Bulletin of Faculty of Pharmacy, Cairo University最新文献_第6页

Chronomodulated drug delivery system of Irbesartan: Formulation and development using Desing of Experiment (DoE) 厄贝沙坦时间调节给药系统的研制与实验设计

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-06-01 DOI: 10.1016/j.bfopcu.2017.11.004

Komal Parmar, Almas Shaikh, Hitesh Dalvadi

{"title":"Chronomodulated drug delivery system of Irbesartan: Formulation and development using Desing of Experiment (DoE)","authors":"Komal Parmar, Almas Shaikh, Hitesh Dalvadi","doi":"10.1016/j.bfopcu.2017.11.004","DOIUrl":"10.1016/j.bfopcu.2017.11.004","url":null,"abstract":"<div><p>The work is based on pulsatile principles to deliver a programmed dose of Irbesartan, an angiotensin-II receptor antagonist for chronotherapy of hypertension induced by excessive secretion of aldosterone, thereby lower the blood pressure at early morning. Solid dispersion of Irbesartan, a BCS class II drug, was prepared by using Poloxamer-188 by melt method in ratio of 1:1 to increase the dissolution properties of drug. Compressed coated pulsatile tablets included a core layer consisting of Kyron T-134 as a super-disintegrant and pulsatile layer comprising of HPMC K4M and Eudragit RLPO. The prepared core tablets were evaluated for weight variation, hardness, thickness, friability, drug content, disintegration time and <em>In vitro</em> dissolution studies. Final core tablet (C8) was selected on the basis of disintegration time (23.33 ± 2.08 s). For optimization Face centred central composite design was employed to study the effect of independent variables viz. Weight ratio of HPMC K4M: Eudragit RLPO (X<sub>1</sub>) and Total weight of coating (X<sub>2</sub>) on dependent variables viz. Drug release lag time (Y<sub>1</sub>) and Drug release after lag time within 15 min (D<sub>15</sub>) (Y<sub>2</sub>). Results revealed positive influence of independent factors on responses. The data were statistically analyzed using ANOVA and were found to be statistically significant (P < .05). Mathematical modeling for kinetic studies revealed that the release profile after lag time followed first order kinetics. Accelerated stability studies for one month at 40 ± 2 °C/75 ± 5% RH showed no remarkable changes concluding that a successful pulsatile drug delivery system of Irbesartan was developed.</p></div>","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"56 1","pages":"Pages 11-17"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bfopcu.2017.11.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78874294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A comparative study of in vitro antimicrobial, antioxidant and cytotoxic activity of Albizia lebbeck and Acacia nilotica stem bark 合欢花与阿拉伯合欢茎皮体外抗菌、抗氧化及细胞毒活性的比较研究

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-06-01 DOI: 10.1016/j.bfopcu.2017.10.002

Mohammad Tuhin Ali , Sheikh Tanzina Haque , Md. Lutful Kabir , Sohel Rana , Md. Enamul Haque

{"title":"A comparative study of in vitro antimicrobial, antioxidant and cytotoxic activity of Albizia lebbeck and Acacia nilotica stem bark","authors":"Mohammad Tuhin Ali , Sheikh Tanzina Haque , Md. Lutful Kabir , Sohel Rana , Md. Enamul Haque","doi":"10.1016/j.bfopcu.2017.10.002","DOIUrl":"10.1016/j.bfopcu.2017.10.002","url":null,"abstract":"<div><p>Petroleum ether, ethyl acetate and methanol extracts of the stem bark of <em>Albizia lebbeck</em> and <em>Acacia nilotica</em> was investigated for antimicrobial, antioxidant and cytotoxicity assay. The powdered stem bark was extracted successively with petroleum ether, ethyl acetate and methanol solution. The crude extracts were subjected to antimicrobial, antioxidant and cytotoxicity assay by using disc diffusion method, DPPH and hydroxyl free radical scavenging assay, and brine shrimp lethality test, respectively. The petroleum ether and ethyl acetate extracts of both plants showed the most prominent activity in antimicrobial susceptibility test as compared to methanol extracts. These extracts showed moderate activity against the <em>Bacillus subtilis</em>, <em>Staphylococcus aureus</em>, <em>Vibrio mimicus</em>, <em>Salmonella typhi</em>, <em>Shigella dysenteriae</em>, <em>Candida arrizae</em> and <em>Aspergillus niger</em>. The zone of inhibition against the tested bacteria and fungi were 11–14 mm and 8–10 mm, respectively. The ethyl acetate extract of both plants showed the highest antioxidant and cytotoxic activity when compared with that of petroleum ether and methanol extracts. All the tested extracts showed higher free radical scavenging activity than that of the standard, ascorbic acid. In compared with <em>A. lebbeck</em>, <em>A. nilotica</em> was found to have the lower IC<sub>50</sub> value which was 74.29 µg/ml and 68.03 µg/ml in DPPH and hydroxyl free radical scavenging assay, respectively. The LC<sub>50</sub> value was 42.36 and 37.32 µg/ml for the ethyl acetate extract of <em>A. lebbeck</em> and <em>A. nilotica</em>, respectively. We suggest further study for the identification of active compounds from the bark extracts of <em>A. lebbeck</em> and <em>A. nilotica</em>.</p></div>","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"56 1","pages":"Pages 34-38"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bfopcu.2017.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73425312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

