Brain and neurological disorders最新文献

{"title":"Depression as a Risk Factor for Dementia in older people with type 2 Diabetes and the Mediating Effect of Inflammation","authors":"Ahmed Esmael","doi":"10.31579/2642-9730/021","DOIUrl":"https://doi.org/10.31579/2642-9730/021","url":null,"abstract":"Objective: The aim of this study is to detect the relation between depression and dementia in patients with type 2 diabetes. Methods: Clinically diagnosed Type 2 diabetes underwent screening for depression using Beck's Depression Inventory scale and subsequent risk of dementia defined using medical reports, prescription data and death certificates. The mediating act of inflammation systemically was measured by assessing four inflammatory markers (C reactive protein, ESR and Fibrinogen). Results: The study was conducted on 102 diabetic type 2 patients, included 48 males and 54 females. Patients divided into 12 (11.7%) patients with depression and 90 (88.3%) patients without depression (mean age 61±8.6 and 60.9±9.2 respectively). Mean BMI in depressive patients was 33.5 ± 9.3 and was 31.9 ± 8.9 in non-depressive cases (P value 0.01). There were no significant differences in patients with and without depression regarding the presence of hypertension, hyperlipidemia and smoking as risk factors of dementia. Patients with depression had significant impaired cognition and the total MoCA scores were significantly lower than those of patients without depression (23.21 ± 3.48 vs 26.34 ± 3.78, P <0.05). Complication of diabetes in patients with depression as neuropathy was significant (P value 0.005). Other complications as diabetic retinopathy and nephropathy were non-significant. Inflammatory markers levels in patients with depressive symptoms were significantly higher (P value < 0.01). Conclusion: In patients with type 2 diabetes, there is an important association between dementia and depression. Systemic inflammation had a significant role in the relation between depression and dementia.","PeriodicalId":93528,"journal":{"name":"Brain and neurological disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42580307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological assistance to long-distance seafarers\" V.Stepanenko","authors":"V. Stepanenko","doi":"10.31579/2642-9730/032","DOIUrl":"https://doi.org/10.31579/2642-9730/032","url":null,"abstract":"In the conditions of long voyages, the need for psychological help arises when the team has the following more or less pronounced psychological characteristics that manifest themselves in relationships and relationships. A state of stress arises and developsas a consequence of increasedinternal (psychological) tension.","PeriodicalId":93528,"journal":{"name":"Brain and neurological disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45310571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Image Distortion in Patients with Depression and Normal Persons as Good Enough Draw a Person Test","authors":"R. Bidaki","doi":"10.31579/2642-9730/017","DOIUrl":"https://doi.org/10.31579/2642-9730/017","url":null,"abstract":"Aim and Background: Body image refers to the perception and feeling that a person has about his/her physical self and its constituents. This research studies the comparison of body image distortion in patients with depression and normal in Rafsanjan city, Iran. Method: This is a descriptive-analytical study with case and control group. The investigated population consists of all patients with depressive disorder who referred to psychiatric Children and Adolesce outpatient clinics of Rafsanjan City (A city in southwest of Iran) in 2014. Drawing test of \"Good enough - Harris\" had been used in 40 depressed patients and 40 non-depressed as a control group.Chi-square test for data analyzing had been used. Results: The results showed that depressed patients in painting of the dummies were different in the most aspects as compared to control group. Conclusion: We suggest using \"dummy test Good enough- Harris \" in order to complementary diagnosis of depressed Persons.","PeriodicalId":93528,"journal":{"name":"Brain and neurological disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48202914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Paroxysmal Atrial Fibrillation in Patients with Embolic Stroke of Undetermined Source (Esus) In the Real-World Practice: Comparison Between Brown-Af, As5f And Cha2ds2-Vasc Scores","authors":"L. Masotti","doi":"10.31579/2642-9730/018","DOIUrl":"https://doi.org/10.31579/2642-9730/018","url":null,"abstract":"Introduction: Searching paroxysmal atrial fibrillation (PAF) is fundamental and strongly recommended in patients suffering from cryptogenic stroke or embolic stroke of undetermined source (ESUS). In the latest years some prediction scores for detecting post-stroke PAF have been proposed, such as Brown-AF and AS5F. However, external validations lack. The aim of the present study was to analyze the predictive power of AS5F and Brown-AF