Djabo Eric Adrien Tangmi, Mubarak Jolayemi Mustapha, Voufo Jolyvette Mbougo, Mubanga Ndashi Chitalu, Jonas Lotanna Ibekwe, Yee Siew Lim, Joyce Gasper Kweka, Temitayo Ayantayo, Mazin M Eltingary, Olobatoke Tunde, Marwa SaedAli Emhemed, Nicaise Kpègnon Agada, Nourou Dine Adeniran Bankole, Victor Meza Kyaruzi
{"title":"A systematic review of the therapeutic effect of platelet-rich plasma for treating traumatic brain injury","authors":"Djabo Eric Adrien Tangmi, Mubarak Jolayemi Mustapha, Voufo Jolyvette Mbougo, Mubanga Ndashi Chitalu, Jonas Lotanna Ibekwe, Yee Siew Lim, Joyce Gasper Kweka, Temitayo Ayantayo, Mazin M Eltingary, Olobatoke Tunde, Marwa SaedAli Emhemed, Nicaise Kpègnon Agada, Nourou Dine Adeniran Bankole, Victor Meza Kyaruzi","doi":"10.1093/jsprm/snad010","DOIUrl":"https://doi.org/10.1093/jsprm/snad010","url":null,"abstract":"Abstract Traumatic brain injury (TBI) is the leading cause of death and disability worldwide and thus a significant public health concern. It can result in a range of physical, cognitive, and emotional impairments, which can significantly impact the quality of life of affected individuals and their families. Despite advances in the management of TBI, no effective treatment fully restores neurological function. Platelet-rich plasma (PRP) is a promising therapeutic approach for the treatment of TBI that has gained increasing attention in recent years. PRP is a blood product containing high concentration of platelets rich in growth factors and other bioactive molecules that can promote tissue repair and regeneration. PRP has been used in various clinical settings to accelerate healing and reduce inflammation, and there is growing evidence that it may have therapeutic benefits for TBI. This study seeks to gather evidence-based information on the therapeutic effect of PRP in the treatment of TBI. This protocol will follow the criteria of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis [PRISMA] guideline 2020. In this review, we determined four primary central databases as sources of information: PubMed, EMBASE, SCOPUS, and Cochrane Central Register of Controlled Trails. This Project was registered on the International Prospective Register of Systematic Reviews [PROSPERO]. Ethics and dissemination: Ethical approval for this study was not needed as we used alread y published studies to run this current study. Study findings will be published in journals and presented at conferences for broader dissemination. PROSPERO Registration N°: CRD42023426358.","PeriodicalId":93590,"journal":{"name":"Journal of surgical protocols and research methodologies","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135762060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Temitayo Ayantayo, Michael Eze Chukwu, Mubarak Jolayemi Mustapha, Muhammad Ammar Haider, Mobeen Farooqi, Fegor Owho-Ovuakporie, Ugochukwu Odekpe
{"title":"A systematic review protocol of recent surgical approaches to pediatric thalamic tumors","authors":"Temitayo Ayantayo, Michael Eze Chukwu, Mubarak Jolayemi Mustapha, Muhammad Ammar Haider, Mobeen Farooqi, Fegor Owho-Ovuakporie, Ugochukwu Odekpe","doi":"10.1093/jsprm/snad012","DOIUrl":"https://doi.org/10.1093/jsprm/snad012","url":null,"abstract":"Abstract Thalamic tumors are relatively rare deep-seated lesions located in an eloquent region of the brain. They are commoner in the pediatric population and surgery is usually challenging with associated significant morbidity. Recent improvements in therapeutic approaches and surgical techniques have allowed a more accurate approach to these lesions and a reduction in morbidity and mortality. This protocol seeks to serve as an exhaustive review of literature to determine recent surgical approaches in the management of pediatric thalamic tumors. This study protocol seeks to guide the comprehensive review of literature describing surgical approaches to pediatric thalamic tumors and it follows the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guideline 2020. Three databases were determined to be primary sources of information: PubMed, Google Scholar and SCOPUS. All observational and human randomized controlled studies describing surgical management of thalamic tumors in the pediatric population will be included. Excluded studies include non-human randomized control trials, abstract only articles, letters to the editor, conference proceedings and single subject case reports. Our outcomes tumor characteristics, types of surgical intervention, surgical complications, recurrence rate and overall and progression-free survival. This study aims to describe various surgical approaches in the management of pediatric thalamic tumors and compare the outcomes in these patients.","PeriodicalId":93590,"journal":{"name":"Journal of surgical protocols and research methodologies","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135805363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Temitayo Ayantayo, M. S. Emhemed, Asadur R Nabin, R. B. Murhega, Mazin M Eltingary, A. Naeem, N. Mugenyi, Jonas L Ibekwe, Lordstrong Akano, M. J. Mustapha, B. Maroo, G. B. Abongha, M. W. Dossou, N. Agada, Nourou Dine Adeniran Bankole, V. M. Kyaruzi