In vitro activity of dihydropyrazole derivatives against Candida species 二氢吡唑衍生物对念珠菌的体外活性研究

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-06-01 DOI: 10.1016/j.bfopcu.2017.11.002

Khadija Abdelrahmman , Mohammed F. El-Behairy , Muhammad A. Alsherbiny , Tarek E. Mazeed

引用次数: 6

Knowledge and practice of health care workers towards post exposure prophylaxis in the era of low and stable HIV prevalence in Southwestern Nigeria 在尼日利亚西南部低和稳定的艾滋病毒流行时期，卫生保健工作者对接触后预防的知识和实践

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-06-01 DOI: 10.1016/j.bfopcu.2018.03.003

Wasiu Olalekan Adebimpe

{"title":"Knowledge and practice of health care workers towards post exposure prophylaxis in the era of low and stable HIV prevalence in Southwestern Nigeria","authors":"Wasiu Olalekan Adebimpe","doi":"10.1016/j.bfopcu.2018.03.003","DOIUrl":"10.1016/j.bfopcu.2018.03.003","url":null,"abstract":"<div><p>Nigeria ranks top among the countries with the highest burden of Human Immune-deficiency Virus (HIV) infection. Despite ready-made access to HIV care, Post-Exposure Prophylaxis (PEP) practices have not increased commensurately due to several gaps within the health sector. This research was undertaken to assess knowledge and practice of health care workers towards PEP of HIV in Southwestern Nigeria. A descriptive cross sectional study was carried out among 300 health care workers selected using the multi-staged sampling method. Research instruments used were self-administered pre tested and semi structured questionnaires. Data collected were analyzed using the SPSS software version 17.0.</p><p>One hundred and four (34.7%) of respondents said they occasionally recap used needles, one hundred and eighty-one (60.3%) have heard about PEP. Only 2.7% had good mean knowledge scores while 57.3% and 40.0% had moderate and poor mean knowledge scores of PEP respectively. Only 24 (13.3%) knew the correct number of drugs combinations, 36 (19.9%) knew the antiretroviral drugs administered; 113 (62.4%) believed that the drugs were antibiotics. Forty-four (14.7%) had needle stick injuries in the last 6 months, out of which 29 (65.9%) used PEP. Predictors of good knowledge of PEP on logistic regression include male gender, having spent more than 5 years in hospital practice, having heard about PEP and being aware of the national PEP guidelines. There is a need to create better awareness about PEP among health care workers to reduce and prevent occupational HIV transmission.</p></div>","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"56 1","pages":"Pages 104-108"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bfopcu.2018.03.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73394040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Quality risk management during pharmaceutical ‘good distribution practices’ – A plausible solution 药品“良好销售规范”期间的质量风险管理——一个合理的解决方案

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-06-01 DOI: 10.1016/j.bfopcu.2017.12.002

Nirmal Kumar, Ajeya Jha

{"title":"Quality risk management during pharmaceutical ‘good distribution practices’ – A plausible solution","authors":"Nirmal Kumar, Ajeya Jha","doi":"10.1016/j.bfopcu.2017.12.002","DOIUrl":"10.1016/j.bfopcu.2017.12.002","url":null,"abstract":"<div><p>Quality of medicinal product is an important facet throughout lifecycle owing to its importance as acceptance criteria at customer’s end. Drugs regulatory agencies have issued guidelines for quality risk evaluation, mitigation and review management. Quality risk management has become an integral part of quality management system at manufacturing plants. Procedures for deviation control, change control, investigations of market complaints and batch failures are dealt with the principle of quality risk management at the manufacturing facility. The exploratory study shows a dearth of research on quality risk management during supply chain operation, however, a few study has been carried out by keeping financial risk into account. This study addresses the gap in literature on quality risk management during supply chain operations. There are cases of unresolved customer complaints and batch failures originated due to inadequacies during distribution of pharmaceutical products. In absence of established quality risk management system during product shipment, there is no effective preventive plan related to risk factors. A corollary of manufacturing quality risk management has been drawn to the distribution of pharmaceutical products through this study. The quality risk management during pharmaceutical distribution may be useful to avoid market complaints, drug recalls, and regulatory actions. This study produces one unique model solution for industry professionals and policymakers opening a scope to reduce the product rejection thereby paving the way for substantial business growth.</p></div>","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"56 1","pages":"Pages 18-25"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bfopcu.2017.12.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86166933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Quinazolino-thiadiazoles as antimicrobial agents 喹唑啉-噻二唑类抗菌药物

