International journal of oncology research最新文献_第3页

Feasibility and value of salivary cortisol sampling to reflect distress in head and neck cancer patients undergoing chemoradiation: A proof-of-concept study. 唾液皮质醇取样反映头颈癌放化疗患者痛苦的可行性和价值:一项概念验证研究

International journal of oncology research Pub Date : 2022-01-01 Epub Date: 2022-09-12 DOI: 10.23937/2643-4563/1710043

Karishma Chhabria, Mark Bonnen, Joshua Asper, Giselle D Carnaby

{"title":"Feasibility and value of salivary cortisol sampling to reflect distress in head and neck cancer patients undergoing chemoradiation: A proof-of-concept study.","authors":"Karishma Chhabria, Mark Bonnen, Joshua Asper, Giselle D Carnaby","doi":"10.23937/2643-4563/1710043","DOIUrl":"https://doi.org/10.23937/2643-4563/1710043","url":null,"abstract":"Background: Head and neck cancer (HNC) patients undergoing chemo/radiation commonly experience severe and persistent distress associated with treatment related fear and physical side effects such as xerostomia, dysphagia, and dryness of mouth. Cortisol, a stress sensitive hormone, can be easily measured in saliva to reflect biobehavioral responses to such stressors. Unfortunately, it has not been used in this population due to concerns associated with chemoradiation (C/RT) related xerostomia.Methods: In a proof-of-concept study, we explored the feasibility of collecting salivary cortisol as a marker of fear and distress in HNC patients. Ten HNC subjects undergoing C/RT provided saliva samples for 3 consecutive days across three timepoints (pre-treatment, 3-weeks and 1-month post-treatment) and completed concurrent depression, anxiety and swallowing related fear measures.Results: Salivary cortisol collection adherence was between 80-60%. It was not impacted by xerostomia. Diurnal cortisol pattern demonstrated dysregulation at pretreatment in 62%, and flattened aberrant slopes continued at 3-weeks and beyond in 50% of subjects.Conclusions: Our study supports the feasibility and utility of salivary cortisol measurement in HNC patients across the treatment trajectory. Diurnal cortisol measures may be a valuable tool to detect and monitor treatment distress during C/RT in this population.","PeriodicalId":93572,"journal":{"name":"International journal of oncology research","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671390/pdf/nihms-1844130.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40479851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nivolumab Induced Acute Pancreatitis and Hyperbilirubinemia 尼沃单抗诱导的急性胰腺炎和高胆红素血症

International journal of oncology research Pub Date : 2021-12-31 DOI: 10.23937/2643-4563/1710032

Bhatia Unnati, Bajaj Suryansh, Gandhi Darshan, Bajaj Divyansh

引用次数: 0

On the Impact of Premature Termination of Chemotherapy on Relapse of Breast Cancer 过早终止化疗对乳腺癌复发的影响

International journal of oncology research Pub Date : 2021-03-15 DOI: 10.23937/2643-4563/1710028

