Biomolecular and Health Science Journal最新文献_第9页

Epidemiological Study of Clinical and Laboratory Profiles of Patients with Acute Lymphoblastic Leukemia at Dr. Soetomo Hospital Surabaya 泗水Soetomo医生医院急性淋巴细胞白血病患者临床和实验室概况的流行病学研究

Biomolecular and Health Science Journal Pub Date : 2019-06-30 DOI: 10.20473/BHSJ.V2I1.13247

Kezia Warokka Putri, I. Ugrasena, Y. Hernaningsih

{"title":"Epidemiological Study of Clinical and Laboratory Profiles of Patients with Acute Lymphoblastic Leukemia at Dr. Soetomo Hospital Surabaya","authors":"Kezia Warokka Putri, I. Ugrasena, Y. Hernaningsih","doi":"10.20473/BHSJ.V2I1.13247","DOIUrl":"https://doi.org/10.20473/BHSJ.V2I1.13247","url":null,"abstract":"Introduction: Considering the high number of acute lymphoblastic leukemia (ALL) and it being the type of cancer with the highest fatality rate among the children, this study seeks to determine the epidemiological description of the clinical and laboratory profiles of patients with ALL.Methods: This research used a descriptive study by using medical data record of patients with ALL. The research variables were gender, age, leukemia history of the patient’s family, nutritional status, symptoms and signs, laboratory examination, ALL subtypes, risk factors, and result outcomes. All data presented descriptively.Results: From a total of 50 patients, 54 % of them were male aged 1,5 – 10 years old. 84% of the patients’ family had no medical record related to leukemia. 42% of the patient malnutrition. Pale (78%), fever (64%), pain (32%), hepatomegaly (38%), lymphadenopathy (28%), splenomegaly (26%), patients with anemia (82%), leukocytosis (38%), thrombocytopenia (54%). The highest types were ALL–LI (68%), SR-ALL (54%), and remission outcome reached 82%.Conclusion: Insidence higher in male, aged 1,5 – 10 years old, malnourished at the start of the diagnosis. Most of the patients’ family had no medical history of leukemia. Symptoms and medical signs mostly appeared were pale, fever, and bone/joint pain. The physical examination showed hepatomegaly, lymphadenopathy, and splenomegaly and laboratory first test showed the patients had anemia, leukocytosis, and thrombocytopenia.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76654903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Combination Effect of The Extract of Avocado Leaf and Seed (Persea americana) on Level of Total Cholesterol, LDL, and HDL in Mice (Mus musculus) with Hypercholesterolemia 美洲鳄梨叶和种子提取物对高胆固醇血症小鼠总胆固醇、低密度脂蛋白和高密度脂蛋白水平的联合影响

Biomolecular and Health Science Journal Pub Date : 2019-06-30 DOI: 10.20473/BHSJ.V2I1.13907

M. Dita, I. S. Mukono, M. Rochmanti

{"title":"Combination Effect of The Extract of Avocado Leaf and Seed (Persea americana) on Level of Total Cholesterol, LDL, and HDL in Mice (Mus musculus) with Hypercholesterolemia","authors":"M. Dita, I. S. Mukono, M. Rochmanti","doi":"10.20473/BHSJ.V2I1.13907","DOIUrl":"https://doi.org/10.20473/BHSJ.V2I1.13907","url":null,"abstract":"Introduction: Traditional and herbal medicine are two of the primary treatments in a developing country. Both avocado leaf extract and avocado seed extract (Persea americana) have been proven to have an antihyperlipidemic effect in experimental animals. This study was conducted to analyze the effect of avocado leaf and seed extract in a combination form on total cholesterol, LDL, and HDL of hypercholesterolemia mice induced by high fat diet and duck egg yolk.Methods: The sample unit of this study consisted of 25 mice (Mus musculus) and divided into 5 groups: KO1 (control), KO2 (hypercholesterolemia group), KO3 (1st treatment group), KO4 (2nd treatment group), and KO5 (3rd treatment group). The induction phase was done for 35 days, whilst the treatment phase was done for 28 days. All data were analyzed using t test and one-way ANOVA.Results: Administration of the combination including avocado leaf and seed extract (CALSE) in all treatment group proved to decrease total cholesterol and LDL level in mice although it was not statistically significant (p=0,420; p=0,882). Meanwhile, CALSE had a different effect on HDL KO3 level with HDL KO4 and KO5 level, in which HDL KO3 level tended to decrease and HDL KO4 and KO5 level tended to increase.Conclusion: In conclusion, CALSE has the potential to act as an antihyperlipidemic agent which derive from flavonoid and saponin. The potential efficacy might be achieved in a combination rather than in an individual form.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73056458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effects of Climatic Factors on The Incidence Rate of Dengue Virus Infection in Surabaya During 2010-2013 2010-2013年气候因素对泗水登革热病毒感染率的影响

