Annals of Saudi medicine最新文献

{"title":"Impact of ileostomy creation on apixaban plasma concentrations: a retrospective case-series.","authors":"Hakeam A Hakeam, Sandra McGrath, Ghader Alrebeh, Abdullah F Alrebdi","doi":"10.5144/0256-4947.2026.42","DOIUrl":"10.5144/0256-4947.2026.42","url":null,"abstract":"<p><strong>Background: </strong>Apixaban is a direct-acting oral anticoagulant indicated for stroke and systemic embolism prevention in atrial fibrillation (AF) and for the treatment of venous thromboembolism (VTE). It is absorbed throughout the small intestine, with possible contribution from the distal ileum and ascending colon. The effect of ileostomy creation, which excludes the colon from the gastrointestinal tract, on apixaban plasma concentrations remains unclear.</p><p><strong>Objectives: </strong>To evaluate the impact of ileostomy creation on apixaban plasma concentrations.</p><p><strong>Design: </strong>Retrospective case series.</p><p><strong>Setting: </strong>A single tertiary care center in Saudi Arabia.</p><p><strong>Patients and methods: </strong>Patients receiving apixaban who had peak apixaban plasma concentrations measured following ileostomy creation between January 2021 and June 2025 were included. Patients were followed for at least three months and up to 12 months, or until ileostomy closure, discontinuation of apixaban, or death, whichever occurred first.</p><p><strong>Main outcome measures: </strong>Peak apixaban plasma concentrations, proportion of patients within the expected 5th-95th percentile range reported in Phase II and Phase III trials, the distribution of apixaban plasma concentrations below or above the median of the expected range, and clinical bleeding or thrombotic events.</p><p><strong>Sample size: </strong>Ten patients.</p><p><strong>Results: </strong>Apixaban was prescribed for VTE in six patients and AF in four. Eight patients (80%) had peak apixaban concentrations within the expected 5th-95th percentile range of apixaban concentrations; one patient was below the 5th percentile, and one was above the 95th percentile. Six patients had apixaban plasma peak concentrations below the median of the expected 5th-95th percentile range. Two patients experienced rectal bleeding, and no thrombotic events were observed.</p><p><strong>Conclusions: </strong>In patients with an ileostomy, apixaban peak concentrations generally fall within the expected 5th-95th percentile range, though frequently below the median. Ileostomy may slightly affect apixaban absorption, but does not appear to result in underexposure. Standard apixaban dosing seems appropriate.</p><p><strong>Limitations: </strong>Small sample size, lack of control, and retrospective design.</p>","PeriodicalId":93875,"journal":{"name":"Annals of Saudi medicine","volume":"46 1","pages":"42-47"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12820759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the susceptibility rates to ceftazidime-avibactam and colistin, clonal relationships, and clinical data of patients with carbapenem-resistant <i>Klebsiella pneumoniae</i> isolates detected in the ICUs of a hospital in İstanbul.","authors":"Yüksel Akkaya, İrfan Aydın, Sebile Harmankaya, Mehmet Karakuş, Mehtap Aydin, Begüm Nalça Erdin, Ahmet Münir Yılmaz, Emine Hüdanur Büyükavcı, Zülal Așçı Toraman, İbrahim Halil Kılıç","doi":"10.5144/0256-4947.2026.9","DOIUrl":"10.5144/0256-4947.2026.9","url":null,"abstract":"<p><strong>Background: </strong>The increase in carbapenem-resistant <i>K. pneumoniae</i> (CR-Kp) in intensive care units (ICUs) causes treatment difficulties and increases risk in mortality.</p><p><strong>Objectives: </strong>The aim of this study was to investigate the susceptibility rates of CR-Kp isolates obtained from ICUs to ceftazidime-avibactam (CAZ-AVI) and colistin, carbapenem resistance genes, clonal relationships and clinical characteristics of the patients.</p><p><strong>Design: </strong>Retrospective cohort.