Bulletin of Faculty of Pharmacy, Cairo University最新文献_第5页

Formulation and evaluation of gastro retentive tablets of clarithromycin prepared by using novel polymer blend 新型聚合物共混法制备克拉霉素保胃片的配方及评价

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-12-01 Epub Date: 2018-07-26 DOI: 10.1016/j.bfopcu.2018.07.001

Sharwaree Hardikar , Ashok Bhosale

{"title":"Formulation and evaluation of gastro retentive tablets of clarithromycin prepared by using novel polymer blend","authors":"Sharwaree Hardikar , Ashok Bhosale","doi":"10.1016/j.bfopcu.2018.07.001","DOIUrl":"10.1016/j.bfopcu.2018.07.001","url":null,"abstract":"<div><p>Clarithromycin is a semi synthetic macrolide antibiotic that is proved to be extremely effective mono therapy in treating <em>H. pylori</em> infection. One of the various reasons reported for partial eradication of <em>H. pylori</em> infection is that the short dwelling time of antimicrobial agents in the stomach. Hence the principal object of the present work was to design and develop floating and swellable gastro retentive tablet of clarithromycin to obtain its prolonged release in the stomach. HPMC K 100LV was blended in the present study with the Gel isolated from the seeds of <em>Ocimum basilicum</em> to overcome the drawback of time dependent erosion of former. This novel polymer blend was investigated and exploited as a matrix material for the development of gastro retentive tablets of clarithromycin as drug delivery system. Hydrogen bonding between the Glucomannan – a component of the Gel and HPMC K100LV was envisaged and further confirmed by ATR-FTIR. Tablets of clarithromycin prepared by using the polymer blend of Gel and HPMC K100LV exhibited fast swelling with almost instantaneous buoyancy followed by prolonged release of drug from the swollen, floating dosage form. The retention of the optimized tablet formulation of clarithromycin in the stomach was confirmed by γ scintigraphy.</p></div>","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"56 2","pages":"Pages 147-157"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bfopcu.2018.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81673025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Differential diagnosis of mucopolysaccharidosis and oligosaccharidosis of a sample of Egyptian children 埃及儿童粘多糖病和寡糖病的鉴别诊断

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-12-01 Epub Date: 2018-11-08 DOI: 10.1016/j.bfopcu.2018.10.005

Ekram Fateen , Manal Fouad Ismail , Noha Ahmed El-Boghdady , Mona Aglan , Mona Ibrahim , Amira Radwan

{"title":"Differential diagnosis of mucopolysaccharidosis and oligosaccharidosis of a sample of Egyptian children","authors":"Ekram Fateen , Manal Fouad Ismail , Noha Ahmed El-Boghdady , Mona Aglan , Mona Ibrahim , Amira Radwan","doi":"10.1016/j.bfopcu.2018.10.005","DOIUrl":"10.1016/j.bfopcu.2018.10.005","url":null,"abstract":"<div><p>Mucopolysaccharidosis (MPS) and oligosaccharidosis are lysosomal storage disorders (LSDs) that share many clinical features. The present study aimed to establish a protocol for the biochemical diagnosis of these disorders and their subtypes in affected Egyptian children as well as in pregnant females, in order to prepare children or fetus for enzyme replacement therapy. Urine, plasma and leukocyte samples were collected from 280 children with symptoms suggestive of LSDs. Fourteen amniotic fluid samples were collected from pregnant females having positive family history or having one affected sibling. Assessment of urinary glycosaminoglycans (GAGs) followed by two dimensional electrophoresis (2-DEP), thin layer chromatographic (TLC) for separation of oligosaccharides and plasma or leukocyte enzyme activity were performed. Six of pregnancies were diagnosed to have affected fetuses. 84 children had abnormal 2-DEP and classified as 26 MPS I, 10 MPS II, 24 MPS III and 24 MPS VI. Two were diagnosed as α-mannosidosis and 2 as GM<sub>1</sub> gangliosidosis. In conclusion; MPS should be excluded before suspecting oligosaccharidosis. 2-DEP and TLC alone cannot rule out the diagnosis of either MPS or oligosaccharidosis and confirmation must be done by specific lysosomal enzymatic assay. Analysis of GAGs by 2-DEP in amniotic fluid can be promising method for prenatal diagnosis of MPS.</p></div>","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"56 2","pages":"Pages 213-217"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bfopcu.2018.10.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81860003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Acute and chronic toxicity profiles of the methanol leaf extract of Acacia ataxacantha D.C (Leguminosae) in Wistar rats 豆科植物刺槐甲醇叶提取物对Wistar大鼠的急性和慢性毒性研究

