{"title":"Edrophonium and plasma cholinesterase activity.","authors":"R K Mirakhur","doi":"10.1007/BF03014265","DOIUrl":"https://doi.org/10.1007/BF03014265","url":null,"abstract":"<p><p>Plasma cholinesterase activity was estimated following administration of edrophonium 0.5 or 1.0 mg X kg-1 given for antagonism of atracurium-induced neuromuscular block. There was no inhibition of enzyme activity for up to three hours following edrophonium administration. This is in contrast to profound and prolonged inhibition of enzyme activity seen following neostigmine and pyridostigmine.</p>","PeriodicalId":9371,"journal":{"name":"Canadian Anaesthetists' Society journal","volume":"33 5","pages":"588-90"},"PeriodicalIF":0.0,"publicationDate":"1986-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03014265","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14887125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Open drop ether anaesthesia for caesarean section: a review of 420 cases in Nepal.","authors":"J R Maltby, D S Malla, H Dangol","doi":"10.1007/BF03014272","DOIUrl":"https://doi.org/10.1007/BF03014272","url":null,"abstract":"<p><p>Anaesthesia for Caesarean sections performed during 1982-83 at the Women's Hospital in Kathmandu, Nepal is reviewed. In a twelve-month period 535 Caesarean sections were performed, representing 7.36 per cent of 7,263 deliveries. Many pregnant women in Nepal do not have antenatal care and the mean haemoglobin of these mothers was 86 g X L-1. In the absence of an on-call anaesthetist for obstetrics, more than 90 per cent of the anaesthetics were given by junior obstetric residents, using open drop diethyl ether without endotracheal intubation. Eleven patients developed postoperative chest infection; in none of these was there any suggestion of inhalation of gastric contents and all recovered uneventfully. Of the 18 maternal deaths in the 7,263 deliveries during this period, one occurred during Caesarean section. This was due to uncontrollable haemorrhage and was not attributable to the anaesthetic. For poor risk patients, and in unskilled hands, diethyl ether remains a remarkably safe anaesthetic.</p>","PeriodicalId":9371,"journal":{"name":"Canadian Anaesthetists' Society journal","volume":"33 5","pages":"651-6"},"PeriodicalIF":0.0,"publicationDate":"1986-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03014272","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14887129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacokinetics of meperidine in spinal anaesthesia.","authors":"M. Naguib, C. E. Famewo, A. Absood","doi":"10.1097/00132582-198609000-00028","DOIUrl":"https://doi.org/10.1097/00132582-198609000-00028","url":null,"abstract":"Five male patients undergoing haemorrhoidectomy received intrathecal meperidine 1 mg X kg-1 as the sole anaesthetic agent. Plasma concentration-time profiles were investigated. The peak plasma concentration of meperidine was 175 +/- 78.8 ng X ml-1 (mean +/- SD) and this occurred 90 minutes after intrathecal injection. The plasma concentrations generally were lower than those necessary for systemic analgesic effects. The terminal elimination half life of meperidine (t 1/2 beta) in the plasma was 198 minutes. Intrathecal meperidine produced good surgical anaesthesia in all patients studied. The mean duration of sensory and motor block was 77 +/- 18.8 and 47 +/- 7.4 minutes respectively. Four patients did not require any analgesic supplement during the postoperative period. No patient developed clinically evident respiratory depression or neurological sequelae. The pharmacokinetic data suggests that intrathecal meperidine provides prolonged postoperative analgesia through a regional effect on opioid receptors in the spinal cord.","PeriodicalId":9371,"journal":{"name":"Canadian Anaesthetists' Society journal","volume":"96 1","pages":"162-6"},"PeriodicalIF":0.0,"publicationDate":"1986-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80573132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contribution of muscle relaxant to the haemodynamic course of high-dose fentanyl anaesthesia: a comparison of pancuronium, vecuronium and atracurium.","authors":"J Heinonen, M Salmenperä, M Suomivuori","doi":"10.1007/BF03014267","DOIUrl":"https://doi.org/10.1007/BF03014267","url":null,"abstract":"<p><p>To define the role of muscle relaxants in haemodynamic responses to high-dose (75 micrograms X kg-1) fentanyl anaesthesia and to noxius stimuli associated with intubation and sternal spread during coronary artery bypass