</p><p><strong>Setting: </strong>Single-center, University of Health Sciences, Ümraniye Training and Research Hospital.</p><p><strong>Materials and methods: </strong>This study was conducted between June 2023 and December 2024. Isolates were identified using VITEK MS v.3.2, and antibiotic susceptibility testing was performed using the VITEK 2 Compact system. CAZ-AVI susceptibility was determined using disk diffusion, and colistin susceptibility was determined using broth microdilution to determine minimum inhibitory concentration (MIC) values. Carbapenem resistance genes were determined using multiplex real-time polymerase chain reaction (RT-PCR) and clonal relationship arbitrarily primed-polymerase chain reaction (AP-PCR).</p><p><strong>Main outcome measures: </strong>Resistance genes of CR-Kp isolates, clonal relationships, CAZ-AVI and colistin resistance, and clinical characteristics of patients.</p><p><strong>Sample size: </strong>Ninety-seven isolates from 76 patients.</p><p><strong>Results: </strong>Among patients with CR-Kp isolates, central venous catheter use was detected in 59 cases (78%), ventilator-associated pneumonia in 44 cases (58%), and bacteremia in 39 cases (51%), respectively. It was determined that 53 of the patients (70%) died. Using the AP-PCR method, 60 different genotypes were identified among 97 isolates, and clustering was determined in 42 of the isolates (46%). It was determined that 36 (37%) of the isolates were resistant to colistin and 42 (45%) were resistant to CAZ-AVI. NDM+OXA-48, OXA-48, KPC, KPC+NDM, and NDM genes were detected in 40 (43%), 32 (35%), 10 (11%), 2 (2%), and 3 (3%) isolates, respectively. It was determined that 30 (75%) of the isolates with NDM+OXA-48 and only 4 (12%) of the isolates with OXA-48 were resistant to CAZ-AVI.</p><p><strong>Conclusion: </strong>In addition to OXA-48, an increase in the frequency of CR-Kp isolates containing the NDM, NDM+OXA-48, KPC+NDM, and OXA-48+KPC genes were also detected. It was also determined that resistance to colistin and CAZ-AVI is increasing. The AP-PCR method can also be used to investigate infections.</p><p><strong>Limitations: </strong>Single center, Pulsed Field Gel Electrophoresis (PFGE) could not be performed together with AP-PCR.</p>","PeriodicalId":93875,"journal":{"name":"Annals of Saudi medicine","volume":"46 1","pages":"9-19"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12820766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the use of perioperative corticosteroids reduce the incidence of seroma formation after breast cancer surgery? A systematic review and meta-analysis.","authors":"Jawad S Alnajjar, Hadeel Abdullah Bakheet, Mohamed Azzam M Addas, Reem A Alghamdi, Mohammed Abdulmohsen AlSharit, Nadine Nasser Farghal, Nora Hatem Trabulsi, Ali Farsi","doi":"10.5144/0256-4947.2025.435","DOIUrl":"10.5144/0256-4947.2025.435","url":null,"abstract":"<p><strong>Background: </strong>Seroma is a common complication of breast cancer surgery, affecting up to 85% of cases.</p><p><strong>Objective: </strong>To assess the effectiveness of perioperative corticosteroids in reducing seroma formation.</p><p><strong>Design: </strong>Systematic review and meta-analysis of published literature from PubMed, Ovid, Google Scholar, and Web of Science databases.</p><p><strong>Methods: </strong>A systematic search identified randomized controlled trials (RCTs) on corticosteroids in breast cancer surgery. Data were pooled using a random-effects model. Subgroup analyses were performed by corticosteroid type, timing, and route. Risk of bias (RoB) was assessed using the Cochrane Collaboration's RoB Tool for RCTs. Articles were collected from inception to August 2024. Inclusion criteria: RCTs and observational studies evaluating perioperative corticosteroids in breast cancer surgery. Exclusion criteria: non-breast surgery populations and absence of seroma outcome data.</p><p><strong>Main outcomes measures: </strong>Incidence of postoperative seroma.