Biomolecular and Health Science Journal Pub Date : 2019-06-30 DOI: 10.20473/BHSJ.V2I1.9340

Winni Aprillia Putri, Abu Rohiman, S. Sulistiawati, Dwiyanti Puspitasari

{"title":"Effects of Climatic Factors on The Incidence Rate of Dengue Virus Infection in Surabaya During 2010-2013","authors":"Winni Aprillia Putri, Abu Rohiman, S. Sulistiawati, Dwiyanti Puspitasari","doi":"10.20473/BHSJ.V2I1.9340","DOIUrl":"https://doi.org/10.20473/BHSJ.V2I1.9340","url":null,"abstract":"Introduction: Dengue Virus Infection (DVI) is one of cautious mosquito-borne virus disease that transmitted by Aedes aegypti and Aedes albopictus. Surabaya has the highest incidence rate of DVI in East Java. Transmission of dengue virus were significantly affected by the change of climatic factor components (precipitation, temperature, and humidity). This study is aimed to analyze the correlation between climatic factor components with the incidence rate of DVI in Surabaya and its distribution.Methods: This is a cross-sectional study using analytic observational approach. The Incidence rate of DVI during 2010-2013 datas were taken from Surabaya Health Office. Climatic factor datas on the same years were taken from Juanda Meteorological Station. Correlation tests were performed by using Spearman Test.Results: As the result, there were 7,685 DVI patients during 2010-2013. Male patients have less proportion (51.89%). The highest DVI cases are from the age group of 5-14 years (>40%). Incidence rate of DVI was increased during February to April, and highest incidence rate occured in 2010 (n=3,379). There were significant correlation between precipitation (r=0.419, p-value p=0.003) and humidity (r=0.502, p-value=0.000) with the incidence rate of DVI in Surabaya during 2010-2013.Conclusion: Therefore, precipitation and humidity are two climatic factor components that may effect the incidence rate of DVI in Surabaya.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86183260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

CHOP and R-CHOP Therapeutic Responses in Non-Hodgkin Lymphoma Patients in Dr. Soetomo General Hospital Surabaya 泗水Soetomo总医院非霍奇金淋巴瘤患者CHOP和R-CHOP治疗反应

Biomolecular and Health Science Journal Pub Date : 2018-11-26 DOI: 10.20473/BHSJ.V1I2.9244

Rina Syarifah Salma, M. Sedana, S. Yudho

{"title":"CHOP and R-CHOP Therapeutic Responses in Non-Hodgkin Lymphoma Patients in Dr. Soetomo General Hospital Surabaya","authors":"Rina Syarifah Salma, M. Sedana, S. Yudho","doi":"10.20473/BHSJ.V1I2.9244","DOIUrl":"https://doi.org/10.20473/BHSJ.V1I2.9244","url":null,"abstract":"Introduction: Non-Hodgkin Lymphoma (NHL) is a group of lymphoid-derived malignant disease with heterogenic biological and clinical manifestations. For over 30 years, CHOP (Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) has been the first choice of chemotherapy for aggressive NHL. Later in 1997 Rituximab as anti-CD20 monoclonal antibody was introduced and then combined with CHOP as R-CHOP. The objective of this study is to acknowledge the response of the CHOP and R-CHOP therapy in Non-Hodgkin Lymphoma patients at Dr. Soetomo General Hospital.Methods: The design of this study was retrospective observational study using secondary data obtained from patient’s medical records from 2011 to 2015. The data selected from the medical records are the result of the therapy, as well as patient’s gender and age. Results: The results of patients’ therapy were classified into four categories: The study showed that 51.28% patients had Complete Response, followed by Partial Response (28.21%), Progressive Disease (17.95%), and No Change (2.56%). Sample characteristics showed male patients in higher percentage (66.67%), and the majority of patients’ age between 51-60 years old (30.77%). The use of CHOP and R-CHOP regiment were 76.92% and 20,52% respectively.Conclusion: Most of the patients had a complete response. The CHOP regiment is more commonly used in patients compared to R-CHOP.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73557206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Effect of Antioxidant Vitamin C and E Administration on Spermatozoa Quality of White Rat (Rattus Norvegicus) Strain Wistar Male Against Allethrin Exposure 抗氧化维生素C和E对褐家鼠Wistar雄性抗乙酰氰菊酯精子质量的影响