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-12-01 Epub Date: 2018-09-24 DOI: 10.1016/j.bfopcu.2018.09.001

Medinat. Y. Abbas , Jane. I. Ejiofor , Musa. I. Yakubu

{"title":"Acute and chronic toxicity profiles of the methanol leaf extract of Acacia ataxacantha D.C (Leguminosae) in Wistar rats","authors":"Medinat. Y. Abbas , Jane. I. Ejiofor , Musa. I. Yakubu","doi":"10.1016/j.bfopcu.2018.09.001","DOIUrl":"10.1016/j.bfopcu.2018.09.001","url":null,"abstract":"<div><p><em>Acacia ataxacantha</em> various parts have been reportedly used as herbal remedy for treatment of pains, microbial infections, ulcers, respiratory infection, mineral and vitamins supplements and dysentery. This study was conducted to ascertain the toxicity profile of methanol extract of <em>Acacia ataxacantha</em> in laboratory animals. The acute and chronic toxicity study was conducted according to the method of Lorke (1983) and OECD guidelines (2008) respectively. The oral lethal median dose (LD<sub>50</sub>) of the extract was estimated to ≥5000 mg/kg. The extract significantly increases (<em>p ≤ 0.05</em>) the liver (alanine transaminase, aspartate transaminase, alkaline phosphatase) and kidney (creatinine, urea and sodium ion) parameters at the dose of 400 mg/kg body weight. Histological examination revealed moderate glomerular necrosis and lymphocytes hyperplasia on the kidney (50, 200 and 400 mg/kg), the liver showed hepatocellular necrosis with kupffer cells hyperplasia, while mild mucosa necrosis was observed on stomach tissues. The extract is safe on acute administration, however prolong use may produce harmful effect on the liver, kidney and stomach.</p></div>","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"56 2","pages":"Pages 185-189"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bfopcu.2018.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74630413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Atherogenicity of diabetic rats administered single and combinatorial herbal extracts 单药和复方中药提取物对糖尿病大鼠动脉粥样硬化的影响

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-12-01 Epub Date: 2018-10-19 DOI: 10.1016/j.bfopcu.2018.10.001

Chinwendu M. Chikezie , Okey A. Ojiako , Adamma A. Emejulu , Paul C. Chikezie

{"title":"Atherogenicity of diabetic rats administered single and combinatorial herbal extracts","authors":"Chinwendu M. Chikezie , Okey A. Ojiako , Adamma A. Emejulu , Paul C. Chikezie","doi":"10.1016/j.bfopcu.2018.10.001","DOIUrl":"10.1016/j.bfopcu.2018.10.001","url":null,"abstract":"<div><h3>Objective</h3><p>The present study sought to investigate atherogenicity of alloxan-induced diabetic rats administered single and combinatorial herbal formulations of <em>Acanthus montanus</em>, <em>Asystasia gangetica, Gongronema latifolium</em> and <em>Solanum melongena</em>.</p></div><div><h3>Methods</h3><p>A single intra-peritoneal (<em>i.p.</em>) injection of 90 mg/kg <em>b.w.</em> of alloxan monohydrate was given to the rats to induce diabetes mellitus (DM). Serum lipid profiles were measured using standard spectrophotometric methods, whereas atherogenicity, serum lipid ratios and atherogenic coefficient/indices were calculated using standard formulae.</p></div><div><h3>Results</h3><p>Serum total cholesterol (TC) concentrations of experimental rat groups varied between 1.59 ± 0.10 mmol/L and 2.72 ± 0.16 mmol/L (<em>p</em> < 0.05). Serum high-density lipoprotein cholesterol (HDL-C) concentration of untreated DM rat (DM-r) group was significantly lower (<em>p</em> < 0.05) than those of treated DM-r groups. Atherogenic risk indices (ARIs) of treated DM-r groups were within the range of 0.74 ± 0.03 and 2.64 ± 0.21, whereas ARI of untreated DM-r was 4.04 ± 0.25. The linear regression analysis of atherognic index of plasma (AIP) versus serum low-density lipoprotein cholesterol (LDL-C) concentrations of the experimental rat groups gave a relatively close fitted regression line (<em>R</em><sup>2</sup> = 0.8275). Atherogenic protection of herbal extract treated DM-r groups was within the range of 33.4–81.7%.</p></div><div><h3>Conclusion</h3><p>The present study showed that double herbal formulations (DHFs): <em>A. gangetica</em> + <em>G. latifolium</em> and <em>A. gangetica</em> + <em>A. montanus</em> offered comparatively high protection to DM-r against atherogenic outcomes, which paralleled the capacities of these DHFs to reverse dyslipidemia.</p></div>","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"56 2","pages":"Pages 169-174"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bfopcu.2018.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87801969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Reproductive indices in malaria infested mice treated with antimalarials, Phyllanthus amarus combined with vitamins 抗疟药、叶兰复合维生素对疟疾感染小鼠生殖指标的影响

