Doxorubicin-Induced Cardiotoxicity in Adult Male Albino Rats and the Ameliorative Effects of Achillea Fragrantissima Crude Extract, Its Combined Ethyl Acetate/n. Butanol Fraction, and Vitamin E

Abstract

Doxorubicin (DOX) is a potent chemotherapeutic agent. Unfortunately, due to the incidence of dose-dependent cardiotoxicity, its clinical usage is hampered. Natural products are gaining popularity as a means of preventing DOX-induced cardiotoxicity. In the present study, we investigated the cardiotoxic effects of DOX and assessed the potential ameliorative effects of Achillea fragrantissima extract, its combined ethyl acetate/ n . butanol (EtOAc-Bu) fraction