{"title":"The safety and utility of low-intensity pulsed ultrasound for effective blood–brain barrier penetration in the treatment of glioblastoma: a scoping review protocol","authors":"Temitayo Ayantayo, M. S. Emhemed, Asadur R Nabin, R. B. Murhega, Mazin M Eltingary, A. Naeem, N. Mugenyi, Jonas L Ibekwe, Lordstrong Akano, M. J. Mustapha, B. Maroo, G. B. Abongha, M. W. Dossou, N. Agada, Nourou Dine Adeniran Bankole, V. M. Kyaruzi","doi":"10.1093/jsprm/snad009","DOIUrl":"https://doi.org/10.1093/jsprm/snad009","url":null,"abstract":"\u0000 Glioblastoma (GBM) is one of the most aggressive central nervous system tumours with suboptimal treatment options and associated poor prognosis. A major impediment to systemic treatment is the limitation of drug delivery to the tumour by the blood-brain barrier (BBB). Several novel techniques to permeate the BBB have been described, however of significant promise is the disruption of the blood brain barrier with low-intensity pulsed ultrasound (LIPU) to facilitate the delivery of varying therapeutic agents. This emerging technique has been demonstrated in clinical studies to enhance delivery of chemotherapeutic agents to the tumour. This study protocol seeks to guide the comprehensive review of literature concerning the safety and utility of LIPU for effective BBB penetration in the treatment of GBM. This protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews (PRISMA ScR) guideline 2020. The search strategy was performed on four databases: PubMed, EMBASE, SCOPUS, and Cochrane Central Register of Controlled Trials. All observational and human randomised controlled studies describing the use of LIPU in the treatment of GBM will be included. Excluded studies include non-human randomized control trials, abstract only articles, letters to the editor, conference proceedings. Our outcomes include frequency of LIPU used, duration of intervention, clinical outcomes, complications, and challenges associated with the use of LIPU. This study aims to assess the safety and feasibility of this technique in the management of the GBM and proscribe its use if found effective to improve the outcomes in these patients.","PeriodicalId":93590,"journal":{"name":"Journal of surgical protocols and research methodologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49333540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Victor Meza Kyaruzi, Emmanuel Mduma, Ahmed Abdelhammed, Tarun Kumar Suvvari, Tumusifu Manegabe Jean de Dieu, Banturaki Davis, N. Sakaiwa, Z. Hammoud, T. Tango, Wesley Harrisson Bouche Djatche, Emmanuel Chileshe Phiri, O. Tunde, Z. Waffa, Ramadhan M. Ngamba, Zobidah Yousif Elamin, Aymar Akilimali, P. Kambey, R. Khamisi, A. Mwanga, E. Shimber, S. Mfinanga, A. Mwakigonja, Christopher Dodgion
{"title":"Epigenetics and field cancerization as the caveats of carcinogenesis and recurrence of gastrointestinal malignancies: a systematic review and meta-analysis protocol","authors":"Victor Meza Kyaruzi, Emmanuel Mduma, Ahmed Abdelhammed, Tarun Kumar Suvvari, Tumusifu Manegabe Jean de Dieu, Banturaki Davis, N. Sakaiwa, Z. Hammoud, T. Tango, Wesley Harrisson Bouche Djatche, Emmanuel Chileshe Phiri, O. Tunde, Z. Waffa, Ramadhan M. Ngamba, Zobidah Yousif Elamin, Aymar Akilimali, P. Kambey, R. Khamisi, A. Mwanga, E. Shimber, S. Mfinanga, A. Mwakigonja, Christopher Dodgion","doi":"10.1093/jsprm/snad005","DOIUrl":"https://doi.org/10.1093/jsprm/snad005","url":null,"abstract":"\u0000 Gastrointestinal malignancies constitute the most common neoplasms with increasing prevalence worldwide, which portend a dismal morbidity and higher mortality rate. Epigenetic phenotypes and field cancerization impute a cutting edge for precursor of several gastrointestinal malignancies; this genetic aberration has been implicated in tumorigenesis and recurrence of gastrointestinal malignancies. This systematic review aims at assessing the effect of epigenetics and field cancerization on carcinogenesis and recurrence of gastrointestinal malignancies. This systematic review and meta-analysis will administer the provisions of Preferred Reporting Items for Systematic Review and Meta-analysis 2020 guideline, and the review protocol has been registered at PROSPERO. The literature search will be executed through several electronic databases including EMBASE, PubMed, Scopus, Web of Science, Cochrane, Global Index Medicus, Semantic Scholar and Google Scholar. All original research articles reporting on the effect of epigenetic signatures, epigenetics and field cancerization on the carcinogenesis and recurrence of gastrointestinal cancers in adults will be included. Only articles with Newcastle–Ottawa Scale score above 4 and low risk of bias based on D1–D5 for randomized controlled trials will be included for a meta-analysis. There is no involvement of human subject participation in this review, thus giving no effect to ethical clearance approval. The evidence report of this review will be disseminated on scientific conferences and will be published to a reputable journal of gastroenterology oncology. This review has been registered at PROSPERO registry ID CRD 42023391339.","PeriodicalId":93590,"journal":{"name":"Journal of surgical protocols and research methodologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48437397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bright Huo, Yung Lee, Katerina-Maria Kontouli, Pooja Patel, Kevin Yang, Audrey Jong, Kassandra Coyle, Daniel G French, Alison M Wallace, Madelaine Plourde