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-12-01 Epub Date: 2018-10-25 DOI: 10.1016/j.bfopcu.2018.10.004

Matthew Obaineh Ojezele , Ighodaro Igbe , Agbonlahor Okhuarobo

{"title":"Reproductive indices in malaria infested mice treated with antimalarials, Phyllanthus amarus combined with vitamins","authors":"Matthew Obaineh Ojezele , Ighodaro Igbe , Agbonlahor Okhuarobo","doi":"10.1016/j.bfopcu.2018.10.004","DOIUrl":"10.1016/j.bfopcu.2018.10.004","url":null,"abstract":"<div><p>Malaria disease is caused by the plasmodium organism transmitted into humans by the female anopheles mosquito. The effect of chloroquine, artesunate or <em>Phyllantus amarus</em> alone or combined with vitamins A, B, C or K on male fertility indices has received no attention. Hence this study was designed to investigate the effect of chloroquine, artesunate or seed extract of <em>Phyllanthus amarus</em> with or without vitamins A, B, C or E on testosterone levels, sperm motility, morphology, viability and count in mice infected with <em>Plasmodium berghei</em>. Four days following inoculation of adult male mice with <em>Plasmodium berghei</em>, the mice were treated with artesunate, chloroquine or <em>Phyllanthus amarus</em> seed extract alone or in combination with vitamins A, B, C or E once daily. Thereafter the mice were sacrificed and semen was collected for the determination of sperm count, motility, morphology and viability and blood sample collected for the determination of serum testosterone level by standardized methods. Treatment with chloroquine, artesunate or <em>Phyllanthus amarus</em> seed extract with or without vitamins A, B, C or E caused a significant (p < 0.05) increase in serum and semen testosterone levels in <em>Plasmodium berghei</em> infected mice. Treatment with chloroquine, artesunate or <em>Phyllanthus amarus</em> seed extract also caused a significant (p < 0.05) increase in sperm count, motility and viability as well as significant (p < 0.05) restoration of sperm morphology in <em>Plasmodium berghei</em> infected mice compared to untreated <em>Plasmodium berghei</em> infected mice. Results from our study suggest that vitamin supplement with antimalarial could enhance reproductive indices.</p></div>","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"56 2","pages":"Pages 179-184"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bfopcu.2018.10.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77544180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

POM analyses, immunomodulatory, cytotoxic activities and polyphenolic constituents of Callistemon viridiflorus fruits 翠绿calliemon果实POM分析、免疫调节、细胞毒活性及多酚成分

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-12-01 Epub Date: 2018-06-28 DOI: 10.1016/j.bfopcu.2018.06.001

Mohamed I.S. Abdelhady , Amel M. Kamal , Mohamed F. Barghash

引用次数: 3

Notes on the genus Paramignya: Phytochemistry and biological activity 标题Paramignya属植物的植物化学和生物活性