Männle Heidrun, M. Karsten, M. Felix, Siebers Jan Willem

{"title":"On the Impact of Premature Termination of Chemotherapy on Relapse of Breast Cancer","authors":"Männle Heidrun, M. Karsten, M. Felix, Siebers Jan Willem","doi":"10.23937/2643-4563/1710028","DOIUrl":"https://doi.org/10.23937/2643-4563/1710028","url":null,"abstract":"Background: Some breast cancer patients receive a recommendation for adjuvant chemotherapy if necessary. In some cases, patients refuse this recommendation. In other cases, they start with chemotherapy, but then discontinue it. The question raised here are the effects of patients’ rejection or premature termination of recommended chemotherapies. Methods: 1916 patients, who received a recommendation for chemotherapy, were analyzed between 1997 and 2017. The analyses included descriptive analyses and Kaplan-Meier survival analyses. Results: A percentage of the patients stopped prematurely (8.4%) or totally refused adjuvant chemotherapy (7.2%). They differed from those who completed the recommended chemotherapy with respect to age (F = 82.483; p < 0.001; ONEWAY-ANOVA), HER2-status (chi2 = 8.290; df = 2; p = 0.016), nodal status (chi2 = 12.785; df = 6; p = 0.047) and type of surgery (breast conserving vs. mastectomy) (chi2 = 6.267; df = 2; p = 0.044). The Kaplan Meier disease-free survival analyses showed significant differences between these groups (Log RankDFS = 21.012; df = 2; p < 0.001). A significant influence on the overall survival was found in the subgroup of hormone-receptor-positive/HER2-negative patients (Log RankHR positive = 4.728; df = 1; p = 0.030). Conclusions: Disease-free and disease-specific overall survival rates worsened in the subgroup of patients with hormone receptor positive/HER2 negative tumors if chemotherapy was stopped prematurely. It seems important to assess the patients’ reasons for discontinuing, to emphasize the importance of chemotherapy and to explicitly encourage patients in this group to see it through to the very end.","PeriodicalId":93572,"journal":{"name":"International journal of oncology research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47146646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Is there an Association between Vaginal Cancer and Genital Prolapse? A Data-Analysis and Review of Literature 阴道癌症和生殖器脱垂之间有联系吗？数据分析与文献综述

International journal of oncology research Pub Date : 2021-03-13 DOI: 10.23937/2643-4563/1710027

Männle Heidrun, Osorio Birthe, M. Felix, M. Karsten

{"title":"Is there an Association between Vaginal Cancer and Genital Prolapse? A Data-Analysis and Review of Literature","authors":"Männle Heidrun, Osorio Birthe, M. Felix, M. Karsten","doi":"10.23937/2643-4563/1710027","DOIUrl":"https://doi.org/10.23937/2643-4563/1710027","url":null,"abstract":"Purpose: Primary vaginal cancer represents a rare disease. The main risk factor for vaginal carcinoma is a persistent human papillomavirus (HPV) infection. However, chronic mechanic irritation of the vagina, have long been suspected to contribute to the development of vaginal cancer. This study examined to assess possible associations between genital prolapse and the incidence of vaginal cancer. Methods: We conducted a systematic literature search regarding the association between vaginal cancer and genital prolapse, supplemented with our own data set of the Centre for Gynaecological Oncology of the Ortenau Clinic Offenburg. Results: Our case analysis of prolapse-associated vaginal carcinomas corresponds to a large extent with the total collective of vaginal carcinomas. The most frequent histological subtype was squamous cell carcinoma in 90%. The median age of patients with genital prolapse-associated vaginal carcinomas was 75 years (72.9 ± 12.1 years). However prolapse associated vaginal cancers had FIGO stage IV more often than cases of vaginal cancer in general. FIGO stage I was reported as most frequent (39%). FIGO stage IV was the second most frequent stage in prolapse associated cases (25%). Furthermore, the Kaplan-Meier curves are significantly different from unselected vaginal cancer cases. In the prolapse associated cases FIGO stages I and II have a far better disease-free survival; in contrast, the prognosis in the advanced stages is much worse. Conclusion: In addition to the HPV infection, patients with genital prolapsed and those with ongoing systemic corticosteroid therapy or other immunocompromising medications, should be perceived as risk groups and regularly examined.","PeriodicalId":93572,"journal":{"name":"International journal of oncology research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47966930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Destructive Mono-Arthritis Caused by Mycobacterium bovis during Treatment with Pembrolizumab in a Patient Previously Treated with BCG Instillations for Bladder Cancer: A Case Report 一例先前接受BCG灌注治疗膀胱癌症的患者在接受Pembrolizumab治疗期间由牛分枝杆菌引起的破坏性单关节炎：病例报告

International journal of oncology research Pub Date : 2021-02-10 DOI: 10.23937/2643-4563/1710026