{"title":"Protocol for the systematic review and network meta-analysis of open versus video-assisted and robotic-assisted thymectomy for the treatment of thymic neoplasms","authors":"Bright Huo, Yung Lee, Katerina-Maria Kontouli, Pooja Patel, Kevin Yang, Audrey Jong, Kassandra Coyle, Daniel G French, Alison M Wallace, Madelaine Plourde","doi":"10.1093/jsprm/snad006","DOIUrl":"https://doi.org/10.1093/jsprm/snad006","url":null,"abstract":"Abstract The surgical management of thymic neoplasms includes open and minimally invasive approaches. Previous studies have compared these techniques, but application in practice remains varied. This systematic review and network meta-analysis (NMA) will adhere to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) checklist. MEDLINE, Embase, Cochrane Centrale and Scopus will be searched from inception to perform a systematic review, NMA and evidence appraisal using the Grading of Recommendations Assessment, Development and Evaluations and the Confidence in Network Meta-Analysis methodologies. Randomized controlled trials and cohort studies will be included. Full texts of any citation will be included if they assessed a minimum of two arms of any type of thymectomy technique, including open, video-assisted thoracoscopic surgery, or robotic-assisted thoracoscopic surgery thymectomy, for the treatment of thymic neoplasms such as thymoma, thymic carcinoma or thymic neuroendocrine tumors with or without myasthenia gravis. Studies assessing operative thymectomy techniques for benign disease will be excluded. Short- and long-term perioperative safety and oncologic outcomes will be compared between open versus video-assisted versus robotic-assisted thymectomy for the surgical management of thymic neoplasms. The Risk of Bias In Non-Randomized Studies—of Interventions tool will be used to assess the risk of bias in nonrandomized studies. We will conduct a frequentist fixed- and random-effects NMA using the graph theory approach for each outcome. Summary of odds ratios will be estimated for all dichotomous outcomes with their 95% confidence interval.","PeriodicalId":93590,"journal":{"name":"Journal of surgical protocols and research methodologies","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135672885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Romeu, A. Taylor, E. Guthrie, A. Peckham-Cooper, Max Henderson, G. Toogood
{"title":"Presentations and outcomes of people with unexplained symptoms in acute general surgery: protocol for a mixed-methods study","authors":"D. Romeu, A. Taylor, E. Guthrie, A. Peckham-Cooper, Max Henderson, G. Toogood","doi":"10.1093/jsprm/snad004","DOIUrl":"https://doi.org/10.1093/jsprm/snad004","url":null,"abstract":"\u0000 \u0000 \u0000 Unexplained symptoms are common across healthcare settings and are associated with increased mental and physical morbidity and healthcare expenditure. Improving the identification, explanation and management of unexplained symptoms will be helpful to patientsand healthcare systems. Limited data exists exploring unexplained acute abdominal pain in the surgical setting.\u0000 \u0000 \u0000 \u0000 This protocol describes three interlinked studies. Study one will determine the prevalence of anxiety and depression in patients presenting with explained and unexplained abdominal pain in an acute surgical setting. Study two will explore how the explanation and management of unexplained symptoms is conveyed to patients. Study three will explore how patients with unexplained symptoms understand these explanations.\u0000 \u0000 \u0000 \u0000 Patients aged ≥18 years who present to a surgical same day emergency care unit with acute abdominal pain will be eligible. In study one, participants will be asked to complete a questionnaire, including validated self-report measures, at the time of presentation and six months later. They will be divided into explained and unexplained symptom groups based on clinical presentation and investigation outcomes. The proportion in each group meeting diagnostic thresholds for anxiety and depression will be compared and baseline predictors of pain and quality of life six months later will be determined. In study two, recordings of consultations between patients and surgeons involving the explanation and management of unexplained abdominal pain will be analysed. In study three, participants will be interviewed to explore their experiences and understanding of their symptoms.\u0000","PeriodicalId":93590,"journal":{"name":"Journal of surgical protocols and research methodologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47695027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Jesuyajolu, Temitayo Ayantayo, E. Oyesiji, Sofia Bakare, Samuel Oreoluwa David, Rosola Sule, J. Daniel, Okere Madeleine, Tomiwa Olukoya, T. Osunronbi, Olaniyan Adewale, E. Morgan.