</p><p><strong>Sample size: </strong>Seven RCTs involving 689 patients were included.</p><p><strong>Results: </strong>Pooled analysis using random-effects model demonstrated that corticosteroids reduced seroma risk (OR: 0.31, 95% CI: 0.20-0.48). Hydrocortisone was more effective than methylprednisolone (OR: 0.14 vs. 0.41; <i>P</i>=.0155). Heterogeneity was low (I²=17.3%).</p><p><strong>Risk of bias: </strong>Publication bias assessment using Duval and Tweedie method identified three hypothetically missing studies; adjusted pooled estimate: OR 0.42 (95% CI: 0.28-0.63, <i>P</i><.001).</p><p><strong>Conclusion: </strong>Corticosteroids, especially hydrocortisone, appears to be effective in reducing seroma formation.</p><p><strong>Limitations: </strong>Small sample size, protocol variability, and moderate publication bias as evidenced by funnel plot asymmetry and heterogeneity in timing subgroups (I²=48.1%).</p><p><strong>Registration no: </strong>CRD42024590767.</p>","PeriodicalId":93875,"journal":{"name":"Annals of Saudi medicine","volume":"45 6","pages":"435-444"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12640528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and risk factors of obstetric anal sphincter injuries: a retrospective study.","authors":"Felwa Faisal Althaher, Deama Saeed Alghamdi, Heba Emad Bayoumi, Lamees Fadhely Alshanqity, Samera Fahad Al Basri, Nashwa Fahad Aldardeir, Hanan Mohammed Shamrani, Feras Mohammed Allagany","doi":"10.5144/0256-4947.2025.395","DOIUrl":"10.5144/0256-4947.2025.395","url":null,"abstract":"<p><strong>Background: </strong>Obstetric anal sphincter injuries (OASIS) are severe complications of vaginal deliveries with long-term physical and psychological sequelae. Data on the prevalence and risk factors of OASIS are limited in Saudi Arabia. This study aimed to assess the incidence of OASIS annually from 2017 to 2020, identify associated maternal and delivery factors, and investigate patients' characteristics related to OASIS Grades.</p><p><strong>Objective: </strong>To evaluate the annual incidence of OASIS from 2017 to 2020, identify maternal and delivery-related risk factors, and assess characteristics associated with different OASIS grades.</p><p><strong>Design: </strong>Single-center, retrospective observational study.</p><p><strong>Setting: </strong>King Abdulaziz University Hospital, Jeddah, Saudi Arabia.</p><p><strong>Methods: </strong>Medical records of all vaginal deliveries from 2017 to 2020 were reviewed. The study included 112 patients with singleton vaginal deliveries complicated by OASIS, out of a total of 12 081 deliveries. Exclusion criteria included preterm births and incomplete records. Data on maternal demographics, obstetric history, labor type, mode of delivery, episiotomy use, and neonatal outcomes were collected. The Royal College of Obstetricians and Gynaecologists (RCOG) classification was used to grade OASIS severity. Chi-square and t-tests were used for analysis.</p><p><strong>Main outcome measures: </strong>Annual incidence of OASIS, distribution of OASIS grades, and associations between clinical variables and injury severity.</p><p><strong>Sample size: </strong>112 cases of OASIS among 12081 vaginal deliveries.</p><p><strong>Results: </strong>The incidence of OASIS was 0.93%, showing a decreasing trend from 2017 to 2020. Most patients were Saudis (78.6%), primigravidae (58%), and nulliparous (67%). Spontaneous vaginal delivery occurred in 73.2% of cases, with episiotomies performed in 62%. Grade III tears were observed in 79.5% of cases, whereas 8.0% were classified as Grade IV. No significant differences were observed between Grades III and IV in terms of maternal and delivery characteristics, except for higher estimated blood loss in Grade IV cases. Incomplete documentation was noted in repair techniques and episiotomy details.