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-06-01 DOI: 10.1016/j.bfopcu.2018.03.001

Harun Patel , Atul Shirkhedkar , Sanjay Bari , Kamalkishor Patil , Amit Arambhi , Chandrakantsing Pardeshi , Abhijeet Kulkarni , Sanjay Surana

{"title":"Quinazolino-thiadiazoles as antimicrobial agents","authors":"Harun Patel , Atul Shirkhedkar , Sanjay Bari , Kamalkishor Patil , Amit Arambhi , Chandrakantsing Pardeshi , Abhijeet Kulkarni , Sanjay Surana","doi":"10.1016/j.bfopcu.2018.03.001","DOIUrl":"10.1016/j.bfopcu.2018.03.001","url":null,"abstract":"<div><p>In the present research, we report the synthesis and <em>in vitro</em> antimicrobial activity of a new series of novel quinazolino-thiadiazoles as fused pharmacophore (3–20). In general, the results of the <em>in vitro</em> antibacterial activity are encouraging, as out of 18 compounds tested, Compounds 3 and 8 with a 4-chlorophenyl and 4-nitro phenyl at C-2 of thiadiazole and chloromethyl substituent at C-2 of quinazolinone displayed a broad spectrum antimicrobial activity against all the strains, while compounds 13 and 16 again with a 4-chlorophenyl and 4-nitrophenyl at C-2 of thiadiazole and ethyl substituent at C-2 of quinazolinone showed the same potency but with a narrower spectrum (Bacterial and Fungal strains) with MIC values of 62.5 µg/ml. The structures of the compounds were confirmed by IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR and Mass analysis. It is worth to mention that the combination of two biologically active moieties quinazoline and thiadiazole profoundly influences the biological activity.</p></div>","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"56 1","pages":"Pages 83-90"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bfopcu.2018.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73486909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Botanical and genetic characterization of Hydrocotyle umbellata L. cultivated in Egypt 在埃及栽培的伞形水子叶的植物学和遗传特征

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-06-01 DOI: 10.1016/j.bfopcu.2018.03.006

Sherif A. Hamdy, Hala M. El Hefnawy, Shadia M. Azzam, Elsayed A. Aboutabl

引用次数: 2

Exploring community pharmacists’ knowledge, perception and experiences towards branded and generic medicines in Kuwait: Highlighting the role of pharmacist 探索社区药剂师的知识，感知和经验，对品牌和仿制药在科威特:突出药师的作用

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-06-01 DOI: 10.1016/j.bfopcu.2018.03.005

M. Al Hussaini, N. Alsaffar, A. Abdulraheem

{"title":"Exploring community pharmacists’ knowledge, perception and experiences towards branded and generic medicines in Kuwait: Highlighting the role of pharmacist","authors":"M. Al Hussaini, N. Alsaffar, A. Abdulraheem","doi":"10.1016/j.bfopcu.2018.03.005","DOIUrl":"10.1016/j.bfopcu.2018.03.005","url":null,"abstract":"<div><h3>Background</h3><p>Substituting brand drugs with generic drugs without affecting patients’ health is considered a cost-effective measure to reduce health care expenditure.</p></div><div><h3>Objectives</h3><p>The study was designed to explore the community pharmacists’ knowledge, perception and experiences toward generic drug substitution and highlight the role of pharmacist in practicing substitution.</p></div><div><h3>Method</h3><p>A descriptive cross sectional survey among community pharmacists was carried out in Kuwait. A validated questionnaires consisting of 3 sections with total of 22 questions were distributed to 180 pharmacists and collected after 3–5 days.</p></div><div><h3>Results</h3><p>Less than half of respondents (46.1%) thought that generic drugs are equivalent to the original brands. 60% of pharmacists believed that OTC are as effective as brands while only 42% agreed that generic drugs can be as effective as brand for chronic diseases. Pharmacists agreed that brands have more strength variety (74%), better packaging (72%) and more expensive (66.2%) than generic. Most of the pharmacists agreed on stocking brand (88%) and generic (72%). Also 81% and 62% agreed that drug price and doctor’s opinion could affect patients’ choice, alternatively. 88% of pharmacists would recommend generic substitutes when brands are not available. Whereas 45% would try to persuade patients to shift to a brand when patient is unsatisfied with the generic. Pharmacists were more confident in recommending generic OTC drugs than the branded counterpart for chronic diseases (p = 0.001).</p></div><div><h3>Conclusion</h3><p>A national brand substitution policy should be formulated and implemented to assist pharmacists in the proper substitution practice and to help minimize the healthcare costs.</p></div>","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"56 1","pages":"Pages 109-114"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bfopcu.2018.03.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85522682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Validated determination of diacerein and its active metabolite, rhein, by stability indicating constant pattern method as a novel manipulation of zero order spectra 稳定性指示常数模式法作为一种新的零阶光谱操作方法，验证了二黄芩苷及其活性代谢物大黄的测定