surgery, we compared haemodynamics between three groups of patients given either pancuronium (0.1 mg X kg-1, n = 11), vecuronium (0.086 mg X kg-1, n = 11) or atracurium (0.43 mg X kg-1, n = 12). Additional doses of the relaxants were given to maintain a 90 per cent neuromuscular block. Patients given pancuronium showed no increases in mean values of heart rate, arterial pressure or cardiac output during the induction of anaesthesia or after intubation, whereas a decrease in these variables was observed in the vecuronium group. The haemodynamics in the atracurium group were intermediate compared with the other two study groups. In spite of a decrease in coronary perfusion pressure, no patient given vecuronium developed myocardial ischaemia. An advantage of vecuronium over pancuronium and atracurium was an attenuation of the blood pressure response to sternotomy. Patients given atracurium had a small increase in pulmonary vascular resistance during sternotomy. Our patients continued their beta-adrenergic antagonist medication until the morning of the day of operation and they were pretreated with a small intravenous dose of diazepam (0.1 mg X kg-1) before induction of anaesthesia. These drugs may have prevented the deleterious haemodynamic effects observed by some investigators after the administration of pancuronium during high-dose fentanyl anaesthesia.</p>","PeriodicalId":9371,"journal":{"name":"Canadian Anaesthetists' Society journal","volume":"33 5","pages":"597-605"},"PeriodicalIF":0.0,"publicationDate":"1986-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03014267","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14014323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Respiratory depression following epidural morphine: a clinical study.","authors":"A N Sandler, P Chovaz, W Whiting","doi":"10.1007/BF03014258","DOIUrl":"https://doi.org/10.1007/BF03014258","url":null,"abstract":"<p><p>Thirteen post-thoracotomy patients were entered into a double-blind, randomized clinical trial comparing the effects of epidural morphine (Group E) and intravenous morphine (Group I) on postoperative respiratory depression. Postoperative respiratory depression was assessed for 24 hours by (a) PaCO2 at 2, 6, 12 and 24 hours (b) hourly assessment of respiratory rate (RR) (c) presence of respiratory rate of less than ten breaths per min for greater than 5 min (SRR) (d) hypopnoea/apnoea (H/A). RR, SRR, and H/A were measured using respiratory inductive plethysmography. PaCO2 was significantly elevated at 2, 6 and 12 hours in Group E and only at two hours in Group I. One of five patients in Group I had a single episode of SRR whereas five of eight patients in Group E had multiple episodes of SRR. None of the patients in Group I had H/A episodes, in contrast to six of eight in Group E who had numerous H/A episodes post-operatively. This difference was statistically significant. Multiple doses of epidural morphine produce an insidious and unpredictable change in respiratory pattern. Electronic monitoring is useful to assess those at risk of overdose and possible respiratory arrest.</p>","PeriodicalId":9371,"journal":{"name":"Canadian Anaesthetists' Society journal","volume":"33 5","pages":"542-9"},"PeriodicalIF":0.0,"publicationDate":"1986-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03014258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14225976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pulmonary hypertension in children: perioperative management.","authors":"F A Burrows, J R Klinck, M Rabinovitch, D J Bohn","doi":"10.1007/BF03014268","DOIUrl":"https://doi.org/10.1007/BF03014268","url":null,"abstract":"","PeriodicalId":9371,"journal":{"name":"Canadian Anaesthetists' Society journal","volume":"33 5","pages":"606-28"},"PeriodicalIF":0.0,"publicationDate":"1986-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03014268","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14656075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding and selecting monitoring equipment in anaesthesia and intensive care.","authors":"C E Hope, D L Morrison","doi":"10.1007/BF03014276","DOIUrl":"https://doi.org/10.1007/BF03014276","url":null,"abstract":"<p><p>Techniques for sensing, acquiring, processing and displaying physiological variables used to assist the process of monitoring in anaesthesia and intensive care have been reviewed. The role of instrumental monitoring in clinical practice and the comparative effectiveness of Man versus Machine has been outlined. Future developments in monitoring in clinical practice have been identified. It is important that physicians stay abreast of developments in the technology of measurement and monitoring instrumentation so that they not only assist in the development of standards but also have a complete understanding of the precision and real usefulness of any given item of equipment. To this end, guidelines have been tabulated which may permit those who have the responsibility for acquiring updating or using monitoring equipment, to more completely examine the features of any apparatus which is being considered for purchase.