Biomolecular and Health Science Journal Pub Date : 2018-11-26 DOI: 10.20473/BHSJ.V1I2.9282

Faisal Yusuf Ashari, R. Yudiwati, R. H. Aswin

{"title":"The Effect of Antioxidant Vitamin C and E Administration on Spermatozoa Quality of White Rat (Rattus Norvegicus) Strain Wistar Male Against Allethrin Exposure","authors":"Faisal Yusuf Ashari, R. Yudiwati, R. H. Aswin","doi":"10.20473/BHSJ.V1I2.9282","DOIUrl":"https://doi.org/10.20473/BHSJ.V1I2.9282","url":null,"abstract":"Introduction: Allethrin is an active ingredient used in anti-mosquito drugs. Allethrin enters the body through inhalation, allegedly can disrupt the quality of spermatozoa by decreasing its amount, motility, viability and morphology. Many studies suggested that with sufficient intake of vitamin C and E would be able to minimize free radicals caused by allethrin. This study aims to investigate the effect of giving antioxidant vitamin C and E on spermatozoa quality of white rat (Rattus norvegicus) strain Wistar male with allethrin exposure.Methods: This research was a post-test design randomized control group design using Rattus novergicus male strains Wistar exposed to allethrin (LPB IPB veterinary stem cell). A total of 16 white rat strains Wistar male divided into 4 groups, one control group (without any treatment) and 3 treatment groups (given antioxidant vitamin C, vitamin E and both). The exposure of mosquito coils was performed 8 hours per day for 45 days and on the 46th day, spermatozoa was observed. The data were analyzed using ANOVA one way and BNT.Results: The results showed that treatment with vitamins affected the amount, motility and viability of rat spermatozoa exposed to allethrin. The mean amount of control group spermatozoa and treatment was 14,93, the mean spermatozoa motility control and treatment groups were 45,13 and the mean spermatozoa viability of control and treatment groups was 58,88. This is shown by the real difference between the control group and the treatment (p <0,05). Similarly, in the control group found morphological abnormalities.Conclusion: Exposure of mosquito coils 8 hours/day for 45 days decreased the spermatozoa quality. Overall, the admission of antioxidant vitamin C and E are able to maintain the quality of spermatozoa instead of one type of vitamin.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85689945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Correlation Between Nutritional Status Of Children Aged 12 – 36 Months And Mother’s Working Status In Taman, Sidoarjo Sidoarjo Taman地区12 - 36个月儿童营养状况与母亲工作状况的相关性

Biomolecular and Health Science Journal Pub Date : 2018-11-26 DOI: 10.20473/BHSJ.V1I2.9266

Nur Annisa Nugraheningtyasari, Ninik Asmaningsih Soemayarso, D. Susanti

{"title":"Correlation Between Nutritional Status Of Children Aged 12 – 36 Months And Mother’s Working Status In Taman, Sidoarjo","authors":"Nur Annisa Nugraheningtyasari, Ninik Asmaningsih Soemayarso, D. Susanti","doi":"10.20473/BHSJ.V1I2.9266","DOIUrl":"https://doi.org/10.20473/BHSJ.V1I2.9266","url":null,"abstract":"Introduction: The correlation between child’s nutritional status and mother’s working status in Indonesia is still unclear. Some research report a high prevalence of low-nourished children whose mother is working, while others report a non significant correlation between child’s nutritional status and mother’s working status.Methods: This study was case-control study, sample of low-nourished children (treatment group) & well-nourished children (control) are taken from 21 Posyandu in Taman, Sidoarjo in 2015. All data were analyzed using Chi Square test.Results: There are 72 samples which are suitable with the inclusion criteria, consisted of 36 low-nourished children and 36 well-nourished children. From 72 samples, 28 children have a working mother and 44 children have a non working mother. There were no correlation between Mother’s working status (p=0,486), Number of children in the family (p=0,468), History of chronic disease (p=0,054) with child’s nutritional status. Level of family income, Mother’s education level, History of exclusive breastfeeding, Energy consumption level, Protein consumption level were correlated with child’s nutritional status with value (p=0,000), (p=0,002), (p=0,002), (p=0,000), (p=0,001) respectively.Conclusion: Mother’s working status is proved that is not correlated with child’s nutritional status. But, level of family income, mother’s education level, energy & protein consumption level, and history of exclusive breastfeeding are significantly correlated with child’s nutritional status.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74783049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Correlation Between Nutritional Status of Pregnant Women Based on Upper Arm Circumference and Preeclampsia/Eclampsia Severity Degree at Jagir Public Health Center During January 2014 - March 2014 2014年1月- 2014年3月Jagir公共卫生中心孕妇上臂围营养状况与子痫前期/子痫严重程度的相关性

