018) were independent prognostic factors of local effective rate after lung cancer seed implantation. Radioactive iodine 125 seed implantation showed good efficacy in the treatment of patients with advanced lung cancer. Preoperative NLR and postoperative D90 were independent prognostic factors for the effective rate after lung cancer seed implantation, High NLR is a poor prognostic factor for lung cancer seed implantation.
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