{"title":"Burden of traumatic spinal cord injury in Africa: a scoping review protocol","authors":"D. Jesuyajolu, Temitayo Ayantayo, E. Oyesiji, Sofia Bakare, Samuel Oreoluwa David, Rosola Sule, J. Daniel, Okere Madeleine, Tomiwa Olukoya, T. Osunronbi, Olaniyan Adewale, E. Morgan.","doi":"10.1093/jsprm/snad003","DOIUrl":"https://doi.org/10.1093/jsprm/snad003","url":null,"abstract":"\u0000 Trauma accounts for about 90% of spinal cord injuries worldwide. Traumatic spinal cord injury (TSCI) is recognized as a neurotrauma of global health priority due to the preventability of the injuries and the specialized and expensive medical and surgical care they necessitate. This study protocol guides the comprehensive and exhaustive review of the literature concerning the epidemiology, management and outcomes of TSCIs in Africa. This protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines. The search strategy was performed primarily on PubMed and OVID Embase. A secondary literature search was carried out on African Journal Online and Google Scholar. All observational studies on the prevalence/incidence, presentation, management and outcomes of TSCIs in African countries were included. The following study types were excluded: literature reviews, meta-analyses, case reports, abstract-only articles, conference proceedings, randomized control trials and letters to the editor. Our outcomes include incidence of TSCIs in Africa, mechanisms of injury, different imaging and treatment modalities offered (e.g. conservative vs. operative intervention), clinical outcomes following TSCIs in Africa and challenges regarding the management of TSCIs in African surgical centres. This study aims to provide region-specific data that will guide and inform local practices regarding TSCIs. It will also map out areas that need more research and areas amenable to intervention by global health stakeholders.","PeriodicalId":93590,"journal":{"name":"Journal of surgical protocols and research methodologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47895110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Wong, S. Bandyopadhyay, H. Zuberi, M. R. Raza, Abdullahi N Koko, N. Peter, K. Lakhoo
{"title":"Investigating paediatric sarcoma management worldwide: a study protocol","authors":"W. Wong, S. Bandyopadhyay, H. Zuberi, M. R. Raza, Abdullahi N Koko, N. Peter, K. Lakhoo","doi":"10.1093/jsprm/snac024","DOIUrl":"https://doi.org/10.1093/jsprm/snac024","url":null,"abstract":"\u0000 \u0000 \u0000 Cancer is the leading cause of non-accidental death among children worldwide. The most common types of paediatric cancers include sarcomas: a group of cancers that are difficult to manage due to their heterogeneity and lack of defining features. We have designed an international multicentre cohort study to assess the management of paediatric sarcomas at tertiary healthcare centres in Nigeria, Pakistan and the UK.\u0000 \u0000 \u0000 \u0000 The centres will screen patient databases to identify eligible patients under the age of 18 with a clinical or histological diagnosis of sarcoma. Data will be extracted from the patient notes through an anonymized form. Patients will be recruited consecutively into the study from January 2015 to January 2021, with a minimum 12-month follow up period. The primary objectives of the study will be to determine all-cause mortality rates at 30 days, 90 days, 12 months and 3 years. Significant differences in mortality rates between countries will be determined using χ2 analysis or Fisher’s exact test. Univariate and multivariable logistic regression will be used to examine the influence of different factors and patient characteristics on outcomes.\u0000 \u0000 \u0000 \u0000 At the host centre, this study was deemed to be exempt from ethical committee approval due to the use of anonymized data. At other centres, participating collaborators have gained local approvals in accordance with institutional ethical regulations. Collaborators will present the data to inform decision makers about how sarcoma management may be improved. The results will be submitted for publication in a peer-reviewed journal.\u0000","PeriodicalId":93590,"journal":{"name":"Journal of surgical protocols and research methodologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43190482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raahulan Rathagirishnan, Benjamin R Ritsma, Jessica Trier, P. Daneshvar, Michael Hendry
