Cardiovascular Diabetology最新文献

{"title":"Association of prediabetes and insulin resistance on prognosis of patients with moderate-to-severe coronary artery calcification: a prospective cohort study.","authors":"Enmin Xie, Huimin Cai, Zixiang Ye, Min Yang, Lei Feng, Chenggang Zhu, Jia Li, Kefei Dou","doi":"10.1186/s12933-025-02807-4","DOIUrl":"10.1186/s12933-025-02807-4","url":null,"abstract":"<p><strong>Background: </strong>Prediabetes and insulin resistance are linked to the presence and progression of coronary artery calcification, but their prognostic significance in individuals with moderate-to-severe coronary artery calcification (MSCAC) remains unclear. The triglyceride-glucose (TyG) index, a validated surrogate marker of insulin resistance and a reliable predictor of cardiovascular outcomes, has not been thoroughly investigated for its role in risk stratification in patients with MSCAC. This study sought to evaluate the prognostic value of different prediabetes definitions and to determine whether the TyG index enhances risk stratification in this population.</p><p><strong>Methods: </strong>This prospective cohort study consecutively enrolled 4195 patients with angiography-detected MSCAC. Prediabetes was defined using two criteria: the American Diabetes Association (ADA) criteria (fasting plasma glucose [FPG] 5.6-6.9 mmol/L and/or hemoglobin A1c [HbA1c] 5.7-6.4%), and the World Health Organization (WHO)/International Expert Committee (IEC) criteria (FPG 6.1-6.9 mmol/L and/or HbA1c 6.0-6.4%). The primary outcome was the incidence of major adverse cardiovascular events (MACE), including cardiovascular death, nonfatal myocardial infarction, and stroke.</p><p><strong>Results: </strong>The prevalence of ADA-defined prediabetes was 36.6%, nearly twice that of WHO/IEC-defined prediabetes (17.9%). Over a median follow-up of 3.1 years, WHO/IEC-defined prediabetes was significantly associated with an increased risk of MACE compared to normoglycemia (adjusted hazard ratio [HR] 1.79, 95% confidence interval [CI] 1.07-2.99), while ADA-defined prediabetes was not. Patients in the highest TyG index tertile had a significantly higher MACE risk than those in the lowest tertile (adjusted HR 2.25, 95% CI 1.30-3.90). Restricted cubic spline analysis demonstrated a positive linear association between the TyG index and MACE risk (P for nonlinearity > 0.05). Notably, individuals with both WHO/IEC-defined prediabetes and a high TyG index had an even higher MACE risk (adjusted HR 2.43, 95% CI 1.12-5.32), whereas those with prediabetes and a low TyG index did not demonstrate a comparable increase (adjusted HR 1.60, 95% CI 0.90-2.85). Incorporating both WHO/IEC-defined glycemic status and the TyG index into the baseline risk model significantly improved its predictive accuracy compared to including either marker alone, as indicated by enhancements in the C-statistic, continuous net reclassification improvement, and integrated discrimination improvement. These findings were consistent in subgroup analyses and sensitivity analyses.</p><p><strong>Conclusion: </strong>This study highlights the prognostic value of WHO/IEC-defined prediabetes and the TyG index in identifying high-risk individuals among patients with MSCAC. Integrating these measures into clinical risk assessment may enhance prognostic accuracy and inform more targeted prevention strategies.</p","PeriodicalId":9374,"journal":{"name":"Cardiovascular Diabetology","volume":"24 1","pages":"262"},"PeriodicalIF":8.