Bulletin of Egyptian Society for Physiological Sciences最新文献_第3页

COVID 19 m-RNA (Pfizer) vaccination impairs cardiac functions in adult male rats COVID - 19 m-RNA(辉瑞)疫苗接种损害成年雄性大鼠的心功能

Bulletin of Egyptian Society for Physiological Sciences Pub Date : 2023-07-01 DOI: 10.21608/besps.2023.213045.1144

Ghida Hassan, Marwa Tarek

引用次数: 1

Protective effect of Vitamin D against type II diabetic nephropathy in rats: a possible role of adropin 维生素D对大鼠II型糖尿病肾病的保护作用:adropin的可能作用

Bulletin of Egyptian Society for Physiological Sciences Pub Date : 2023-07-01 DOI: 10.21608/besps.2023.203879.1137

M. Allam, N. Mohamed, H. Abdallah, N. El-shaer, Mohamed Y. Salem

{"title":"Protective effect of Vitamin D against type II diabetic nephropathy in rats: a possible role of adropin","authors":"M. Allam, N. Mohamed, H. Abdallah, N. El-shaer, Mohamed Y. Salem","doi":"10.21608/besps.2023.203879.1137","DOIUrl":"https://doi.org/10.21608/besps.2023.203879.1137","url":null,"abstract":"Background: Diabetic nephropathy (DN) is a common complication among type II diabetic patients which may lead to end stage renal disease. Oxidative stress has been found to play a part in the pathophysiology of DN. Several studies have demonstrated the effective nephroprotective role of vitamin D to counteract the progression of DN, although the exact mechanisms are not yet fully understood. Adropin release has been recently linked to be one of the vitamin D effects and was reported to exert its antioxidant effects via nuclear factor erythroid 2-related factor 2 (Nrf2). Aim: To examine the nephroprotective effects of Vitamin D focusing on adropin-Nrf2 axis as one of the possible underlying mechanisms of vitamin D in rats. Materials and Methods: Thirty two albino male adult rats were used in this experiment. Rats were randomly and equally divided into four groups:(GI) was the control, (GII) received vitamin D, (GIII) was the diabetic model, and (GIV) was the diabetes+ vitamin D group. Results: Rats that received vitamin D (0.03 µg/kg/day) for 8 weeks revealed significant lower insulin resistance and oxidative stress state, a significant improvement of kidney dysfunction that was confirmed with histopathological examinations for kidney, and significantly higher levels of serum adropin in association with a significant higher renal mRNA expression of Nrf2. Conclusion: Vitamin D administration has a renoprotective effect in DN in type II diabetic rats. The antioxidant effects of vitamin D may be in part related to the adropin- Nrf2 axis.","PeriodicalId":9347,"journal":{"name":"Bulletin of Egyptian Society for Physiological Sciences","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73362942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Toll -like Receptor 4 and Colony Stimulating Factor 2 Gene Expression for Early Recognition of Axial Spondyloarthritis Changes in Psoriatic cases. Toll样受体4和集落刺激因子2基因表达对银屑病中轴性脊柱炎早期识别的研究

Bulletin of Egyptian Society for Physiological Sciences Pub Date : 2023-07-01 DOI: 10.21608/besps.2023.209806.1142

M. Ellaithy, Sherin S Elnaidany, W. Shehata, D. Saif, S. El-Hefnawy

{"title":"Study of Toll -like Receptor 4 and Colony Stimulating Factor 2 Gene Expression for Early Recognition of Axial Spondyloarthritis Changes in Psoriatic cases.","authors":"M. Ellaithy, Sherin S Elnaidany, W. Shehata, D. Saif, S. El-Hefnawy","doi":"10.21608/besps.2023.209806.1142","DOIUrl":"https://doi.org/10.21608/besps.2023.209806.1142","url":null,"abstract":"Background: About 30% of cases with psoriasis will suffer from psoriatic arthritis (PsA). Heritable element plays a role in PsA as different genes are involved. However, few genes are involved in both psoriasis and PsA. This study aimed to investigate the predictive value of Toll-like receptor (TLR) 4 and colony stimulating factor (CSF) 2 gene expression for early detection of axial spondyloarthritis in psoriatic patients. Methods: This study included 200 subjects; 100 psoriatic patients, subdivided into two groups; Group 1: included 66 patients with plaque psoriasis without any articular complaint, and Group 2: included 44 patients with psoriatic arthritis. Group 3 included: 100 age and sex matched healthy controls. Laboratory assessment of TLR4 and CSF2 gene expression by real time polymerase chain reaction technique, and axial joint radiological assessment by Magnetic Resonance Imaging. Results: There were significant increase of CSF2 and TLR4 gene expression levels in cases compared with controls (p <0.001) for both. Additionally, a significant rise of CSF2 and TLR4 gene expression levels in cases with psoriatic arthritis compared to cases with psoriatic skin affection only (U=2.45, p= 0.01, 3.34, p= 0.001 respectively. Receiver operating characteristic curve done for earlier detection of sub-clinical changes of axSpA regarding positive MRI results in cases with psoriasis and PsA respectively with P value <0.001. Conclusion: TLR4 and CSF2 gene expression have strong predictive value in early detection of axial SpA changes in asymptomatic and non-radiographic psoriatic patients which is equivalent and equal to the MRI predictive value.","PeriodicalId":9347,"journal":{"name":"Bulletin of Egyptian Society for Physiological Sciences","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88028721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studying the effect of vitamin B12 and folic acid on the levels of brain-derived neurotrophic factor in the blood and the brain of obese male rats. 研究维生素B12和叶酸对肥胖雄性大鼠血液和大脑中脑源性神经营养因子水平的影响。

