Agustín Muñoz-Cutillas , Sara Bellón-Alonso , Eduardo Bardón-Cancho , Santiago Rodríguez-Tubío-Dapena , Lucía Díez-Llamazares , Rosa Rodríguez-Fernández , Juan Luis Rodríguez-Cimadevilla
{"title":"Role of fractional exhaled nitric oxide in patients with sickle cell disease","authors":"Agustín Muñoz-Cutillas , Sara Bellón-Alonso , Eduardo Bardón-Cancho , Santiago Rodríguez-Tubío-Dapena , Lucía Díez-Llamazares , Rosa Rodríguez-Fernández , Juan Luis Rodríguez-Cimadevilla","doi":"10.1016/j.anpede.2024.09.003","DOIUrl":"10.1016/j.anpede.2024.09.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Patients with sickle cell disease exhibit different patterns in pulmonary function tests. In particular, there is little evidence on the fractional exhaled nitric oxide (FeNO) test, and its value ranges and its interpretation in these patients have been under debate in recent years.</div></div><div><h3>Methods</h3><div>We conduced a cross-sectional, observational and descriptive study between November 2021 and January 2023 including patients aged 6–18 years with sickle cell disease able to perform the FeNO test. We applied the GLI-2012 reference values and the ERS/ATS standards. We defined statistical significance as <em>P</em> < 0.05.</div></div><div><h3>Results</h3><div>The sample included 43 patients with a median age of 12 years (IQR, 10−15). We did not find an association between significantly elevated FeNO (≥25 ppb) and the diagnosis of asthma (<em>P =</em> 0.37), an obstructive pattern in spirometry (<em>P =</em> 0.67), a positive bronchodilator test (<em>P =</em> 0.53), clinical bronchial hyperreactivity in the context of cold or flu-like symptoms (<em>P =</em> 0.48), cough with exercise (<em>P =</em> 0.42) or nocturnal cough (<em>P =</em> 1.0), but found an association with peripheral eosinophilia (<em>P <</em> 0.01).</div></div><div><h3>Conclusions</h3><div>We found no association between FeNO values and the classic features of asthma (clinical or spirometric) in patients with sickle cell disease. Therefore, airway inflammation mechanisms are probably different in these patients.</div></div>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"101 4","pages":"Pages 258-266"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Toro-Pérez , Joaquin T. Limonero , Catalina Bolancé , Montserrat Guillen , Sergi Navarro-Vilarrubí , Ester Camprodon-Rosanas
{"title":"Suffering in children and adolescents in paediatric palliative care in Spain: psychometric properties of the qESNA scale","authors":"Daniel Toro-Pérez , Joaquin T. Limonero , Catalina Bolancé , Montserrat Guillen , Sergi Navarro-Vilarrubí , Ester Camprodon-Rosanas","doi":"10.1016/j.anpede.2024.09.005","DOIUrl":"10.1016/j.anpede.2024.09.005","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the psychometric properties of the qESNA scale and its usefulness to assess the suffering of paediatric patients with life-limiting and/or life-threatening diseases (children with LLTC) in clinical practice.</div></div><div><h3>Methods</h3><div>Cross-sectional and longitudinal study in 58 patients in Spain (female, 32.8%; mean age, 15.6 [SD, 4.5]; age range, 8–23 years), with administration of the qESNA scale along with other scales to assess anxiety, depression, emotion regulation and psychosocial functioning. We performed exploratory and confirmatory factor analyses and calculated goodness-of-fit indices were calculated; we assessed reliability by means of the Cronbach alpha and temporal stability and convergent validity through the intraclass correlation coefficient with scales used to assess psychological disorders and the specificity and sensitivity through ROC curves.</div></div><div><h3>Results</h3><div>The factor analysis identified a 14-item scale with 3 factors, a comparative fit index of 0.93, a Tucker-Lewis index of 0.91 and a root mean square error of approximation of 0.07. The Cronbach alpha was 0.85 and the intraclass correlation coefficient was 0.66. The convergent validity was high for the correlation to the risk of depression (−0.69) and of anxiety (−0.60) and emotional changes (−0.59). The analysis of the ROC curves showed that a score of less than 81 would be indicative of suffering, with a sensitivity of 83.33% and a specificity of 93.48%.</div></div><div><h3>Conclusions</h3><div>This study confirmed that the psychometric properties of the qESNA scale are good and the scale’s usefulness as an instrument to detect emotional suffering in children with life-limiting or life-threatening illnesses in clinical practice.</div></div>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"101 4","pages":"Pages 238-248"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joan Lorente-Piera , Eduardo Arnaus Martín , Christian Espinoza-Vinces , Beatriz Remon-González , Carla Rodríguez-Zanetti , Raquel Manrique-Huarte
{"title":"Characterization and management of vertigo in the pediatric population: comprehensive study on the most common etiology, audiovestibular, and psychosomatic manifestations","authors":"Joan Lorente-Piera , Eduardo Arnaus Martín , Christian Espinoza-Vinces , Beatriz Remon-González , Carla Rodríguez-Zanetti , Raquel Manrique-Huarte","doi":"10.1016/j.anpede.2024.09.007","DOIUrl":"10.1016/j.anpede.2024.09.007","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"101 4","pages":"Pages 288-291"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Enriqueta Roman , Josefa Barrio , Maria Luz Cilleruelo , Ricardo Torres , Vega Almazán , Cristobal Coronel , Beatriz Espin , Eva Martinez-Ojinaga , David Perez Solís , Maria Antonia Moreno , Joaquín Reyes , Luis Fernandez Salazar , Sergio Farrais , Gemma Castillejo , Noelia Fontanillas , Mar Noguerol , Alicia Prieto , y Ester Donat , Sociedad de Gastroenterología, Hepatología y Nutrición Pediátrica (SEGHNP), Sociedades de Pediatría de Atención Primaria (AEPap y SEPEAP), Sociedad Española de Enfermedad Celíaca (SEEC), Sociedades de Digestivo de Adultos (AEG y SEPD), Sociedades de Atención Primaria de adultos (SEMFYC, SEMG y SEMERGEN)