E. Cynthia, Huijts Susanne M, Lubbe Peter AHM van der, Robbrecht Debbie G.J.

{"title":"Destructive Mono-Arthritis Caused by Mycobacterium bovis during Treatment with Pembrolizumab in a Patient Previously Treated with BCG Instillations for Bladder Cancer: A Case Report","authors":"E. Cynthia, Huijts Susanne M, Lubbe Peter AHM van der, Robbrecht Debbie G.J.","doi":"10.23937/2643-4563/1710026","DOIUrl":"https://doi.org/10.23937/2643-4563/1710026","url":null,"abstract":"Immune checkpoint inhibitor (ICI) treatment is an integral part of second line treatment of patients with urothelial carcinoma (UC) as well as in first line in cisplatin-ineligible patients with PD-L1 positive tumours. A substantial proportion of patients with bladder cancer have been treated with intravesical Mycobacterium bovis BCG in the past. Although it is rare, disseminated infections with Mycobacterium bovis have been described, but not in association with ICI treatment. We herein report a case of destructive monoarthritis caused by Mycobacterium bovis in a patient previously treated with intravesical BCG and a recent initiation of the ICI pembrolizumab in first line for metastatic UC. A culture of synovial fluid from the involved wrist was positive for Mycobacterium bovis. Based on whole genome sequencing based-subtyping, the identified Mycobacterium was shown to be related with the previous BCG instillations. Because of severe complaints and progressive destruction of the patients’ wrist, it was decided to interrupt the pembrolizumab. At that moment, following the seventh cycle of pembrolizumab, evaluation showed a partial disease response. Following systemic treatment with triple combination therapy (Isoniazid, Rifampicin, Ethambutol) and surgery, the complaints of the wrist gradually improved. This is the first report describing a disseminated Mycobacterium bovis infection in a patient treated with an ICI and previous BCG instillations for bladder cancer. This is of relevance, because an increasing number of bladder cancer patients, previously treated with BCG instillations, will be treated with an ICI in advanced disease setting.","PeriodicalId":93572,"journal":{"name":"International journal of oncology research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47813443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast Metastases from Ovarian Primary: A Rare Entity and Review of Literature 卵巢原发乳腺癌转移:罕见病例及文献回顾

International journal of oncology research Pub Date : 2021-01-01 DOI: 10.23937/2643-4563/1710030

S. Suresh, Sanjay Bhalgat Bhushan, K. Pravin, Kamal Kishore Lakhera Kamal Kishore Lakhera, Swain Phanindra Kumar, Sharma Raj Govind

引用次数: 0

Incidentally Found Thyroid Metastases in Head and Neck Squamous Cell Carcinoma - How to Manage It? 头颈部鳞状细胞癌偶然发现甲状腺转移-如何处理?

International journal of oncology research Pub Date : 2021-01-01 DOI: 10.23937/2643-4563/1710031

R. Gama, P. Oliveira, M. Teixeira, F. Castro, A. Conde

引用次数: 0

Hepatosplenic Gamma Delta T-cell Lymphoma Presenting as Progressive Hepatosplenomegaly Highlighted during Pregnancy 妊娠期肝脾γ δ t细胞淋巴瘤表现为进行性肝脾肿大

International journal of oncology research Pub Date : 2020-06-19 DOI: 10.23937/2643-4563/1710024

A. Hussam, Petkar Mahir, Z. Abdulaziz, A. Mohammed, A. Mohammad, Ahmad Rita, Eldean Mouhammad Sharaf

引用次数: 0

Supporting the Supporters: What are the Unmet Needs and Quality of Life of Caregivers of Cancer Patients in Singapore? 支持支持者：新加坡癌症患者护理人员的未满足需求和生活质量是什么？

International journal of oncology research Pub Date : 2020-05-22 DOI: 10.23937/2643-4563/1710023