</p><p><strong>Conclusion: </strong>Incidence of OASIS shows a decreasing trend in both the number of cases and the incidence rate over the four years between 2017 and 2020. Further research is necessary to address documentation gaps and refine regional prevention and management practices.</p><p><strong>Limitation: </strong>Retrospective design and missing values limited the ability to analyze some variables thoroughly.</p>","PeriodicalId":93875,"journal":{"name":"Annals of Saudi medicine","volume":"45 6","pages":"395-405"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12640527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequencies and causes of pre-analytical errors in a tertiary care hospital laboratory in Saudi Arabia.","authors":"Nasser Thufayl Alenezy, Shoukat Ali Arain, Amir Omair, Rida Afnan, Ameen Nadheef, Abeer Farouk Ahmed, Hashim Mohammed Sindi","doi":"10.5144/0256-4947.2025.381","DOIUrl":"10.5144/0256-4947.2025.381","url":null,"abstract":"<p><strong>Background: </strong>Errors in clinical laboratory tests can have a detrimental effect on healthcare delivery. The pre-analytical phase accounts for most laboratory errors, known as pre-analytical errors (PAEs).</p><p><strong>Objective: </strong>This study investigated the causes and frequencies of PAEs occurring within a laboratory of a tertiary care hospital.</p><p><strong>Design: </strong>A single-center, retrospective, observational study.</p><p><strong>Setting: </strong>King Abdul-Aziz Specialist Hospital, Taif, Saudi Arabia.</p><p><strong>Materials and methods: </strong>All laboratory test orders and repeated or rejected specimens in the Laboratory Information System (LIS) during 2021. The data consisted of the types of PAEs, their distribution across laboratory sections, the patient source among hospital departments, and the working shift during which PAEs were recorded.</p><p><strong>Main outcome measures: </strong>The causes and frequencies of PAEs across laboratory sections, hospital departments, and work shifts were analyzed.</p><p><strong>Sample size: </strong>2104 PAEs from a total of 3 346 199 test orders.</p><p><strong>Results: </strong>Of the 3 346 199 test orders, 3137 were recorded as either repeated or rejected. Of these, 2104 (67.1%) were attributed to PAEs, representing a rate of 0.063% (95% CI: 0.060-0.066%) of the total test orders. 'Clotted specimens' (32%) and 'insufficient quantity' (31%) were the most frequent PAEs. Significant differences were identified in the error rate and type of PAEs across laboratory sections, hospital departments, and working shifts (<i>P</i><.001 for each). The highest error rate was in the blood bank (0.4%). The hematology section accounted for the largest proportion of errors (48.4%). Most PAEs were test orders from the inpatient department (47.3%), with a majority occurring in the morning shift (58.2%).</p><p><strong>Conclusion: </strong>Our study revealed a low overall PAE rate of 0.063%. 'Clotted specimens' and 'insufficient quantity' were the most frequent errors. Importantly, we identified significant differences in the types of PAEs across laboratory sections, hospital departments, and working shifts, indicating their multifaceted and context-dependent nature.</p><p><strong>Limitations: </strong>A retrospective, single-center study.</p>","PeriodicalId":93875,"journal":{"name":"Annals of Saudi medicine","volume":"45 6","pages":"381-387"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12640526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age, not tumor size, modifies the association between extrathyroidal extension and long-term outcomes in patients with follicular cell-derived thyroid carcinoma.","authors":"Shaza Ahmed Samargandy, Saad Samargandy, Hanan Mohammed Faruqui, Asala Baharoon, Mazin Merdad, Ahad Khalaf M Alsuwat","doi":"10.5144/0256-4947.2025.414","DOIUrl":"10.5144/0256-4947.2025.414","url":null,"abstract":"<p><strong>Background: </strong>Follicular cell-derived thyroid carcinomas (FCTC) are common, with stable mortality rates but significant recurrence risks. Extrathyroidal extension (ETE) affects recurrence risk and staging. The 8th edition of the AJCC/TNM classification excludes microscopic ETE from upstaging but considers gross ETE a significant factor in older patients.