Bulletin of Egyptian Society for Physiological Sciences Pub Date : 2023-04-01 DOI: 10.21608/besps.2023.201192.1136

Ayda Maryoud, Rasha Elghaba, G. Gad, S. El-Desouky, M. Adel

{"title":"Studying the effect of vitamin B12 and folic acid on the levels of brain-derived neurotrophic factor in the blood and the brain of obese male rats.","authors":"Ayda Maryoud, Rasha Elghaba, G. Gad, S. El-Desouky, M. Adel","doi":"10.21608/besps.2023.201192.1136","DOIUrl":"https://doi.org/10.21608/besps.2023.201192.1136","url":null,"abstract":"Objective: We aimed to investigate the potential benefits and mechanisms of vitamin B12 and folic acid supplementation in obesity. Materials and methods: Thirty two Sprague-Dawley rats were separated into four groups, eight rats each: controls were fed normal chow diet (ND), obese controls were fed high fat diet (HFD) (60% of their diet as saturated fats), vitamin B12-treated rats were fed HFD concomitant with an intraperitoneal injection of 1 mg/kg/day of vitamin B12 for 5 days in week, and folic acid-treated rats were fed HFD with a concomitant administration of 50 mg/kg day of folic acid by gastric gavage, all for 12 weeks. At the end of the experiment, behavioural tests were performed, and blood samples were gathered for lipid profiles, serum vitamin B12, folic acid, and BDNF. The hippocampus and hypothalamus were isolated for oxidative stress and BDNF testing. Results: Obese rats showed hypercholesterolemia, hypertriglyceridemia (TG), hyperleptinemia, elevated oxidative stress markers, and a decline in cognitive and behavioural test parameters. Obesity had a negative effect on BDNF levels in the blood, hypothalamus, and hippocampus, which was reversed by the administration of vitamin B12 and folic acid. Treatment with vitamin B12 resulted in a significant rise in BDNF levels, a decrease in serum total cholesterol and TG, and a significant improvement in cognitive functions and behavioural test parameters. However, while the folic acid improved cognitive function parameters and oxidative stress markers, it had no effect on the lipid profile and showed a non-significant increase in BDNF levels. Conclusions: Obesity decreased BDNF levels in the hippocampus and hypothalamus, which was reversed by vitamin B12 and folic acid treatment, they are therefore an intriguing therapeutic approach for obesity and associated cognitive decline.","PeriodicalId":9347,"journal":{"name":"Bulletin of Egyptian Society for Physiological Sciences","volume":"344 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77145743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fetuin-A Ameliorates Lipopolysaccharide-induced Depressive-Like Behavior in Rats Targeting Caspase-1/BDNF/CREB Pathway 针对Caspase-1/BDNF/CREB通路，胎儿素a改善脂多糖诱导的大鼠抑郁样行为

Bulletin of Egyptian Society for Physiological Sciences Pub Date : 2023-04-01 DOI: 10.21608/besps.2022.171592.1131