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The adverse effects of metabolic disorder on left ventricular myocardial mechano-energetic efficiency and dysfunction in ischemic cardiomyopathy: insight from a cardiac MRI study.","authors":"Li Jiang, Yuan Li, Xue-Ming Li, Ke Shi, Han Fang, Wei-Feng Yan, Ying-Kun Guo, Hua-Yan Xu, Zhi-Gang Yang","doi":"10.1186/s12933-025-02817-2","DOIUrl":"10.1186/s12933-025-02817-2","url":null,"abstract":"<p><strong>Purpose: </strong>Metabolic risk factors (MetF) have emerged as the leading drivers of ischemic cardiomyopathy (ICM) worldwide. However, in patients who have already experienced myocardial ischemia/infarction, whether and in what pattern the MetF act on the heart needs to be further elucidated. This study aims to determine the adverse effects of MetF on left ventricular (LV) indexed myocardial mechano-energetic efficiency (MEEi) and dysfunction in patients with ICM, and further clarify which MetF classification is more clinically significant.</p><p><strong>Materials and methods: </strong>This study retrospectively included 201 patients with ICM who underwent cardiac magnetic resonance imaging (MRI) examinations, and further divided them into the following three groups according to the number of coexisting MetF: The groups with no MetF (MetF-0 group, n = 32), with 1-2 MetF (MetF-1, n = 92) and with 3-5 MetF (MetF-2, n = 77). The clinical variables and MRI-derived parameters were measured and compared among the three groups. Multivariate linear regression analysis was performed to determine independent correlation of MetF on LV MEEi and strain in ICM patients.</p><p><strong>Results: </strong>LV global circumferential peak strain (PS) gradually decreased from MetF-0 group, through MetF-1 group, to MetF-2 group (- 9.52 ± 2.70% vs. - 7.62 ± 2.73% vs. - 6.50 ± 2.70%, P < 0.001). MetF-1 and MetF-2 groups both showed lower MEEi, lower LV global radial and longitudinal PS than MetF-0 group (Both P < 0.001), while there was no statistically significant difference between MetF-1 and MetF-2 groups (P > 0.05). Multivariate analyses indicated that the coexisting any MetF was independently associated with decreased LV MEEi (β = - 0.093, P = 0.018) and PS (Radial, β = - 0.232, P < 0.001; Circumferential, β = 0.156, P = 0.002; Longitudinal, β = 0.192, P = 0.008), and the increase in the number of coexisting MetF was only related to the reduction of circumferential PS (β = 0.238, P = 0.006).</p><p><strong>Conclusions: </strong>Our results revealed whether coexisting any MetF, rather than coexisting a greater number of MetF, is associated with the reduction of LV myocardial mechano-energetic efficiency and dysfunction in patients with ICM, suggesting that clinicians should promptly identify and treat any coexisting MetF in the management of ICM patients.</p>","PeriodicalId":9374,"journal":{"name":"Cardiovascular Diabetology","volume":"24 1","pages":"261"},"PeriodicalIF":8.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation-related 5-hydroxymethylation signatures as markers for clinical presentations of coronary artery disease.","authors":"Jing Xu, Hangyu Chen, Jingang Yang, Yanmin Yang, Yuan Wu, Jun Zhang, Jiansong Yuan, Tianjie Wang, Tao Tian, Jia Li, Xueyan Zhao, Xiaojin Gao, Jie Lu, Lin Li, Lei Zhang, Xuehui Li, Long Chen, Chuan He, Chaoran Dong, Jian Lin, Weixian Yang, Yuejin Yang","doi":"10.1186/s12933-025-02749-x","DOIUrl":"10.1186/s12933-025-02749-x","url":null,"abstract":"<p><strong>Background: </strong>Coronary angiography remains the gold standard for diagnosing coronary artery disease (CAD), but its invasive nature limits its applicability for widespread screening. Identifying non-invasive molecular markers could improve CAD classification and risk assessment.</p><p><strong>Methods: </strong>We employed 5hmC-Seal technology to generate genome-wide 5-hydroxymethylcytosine (5hmC) profiles from plasma cell-free DNA (cfDNA) in 724 CAD patients, stratified into stable CAD (sCAD), non-ST-elevation myocardial infarction (NSTEMI), and ST-elevation myocardial infarction (STEMI) groups. Using machine learning algorithms, we identified inflammation-related 5hmC modifications associated with disease severity and constructed a classification model based on key hydroxymethylated markers. The model was validated internally and externally in an independent cohort of 167 patients.