</p><p><strong>Objective: </strong>This study examines clinical outcomes and disease-free survival (DFS) in FCTC patients with and without ETE, evaluating the modifying effects of age and tumor size on incomplete response risk.</p><p><strong>Design: </strong>A single-center retrospective chart review was conducted at King Abdulaziz University Hospital, Jeddah, Saudi Arabia.</p><p><strong>Setting: </strong>King Abdulaziz University Hospital.</p><p><strong>Patients and methods: </strong>Patients aged ≥13 years diagnosed from January 2017 to December 2021 with long-term follow-up (≥18 months) were included. Medullary and anaplastic thyroid cancers were excluded. Data on demographics, tumor characteristics, risk stratification, and clinical outcomes were collected. Response to therapy was categorized per the 2015 ATA guidelines. Chi-square and Multivariable analysis assessed interactions between age, tumor size, and ETE in predicting incomplete response. Kaplan-Meier curves visualized survival differences.</p><p><strong>Main outcome measures: </strong>Identifying the interactions between age and tumor size with ETE to predict the risk of incomplete response to therapy among patients with FCTC.</p><p><strong>Sample size: </strong>255 patients. The median follow-up duration was 4 years.</p><p><strong>Results: </strong>Patients with ETE were present in (n=38) 15.7% (8% microscopic, 7% gross). Older patients (≥55 years) with ETE had 26.47-fold higher odds of incomplete response than younger patients. Tumor size independently predicted incomplete response, but its interaction with ETE was not significant. Patients with ETE had a significantly higher incomplete response rate (58% vs. 17%, <i>P</i>=.0001).</p><p><strong>Conclusion: </strong>Older patients with ETE face a markedly higher risk of incomplete response. Tumor size is an independent risk factor in those patients. Management should be stratified by age, advocating more aggressive management for older patients with ETE.</p><p><strong>Limitations: </strong>Retrospective, and single-center design.</p>","PeriodicalId":93875,"journal":{"name":"Annals of Saudi medicine","volume":"45 6","pages":"414-420"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12640516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"errata.","authors":"","doi":"10.5144/0256-4947.2025.445","DOIUrl":"10.5144/0256-4947.2025.445","url":null,"abstract":"","PeriodicalId":93875,"journal":{"name":"Annals of Saudi medicine","volume":"45 6","pages":"445"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12640525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of permanent hypoparathyroidism following total thyroidectomy: a retrospective analysis.","authors":"Shaza Samargandy, Abdulaziz S Alotaibi, Abdulaziz A Alzahrani, Suhail A Alzahrani, Ahmed H Alghamdi, Abdulrahman M Alotaibi, Hassan A Alsahafi, Ayman A Alsolami, Hani Z Marzouki, Saad Samargandy","doi":"10.5144/0256-4947.2025.406","DOIUrl":"10.5144/0256-4947.2025.406","url":null,"abstract":"<p><strong>Background: </strong>Hypoparathyroidism (HPT) is a significant potential complication following thyroidectomy. Identifying predictors can aid in risk stratification, management, and potentially prevention.</p><p><strong>Objective: </strong>To determine clinical and biochemical predictors of permanent HPT in post-thyroidectomy patients.</p><p><strong>Design: </strong>Single-center, retrospective cohort study.</p><p><strong>Settings: </strong>Tertiary care center in Saudi Arabia.</p><p><strong>Patients and methods: </strong>We conducted a retrospective analysis of 1085 patients who underwent total thyroidectomy from 2015 to 2022. Patients who developed postoperative HPT were categorized into transient and permanent HPT groups. Demographic, surgical, and biochemical variables were analyzed. Multivariable logistic regression was used to identify independent predictors of permanent HPT, using transient HPT as the reference.