Annals of the American Thoracic Society最新文献

{"title":"Social drivers in chronic obstructive pulmonary disease: securing better outcomes may start with food.","authors":"Brandon Peplinski, Cher X Huang, Russell G Buhr","doi":"10.1093/annalsats/aaoag180","DOIUrl":"10.1093/annalsats/aaoag180","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":"1437-1438"},"PeriodicalIF":5.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13492708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-COPD, PRISm, and COPD in young adults born preterm.","authors":"Elizabeth F Smith, Callan Lavery, Shannon J Simpson","doi":"10.1093/annalsats/aaoag182","DOIUrl":"10.1093/annalsats/aaoag182","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":"1562-1565"},"PeriodicalIF":5.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13626232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148414054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twelve-month outcomes of a multicenter cluster randomized controlled trial on the impact of flexible intensive care unit visitation on patients' mental health.","authors":"Regis Goulart Rosa, Rafael Barberena Moraes, Aline Paula Miozzo, Jennifer Menna Barreto de Souza, Gabriela Soares Rech, Rosa da Rosa Minho Dos Santos, Fernando Luis Scolari, Marciane Maria Rover, Luciana D'Amico, Denise de Souza, Marcelo Kern, Claudio da Silva Zachia Alan, Cassiano Teixeira","doi":"10.1093/annalsats/aaoag203","DOIUrl":"10.1093/annalsats/aaoag203","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":"1559-1561"},"PeriodicalIF":5.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population health management in chronic obstructive pulmonary disease: an official American Thoracic Society Workshop Report.","authors":"Lucas M Donovan, Kathryn A Artis, Surya Bhatt, Laura C Feemster, Shawn D Aaron, Arianne K Baldomero, Kevin I Duan, Alex D Federman, Bhrandon A Harris, Kathleen Henderson, Jerry A Krishnan, Stephanie LaBedz, Peter K Lindenauer, Sarah N Miller, Laura C Myers, Edward C Portillo, Valerie G Press, J Daryl Thornton, W Claibe Yarbrough, Josephine C Young, Jenny Zhang, David H Au","doi":"10.1093/annalsats/aaoag184","DOIUrl":"10.1093/annalsats/aaoag184","url":null,"abstract":"<p><p>Despite decades of research and advocacy, the quality of care for chronic obstructive pulmonary disease (COPD) remains poor. Millions of patients fail to receive appropriate care, and fundamental changes are needed to improve care quality and patient outcomes. Guided by the Triple Aim of (1) improving population health, (2) improving individual patient experience, and (3) reducing per capita costs for care, population health management strategies aim to redesign healthcare. By adapting the delivery, coordination, and payment of high-quality services, population health management strategies hold promise to improve care for the large and heterogeneous COPD population. This workshop included a multidisciplinary panel of patients, payers, health system leaders, pulmonologists, primary care providers, pharmacists, nurses, and researchers to envision future models of care that achieve population health management for COPD. Past research demonstrates the effectiveness of population-based health system interventions to improve COPD case finding, primary and specialty care integration, inpatient management, and postdischarge services among patients with COPD. Sustaining these interventions will require value-based payment arrangements and adaptations to clinical care processes. The field will need to define meaningful outcomes and tailor appropriate team member roles and responsibilities. As part of healthcare redesign, workshop members recommended adopting effective strategies to encourage personalized high-quality decision-making (eg, nudges) and employ study designs that rigorously and quickly test interventions (eg, pragmatic and adaptive designs). To ensure patient centeredness, it will be essential to incorporate patient and caregiver perspectives and leadership into redesign efforts.</p>","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":"1397-1413"},"PeriodicalIF":5.