International journal of oncology research最新文献

{"title":"Usefulness of P16 and KI67 Immunostaining in Cervical Smear Cytology in Guatemalan Women: A Cross-Sectional Study","authors":"G. Alberto, V. Angel, Quereda Francisco, O. Jaume, R. Orlando, Soch Erick, Morales H Arturo, Nave Federico, López-López Carlos","doi":"10.23937/2643-4563/1710019","DOIUrl":"https://doi.org/10.23937/2643-4563/1710019","url":null,"abstract":"Background: Conventional cytology is an economic method for screening abnormalities in cervical smears, but with implications in false positive and false negative as compared to better detection of transformed cells with the Dual staining P16/KI67 proteins in cervical smears, therefore, we evaluate the validity and reproducibility of cytology with double staining of P16 and KI67 as compared to conventional cytology in cervical smears. Patients and methods: Participants were 210 Guatemalan women with abnormalities in conventional cytology (ASCUS, AGUS, ASCH, LSIL, HSIL, and cervical cancer) that consulted from 2013-2014 to the colposcopy Unit of Liga Nacional Contra El Cáncer e Instituto de Cancerología y Hospital Dr. Bernardo del Valle S. in Guatemala, from whom smear cytology was processed with P16 and KI67 immunostaining, and histological sections with P16 immunostaining as gold standard. They were evaluated by three blinded pathologists and one independent cytotechnologist. Results: The sensitivity and specificity of Dual staining P16/ KI67 for detecting abnormalities in cervical smears was 78.95%, 95% confidence interval (CI) 71.03-86.87 and 94.74%, 95%CI 89.06-100 respectively, as compare to conventional cytology in which it was 78.64% and 75.85%, respectively; positive predictive value (PPV) and negative predictive value (NPV) of Dual staining P16/KI67 were 95.74%, 95%CI 91.13-100.0 and 75%, 95%CI 65.82-84.18, as compare to conventional cytology in which it was 79.41% and 75% respectively. In women older than 30 years the sensitivity and PPV of Dual staining P16/KI67 was 78.43% and 95.24%, as compare in women less than 30 years in which it was 41.67% and 83.33% respectively. Interobserver agreement weighted Kappa indices for cervical smear cytology with double staining ranged between 0.66 to 0.83. Conclusion: Dual staining P16/KI67 in women older than 30 years showed better sensitivity and PPV values, suggesting greater utility in this age group, although the sensitivity was like conventional cytology, but with greater specificity and PPV.","PeriodicalId":93572,"journal":{"name":"International journal of oncology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48787303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunotherapy with the Vaccine Based On the Canine Neurotropic Virus (CIMT-54) For the Treatment of Cancer","authors":"Puello Hugo Ramiro Segurab, Charry Juan Sebastián Segura, Muñoz-Forero Diana Milena, Mosquera Diana Lorena Nieto, Villamil-Ballesteros Andrea Catalina","doi":"10.23937/2643-4563/1710018","DOIUrl":"https://doi.org/10.23937/2643-4563/1710018","url":null,"abstract":"• Page 1 of 8 • Citation: Segura-Puello HR, Charry JSS, Muñoz-Forero DM, Mosquera DJN, Villamil-Ballesteros AC (2019) Immunotherapy with the Vaccine Based On the Canine Neurotropic Virus (CIMT-54) For the Treatment of Cancer. Int J Oncol Res 2:018. doi.org/10.23937/2643-4563/1710018 Accepted: October 14, 2019; Published: October 16, 2019 Copyright: © 2019 Segura-Puello HR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":93572,"journal":{"name":"International journal of oncology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44691623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacokinetics of Oxaliplatin in a Hemodialysis Patient with Metastatic Colon Cancer","authors":"N. Yoshiaki, I. Yoshinori, N. Tsutomu, Yamashita Kazuhiko, Okuno Mamoru, Yasui Hiroyuki, Hiraoka Jun, Niigata Riho, Kono Keiji, Hyogo Yasuko, S. Hirotaka, Takenaka Kei, Funakoshi Yohei, Toyoda Masanori, K. Naomi, Minami Hironobu","doi":"10.23937/2643-4563/1710017","DOIUrl":"https://doi.org/10.23937/2643-4563/1710017","url":null,"abstract":"• Page 1 of 5 • Citation: Nagatani Y, Imamura Y, Nakamura T, Yamashita K, Okuno M, et al. (2019) Pharmacokinetics of Oxaliplatin in a Hemodialysis Patient with Metastatic Colon Cancer. Int J Oncol Res 2:017. doi. org/10.23937/2643-4563/1710017 Accepted: September 14, 2019; Published: September 16, 2019 Copyright: © 2019 