Biomolecular and Health Science Journal Pub Date : 2018-11-26 DOI: 10.20473/BHSJ.V1I2.9533

Dian Aprilia, B. Prasetyo, S. Sulistiawati

{"title":"Correlation Between Nutritional Status of Pregnant Women Based on Upper Arm Circumference and Preeclampsia/Eclampsia Severity Degree at Jagir Public Health Center During January 2014 - March 2014","authors":"Dian Aprilia, B. Prasetyo, S. Sulistiawati","doi":"10.20473/BHSJ.V1I2.9533","DOIUrl":"https://doi.org/10.20473/BHSJ.V1I2.9533","url":null,"abstract":"Introduction: Preeclampsia/eclampsia is one of the causes of maternal mortality besides bleeding and infection. The exact etiology of this condition is still unknown. Nutritional status of pregnant women who are overweight can increase the risk. This study aims to determine the correlation between obesity and the severity of preeclampsia/eclampsia through upper arm circumference (UAC) measurement.Methods: This study is a cross-sectional analytic study. Data on preeclampsia/eclampsia and UAC obtained from patient medical records in Jagir Public Health Center Surabaya. Data were analyzed using Chi-square test.Results: Prevalence of mild preeclampsia was greater than severe preeclampsia (87.5% and 12.5%). The majority of patients with mild preeclampsia have normal UAC size (91.3%). Severe preeclampsia found higher in obesity group than normal nutritional status group (22.2% and 9.1%). From Chi-square test analysis, found that p = 0.557.Conclusion: There was no significant correlation between the nutritional status of pregnant women based on UAC measurement of and the severity of preeclampsia/eclampsia.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90098682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Profile of Acute Pharyngitis at Dr. Soetomo General Hospital Pediatric Outpatients Clinic in 2013 2013年Soetomo博士综合医院儿科门诊急性咽炎病例分析

Biomolecular and Health Science Journal Pub Date : 2018-11-26 DOI: 10.20473/BHSJ.V1I2.9495

Amanda Trilana, D. Susanti, Satrio Boediman

引用次数: 2

Bacteria Pattern, Results of Antibiotic Sensitivity Test, and Complications of Deep Neck Abscess Patients in Dr. Soetomo General Hospital 苏东莫综合医院深颈脓肿患者细菌类型、抗生素敏感性试验结果及并发症分析

Biomolecular and Health Science Journal Pub Date : 2018-11-26 DOI: 10.20473/BHSJ.V1I2.9832

Syaiful Rijal, A. Romdhoni

{"title":"Bacteria Pattern, Results of Antibiotic Sensitivity Test, and Complications of Deep Neck Abscess Patients in Dr. Soetomo General Hospital","authors":"Syaiful Rijal, A. Romdhoni","doi":"10.20473/BHSJ.V1I2.9832","DOIUrl":"https://doi.org/10.20473/BHSJ.V1I2.9832","url":null,"abstract":"Introduction: Deep Neck Abscess is the accumulation of pus inside the potential space between the deep neck fasciae. The incidence has decreased dramatically since the antibiotic era. Empirical antibiotics are administered before the sensitivity test results out, so it is important to know the map of bacteria and its resistance.Methods: This study was conducted retrospectively using medical records of patients with deep neck abscess in Dr. Soetomo General Hospital Surabaya during January 2014-December 2017. Data recorded included gender, age, location, results of bacteria culture examination, antibiotic sensitivity test, and complications that occurred. Data is processed descriptively. Results: Of the 162 patients, 102 (62.96%) were males, followed by 60 females (37.04%). The 46-60 years old group has the largest percentage (33.95%). Whereas the most common location of abscess was in the submandibular (42.59%). Pus culture test, most bacteria is Klebsiella pneumonia (13.04%). While the sensitivity test shows that meropenem has the highest sensitivity number (73.58). Most complications were sepsis, in 48 patients (29.63%). Conclusion: Klebsiella pneumonia, Staphylococcus aureus, and Streptococcus anginosus are the most common etiologies in deep neck abscess. Meropenem, cefoperazone-sulbactam, and oxacillin are the most sensitive antibiotics.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84808612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Primary Pulmonary Lymphoma with Superior Vena Cava Syndrome 原发性肺淋巴瘤伴上腔静脉综合征

Biomolecular and Health Science Journal Pub Date : 2018-11-26 DOI: 10.20473/BHSJ.V1I2.9858

A. Rosyid, Resti Yudhawati Meliana

引用次数: 0