</p>","PeriodicalId":9371,"journal":{"name":"Canadian Anaesthetists' Society journal","volume":"33 5","pages":"670-9"},"PeriodicalIF":0.0,"publicationDate":"1986-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03014276","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14886250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hydropneumothorax--an unusual complication of lung lavage.","authors":"E T Hudes, J W Bradley, J Brebner","doi":"10.1007/BF03014274","DOIUrl":"https://doi.org/10.1007/BF03014274","url":null,"abstract":"<p><p>Hydropneumothorax is an uncommon but potentially fatal complication for a patient undergoing positive pressure ventilation. The case of a 23-year-old woman with severe asthma requiring lung lavage is described. Twenty minutes after an uneventful left lung lavage, the patient experienced increased peak airway pressure, decreased oxygen saturation and hypercarbia, despite ventilation with 90 per cent oxygen. A chest x-ray revealed mediastinal shift and a left sided pneumothorax. Drainage was carried out, revealing air and clear fluid in the pleural space. The importance of technical problems such as patient and endotracheal tube positioning, elimination of cross-spilling and cardiopulmonary effects of lavage are discussed.</p>","PeriodicalId":9371,"journal":{"name":"Canadian Anaesthetists' Society journal","volume":"33 5","pages":"662-5"},"PeriodicalIF":0.0,"publicationDate":"1986-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03014274","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14887131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Obara, N. Maekawa, H. Hoshina, O. Tanaka, R. Chuma, S. Iwai, H. Hisano, K. Nakamura, T. Yamamoto
{"title":"Plasma levels of vitamin E and lipoperoxide during paediatric anaesthesia.","authors":"H. Obara, N. Maekawa, H. Hoshina, O. Tanaka, R. Chuma, S. Iwai, H. Hisano, K. Nakamura, T. Yamamoto","doi":"10.1097/00132586-198608000-00017","DOIUrl":"https://doi.org/10.1097/00132586-198608000-00017","url":null,"abstract":"We measured plasma levels of vitamin E (total tocopherol) and lipoperoxide in seventeen neonates (less than 10 days), twenty infants (1-12 months) and ten children (1-5 years) during anaesthesia. The seventeen neonates were randomly divided into two groups; seven who received 30 mg X kg-1 of alpha-tocopheryl acetate intramuscularly before anaesthesia and ten who did not. The 20 infants were divided into three groups: Group 1: eight infants who did not receive vitamin E; Group 2: six who received 30 mg X kg-1 of alpha-tocopheryl acetate orally for three days before anaesthesia; Group 3: six who received 30 mg X kg-1 of alpha-tocopheryl acetate intramuscularly three hours before anaesthesia. In the neonates who did not receive alpha-tocopheryl acetate, plasma vitamin E and lipoperoxide levels were unchanged following surgery. In Group 1 infants, plasma vitamin E levels decreased (p less than 0.05) and plasma lipoperoxide levels increased (p less than 0.05). In both neonates who received vitamin E and Group 3 infants the mean plasma vitamin E levels increased significantly (p less than 0.05) following surgery. In Group 2 infants, the levels of plasma vitamin E before surgery were high, as compared to the other groups: however, plasma vitamin E levels decreased following surgery. In the children, the plasma vitamin E levels were unchanged, while the plasma lipoperoxide levels decreased significantly (p less than 0.05) during anaesthesia. It is suggested from our studies that plasma vitamin E levels decrease and plasma lipoperoxide levels increase during anaesthesia and surgery in infants; however, those levels are unchanged in neonates.","PeriodicalId":9371,"journal":{"name":"Canadian Anaesthetists' Society journal","volume":"54 1","pages":"358-63"},"PeriodicalIF":0.0,"publicationDate":"1986-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90759394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}