</p><p><strong>Results: </strong>We found that inflammation-related differentially hydroxymethylated genes (DhMGs) were significantly associated with CAD severity, with enriched pathways linked to immune activation and inflammatory response regulation. A 19-marker panel of 5hmC-based features effectively distinguished CAD patients at different disease stages, with high classification accuracy (AUC = 0.913 in the internal validation cohort). External validation confirmed the robustness of the model, achieving AUCs of 0.784, 0.880, and 0.918 when differentiating between NCA vs. sCAD, sCAD vs. MI, and NCA vs. MI, respectively. Compared to traditional clinical indicators, the 5hmC-based model demonstrated superior discriminatory power for MI.</p><p><strong>Conclusions: </strong>Our findings suggest that 5hmC modifications in cfDNA reflect CAD-related epigenetic changes and may serve as a promising biomarker for disease stratification. These results provide new insights into the epigenetic landscape of CAD and highlight the potential utility of 5hmC profiling for non-invasive disease monitoring. Further studies are warranted to validate these findings and explore their clinical implications.</p>","PeriodicalId":9374,"journal":{"name":"Cardiovascular Diabetology","volume":"24 1","pages":"237"},"PeriodicalIF":8.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Protective role of arachidonic acid against diabetic myocardial ischemic injury: a translational study of pigs, rats, and humans.","authors":"Yunhui Lv, Kai Li, Shuo Wang, Xiaokang Wang, Guangxin Yue, Yangyang Zhang, Xin Lv, Ping Zhao, Shiping Wang, Qi Zhang, Qiuju Li, Jinyan Zhu, Jubo Li, Peng Peng, Yue Li, Jiafei Luo, Xue Zhang, Jianzhong Yang, Baojie Zhang, Xuemin Wang, Min Zhang, Chen Shen, Xin Wang, Miao Wang, Zhen Ye, Yongchun Cui","doi":"10.1186/s12933-025-02822-5","DOIUrl":"10.1186/s12933-025-02822-5","url":null,"abstract":"","PeriodicalId":9374,"journal":{"name":"Cardiovascular Diabetology","volume":"24 1","pages":"260"},"PeriodicalIF":8.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of different insulin resistance-related indices with the incidence and progression trajectory of cardiometabolic multimorbidity: a prospective cohort study from UK biobank.","authors":"Zhenyu Tian, Lu Yang, Yifei Li, Yueqing Huang, Jianmin Yang, Fei Xue","doi":"10.1186/s12933-025-02819-0","DOIUrl":"10.1186/s12933-025-02819-0","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Despite established associations between insulin resistance (IR)-related indices and cardiometabolic diseases (CMDs), most studies are limited to single CMD outcomes. The study aimed to examine the influence of IR-related indices on the incidence, predictive value, and progression trajectory of cardiometabolic multimorbidity (CMM), as well as potential biological mechanisms.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This prospective study included 374,274 individuals from the UK Biobank who were free of CMDs at baseline. CMM was defined as the presence of two or more CMDs, including type 2 diabetes (T2D), coronary heart disease (CHD), and stroke. Five indices were developed to assess IR levels: triglyceride-glucose (TyG) index, TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), TyG-waist-height ratio (TyG-WHtR), and triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio. Cox proportional hazards and multi-state models were utilized to examine the associations between IR-related indices and CMM incidence and transition, respectively, with results expressed as hazard ratios (HRs) and 95% confidence intervals (CIs). The predictive utility of these indices was assessed using the net reclassification index (NRI) and integrated discrimination improvement index (IDI). Mediation analyses were conducted to quantify the potential mediating roles of biomarkers.