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-06-01 DOI: 10.1016/j.bfopcu.2017.11.005

Aml A. Emam, Nouruddin W. Ali

{"title":"Validated determination of diacerein and its active metabolite, rhein, by stability indicating constant pattern method as a novel manipulation of zero order spectra","authors":"Aml A. Emam, Nouruddin W. Ali","doi":"10.1016/j.bfopcu.2017.11.005","DOIUrl":"10.1016/j.bfopcu.2017.11.005","url":null,"abstract":"<div><p>A novel spectrophotometric method named constant absorbance pattern technique was proposed for simple determination of binary mixtures exemplified by diacerein, a treatment of osteoarthritis, and rhein, diacerein main alkaline degradation product and active metabolite. The proposed novel constant absorbance pattern technique was highly accurate, precise, sensitive, specific and stability indicating as well. The proposed technique allowed determination of diacerein and rhein in their binary mixtures manipulating zero order absorption spectra with no need for ratio spectra, derivatization steps, or even preliminary separation. Diacerein was determined at zero absorption spectra depending on the constant absorbance pattern between the two wavelengths 230 and 430 nm while rhein was directly determined at zero order at its λ<sub>max</sub>, 430 nm. The proposed methods showed obeying for Beer-Lambert’s law in the concentration range of 1–16 µg mL<sup>−1</sup> for both diacerein and rhein. Validation of the proposed methods was carried out according to ICH guidelines with respect to accuracy and precision. Moreover, the proposed method was applied for determination of Diacerein in different pharmaceutical formulations and results were statistically compared with those of the reported HPLC one where no significant difference was found concerning Student’s <em>t</em>-test and F-value.</p></div>","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"56 1","pages":"Pages 73-79"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bfopcu.2017.11.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78774909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

In vitro permeation and stability studies on developed drug-in-adhesive transdermal patch of simvastatin 辛伐他汀黏附透皮贴剂的体外渗透及稳定性研究

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-06-01 DOI: 10.1016/j.bfopcu.2018.04.001

Rabinarayan Parhi , Suresh Padilam

{"title":"In vitro permeation and stability studies on developed drug-in-adhesive transdermal patch of simvastatin","authors":"Rabinarayan Parhi , Suresh Padilam","doi":"10.1016/j.bfopcu.2018.04.001","DOIUrl":"10.1016/j.bfopcu.2018.04.001","url":null,"abstract":"<div><p>The transdermal drug-in-adhesive (DIA) patch of simvastatin (SM) was developed using acrylic adhesives such as DURO-TAK® 87-9301, DURO-TAK® 87-4287, DURO-TAK® 87-235A. The patches were evaluated for in vitro drug permeation across the pork ear skin using diffusion cell and stability studies. Among the three acrylic adhesives used, DURO-TAK® 87-9301 exhibited maximum flux (5.18 ± 0.23 µg/cm<sup>2</sup>/h). To further enhance the drug permeation, isopropyl myristate (IPM), <span>d</span>-limonene and 1,8-cineol as penetration enhancers (PEs) were incorporated into the DIA patch prepared from DURO-TAK® 87-9301. Out of those, IPM containing patch exhibited a flux of 16.45 ± 1.67 µg/cm<sup>2</sup>/h revealing that IPM is the best PE. The stability study was carried out on optimized fresh (SA4) and 6 months old patches stored at room and at accelerated condition (40 ± 2 °C/75 ± 5%RH) using FTIR, DSC and SEM techniques. Significant shift of peaks were not observed in FTIR spectra and DSC thermograms of the patches after the stability period. SEM micrographs of patches did not show any evidence of recrystallization indicating the presence of drug in the molecular form throughout the adhesive matrix. The investigation reveals that the DIA patch studied as above is stable and may serve as a potential drug delivery system for simvastatin.</p></div>","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"56 1","pages":"Pages 26-33"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bfopcu.2018.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90930885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12