E. Basha, H. Faheem, H. Ibrahim, R. Ismail, Mounira Seleem, Alaa Elkordy, Haidy Khattab

{"title":"Fetuin-A Ameliorates Lipopolysaccharide-induced Depressive-Like Behavior in Rats Targeting Caspase-1/BDNF/CREB Pathway","authors":"E. Basha, H. Faheem, H. Ibrahim, R. Ismail, Mounira Seleem, Alaa Elkordy, Haidy Khattab","doi":"10.21608/besps.2022.171592.1131","DOIUrl":"https://doi.org/10.21608/besps.2022.171592.1131","url":null,"abstract":"Depression is a mental illness that seriously harms human health. Therefore, it is crucial to create antidepressant treatments that are effective and powerful. Fetuin-A is a multifunctional glycoprotein mainly released by hepatocytes; it has a complex role in inflammatory processes. We aimed to examine the effect of fetuin-A on lipopolysaccharide-induced depressive like behavior in rats. Forty male albino rats were randomly categorized into four groups; Group I: Control group: (saline + vehicle) for 10 days, Group II: Control treated by fetuin-A group: fetuin-A (100 mg/kg/day) for 10 days, Group III: Depression group: 0.5 mg/kg lipopolysaccharide for 10 days, Group IV: Depression treated with fetuin-A group: Lipopolysaccharide (0.5 mg/kg) for 10 days followed by fetuin-A (100 mg/kg) for 10 days. Behavioral impairments were evaluated. Brain levels of malondialdehyde (MDA) and glutathione peroxidase (GPX) were estimated. The levels of tumor necrosis factor-alpha (TNF-α), interleukin (IL) IL-6, and brain-derived neurotrophic factor (BDNF), were measured by ELISA. AMPA glutamate receptors (AMPARs GluA1&2), caspase-1 and cAMP response element-binding protein (CREB) mRNA expression by real-time PCR were done. Histopathological assessment of hippocampus was done. Our results revealed that fetuin-A effectively ameliorated LPS-induced behavioral tests impairment through increasing BDNF and CREB. Additionally, fetuin-A treatment caused a decrease in the levels of MDA, TNF-α and IL-6 together with concomitant elevation of GPX and upregulation of caspase-1 and AMPAR GluA1&2 expression. We concluded that fetuin-A ameliorates depression-like behaviors of rats by controlling the Caspase-1/BDNF/CREB Pathway signaling pathway, which may serve as a new target for treatment of depression.","PeriodicalId":9347,"journal":{"name":"Bulletin of Egyptian Society for Physiological Sciences","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82504181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nephroprotective Effect of Estradiol and Moreinga Oleifera Extract in Ovarictomized Rat 雌二醇和辣木提取物对去卵巢大鼠肾保护作用

Bulletin of Egyptian Society for Physiological Sciences Pub Date : 2023-04-01 DOI: 10.21608/besps.2022.179400.1134

Sally S. Donia, S. Saleh, F. Ahmed, D. Noya, Walaa A. Fadda, G. Amer

引用次数: 0

Doxorubicin-Induced Cardiotoxicity in Adult Male Albino Rats and the Ameliorative Effects of Achillea Fragrantissima Crude Extract, Its Combined Ethyl Acetate/n. Butanol Fraction, and Vitamin E 阿霉素对成年雄性白化大鼠的心脏毒性及阿希勒粗提物及其复方乙酸乙酯/n的改善作用。丁醇部分和维生素E

Bulletin of Egyptian Society for Physiological Sciences Pub Date : 2023-04-01 DOI: 10.21608/besps.2022.170898.1129

Angie M. Ameen, Enas S. Mostafa, Enas E Eltamany, Noha Abd El-Fadeal, Mohamed El-kherbetawy, M. Mansour

引用次数: 0

Methylenetetrahydrofolate Reductase and Peroxisome Proliferator-Activated Receptor-γ Gene Polymorphisms and Risk of Obesity in Females of Madina, Saudi Arabia 沙特阿拉伯麦地那地区女性亚甲基四氢叶酸还原酶和过氧化物酶体增殖物激活受体-γ基因多态性与肥胖风险

Bulletin of Egyptian Society for Physiological Sciences Pub Date : 2023-01-01 DOI: 10.21608/besps.2022.171402.1130

M. Aboonq, Magda H M Youssef, S. El-Kafrawy, Tamer M. Hifnawy, M. Mojaddidi, Eman A-Fadhly, S. Eltarhony, A. Elgendy, E. Eid

引用次数: 0

Title: Comparison of high-protein diet versus ketogenic diet as weight reduction diets in obese rats: hepatic and metabolic effects 题目:高蛋白饮食与生酮饮食作为肥胖大鼠减肥饮食的比较:肝脏和代谢影响

Bulletin of Egyptian Society for Physiological Sciences Pub Date : 2023-01-01 DOI: 10.21608/besps.2022.135542.1124

Sherein F. El-sayed, Islam Wahid, I. Salem, Mona Ahmed, Reham M. Wahid

引用次数: 1

Silent Information Regulator 1 Mediates Quercetin Protective Effect on Cadmium-induced Testicular Damage in Adult Male Rats 沉默信息调节因子1介导槲皮素对镉致成年雄性大鼠睾丸损伤的保护作用

Bulletin of Egyptian Society for Physiological Sciences Pub Date : 2023-01-01 DOI: 10.21608/besps.2022.167068.1128

Eman El-Tabaa, Hanem M Rabah, E. Basha, A. Eid, Dina M. Tahoon, R. Elkholy, Haidy Khattab

引用次数: 1