Bulletin of Medical Sciences最新文献

{"title":"Chemical and pharmacological characterization of triptans","authors":"Kelemen Hajnal, Filep Bíborka-Erzsébet, P. Attila","doi":"10.2478/orvtudert-2019-0007","DOIUrl":"https://doi.org/10.2478/orvtudert-2019-0007","url":null,"abstract":"Abstract Triptans are specific drugs for migraine attack, their use leads to selective vasoconstriction, while the inflammatory condition that usually occurs during migraine is reduced. The structurally indolamine derivatives are selective agonists of the serotonin 1B/1D receptor. This review presents the history, representatives, production, and physico-chemical properties of triptans, but also discusses their pharmacological properties and mechanism of action.","PeriodicalId":9334,"journal":{"name":"Bulletin of Medical Sciences","volume":"140 1","pages":"53 - 60"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73789657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aluminium contamination of several types of tea","authors":"Fogarasi Erzsébet, Fülöp Ibolya, B. Zsuzsa, Márton Kincső, Croitoru Mircea Dumitru","doi":"10.2478/orvtudert-2019-0003","DOIUrl":"https://doi.org/10.2478/orvtudert-2019-0003","url":null,"abstract":"Abstract Introduction: Camellia sinensis, a widely used plant, optimally grows in a low pH soil that in most cases contains high amounts of aluminum. Objectives: The aluminum content of the tea obtained from Camellia sinensis and other plants was compared. The influence of pH on the aluminum content of the tea was also measured. Materials and methods: The aluminum content of 48 samples was measured using a colorimetric method. The method is based on the ability of aluminum to form a stable complex with xylenol orange at low pH; this complex has an absorption maximum of 555 nm. Results: The method was validated for tea obtained with water and for tea obtained with water containing citric acid. The method proved linear over the rage of 0.7 – 7 ug/ml, coefficient of variation ranged between 2.6 – 7.68% (was dependent on the pH of the solution used to obtain the tea), accuracy was suitable for quantitative measurement (92.39-102.92%) and the complex proved to be stable for at least 1 hour. The following concentrations were measured: green tea (1.59 - 7.70 µg/ml), black tea (1.39 - 5.60 µg/ml), fruit tea (1.01 - 5.63 µg/ml) and herbal tea (1.03 - 5.24 µg/ml). Conclusion: The method proved useful and easily applicable for screening aluminum content of plants used for tea brewing. Camellia sinensis both green and black types had significantly higher aluminum contents than other type of teas. Adding citric acid, as would result from use of lemon juice, significantly increased the aluminum extraction from the plants used for tea brewing.","PeriodicalId":9334,"journal":{"name":"Bulletin of Medical Sciences","volume":"92 1","pages":"42 - 46"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78466381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence of internal diseases in the premotor phase of Parkinson’s disease by analyzing a large database covering a whole population","authors":"Szatmári Szabolcs, A. András, Oberfrank Ferenc, B. Dániel","doi":"10.2478/orvtudert-2019-0009","DOIUrl":"https://doi.org/10.2478/orvtudert-2019-0009","url":null,"abstract":"Abstract The premotor phase of Parkinson’s disease (PD) precedes the appearance of motor symptoms by years. Many non-motor diseases have been associated with an increased risk of developing PD, but results of these studies are conflicting. The aim of this study was to investigate the occurrence of certain internal diseases (metabolic, circulatory, gastrointestinal) based on diagnosis codes, before the diagnosis of PD. There were 5209 patients included in the study who received diagnosis of PD at least in 2 years and we analyzed data retrospectively between 2004 and 2016. Out of metabolic diseases dyslipidemia (41%) and diabetes mellitus (32%), out of circulatory diseases hypertension (89%) and ischemic heart disease (51%) and out of gastrointestinal diseases gastroesophageal reflux disease (51%) and gallstones (25%) were the first two most common disorders in the examined PD patients. This is the first study in Hungary which analyzed PD in a large database in the context of internal diseases, and raised the possibility of a link between dyslipidemias, diabetes mellitus, hypertension, ischemic heart disease, gastooesophagial reflux, gallstones and PD.","PeriodicalId":9334,"journal":{"name":"Bulletin of Medical Sciences","volume":"23 1","pages":"35 - 41"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77507894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An event that impacted the Transylvanian pharmacist education 100 years ago","authors":"Péter H. Mária","doi":"10.2478/orvtudert-2019-0005","DOIUrl":"https://doi.org/10.2478/orvtudert-2019-0005","url":null,"abstract":"Abstract In Kolozsvár, on 17th of September 1872, a Hungarian royal university was founded with 4 faculties 1- Law and Political