scores and compare them with the CHA2DS2-VASc score. Materials and Methods We analyzed demographic, clinical, trans-thoracic echocardiography and brain computer tomography characteristics of patients with ESUS undergone to two weeks external ECG monitoring after hospital discharge. PAF was considered detected when any evidence of AF and/or atrial flutter occurred at monitoring. For each patient we calculated the Brown-AF, AS5F and CHA2DS2-VASc scores and we analyzed and compared their predictive power by using area under the Receiver Operating Curve (AUROC). Results: Eighty-two consecutive ESUS patients with mean age ± SD 72 ± 10 years were the study population. Overall, PAF was detected in 43.9% of patients. PAF detection increased from 18.75% of patients with Brown ESUS-AF score 0 to 54.3% of patients with Brown ESUS-AF score ≥ 2. PAF was detected in 37.2% of patients with AS5F < 67.5 and 51.2% of patients with AS5F score ≥ 67.5. AUROC of Brown ESUS-AF score in predicting AF detection was 0.642 (95% CI: 0.528-0.745), while AUROC of AS5F was 0.618 (95% CI: 0.504-0.723)(p=0.6872). No difference between predictive power of Brown ESUS-AF and AS5F scores with CHA2DS2-VASc (AUROC 0.671, 95% CI: 0.559-0.771) was found. Conclusion: Both Brown ESUS-AF and AS5F scores could be used as a screening tool for selecting ESUS patients requiring prolonged ECG monitoring aimed to detect PAF. However, in our study their predictive power was quite low and not superior to that of CHA2DS2-VASc score.","PeriodicalId":93528,"journal":{"name":"Brain and neurological disorders","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70018067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Power of Hemorrhagic Transformation Scores in Real Life Stroke Patients Undergone to Urgent Reperfusion: A Brief Report","authors":"L. Masotti","doi":"10.31579/2642-9730/024","DOIUrl":"https://doi.org/10.31579/2642-9730/024","url":null,"abstract":"Introduction and aim: Hemorrhagic transformation (HT) is the most feared complication in acute phase of ischemic stroke. Predicting HT is of utmost importance in clinical practice. In the latest years a lot of HT prediction scores have been proposed, but their comparison in real life lack. Therefore, the aim of our study was to provide information about this topic. Materials and Methods: We retrospectively calculated THRIVE, SPAN-100, MSS score, SITS-ICH and GRASPS scores in patients consecutively admitted in our Stroke Unit along two years. To evaluate their predictive power, the area under the curve (AUC) of the Receiver Operating Characteristic (ROC) curve was calculated. Results: Study population was composed by ninety-one patients (51.6% females) with mean age 80.1 ± 11.3 years. Seventy-four (81.3%) patients undergone to systemic intravenous alteplase, seven (7.7%) to mechanical thrombectomy, ten (11%) to systemic intravenous alteplase plus mechanical thrombectomy. Eighteen patients (19.7%) presented HT. MSS score was the best prognosticator of HT, however the predictive power of the five analyzed score was low, ranging from and none of the score resulted significantly superior to the others. Conclusion: Our real-life study showed a low predictive power of a lot of HT prediction scores. Further prospective studies are warranted.","PeriodicalId":93528,"journal":{"name":"Brain and neurological disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45400518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Neuroimaging Documentation of Psychedelic Drugs’ Effect on the Brain: dmt, lsd, Psilocybin, and Ibogaine as Examples: A Mini Review","authors":"Abdul Wahab Alahmari","doi":"10.31579/2692-9422/027","DOIUrl":"https://doi.org/10.31579/2692-9422/027","url":null,"abstract":"Many psychedelics drugs are praised on social media platforms like YouTube by non-experts or bias documentaries claiming that these drugs have therapeutic effects on addicted patients or clarity of the mind. The aim of this paper is to collect a neuroimaging documentation of these psychedelics’ drugs and their effect on the brain. That can be documented on MRI, CT, or any other imaging modalities.","PeriodicalId":93528,"journal":{"name":"Brain and neurological disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46604172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confirmatory Factorial Model of Entrepreneurship in the COVID-19 Era","authors":"Cruz García Lirios","doi":"10.31579/2642-9730/031","DOIUrl":"https://doi.org/10.31579/2642-9730/031","url":null,"abstract":"The purpose of the work was to specify a model for the study of social understanding. A documentary, cross-sectional and exploratory study was carried out with a non-probabilistic selection of sources indexed to international repositories, considering the indexation, year of publication and impact factor. Discussion axes were established to address the problem, although the research design limited the findings to the sample analyzed, suggesting the extension of other