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;During a mean follow-up period of 13.7 years, 5048 (1.3%) individuals developed CMM. Elevated baseline IR-related indices were associated with higher risks of incident CMM. The HRs (95% CIs) for each 1-standard deviation increase were as follows: 1.30 (1.26-1.34) for the TyG index, 1.42 (1.39-1.46) for the TyG-BMI, 1.54 (1.49-1.59) for the TyG-WC, 1.52 (1.48-1.57) for the TyG-WHtR, and 1.19 (1.17-1.21) for the TG/HDL-C ratio. Besides, TyG-WHtR and TyG-WC exhibited significantly higher NRI and IDI, indicating superior predictive performance for CMM risk. These indices played critical yet distinct roles in the progression of CMM. For transitions from being free of CMDs to single CMDs, these indices had the strongest impact on T2D (all P &lt; 0.001). Participants initially diagnosed with CHD were more likely to progress to CMM when exposed to higher IR-related indices (all P &lt; 0.001). The effect sizes for TyG-WC and TyG-WHtR were greater than those of other indices across all transitions. Mediation analyses revealed that biomarkers associated with liver function, renal function, and inflammation collectively mediated approximately one-third of the associations of the TyG-WHtR and TyG-WC indices with incident CMM.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Our findings highlight the critical role of IR-related indices, particularly TyG-WHtR and TyG-WC, in the incidence, progression, and prevention of CMM. The mediation effects of biomarkers indicate the potential for targeted interventions to reduce CMM risk in high-IR individuals.&lt;","PeriodicalId":9374,"journal":{"name":"Cardiovascular Diabetology","volume":"24 1","pages":"257"},"PeriodicalIF":8.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrial dysfunction: a contrast-free marker for HFpEF in obese diabetics-insights from comprehensive CMR and serum biomarker analyses.","authors":"Rebecca Elisabeth Beyer, Maximilian Leo Müller, Patrick Doeblin, Stefanie Maria Werhahn, Amedeo Chiribiri, Carsten Tschöpe, Smita Sampath, G Brandon Atkins, Dawn Cislak, An Bautmans, John Palcza, Tom McAvoy, Asad Abu Bakar, Anita Y H Lee, Xuemei Zhao, Maximilian G Posch, Johannes Wieditz, Radu Tanacli, Victoria Zieschang, Mithal Nassar, Seyedeh Mahsa Zamani, Christian Stehning, Frank Edelmann, Djawid Hashemi, Sebastian Kelle","doi":"10.1186/s12933-025-02808-3","DOIUrl":"10.1186/s12933-025-02808-3","url":null,"abstract":"<p><strong>Background: </strong>The diagnostic criteria for HFpEF remain inconsistently defined, further confounded by comorbidities such as obesity and type 2 diabetes mellitus (T2DM), which are thought to contribute to its pathogenesis via chronic pro-inflammatory mechanisms. This study aimed to evaluate the relationship between advanced cardiac magnetic resonance (CMR) imaging and pro-fibrotic and inflammatory serum biomarkers, assessing their potential to discriminate HFpEF from associated comorbid conditions.</p><p><strong>Methods: </strong>This was an exploratory analysis of a prospective cohort study of 35 obese/overweight participants (mean age 64 ± 8 years, 23% females), including 16 with T2DM, 13 with HFpEF (NYHA II-III) and T2DM, and 6 healthy controls. All subjects underwent comprehensive contrast-enhanced CMR at a 3 T scanner (Philips Ingenia, The Netherlands), including assessment of left ventricular and left atrial (LA) volumetry and function, myocardial perfusion reserve (MPR), and diffuse fibrosis imaging (ECV). Obtained serum biomarkers were Pentraxin-3, Galectin-3 and Interleukin-1 Receptor-Like 1 (IL1RL1). Statistical analyses included one-way ANOVA, Tukey test, Pearson's correlation, regression and receiver operating characteristic analyses, and intra-class correlation.