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-06-01 Epub Date: 2017-12-12 DOI: 10.1016/j.bfopcu.2017.12.001

Ninh The Son

引用次数: 0

Radical scavenging potential, antiinflammatory and antiarthritic activity of isolated isomer Methyl-γ-Orsellinate and roccellatol from Roccella montagnei Bel 罗汉草甲基γ-奥sellinate和罗汉草醇异构体自由基清除能力及抗炎、抗关节炎活性研究

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-06-01 Epub Date: 2018-02-13 DOI: 10.1016/j.bfopcu.2018.02.001

Syed Zameer Ahmed Khader , Sidhra Syed Zameer Ahmed , Thangakumar Arunachalam , Sanjeeva Nayaka , Senthil Kumar Balasubramanian , Syed Tajudeen SyedAmeen , Ponmurugan Ponnusamy

{"title":"Radical scavenging potential, antiinflammatory and antiarthritic activity of isolated isomer Methyl-γ-Orsellinate and roccellatol from Roccella montagnei Bel","authors":"Syed Zameer Ahmed Khader , Sidhra Syed Zameer Ahmed , Thangakumar Arunachalam , Sanjeeva Nayaka , Senthil Kumar Balasubramanian , Syed Tajudeen SyedAmeen , Ponmurugan Ponnusamy","doi":"10.1016/j.bfopcu.2018.02.001","DOIUrl":"10.1016/j.bfopcu.2018.02.001","url":null,"abstract":"<div><p>The burden of multiple drug resistance towards chronic diseases is rapidly increasing globally at an alarm rate. The present study aims to isolate active principles via bioassay guided fractionation of traditionally used lichen <em>Roccella montagnei</em> for <em>in vitro</em> radical scavenging activity with potential to combat arthritis and inflammation. The results of proximate composition and mineral analysis revealed the presence of essential amount of micro and macro nutrients which are required for secondary metabolite production. Fractions of Roccella montagnei and pure compounds were assessed for its <em>in vitro</em> antioxidant (DPPH, FRAP, OH radical, SOD, CAT, GPX), antiarthritic and antiinflammatory activity. The results indicates that lichen sample and fractions exhibited potent radical scavenger demonstrated <em>in vitro</em> antiarthritic and antiinflammatory activity in dose dependent manner. Bioassay fractionation lead to isolation of two pure compounds ie., Compound I and Compound II which were characterized using spectral data such as FT-IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, DEPT NMR spectroscopy, COSY & HMQC NMR spectroscopy and LC-MS analysis and was identified as Methyl-γ-Orsellinate (C9H10O4) a novel isomer from fractions E2d5a with a molecular weight of 182.2 and Roccellatol (C<sub>12</sub>H<sub>16</sub>O<sub>7</sub>) from fractions D3d4c with a molecular weight of 272.3. The present findings suggest that the secondary metabolites present in the lichens have direct relation, with biological activities revealing different properties and can be a future novel antioxidant and a potent anti-arthritic agent.</p></div>","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"56 1","pages":"Pages 39-45"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bfopcu.2018.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79999315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Anti-hyperglycaemic activity of tuber extract of Chlorophytum alismifolium Baker in streptozotocin-induced hyperglycaemic rats 吊兰块茎提取物对链脲佐菌素诱导的高血糖大鼠的抗高血糖活性

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-06-01 Epub Date: 2017-11-22 DOI: 10.1016/j.bfopcu.2017.11.003

