Hepatosplenic Gamma Delta T-cell Lymphoma Presenting as Progressive Hepatosplenomegaly Highlighted during Pregnancy

Abstract

Hepatosplenic T-cell lymphoma (HSGDTL) is a rare variant of T-cell lymphoma with few reported cases in literature. It usually presents with hepatosplenomegaly and constitutional symptoms, primarily in young to middle aged patients. The prognosis is generally poor, with maximum reported survival periods of 2-3 years. There is a link to immunode-ficiency and some biological treatments. Liver biopsy with flow cytometry is required to confirm the diagnosis. We report a case of gamma delta ( γδ ) HSTCL in a 37-year-old female presenting as progressive hepatosplenomegaly with cytopenia during pregnancy. The patient underwent chemotherapy, splenectomy and bone marrow transplant and is in remission 10 months after the diagnosis. As far as we are aware, this is the first case of γδ HSGDTL reported in the Middle East and the second documented case of HSGDTL that highlighted during pregnancy.