</p><p><strong>Results: </strong>In multivariable regression, impaired measures of LA structure and function emerged as the only independent discriminators of HFpEF, with LA maximum volume showing an OR of 1.13 (95% CI 1.05-1.28), reservoir strain of 0.71 (95% CI 0.44-0.89), conduit strain of 0.57 (95% CI 0.32-0.82) and booster strain of 0.70 (95% CI 0.48-0.89) per unit increase. No differences in MPR nor ECV were observed between the groups. While serum biomarkers Galectin-3 and Pentraxin-3 were significantly higher in HFpEF vs. obese controls (16.1 ng/ml ± 3.8 ng/ml vs. 10.6 ng/ml ± 3.7 ng/ml, p = 0.011, and 0.84 ng/ml ± 0.67 ng/ml vs. 0.21 ng/ml ± 0.05 ng/ml, p = 0.031, respectively), these biomarkers remained within normal limits and showed only moderate correlations with CMR metrics. Highest inter-study reproducibility was seen in MPR (ICC: 0.94), LA Reservoir Strain (ICC: 0.84) and serum biomarkers (ICC: 0.087-0.93).</p><p><strong>Conclusion: </strong>CMR markers of diffuse fibrosis and microvascular dysfunction may not differentiate HFpEF from obese or diabetic controls. However, left atrial function assessment may evolve to be a reproducible and practical CMR marker, effectively distinguishing HFpEF independent of fibrotic remodeling.</p>","PeriodicalId":9374,"journal":{"name":"Cardiovascular Diabetology","volume":"24 1","pages":"258"},"PeriodicalIF":8.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily low dose aspirin halves incident type 2 diabetes in elderly subjects with prediabetes: a five-year longitudinal cohort study in a real-word population.","authors":"Maria Lembo, Valentina Trimarco, Daniela Pacella, Raffaele Izzo, Maria Virginia Manzi, Stanislovas S Jankauskas, Roberto Piccinocchi, Paola Gallo, Carmine Morisco, Luca Bardi, Gaetano Piccinocchi, Stefano Cristiano, Giuseppe Giugliano, Giovanni Esposito, Gaetano Santulli, Bruno Trimarco","doi":"10.1186/s12933-025-02802-9","DOIUrl":"10.1186/s12933-025-02802-9","url":null,"abstract":"","PeriodicalId":9374,"journal":{"name":"Cardiovascular Diabetology","volume":"24 1","pages":"259"},"PeriodicalIF":8.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of different hypertensive disorders of pregnancy on cardiovascular disease risk and all-cause mortality in women with type 1 diabetes.","authors":"Kaarina Rimpeläinen, Fanny Jansson Sigfrids, Daniel Gordin, Miira M Klemetti, Valma Harjutsalo, Per-Henrik Groop, Lena M Thorn","doi":"10.1186/s12933-025-02804-7","DOIUrl":"10.1186/s12933-025-02804-7","url":null,"abstract":"<p><strong>Objectives: </strong>Our aim was to assess how pre-eclampsia, gestational hypertension, and chronic (pre-pregnancy) hypertension, compared to no hypertensive disorders during pregnancy, impact development of cardiovascular disease and all-cause mortality in type 1 diabetes (T1D).</p><p><strong>Methods: </strong>We included 190 T1D women with median age of 29.4 (interquartile range 26.0-33.3) years at delivery between 1988 and 1994 at the Helsinki University Hospital, and who were later re-examined within the Finnish Diabetic Nephropathy Study. Of these, 43 (22.6%) had had pre-eclampsia, 32 (16.8%) gestational hypertension, 20 (10.5%) chronic hypertension, and 95 (50.0%) had remained normotensive during the index pregnancy. We retrieved follow-up data on cardiovascular events and mortality from national registries until the end of 2020.</p><p><strong>Results: </strong>During a median 27.9 (25.4-30.7) years of follow-up, 46 (24.2%) experienced a composite cardiovascular event and 25 (13.2%) died from any cause. In Cox regression analysis, the risk of a cardiovascular event was increased for chronic hypertension [hazard ratio, HR 3.45 (95% CI 1.25-9.54)], gestational hypertension [HR 3.63 (1.55-8.51)], and pre-eclampsia [HR 5.07 (2.31-11.11)] compared with the non-hypertension group, after adjustment for delivery age and age at T1D onset. The corresponding risk of all-cause mortality was increased for chronic hypertension [HR 3.31 (1.06-10.35)] and pre-eclampsia [HR 2.92 (1.07-7.98)], but not for gestational hypertension [HR 1.26 (0.33-4.85)]. After further adjustment for diabetic kidney disease or diabetic retinopathy as a time-dependent covariate, the association with cardiovascular disease remained for pre-eclampsia and gestational hypertension, while for mortality, none of the associations were significant.