</p><p><strong>Main outcome measures: </strong>Identification of independent predictors associated with permanent HPT.</p><p><strong>Sample size: </strong>1085 patients, 264 with postoperative HPT.</p><p><strong>Results: </strong>We had 264 patients (24.3%) who developed postoperative HPT: 207 (19.1%) had transient and 57 (5.2%) had permanent HPT. Independent predictors of permanent HPT included thyroid cancer (Odds ratio, OR 2.08, 95% Confidence Interval, CI 1.03-4.17), autoimmune thyroid disease (OR 2.01, 95% CI 1.00-4.08), increased thyroid weight (OR 1.52 per 1 SD increase, 95% CI 1.08-2.14), and longer hospital stay (≥7 days) (OR 3.53, 95% CI 1.87-6.68). Preoperative vitamin D deficiency was identified as the only modifiable risk factor (OR 2.25, 95% CI 1.17-4.32). A postoperative parathyroid hormone (PTH) level ≤1.52 pmol/L within 24 hours was strongly associated with the risk of permanent HPT.</p><p><strong>Conclusion: </strong>Permanent HPT is significantly associated with preoperative vitamin D deficiency, thyroid malignancy, autoimmune thyroid disease, and greater thyroid weight. A postoperative PTH level ≤1.52 pmol/L is a reliable early biochemical predictor. Risk-based stratification may support individualized patient management and follow-up planning.</p><p><strong>Limitations: </strong>This was a single-center, retrospective study, limiting generalizability, in addition to the heterogeneity in surgeon experience and the time of PTH measurements post-operatively.</p>","PeriodicalId":93875,"journal":{"name":"Annals of Saudi medicine","volume":"45 6","pages":"406-413"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12640529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiotensin converting enzyme inhibitors (ACEIs) for anthracycline-induced cardiotoxicity: a systematic review and meta-analysis of randomized controlled trials.","authors":"Moaz Safwan, Mariam Safwan Bourgleh, Hani AlShakaki, Khawaja Husnain Haider","doi":"10.5144/0256-4947.2025.421","DOIUrl":"10.5144/0256-4947.2025.421","url":null,"abstract":"<p><strong>Background: </strong>Anthracyclines are widely used in cancer treatment and cause dose-dependent cardiotoxicity 2 different by increasing oxidative stress and RAS activation. Angiotensin converting enzyme inhibitors (ACEIs) show promise in reducing this damage.</p><p><strong>Objectives and design: </strong>This systematic review and meta-analysis evaluated the efficacy and safety of ACEIs in preserving left ventricular function and reducing cardiotoxicity associated with anthracycline therapy.</p><p><strong>Methods: </strong>A comprehensive search of databases up to May 2024 included randomized controlled trials (RCTs) that assessed ACEIs to prevent cardiotoxicity. Random-effects meta-analysis was applied.</p><p><strong>Main outcome measures: </strong>The primary outcome was changes in left ventricular ejection fraction (LVEF). Secondary outcomes included cardiac event incidence and adverse events.</p><p><strong>Sample size: </strong>Nine RCTs were included, encompassing 869 patients (440 ACEI group, 429 control group).</p><p><strong>Results: </strong>ACEIs significantly improved LVEF at six months (mean difference of 7.93%; 95% CI 3.18-12.67%; P=.001) but not at 12 months. Moreover, ACEIs were associated with non-statistically significant lower rates of heart failure and arrhythmia development compared to the control, with no significant differences noted in adverse events.</p><p><strong>Quality of evidence: </strong>Evidence quality was high for short-term LVEF improvement and moderate-to-low for other outcomes. Egger's regression test indicated a low risk of publication bias for LVEF.</p><p><strong>Heterogeneity: </strong>High (I²=97%) for LVEF at 6 months.</p><p><strong>Conclusion: </strong>ACEIs prevent cardiotoxicity in the short term without increasing adverse events. More extensive trials are needed to confirm long-term benefits.