repositories, years and quality indicators.","PeriodicalId":93528,"journal":{"name":"Brain and neurological disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42451434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroleptic Malignant Syndrome: Typical Antipsychotic Drugs Versus Atypical Antipsychotic Medications","authors":"Saeed Shoja Shafti","doi":"10.31579/2642-9730/025","DOIUrl":"https://doi.org/10.31579/2642-9730/025","url":null,"abstract":"Introduction: Neuroleptic malignant syndrome is an idiosyncratic reaction and a severe disorder caused by an adverse reaction to drugs with dopamine receptor- antagonist properties and is characterized by a tetrad of rigidity, fever, altered mental status, and autonomic instability. In the present assessment, typical or conventional antipsychotics have been contrasted with atypical antipsychotics with respect to recorded cases of neuroleptic malignant syndrome among a sample of nonwestern psychiatric inpatients. Methods: For assessment, all the cases with a diagnosis of neuroleptic malignant syndrome during the last sixty-two months, after exclusion of other conceivable differential diagnoses, were incorporated in the current retrospective, record-based evaluation. The clinical diagnosis was based on the Diagnostic and Statistical Manual of Mental Disorders, 5th edition. The valuation of independent variables was analyzed by ‘Compression of proportions. Statistical significance is defined as p value ≤0.05. Results: Amongst 19814 psychiatric inpatients, in the course of sixty-two months, eighteen cases received the diagnosis of neuroleptic malignant syndrome. As said by the findings, neuroleptic malignant syndrome was meaningfully more frequent among males, in comparison with females, and it was importantly more prevalent among cases suffering from schizophrenia, in comparison with bipolar disorder. Also, the highest risk of neuroleptic malignant syndrome was found in the age group of 30-39. In the current assessment, only one of the patients, who had received haloperidol, died due to aspiration pneumonia and respiratory failure, and the most prevalent symptom was fever, which was observable in one hundred percent of cases. In addition to a similar clinical profile, ‘Compression of proportions’ did not show any significant difference between the conventional (typical) antipsychotics versus the atypical antipsychotic medications with respect to the occurrence of neuroleptic malignant syndrome. Conclusion: As said by the findings, no significant difference was evident between the typical antipsychotic drugs versus the atypical antipsychotic medications, with respect to incidence and clinical profile of neuroleptic malignant syndrome.","PeriodicalId":93528,"journal":{"name":"Brain and neurological disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49275557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Governance of the public Administration of water Resources and Services in the COVID-19 era","authors":"Javier Carreón Guillén","doi":"10.31579/2642-9730/023","DOIUrl":"https://doi.org/10.31579/2642-9730/023","url":null,"abstract":"Water problems focused on scarcity, shortages, unhealthiness and high cost have been addressed from the social representations of users of the public drinking water service, although such studies have avoided the incidence of print media on readers. The objective of the present work was to specify a model for the study of the phenomenon, considering a review of press releases of national circulation during the period from 2015 to 2022, as well as the inclusion of frames in the disseminated information. A prevalence of the data was observed towards an intermediate frame of the problems, although the research design limited the results to the study scenario, suggesting the extension of the work to other scenarios such as the contamination of the aquifers and their effects on health Environmental public.","PeriodicalId":93528,"journal":{"name":"Brain and neurological disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46458591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombolysis with Intra-Arterial T-Pa for Acute Ischemic Stroke in Children Treated with Fontan Operation, Case Report","authors":"M. Habib","doi":"10.31579/2642-9730/015","DOIUrl":"https://doi.org/10.31579/2642-9730/015","url":null,"abstract":"We report the case of 7-year-old women with acute ischemic stroke, previously treated with Fontan operation due to complex congenital heart disease at the age of 2 years, who underwent an intra-arterial thrombolysis with a favorable outcome. No controlled randomized trials on thrombolysis among childhood stroke have been conducted yet. This and other similar cases suggest that thrombolysis may also be safe and beneficial in pediatric patients.","PeriodicalId":93528,"journal":{"name":"Brain and neurological disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46276647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}