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Utility of A Complex Breathing Airway Scan for Unexplained Wheeze and Breathlessness.","authors":"James H Hull, Zander J Williams, Dylan Beinart, Giovanni Cenerini, Philip G Bardin, Kenneth K Lau, Christopher M Orton, Jamie Dormand, Thomas Semple","doi":"10.1093/annalsats/aaoag306","DOIUrl":"https://doi.org/10.1093/annalsats/aaoag306","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149119928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effectiveness of elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis in the United States.","authors":"Georgene E Hergenroeder, Jonathan V Todd, Josh S Ostrenga, Christopher H Goss, Raksha Jain, Wayne Morgan, Gregory S Sawicki, Michael S Schechter, Rhonda Szczesniak, Elizabeth A Cromwell, Clement L Ren","doi":"10.1093/annalsats/aaoag095","DOIUrl":"10.1093/annalsats/aaoag095","url":null,"abstract":"<p><strong>Rationale: </strong>Limited data exist on whether the benefits of elexacaftor/tezacaftor/ivacaftor (ETI) seen in randomized controlled trials are sustained in clinical practice in people with cystic fibrosis (PwCF) taking ETI.</p><p><strong>Objectives: </strong>This study evaluated the longitudinal effect of ETI on lung function and nutritional outcomes in clinical practice and analyzed the heterogeneity of response.</p><p><strong>Methods: </strong>PwCF ≥ 12 years with at least one copy of F508del who were enrolled in the CF Foundation Patient Registry (CFFPR) between 2018 and 2022 with documented ETI prescription were included. Mean percent predicted forced expiratory volume in 1 second (ppFEV1) and body mass index (BMI) were examined for 1 year preceding and 3 years following ETI initiation. We used linear regression with generalized estimating equations (GEE) to evaluate longitudinal changes. We compared characteristics of participants who had a clinically meaningful response for both ppFEV1 and BMI to participants with neither a ppFEV1 nor BMI response. We used a negative binomial model to evaluate pulmonary exacerbation (PEx) rates and accounted for effects of viral respiratory trends.</p><p><strong>Measurements and main results: </strong>Among 11 151 PwCF included in the ppFEV1 analysis, we found a mean ppFEV1 increase of 9.9 (95% CI 9.6-10.2) between the pre- and post-ETI initiation periods over 3 years. Mean BMI increased by 1.03 kg/m2 (95% CI 0.98-1.07) in the 3 years post-ETI initiation among 12 119 PwCF in the BMI analysis. Among participants with both ppFEV1 and BMI data, 3594 (32.8%) experienced significant improvement in both ppFEV1 and BMI. Participants with both ppFEV1 and BMI improvement were more likely to have had a PEx prior to ETI initiation, history of Pseudomonas aeruginosa infection, pancreatic insufficiency, CF-related diabetes, and lower BMI pre-ETI. PEx rates were significantly reduced post-ETI initiation, even after adjusting for peak respiratory virus periods (unadjusted incidence rate ratio (IRR) (95% CI) 0.26 (0.25-0.27), adjusted IRR 0.62 (0.57-0.66)).</p><p><strong>Conclusions: </strong>This effectiveness analysis of observational data from the CFFPR found sustained improvements in lung function and nutritional status for 3 years following ETI initiation. Only 32% had an improvement in both FEV1 and BMI, indicating that not all PwCF respond uniformly to ETI therapy.</p>","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":"1466-1475"},"PeriodicalIF":5.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External beam radiation therapy and interventions for malignant central airway obstruction: a false dichotomy.","authors":"Jacob Schwartz, Gabriel Ortiz, Dagny Anderson, Ryan Kern, John Mullon, Dave Midthun","doi":"10.1093/annalsats/aaoag137","DOIUrl":"10.1093/annalsats/aaoag137","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":"1570-1571"},"PeriodicalIF":5.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147990302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving sleep or performance?","authors":"Sara Op de Beeck, Olivier M Vanderveken","doi":"10.1093/annalsats/aaoag122","DOIUrl":"10.1093/annalsats/aaoag122","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":"1444-1445"},"PeriodicalIF":5.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell lysis pneumopathy in patients with hyperleukocytic acute myeloid leukemia.","authors":"Caroline van de Wyngaert, Hélène Kemp, Sofiane Fodil, Véronique Meignin, Etienne Lengliné, Dara Chean, Lara Zafrani, Michael Darmon, Virginie Lemiale, Elie Azoulay","doi":"10.1093/annalsats/aaoag183","DOIUrl":"10.1093/annalsats/aaoag183","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":"1549-1553"},"PeriodicalIF":5.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 has taught us that not all COPD exacerbations are created equal.","authors":"William W Stringer","doi":"10.1093/annalsats/aaoag153","DOIUrl":"10.1093/annalsats/aaoag153","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":"1435-1436"},"PeriodicalIF":5.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148207231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}