Sciences, 2. Medical, 3. Arts (liberal), Language and History of Science, 4. Mathemathics and Natural History faculties. In 1881 the University picked up the Ferencz József University of Science name. There was no independent Medicine trainingfacultyt at this time yet. Pharmacists were taught in the Medical and Natural History faculties. In December 1918, during the first world war, Kolozsvár was moved under Romanian rule. On the 9th of May in 1919 the Romanian authorities called the acadamic senate (school staff) to do loyalty oath for the Romanian king.This was refused by the university teachers. After this event, teachers were moved out from this building along with the entire equipement of the University, and the place was occupied by the Romanian university. As, by this, theHungarian language acadamic education became impossible the first stage of the life of(Hungarian King) Ferencz József University of Sciense ended. First, the major part of theprofessors and students emigrated to Budapest while later on in 1921 the University wastemporarily established in Szeged. The University in Szeged took not onlythe legal continuity of the institute through its name but its professors also maintained and cherished all the traditions of the institute through many long coming years. Starting from 1921/1922 many student with transilvanian origin obtained pharmacist’s degree here many of whom later returned and worked in their native country.","PeriodicalId":9334,"journal":{"name":"Bulletin of Medical Sciences","volume":"26 1","pages":"61 - 65"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84991189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of corticosterone from rat hair samples by HPLC-MS method","authors":"Ferencz Elek, Boda Ferenc, Gáll Zsolt, Kolcsár Melinda, Donáth-Nagy Gabriella, Vancea Szende","doi":"10.2478/orvtudert-2019-0008","DOIUrl":"https://doi.org/10.2478/orvtudert-2019-0008","url":null,"abstract":"Abstract Corticosterone is an adrenocortical steroid hormone with glucocorticoid and mineralocorticoid effects. Based on previous studies, the plasma level of corticosterone correlates with the stress exposure of rodents. Because the half-life of corticosterone in blood is short, its plasma concentration can be used as an acute stress marker. But hair is accumulating the systemic and locally produced corticosterone, therefore it can be used to study chronic stress. However, the accurate quantification of corticosterone is an analytical challenge owing to the very low amount of hormone found in a complicated biological matrix. The high performance liquid chromatography coupled with mass spectrometry (HPLC-MS) can provide the required selectivity and sensitivity for this purpose. Currently published methods for corticosterone quantification involve complicated sample preparation and long run time. Accordingly, the aims of the study were to simplify the extraction method of the corticosterone from rat hair samples and to develop an optimized HPLC-MS method for the accurate quantification. The rat hair samples were washed with methanol, dried and cut, then extracted with methanol at room temperature for 24 hours. The lipids were precipitated with formic acid aqueous solution and eliminated by centrifugation. The corticosterone was separated from other compounds with reverse phase chromatography using acetonitrile and 0,1% aqueous solution of formic acid as mobile phase. The detection was performed in positive SIM mode measuring the 347 m/z molecular ion. A six point calibration was performed in the range of 0,5-20 ng/ml, the accuracy was tested with quality control samples at two different concentration level. The total run time is only 4,2 minutes and the lower limit of quantification (LLOQ) is 0,5 ng/ml, with 10 pg absolute sensitivity. By determining the quantity of the hormone for a well-defined hair region, based on the speed of hair growth, we can characterize the retrospective stress exposure of the animals in different conditions.","PeriodicalId":9334,"journal":{"name":"Bulletin of Medical Sciences","volume":"19 1","pages":"27 - 34"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73904329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presence and upregulation of Transient Receptor Potential Vanilloid 1 (TRPV1) and Ankyrin 1 (TRPA1) in translational rat endometriosis model","authors":"Pohóczky Krisztina, Bohonyi Noémi, M. Péter, Kajtár Béla, H. Zsuzsanna","doi":"10.2478/orvtudert-2019-0011","DOIUrl":"https://doi.org/10.2478/orvtudert-2019-0011","url":null,"abstract":"Abstract The Transient Receptor Potential Vanilloid 1 (TRPV1) and Ankyrin 1 (TRPA1) are non-selective cation channels predominantly localized on capsaicin-sensitive sensory neurons; however both receptors have been described in non-neuronal tissues. It has been published that both receptors upregulated in peritoneal endometriosis in humans. Our research group demonstrated that TRPA1 and TRPV1 expression is elevated in human deep infiltrating endometriosis (DIE) lesions and the receptors have an estrogen-dependent expression pattern in rat endometrium. Here, we investigated the expression changes of TRPA1/V1 and the role of the capsaicin-sensitive sensory-nerve endings in a rat model of peritoneal endometriosis. Peritoneal endometriosis was surgically induced in 8-week-old female rats (n=7-7) for 2-weeks (acute condition) and 8-weeks (chronic condition). TRPA1/V1 mRNAs were quantified with quantitative polymerase chain reaction (qPCR). The expression levels were compared with the results obtained earlier from human DIE samples. The blockade of the TRPA1/V1 expressing capsaicin-sensitive nerve endings was induced with resiniferatoxin (RTX), followed by the measurement of the weight and size of the endometriosis lesions. We detected TRPV1 and TRPA1 mRNA in normal rat endometrium, their expression was not altered in sham-operated animals. In chronic, but not in acute endometriosis the expression was significantly elevated in the lesions, which results are consistent with our previous findings in human DIE. The elimination of capsaicin-sensitive nerve endings decreased the weight of the endometriosis lesions while the size of the ectopic tissue was not altered. Taken together, our results obtained from the rat endometriosis model are consistent with the previous human results, therefore this model is considered to have translational significance and it is suitable for functional analysis of the ion channels. The local, non-neuronal TRPA1 and TRPV1 might play a role in inflammation and sensory neuronal activation in endometriosis related pain, which is mediated by a broad range of pro-inflammatory molecules.","PeriodicalId":9334,"journal":{"name":"Bulletin of Medical Sciences","volume":"216 1","pages":"15 - 26"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75593402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Antidepressants and the Metabolic Syndrome","authors":"Kolcsár Melinda, Gáll Zsolt, Bába László-István, K. Zoltán","doi":"10.2478/orvtudert-2018-0009","DOIUrl":"https://doi.org/10.2478/orvtudert-2018-0009","url":null,"abstract":"Abstract The relationship between antidepressants (AD) and metabolic syndrome (MS) can be approached from many perspectives. We can start from the mutuality of depression and MS: depression often causes MS and vice versa; however, the two diseases aggravate each other. Altered glucocorticoid secretion - among others - may be a common etiological factor for depression and MS. Enhanced glucocorticoid production leads both to sleep disorders and insulin resistance, and several antidepressants cause obesity and insulin resistance. In addition, sympathetic nervous system activity increases in depression, together with the elevated production of counter-insulin hormones such as catecholamines (adrenaline) and glucocorticoids. From the components of MS, body weight changes can be most easily followed by the patient. The obesogenic mechanisms of AD drugs are different. The H1-receptor blocking agents have the most important weight gaining effect, followed by the 5-HT2c-receptor blocking and/or down-regulating ADs. The fattening effect of mirtazapine, paroxetine, and tricyclic antidepressants are based on such central mechanisms. Blocking of alpha1-receptors contributes to the obesogenic effects of certain drugs by inducing sedation: this has been confirmed in case of imipramine, amitriptyline, and doxepin. Fluoxetine behaves differently depending on the dose and duration of treatment: while at the usual doses it induces weight loss at the beginning of therapy, its initial anorexigenic effects reverses during prolonged use; while its activation effect at high doses is favorable in bulimia. The selective noradrenaline reuptake inhibitor reboxetine reduces appetite, similarly to bupropion, which inhibits dopamine reuptake as well. We highlight the effect of fluoxetine on direct adipogenicity, mentioning its preadipocyte-adipocyte transformation-reducing and adipocyte proliferation-inhibiting activity, as well as its ability to enhance fat cell autophagy.","PeriodicalId":9334,"journal":{"name":"Bulletin of Medical Sciences","volume":"27 1","pages":"89 - 98"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74788544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In memory of Fodor József","authors":"Abram Zoltán","doi":"10.2478/orvtudert-2018-0007","DOIUrl":"https://doi.org/10.2478/orvtudert-2018-0007","url":null,"abstract":"Abstract Fodor József (1843–1901) is the founder of Hungarian hygiene who established the second hygiene department and hygiene institute in the world; he was a member of the Hungarian Academy of Sciences. He lived in the era of great microbiological discoveries, and his rich and multidisciplinary work has opened up new directions and approaches in science. For a short period of time he was professor at the newly established university from Cluj (Kolozsvár), later he had important contributions to the Hungarian public health act of 1876. His entire