</p><p><strong>Conclusion: </strong>Hypertension during pregnancy is associated with increased risk of cardiovascular events during long-term follow-up in women with T1D, with pre-eclampsia conferring the highest risk. For all-cause mortality, chronic hypertension and pre-eclampsia, but not gestational hypertension, increases the risk of death, yet not independently of diabetic kidney disease.</p>","PeriodicalId":9374,"journal":{"name":"Cardiovascular Diabetology","volume":"24 1","pages":"255"},"PeriodicalIF":8.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of atherogenic index of plasma and its modified indices with stroke risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a longitudinal analysis based on CHARLS.","authors":"Xiaoyan Wang, Pengfei Wen, Yun Liao, Tao Wu, Lin Zeng, Yuxing Huang, Xiaomei Song, Zhen Xiong, Lisha Deng, Dingjun Li, Shuchuan Miao","doi":"10.1186/s12933-025-02784-8","DOIUrl":"10.1186/s12933-025-02784-8","url":null,"abstract":"<p><strong>Background: </strong>The association between the atherogenic index of plasma (AIP), its modified indices (such as AIP-waist circumference [AIP-WC], AIP-waist-to-height ratio [AIP-WHtR], AIP-body mass index[AIP-BMI]), and incident stroke in individuals with cardiovascular-kidney-metabolic (CKM) stages 0-3 remains understudied. This study investigated these associations and their utility for risk stratification.</p><p><strong>Methods: </strong>Data from 3697 China Health and Retirement Longitudinal Study (CHARLS) participants (≥ 45 years, CKM stages 0-3) were analyzed. Baseline, cumulative, and changes in AIP and its modified indices (AIP-WC, AIP-WHtR, AIP-BMI) were calculated. Logistic regression, Delong's test, integrated discrimination improvement (IDI), weighted quantile sum (WQS) regression, and mediation analysis were used to assess associations, predictive performance, component contributions, and mediation effects.</p><p><strong>Results: </strong>Stroke occurred in 4.8% of participants. Under the fully adjusted Model 3: The third level of AIP, AIP-WHtR, AIP-WC, and AIP-BMI showed increased risks (ORs 1.58 [95% CI 1.05-2.38], 1.99 [95% CI 1.31-3.02], 1.99 [95% CI 1.31-3.02], and 1.92 [95% CI 1.26-2.92], respectively); The third level of cumulative AIP, AIP-WHtR, AIP-WC, and AIP-BMI showed elevated risks (ORs 1.79 [95% CI 1.19-2.69], 2.07 [95% CI 1.37-3.13], 2.01 [95% CI 1.33-3.04], and 1.92 [95% CI 1.27-2.89], respectively); The third category of AIP, AIP-WHtR, AIP-WC, and AIP-BMI changes showed risk increases of 2.28 (95% CI 1.46-3.55), 2.39 (95% CI 1.50-3.79), 2.56 (95% CI 1.61-4.07), and 2.22 (95% CI 1.38-3.56). Modified AIP indices (especially AIP-WHtR) demonstrated superior predictive ability than AIP alone. The association was amplified in advanced CKM (stages 2-3) but not significant in early CKM (stages 0-1). Triglycerides (TG) primarily drove the AIP-WHtR-stroke risk, which was partially mediated by estimated pulse wave velocity (ePWV) (6.48%).</p><p><strong>Conclusions: </strong>AIP and its modified indices, especially AIP-WHtR, are significantly associated with incident stroke in CKM stages 0-3. Dynamically monitoring changes in these indices is crucial for stroke risk assessment and stratification, particularly in advanced CKM. TG primarily drives this risk, while ePWV partially mediates the AIP-WHtR-stroke link.</p>","PeriodicalId":9374,"journal":{"name":"Cardiovascular Diabetology","volume":"24 1","pages":"254"},"PeriodicalIF":8.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study.","authors":"Liye Lai, Dave Laurence Juntilla, Monica Del C Gomez-Alonso, Harald Grallert, Barbara Thorand, Aiman Farzeen, Wolfgang Rathmann, Juliane Winkelmann, Holger Prokisch, Christian Gieger, Christian Herder, Annette Peters, Melanie Waldenberger","doi":"10.1186/s12933-025-02760-2","DOIUrl":"10.1186/s12933-025-02760-2","url":null,"abstract":"","PeriodicalId":9374,"journal":{"name":"Cardiovascular Diabetology","volume":"24 1","pages":"252"},"PeriodicalIF":8.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}