</p><p><strong>Limitations: </strong>The small number of RCTs and high heterogeneity limit the study. Inconsistent reporting of baseline cardiovascular factors and confounders also hindered accurate assessment of treatment effects.</p><p><strong>Registration: </strong>PROSPERO CRD42024555546.</p>","PeriodicalId":93875,"journal":{"name":"Annals of Saudi medicine","volume":"45 6","pages":"421-434"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12640519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of Toxoplasmosis and rubella infection among women of childbearing age in Makkah Province, Saudi Arabia: a five-year, retrospective study.","authors":"Mohammad Ahmad Ramadhan, Raafat AbdelMoneim Hassanein, Mona Ahmed Bahasan, Angham Ahmed Almakki, Talal Adnan Basha, Alya Ali AlKaf, Daniyah Tariq Bayumi, Nawaf Mohammed Al-Dajani","doi":"10.5144/0256-4947.2025.373","DOIUrl":"10.5144/0256-4947.2025.373","url":null,"abstract":"<p><strong>Background: </strong>Toxoplasmosis, an opportunistic intracellular protozoan infection caused by <i>Toxoplasma gondii</i> (<i>T. gondii</i>), and rubella, caused by the rubella virus (RV) are the two most common TORCH infections.</p><p><strong>Objectives: </strong>To evaluate seroprevalence of <i>T. gondii</i> and rubella infection among child bearing age women.</p><p><strong>Design: </strong>Retrospective design.</p><p><strong>Settings: </strong>Multi-center study.</p><p><strong>Patients and methods: </strong>The study included women of childbearing age living in the Western region of Saudi Arabia, who sought medical check-up in one of the governmental public hospitals. Electronic health records of eligible patients were reviewed during the period January 2017 to December 2021 from three major health care institutions.</p><p><strong>Main outcome measures: </strong>Seroprevalence of <i>T. gondii</i> and rubella infection among women of childbearing age in the Western region of Saudi Arabia.</p><p><strong>Sample size: </strong>13 895 women were screened and 2117 women of childbearing age were eligible.</p><p><strong>Results: </strong>Among the 2117 women, seropositive-antibodies-results for <i>T. gondii</i> were 148 (6.1%) for IgG antibodies anti-Toxo-IgG-antibodies, 16 (0.8%) for anti-Toxo-IgM-antibodies, and 14 (0.7%) for anti-Toxo-IgG and IgM-antibodies. Univariate analysis showed that the highest proportion of IgG+ women were recorded among 35-39 years of age followed by 25-29 years. The highest proportion of IgM+ was observed among 40-44 years old followed by 35-39 years. Among the women tested for rubella seroprevalence, 16 (0.8%) were IgM positive, 1346 (63.6%) were immune (IgG positive), and the remaining 755 (35.7%) were susceptible. Rubella immunity was moderately high (63.6%) but dropped significantly with increasing age.</p><p><strong>Conclusion: </strong>The seroprevalence of Toxoplasmosis in our study appears to be lower than the global average. Nevertheless, it highlights the need for targeted educational programs and public health initiatives with interventions to raise awareness in the community. Rubella immunity, while moderately high overall, showed a notable decline with increasing age, highlighting regular assessment of rubella vaccination programs in the country to ensure effective prevention and control of the disease. The study highlights the need for future research focusing on the epidemiologic trends of TORCH infections, given their broader implications on public health in Saudi Arabia.</p><p><strong>Limitations: </strong>The seroprevalence results were based on a small sample size living in the Western region of Saudi Arabia and may not reflect other regions in the country.</p>","PeriodicalId":93875,"journal":{"name":"Annals of Saudi medicine","volume":"45 6","pages":"373-380"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12640515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}