{"title":"Prospective cohort study of electrodiagnostic abnormality characterization in pronator quadratus associated with end-to-side nerve transfers for ulnar neuropathy at the elbow","authors":"Raahulan Rathagirishnan, Benjamin R Ritsma, Jessica Trier, P. Daneshvar, Michael Hendry","doi":"10.1093/jsprm/snac022","DOIUrl":"https://doi.org/10.1093/jsprm/snac022","url":null,"abstract":"\u0000 Ulnar neuropathy at the elbow (UNE) is a common compressive neuropathy that affects the median nerve. Conservative management for mild-to-moderate UNE is an important first step, but generally, develops a plateau in benefit. A specific technique, referred to as a supercharged ‘end-to-side’ (SETS) nerve transfer can successfully restore pinch, fine motor dexterity and grip strength. A pre-surgical workup flow for UNE patients has been developed, which includes electrodiagnostic (EDX) studies completed to assess the recipient ulnar nerve and the donor median nerve to pronator quadratus (PQ). There is little evidence that the assessment of the PQ muscle is necessary in a non-traumatic setting. A prospective cohort study of patients who present with clinical and/or EDX evidence of ulnar compressive neuropathy, with clinical evidence of motor dysfunction, was assessed for health PQ donor in routine pre-operative workup. We aim to provide justification that SETS for UNE should not be delayed to acquire PQ EDX studies.","PeriodicalId":93590,"journal":{"name":"Journal of surgical protocols and research methodologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45344610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Murad Habib, Rafi Raza, Mansoor Ahmed, Khurrum Arif, M. Chaudhary
{"title":"A comparative study of Bianchi versus right upper transverse approach in infantile hypertrophic pyloric stenosis","authors":"Murad Habib, Rafi Raza, Mansoor Ahmed, Khurrum Arif, M. Chaudhary","doi":"10.1093/jsprm/snac025","DOIUrl":"https://doi.org/10.1093/jsprm/snac025","url":null,"abstract":"\u0000 The objective of this study is to compare Bianchi supra umbilical curvilinear incision with a right upper transverse incision in patients presenting with infantile hypertrophic pyloric stenosis (IHPS) in terms of level of difficulty faced during the procedure, operative time, postoperative cosmesis, wound infection and wound dehiscence. A prospective comparative study was conducted at the Department of Paediatric Surgery, The Children’s Hospital, Pakistan Institute of Medical Sciences, Islamabad. The total duration of the study was 1 year from 1st March, 2020 to 28th February, 2021. The anticipated sample was minimum of 20 cases in Group A (Bianchi) and 20 cases in Group B (right upper quadrant incision), i.e. total 40 cases of IHPS. All infants up to 12 weeks admitted with the diagnosis of IHPS were added in the study. The study outcome was determined in terms of duration of surgery, wound infection and cosmetic effect after intervention with Bianchi and right upper transverse incision. Age and gender distribution was found equal when compared between study groups with male preponderance. The mean duration of surgery was 47.0 min in Group A, as compared with 32.5 min in Group B. Similarly, hospital stay was found slightly longer in Group A than Group B (5.3 versus 4.8 days, respectively). The level of difficulty while performing the surgery was slightly greater in Group A. The scar was detectable in all 20 (100.0%) patients in Group B compared with only 2 (10.0%) in Group A. Wound dehiscence was found in one (5.0%) patient in Group A, whereas none (0.0%) in Group B had it. The management of IHPS can be safely and successfully done with both Bianchi technique and right upper quadrant incision. The duration of surgery, level of difficulty while performing surgery and postoperative complications like wound infections and dehiscence were slightly more prevalent in Group A, whereas scar was significantly associated with Group B (100.0 versus 10.0%).","PeriodicalId":93590,"journal":{"name":"Journal of surgical protocols and research methodologies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44353902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}