professional career represents a very special model by the messages left behind. He was proposed for Nobel Prize in medical (biological) sciences, but he suddenly died on 20 March 1901.","PeriodicalId":9334,"journal":{"name":"Bulletin of Medical Sciences","volume":"3 1","pages":"131 - 135"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82750195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Appointment as Professor of Zsigmond Purjesz and his Decorations. A Centennial Commemoration","authors":"G. György","doi":"10.2478/orvtudert-2018-0012","DOIUrl":"https://doi.org/10.2478/orvtudert-2018-0012","url":null,"abstract":"Abstract Zsigmond Purjesz (1846–1918) was born at Szentes (Hungary), and he became MD at Budapest in 1870. In 1880 he applied for and won by competition the professor’s chair of Internal Medicine at Cluj/Kolozsvár University. He taught there for three decades, and founded a medical school. In 1911 he retired and moved to Budapest. According to his wish, he was buried at Kolozsvár. The first part of our study presents the preliminaries of Purjesz’s appointment to Kolozsvár, based on the documents of the Kolozsvár Medical Faculty kept in the State Archives at Marosvásárhely/Târgu Mureş. Endre Takács from Budapest and Ignác Büchler from Kolozsvár were the other two applicants. A board of three university professors proposed Purjesz on the first, Takács on the second and Büchler on the third place to be appointed as professor. On ministerial proposal the king decided to appoint Purjesz on the 2nd of May, 1880. In the second part of the study we take into account the recognitions and decorations Purjesz got. In 1893 for his activity during the cholera epidemic he was awarded with the Iron-Crown Order, 3rd class. In 1901 he got the title of Court councilor, which implied the form of address “Right Honorable”. In 1906 at the 25th anniversary of his professorship his students and colleagues compiled a memorial volume dedicated to him. In 1910 the Royal City of Kolozsvár declared him Honorary Citizen. Following his retirement his bust made by György Vastagh was unveiled at the courtyard of the hospital. In 1911, the king recognizing his healing and teaching activity raised him to the rank of Hungarian nobility.","PeriodicalId":9334,"journal":{"name":"Bulletin of Medical Sciences","volume":"3 1","pages":"137 - 144"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81971565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To the memory of Pápai Páriz Ferenc. The „Pax Corporis”, a home medical book for people","authors":"Balla Árpád, Pelok Benedek-György","doi":"10.2478/orvtudert-2018-0015","DOIUrl":"https://doi.org/10.2478/orvtudert-2018-0015","url":null,"abstract":"Abstract We present the life, career and memory of Pápai Páriz Ferenc (1649, Dés - 1716, Nagyenyed), professor and rector of the Protestant College of Nagyenyed, the famous Transylvanian humanist, medical doctor, poet, philosopher, church historian, heraldist. He studied in Dés (now Dej, Romania), Gyulafehérvár (now Alba Iulia, Romania), Kolozsvár (now Cluj-Napoca, Romania), Marosvásárhely (now Târgu-Mureş, Romania) and Nagyenyed (now Aiud, Romania). In the spring of 1672 he set off from Nagyenyed for a pedestrian trip abroad. He admired the Treasury in Dresden, and attended medical studies in Leipzig and Heidelberg. He completed his medical studies in Basel. In 1674 he became doctor medicus and was elected member of the board of the medical faculty. He returned to Nagyenyed in 1675. Between 1676 and 1690 he is the physician of the court of the Transylvanian princely couple. In 1678 he got a department in the College of Nagyenyed, extended in 1680 with Greek, physics, natural sciences and medical knowledge departments. Between 1681 and 1715 he was the rector of the College. Above all he cherished peace. He was a versatile writer. His medical book written in Hungarian, the PAX CORPORIS, i.e. “the peace of the body” was printed and published at Kolozsvár in 1690. This was dedicated to the target community: “for the benefit of the stupid poor”, it substituted the physician in the family. The rules of a healthy lifestyle were formulated also. The popularity of the book was proved by those eleven editions we know about. Another great work was the Hungarian-Latin, Latin-Hungarian dictionary (Lőcse, now Levoca, Slovakia, 1708). His memory is kept by a bust and plate in the courtyard of the Protestant College of Nagyenyed. The Hungarian postal service (Magyar Posta) released a stamp on his 350th anniversary. His life, work and importance were appreciated by a number of authors across centuries. An internet search on the terms “Pápai” + “Páriz” + “Ferenc” returns an important number of hits. Many foundations and associations are dedicated to his memory.","PeriodicalId":9334,"journal":{"name":"Bulletin of Medical Sciences","volume":"198 Pt 2 1","pages":"119 - 124"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79670946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}