Chua Gek Phin, Ng Quan Sing, T. H. Khoon, O. W. Sze

{"title":"Supporting the Supporters: What are the Unmet Needs and Quality of Life of Caregivers of Cancer Patients in Singapore?","authors":"Chua Gek Phin, Ng Quan Sing, T. H. Khoon, O. W. Sze","doi":"10.23937/2643-4563/1710023","DOIUrl":"https://doi.org/10.23937/2643-4563/1710023","url":null,"abstract":"Background: Caregivers of cancer patients may assume diverse responsibilities during the patient’s cancer trajectory, providing physical assistance, emotional and financial support. These responsibilities can be highly demanding, emotionally stressful and financially draining and can impact on the caregivers’ quality of life (QOL). This study aims to determine the unmet needs of caregivers of cancer patients in Singapore and establish if the unmet needs are associated with their QOL in order to guide practice. Methods: A cross-sectional survey was conducted with 986 caregivers of cancer patients. Determinants of caregivers’ unmet needs and QOL were assessed by the Support Person Unmet Needs Survey (SPUNS-SF) and the Singapore version of the Caregiver Quality of Life Index-Cancer (CQOLC-S25). Results: The mean overall score of unmet needs was 20.98 ± 20.1. The top 3 items with the highest mean score of unmet needs were all from the “Future” domain viz. “dealing with worry about cancer getting worse” (1.50 ± 1.4), “dealing with not knowing what lies in the future” (1.43 ± 1.3) and “dealing with worry about cancer coming back” (1.20 ± 1.3). Caregivers who were younger, the primary caregivers, caregivers who provided financial assistance to the patients they cared for, caregivers whose health status were made worse by caregiving activities, caregivers who were taking care of female patients, lung cancer patients and patients on palliative care had significantly higher mean overall score of unmet needs. The mean overall QOL score was 71.34 ± 17.5. The overall QOL scores were negatively correlated with the overall scores of unmet needs. There were significant negative correlation between QOL and all domains of unmet needs. Conclusion: Our results demonstrate that caregivers of cancer have many unmet needs and these unmet needs have a significant negative effect on their QOL. Thus, addressing their unmet needs is critical to enhance their coping skills and ultimately their QOL.","PeriodicalId":93572,"journal":{"name":"International journal of oncology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45296156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concerns and Quality of Life of Cancer Survivors across the Survivorship Trajectory 癌症幸存者对生存轨迹的关注与生活质量

International journal of oncology research Pub Date : 2020-04-25 DOI: 10.23937/2643-4563/1710021

Chua Gek Phin, Ng Quan Sing, T. H. Khoon, O. W. Sze

{"title":"Concerns and Quality of Life of Cancer Survivors across the Survivorship Trajectory","authors":"Chua Gek Phin, Ng Quan Sing, T. H. Khoon, O. W. Sze","doi":"10.23937/2643-4563/1710021","DOIUrl":"https://doi.org/10.23937/2643-4563/1710021","url":null,"abstract":"Background The aim of this study is to determine the main concerns of survivors at various stages of the cancer survivorship of the cancer survivorship trajectory and to assess whether these concerns have any effect on their quality of life (QOL). The overall goal was to use the insights from the study to guide practice on patient care. Methods A cross-sectional survey of 1107 cancer survivors diagnosed with colorectal, breast, lung, gynaecological, prostate or liver cancers from a cancer centre in Singapore. Eligible patients self-completed a questionnaire adapted from the Mayo Clinic Cancer Centre’s Cancer Survivors Survey of Needs. Results The top 5 concerns among all survivors were cancer treatment and recurrence risk (51%), followed by long-term treatment effects (49%), fear of recurrence (47%), financial concerns (37%) and fatigue (37%). Cancer treatment and recurrence risk, long-term treatment effects and fear of recurrence were amongst the top concerns across the survivorship trajectory. Mean QOL was 7.3 on a scale of 0 – 10. Completed treatment patients had higher QOL score than the newly diagnosed and on treatment patients and the patients dealing with recurrence or second cancer patients. Predictors for QOL included the economic status and housing type of patients and whether patients were concerned with pain and fatigue Conclusion This study confirms that cancer survivors in Singapore face multiple challenges and had various concerns at various stages of cancer survivorship, some of which negatively affect their QOL It is critical to design patient care delivery that appropriately address the various concerns of cancer survivors in order for them to cope and improve their QOL.","PeriodicalId":93572,"journal":{"name":"International journal of oncology research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45716589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1