{"title":"Rational application of the ESPGHAN 2022 recommendations for the follow-up of the paediatric coeliac patient: consensus document of scientific societies (SEGHNP, AEPAP, SEPEAP, SEEC, AEG, SEPD, SEMFYC, SEMG and SEMERGEN)","authors":"Enriqueta Roman , Josefa Barrio , Maria Luz Cilleruelo , Ricardo Torres , Vega Almazán , Cristobal Coronel , Beatriz Espin , Eva Martinez-Ojinaga , David Perez Solís , Maria Antonia Moreno , Joaquín Reyes , Luis Fernandez Salazar , Sergio Farrais , Gemma Castillejo , Noelia Fontanillas , Mar Noguerol , Alicia Prieto , y Ester Donat , Sociedad de Gastroenterología, Hepatología y Nutrición Pediátrica (SEGHNP), Sociedades de Pediatría de Atención Primaria (AEPap y SEPEAP), Sociedad Española de Enfermedad Celíaca (SEEC), Sociedades de Digestivo de Adultos (AEG y SEPD), Sociedades de Atención Primaria de adultos (SEMFYC, SEMG y SEMERGEN)","doi":"10.1016/j.anpede.2024.09.008","DOIUrl":"10.1016/j.anpede.2024.09.008","url":null,"abstract":"<div><div>Coeliac disease is a common condition for which the only current treatment is a gluten-free diet. Adherence to this diet is not always easy and is associated with a reduction in quality of life for the patient and their family. Non-adherence is associated with complications of varying severity. The lack of control at the outpatient care level in a high percentage of these patients evinces the need to improve follow-up protocols and the approach to care delivery with coordination of paediatric gastroenterology units (PGU) and primary care paediatricians. With this aim in mind, the present document was developed by consensus to offer a set of recommendations adapted to our region, based on the recent recommendations published by the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN), and with participation of the pertinent scientific societies, including those concerning the adult population, for the management and follow-up of adolescents and the transition to adult care.</div></div>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"101 4","pages":"Pages 267-277"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Garcia de Oteyza , Miguel Ángel Molina Gutiérrez , Carlota Marín Córdoba , María de Ceano-Vivas
{"title":"Use of topical antibiotic therapy in acute otitis media with otorrhea: Results of a national survey","authors":"Maria Garcia de Oteyza , Miguel Ángel Molina Gutiérrez , Carlota Marín Córdoba , María de Ceano-Vivas","doi":"10.1016/j.anpede.2024.07.018","DOIUrl":"10.1016/j.anpede.2024.07.018","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"101 4","pages":"Pages 291-292"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Villamañán Montero , Carlos Martín de Vicente , Juan Pablo García Íñiguez , Feliciano Ramos Fuentes
{"title":"Reference charts for the six-minute walk test in healthy school-aged children from the city of Zaragoza, Spain","authors":"Ana Villamañán Montero , Carlos Martín de Vicente , Juan Pablo García Íñiguez , Feliciano Ramos Fuentes","doi":"10.1016/j.anpede.2024.09.002","DOIUrl":"10.1016/j.anpede.2024.09.002","url":null,"abstract":"<div><h3>Introduction</h3><div>The six-minute walk test is a stress test that provides information about exercise tolerance in chronic diseases. The aim of the study was to develop reference equations with normal values for the test in healthy children aged 6–12 years in our paediatric reference population.</div></div><div><h3>Patients and methods</h3><div>The six-minute walk test was carried out in a sample of 236 healthy children, analyzing pre- and post-test variables, and we developed reference equations selecting variables that turned out to be significant (<em>P</em> < .05).</div></div><div><h3>Results</h3><div>The pre- and post-test values, respectively, were 97.82% (SD, 0.64) vs 97.82% (SD, 0.59) for oxygen saturation; 96.59 bpm (SD, 16.11) vs 131.89 bmp (SD, 22.64) for the heart rate; 0.52 (SD, 0.83) vs 3.01 (SD, 2.42) for the degree of dyspnea (Borg scale) and 0.68 (SD, 0.98) vs 2.95 (SD, 2.26) for the degree of lower extremities fatigue (Borg scale). The average distance walked was 668.03 m (SD, 87.36) (671.42 m in boys [SD, 92.2] vs 664.22 m in girls [SD, 81.81]). We fitted predictive equations that included the variables age, height and difference between baseline and final heart rate. We also generated percentile charts of the distance walked for height.</div></div><div><h3>Conclusions</h3><div>Age, height, regular physical activity and obesity had an impact on test results. Obtaining reference values for the 6-min walk test in healthy children is necessary for its application in clinical practice.</div></div>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"101 4","pages":"Pages 230-237"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fernando Moraga-Llop , María Garcés-Sánchez , Juan José González-López
{"title":"Reemergence of pertussis: Strategies and challenges in its control in Spain","authors":"Fernando Moraga-Llop , María Garcés-Sánchez , Juan José González-López","doi":"10.1016/j.anpede.2024.07.017","DOIUrl":"10.1016/j.anpede.2024.07.017","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"101 4","pages":"Pages 227-229"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}