Nagatani Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":93572,"journal":{"name":"International journal of oncology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42232634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nimotuzumab in Advanced Cervical Cancer: Safety and Efficacy Profile","authors":"Lorente Raiza Ruiz, Alfonso Sayly, Sanchez Yamilka, Viada Carmen Elena, O. Ramón, Troche Mayelin, C. Meylan, Vals Ana Rosa, Cabrera Leticia, Gorte Annia, Batista Delmis Maira, D. Milagros, Viamontes Jessica Garcia, Mico Conrado Ramos, Suzarte Mayra Ramos","doi":"10.23937/2643-4563/1710016","DOIUrl":"https://doi.org/10.23937/2643-4563/1710016","url":null,"abstract":"• Page 1 of 8 • Citation: Lorente RR, Alfonso S, Sanchez Y, Viada C, Ortiz R, Ortiz CEVR, Troche M, et al. (2019) Nimotuzumab in Advanced Cervical Cancer: Safety and Efficacy Profile. Int J Oncol Res 2:016. doi. org/10.23937/2643-4563/1710016 Accepted: July 27, 2019; Published: July 29, 2019 Copyright: © 2019 Lorente RR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":93572,"journal":{"name":"International journal of oncology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47079940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Presentation of Denny-Brown Syndrome: A Case Report and Review of Literature","authors":"Romeo V. Porlas, S. K. Ong, G. Saranza, J. P. Reyes","doi":"10.23937/2643-4563/1710014","DOIUrl":"https://doi.org/10.23937/2643-4563/1710014","url":null,"abstract":"","PeriodicalId":93572,"journal":{"name":"International journal of oncology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47424691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydropneumopericardium: Unusual Complication of Proton Radiotherapy","authors":"Yasuhiro Nakamura","doi":"10.23937/2643-4563/1710012","DOIUrl":"https://doi.org/10.23937/2643-4563/1710012","url":null,"abstract":"","PeriodicalId":93572,"journal":{"name":"International journal of oncology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47357759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostatic Ductal Adenocarcinoma: An Unusual Subtype of Prostate Cancer","authors":"D. Kumar, J. Lobo","doi":"10.23937/2643-4563/1710013","DOIUrl":"https://doi.org/10.23937/2643-4563/1710013","url":null,"abstract":"• Page 1 of 2 • Citation: Kumar D, Lobo J (2019) Prostatic Ductal Adenocarcinoma: An Unusual Subtype of Prostate Cancer. Int J Oncol Res 2:013 Accepted: May 23, 2019; Published: May 25, 2019 Copyright: © 2019 Kumar D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":93572,"journal":{"name":"International journal of oncology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68754682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Specific Music on Psychoneuroimmunological Responses","authors":"Waheed Abdul, K. David, C. William, C. Amy","doi":"10.23937/ijor-2017/1710011","DOIUrl":"https://doi.org/10.23937/ijor-2017/1710011","url":null,"abstract":"• Page 1 of 16 • Citation: Waheed A, Kossor D, Collins W, Camie A (2018) Effect of Specific Music on Psychoneuroimmunological Responses. Int J Oncol Res 1:011. Accepted: December 29, 2018; Published: December 31, 2018 Copyright: © 2018 Waheed A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":93572,"journal":{"name":"International journal of oncology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68755148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic Costs of Lung Cancer in China","authors":"Fan Shaoyu, M. Zhengzhong, H LeeAnita, Hu Teh-wei","doi":"10.23937/IJOR-2017/1710007","DOIUrl":"https://doi.org/10.23937/IJOR-2017/1710007","url":null,"abstract":"• Page 1 of 5 • Citation: Fan S, Mao Z, Lee AH, Teh-wei H (2018) Economic Costs of Lung Cancer in China. Int J Oncol Res 1:007. Accepted: September 27, 2018; Published: September 29, 2018 Copyright: © 2018 Fan S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":93572,"journal":{"name":"International journal of oncology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41367150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organoids as Reliable Breast Cancer Study Models: An Update","authors":"Sasmita Andrew Octavian, Wong Ying Pei","doi":"10.23937/ijor-2017/1710008","DOIUrl":"https://doi.org/10.23937/ijor-2017/1710008","url":null,"abstract":"","PeriodicalId":93572,"journal":{"name":"International journal of oncology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68755136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}