Abdulhakim Abubakar , Nuhu M. Danjuma , Ben A. Chindo , Abdullahi B. Nazifi

{"title":"Anti-hyperglycaemic activity of tuber extract of Chlorophytum alismifolium Baker in streptozotocin-induced hyperglycaemic rats","authors":"Abdulhakim Abubakar , Nuhu M. Danjuma , Ben A. Chindo , Abdullahi B. Nazifi","doi":"10.1016/j.bfopcu.2017.11.003","DOIUrl":"10.1016/j.bfopcu.2017.11.003","url":null,"abstract":"<div><p>The tubers of <em>Chlorophytum alismifolium</em> (Liliaceae) are widely used in Nigerian Herbal Medicine to treat diabetes mellitus and their efficacy is widely acclaimed among the rural communities of Northern Nigeria. This study was aimed at investigating the antihyperglycaemic potential of the tuber extract of <em>Chlorophytum alismifolium</em> (CAE) in streptozotocin-induced hyperglycaemic rats. Phytochemical screening and oral median lethal dose (LD<sub>50</sub>) estimation of CAE in rats were carried out. Antihyperglycaemic screening of the extract (at oral doses of 150, 300 and 600 mg/kg) was performed using normal and streptozotocin-induced hyperglycaemic rats for 28 days. Fasting blood glucose levels were measured and serum lipids were analyzed. Liver, kidney, heart and pancreatic tissues were examined for histopathological damages using standard histological processing. Phytochemical screening revealed the presence alkaloids, saponins, flavonoids, triterpenes and glycosides. Oral LD<sub>50</sub> was estimated to be >5000 mg/kg body weight in rats. <em>C. alismifolium</em> extract at all the doses tested showed blood glucose lowering effect. Statistical significant (p < .01) blood glucose lowering effect at 150 mg/kg on day 21, at 300 mg/kg on days 21 and 28 (p < .001 and p < .01 respectively) and 600 mg/kg on days 7, 14, 21 and 28 (p < .05, p < .01, p < .001 and p < .01 respectively) was produced by the extract. The extract also reduced the levels of total cholesterol, triglycerides and low density lipoprotein. Histopathological examination of the pancreas showed restoration of pancreatic islet cells at the doses of 300 and 600 mg/kg of the extract. In conclusion, the results obtained suggest the tuber extract of <em>Chlorophytum alismifolium</em> possesses antihyperglycaemic activity.</p></div>","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"56 1","pages":"Pages 60-67"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bfopcu.2017.11.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90843217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Chronomodulated drug delivery system of Irbesartan: Formulation and development using Desing of Experiment (DoE) 厄贝沙坦时间调节给药系统的研制与实验设计

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2018-06-01 Epub Date: 2017-11-26 DOI: 10.1016/j.bfopcu.2017.11.004

Komal Parmar, Almas Shaikh, Hitesh Dalvadi

{"title":"Chronomodulated drug delivery system of Irbesartan: Formulation and development using Desing of Experiment (DoE)","authors":"Komal Parmar, Almas Shaikh, Hitesh Dalvadi","doi":"10.1016/j.bfopcu.2017.11.004","DOIUrl":"10.1016/j.bfopcu.2017.11.004","url":null,"abstract":"<div><p>The work is based on pulsatile principles to deliver a programmed dose of Irbesartan, an angiotensin-II receptor antagonist for chronotherapy of hypertension induced by excessive secretion of aldosterone, thereby lower the blood pressure at early morning. Solid dispersion of Irbesartan, a BCS class II drug, was prepared by using Poloxamer-188 by melt method in ratio of 1:1 to increase the dissolution properties of drug. Compressed coated pulsatile tablets included a core layer consisting of Kyron T-134 as a super-disintegrant and pulsatile layer comprising of HPMC K4M and Eudragit RLPO. The prepared core tablets were evaluated for weight variation, hardness, thickness, friability, drug content, disintegration time and <em>In vitro</em> dissolution studies. Final core tablet (C8) was selected on the basis of disintegration time (23.33 ± 2.08 s). For optimization Face centred central composite design was employed to study the effect of independent variables viz. Weight ratio of HPMC K4M: Eudragit RLPO (X<sub>1</sub>) and Total weight of coating (X<sub>2</sub>) on dependent variables viz. Drug release lag time (Y<sub>1</sub>) and Drug release after lag time within 15 min (D<sub>15</sub>) (Y<sub>2</sub>). Results revealed positive influence of independent factors on responses. The data were statistically analyzed using ANOVA and were found to be statistically significant (P < .05). Mathematical modeling for kinetic studies revealed that the release profile after lag time followed first order kinetics. Accelerated stability studies for one month at 40 ± 2 °C/75 ± 5% RH showed no remarkable changes concluding that a successful pulsatile drug delivery system of Irbesartan was developed.</p></div>","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"56 1","pages":"Pages 11-17"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bfopcu.2017.11.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78874294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4